Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer

Science

Volumn 348, Issue 6230, 2015, Pages 124-128

  Rizvi, Naiyer A ^a,b,d   Hellmann, Matthew D ^a,b   Snyder, Alexandra ^a,b   Kvistborg, Pia ^c   Makarov, Vladimir ^a   Havel, Jonathan J ^a   Lee, William ^a   Yuan, Jianda ^a   Wong, Phillip ^a   Ho, Teresa S ^a   Miller, Martin L ^a   Rekhtman, Natasha ^a   Moreira, Andre L ^a   Ibrahim, Fawzia ^a   Bruggeman, Cameron ^d   Gasmi, Billel ^a   Zappasodi, Roberta ^a   Maeda, Yuka ^a   Sander, Chris ^a   Garon, Edward B ^e   Merghoub, Taha ^a   Wolchok, Jedd D ^a,b   Schumacher, Ton N ^c   Chan, Timothy A ^a,b   more..

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c NETHERLANDS CANCER INSTITUTE   (Netherlands)

^d Och Spine at New York Presbyterian Hospitals   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PEMBROLIZUMAB; PROGRAMMED DEATH 1 LIGAND 1; PROGRAMMED DEATH 1 RECEPTOR; ANTINEOPLASTIC AGENT; MONOCLONAL ANTIBODY; PDCD1 PROTEIN, HUMAN;

CANCER; DISEASE TREATMENT; DRUG; IMMUNITY; INHIBITOR; MUTATION; SURVIVAL; TUMOR;

ARTICLE; CANCER REGRESSION; CD8+ T LYMPHOCYTE; DNA REPAIR; EXOME; GENE MUTATION; GENE SEQUENCE; HUMAN; NON SMALL CELL LUNG CANCER; PRIORITY JOURNAL; PROGRESSION FREE SURVIVAL; TREATMENT RESPONSE; ANTAGONISTS AND INHIBITORS; CARCINOMA, NON-SMALL-CELL LUNG; COHORT ANALYSIS; DISEASE FREE SURVIVAL; DRUG RESISTANCE; GENETICS; IMMUNOLOGY; LUNG NEOPLASMS; MUTATION; SMOKING;

ANTIBODIES, MONOCLONAL, HUMANIZED; ANTINEOPLASTIC AGENTS; CARCINOMA, NON-SMALL-CELL LUNG; CD8-POSITIVE T-LYMPHOCYTES; COHORT STUDIES; DISEASE-FREE SURVIVAL; DNA REPAIR; DRUG RESISTANCE, NEOPLASM; HUMANS; LUNG NEOPLASMS; MUTATION; PROGRAMMED CELL DEATH 1 RECEPTOR; SMOKING;

EID: 84928761118     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aaa1348     Document Type: Article

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