-
1
-
-
18244379872
-
Homeodomain-interacting protein kinase-2 phosphorylates p53 at ser 46 and mediates apoptosis
-
D'Orazi G, Cecchinelli B, Bruno T, Manni I, Higashimoto Y, Saito S et al. Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis. Nat Cell Biol 2002; 4: 11-19.
-
(2002)
Nat Cell Biol
, vol.4
, pp. 11-19
-
-
D'Orazi, G.1
Cecchinelli, B.2
Bruno, T.3
Manni, I.4
Higashimoto, Y.5
Saito, S.6
-
2
-
-
33748372107
-
Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation
-
Aikawa Y, Nguyen LA, Isono K, Takakura N, Tagata Y, Schmitz ML et al. Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation. EMBO J 2006; 25: 3955-3965.
-
(2006)
EMBO J
, vol.25
, pp. 3955-3965
-
-
Aikawa, Y.1
Nguyen, L.A.2
Isono, K.3
Takakura, N.4
Tagata, Y.5
Schmitz, M.L.6
-
3
-
-
33645238760
-
Overlapping roles for homeodomain-interacting protein kinases hipk1 and hipk2 in the mediation of cell growth in response to morphogenetic and genotoxic signals
-
Isono K, Nemoto K, Li Y, Takada Y, Suzuki R, Katsuki M et al. Overlapping roles for homeodomain-interacting protein kinases hipk1 and hipk2 in the mediation of cell growth in response to morphogenetic and genotoxic signals. Mol Cell Biol 2006; 26: 2758-2771.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 2758-2771
-
-
Isono, K.1
Nemoto, K.2
Li, Y.3
Takada, Y.4
Suzuki, R.5
Katsuki, M.6
-
4
-
-
34548740091
-
HIPK2 represses beta-cateninmediated transcription, epidermal stem cell expansion, and skin tumorigenesis
-
Wei G, Ku S, Ma GK, Saito S, Tang AA, Zhang J et al. HIPK2 represses beta-cateninmediated transcription, epidermal stem cell expansion, and skin tumorigenesis. Proc Natl Acad Sci USA 2007; 104: 13040-13045.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 13040-13045
-
-
Wei, G.1
Ku, S.2
Ma, G.K.3
Saito, S.4
Tang, A.A.5
Zhang, J.6
-
5
-
-
65349105355
-
HIPK2 is involved in cell proliferation and its suppression promotes growth arrest independently of DNA damage
-
Iacovelli S, Ciuffini L, Lazzari C, Bracaglia G, Rinaldo C, Prodosmo A et al. HIPK2 is involved in cell proliferation and its suppression promotes growth arrest independently of DNA damage. Cell Prolif 2009; 42: 373-384.
-
(2009)
Cell Prolif
, vol.42
, pp. 373-384
-
-
Iacovelli, S.1
Ciuffini, L.2
Lazzari, C.3
Bracaglia, G.4
Rinaldo, C.5
Prodosmo, A.6
-
6
-
-
84878870624
-
Homeodomaininteracting protein kinase 2-dependent repression of myogenic differentiation is relieved by its caspase-mediated cleavage
-
de la Vega L, Hornung J, Kremmer E, Milanovic M, Schmitz ML. Homeodomaininteracting protein kinase 2-dependent repression of myogenic differentiation is relieved by its caspase-mediated cleavage. Nucleic Acids Res 2013; 41: 5731-5745.
-
(2013)
Nucleic Acids Res
, vol.41
, pp. 5731-5745
-
-
De La Vega, L.1
Hornung, J.2
Kremmer, E.3
Milanovic, M.4
Schmitz, M.L.5
-
7
-
-
84901020401
-
Identification of Hipk2 as an essential regulator of white fat development
-
Sjolund J, Pelorosso FG, Quigley DA, DelRosario R, Balmain A. Identification of Hipk2 as an essential regulator of white fat development. Proc Natl Acad Sci U S A 2014; 111: 7373-7378.
-
(2014)
Proc Natl Acad Sci U S A
, vol.111
, pp. 7373-7378
-
-
Sjolund, J.1
Pelorosso, F.G.2
Quigley, D.A.3
DelRosario, R.4
Balmain, A.5
-
8
-
-
33947273628
-
Homeodomain-interacting protein kinase 2 is the ionizing radiation-activated p53 serine 46 kinase and is regulated by ATM
-
Dauth I, Kruger J, Hofmann TG. Homeodomain-interacting protein kinase 2 is the ionizing radiation-activated p53 serine 46 kinase and is regulated by ATM. Cancer Res 2007; 67: 2274-2279.
-
(2007)
Cancer Res
, vol.67
, pp. 2274-2279
-
-
Dauth, I.1
Kruger, J.2
Hofmann, T.G.3
-
9
-
-
58149354210
-
An inducible autoregulatory loop between HIPK2 and Siah2 at the apex of the hypoxic response
-
Calzado MA, de la Vega L, Moller A, Bowtell DD, Schmitz ML. An inducible autoregulatory loop between HIPK2 and Siah2 at the apex of the hypoxic response. Nat Cell Biol 2009; 11: 85-91.
-
(2009)
Nat Cell Biol
, vol.11
, pp. 85-91
-
-
Calzado, M.A.1
De La Vega, L.2
Moller, A.3
Bowtell, D.D.4
Schmitz, M.L.5
-
10
-
-
84861452914
-
A redoxregulated SUMO/acetylation switch of HIPK2 controls the survival threshold to oxidative stress
-
de la Vega L, Grishina I, Moreno R, Kruger M, Braun T, Schmitz ML. A redoxregulated SUMO/acetylation switch of HIPK2 controls the survival threshold to oxidative stress. Mol Cell 2012; 46: 472-483.
-
(2012)
Mol Cell
, vol.46
, pp. 472-483
-
-
De La Vega, L.1
Grishina, I.2
Moreno, R.3
Kruger, M.4
Braun, T.5
Schmitz, M.L.6
-
11
-
-
84879379203
-
Glucose restriction induces cell death in parental but not in homeodomain-interacting protein kinase 2-depleted RKO colon cancer cells: Molecular mechanisms and implications for tumor therapy
-
Garufi A, Ricci A, Trisciuoglio D, Iorio E, Carpinelli G, Pistritto G et al. Glucose restriction induces cell death in parental but not in homeodomain-interacting protein kinase 2-depleted RKO colon cancer cells: molecular mechanisms and implications for tumor therapy. Cell Death Dis 2013; 4: e639.
-
(2013)
Cell Death Dis
, vol.4
, pp. e639
-
-
Garufi, A.1
Ricci, A.2
Trisciuoglio, D.3
Iorio, E.4
Carpinelli, G.5
Pistritto, G.6
-
12
-
-
1542317686
-
US11 of herpes simplex virus type 1 interacts with HIPK2 and antagonizes HIPK2-induced cell growth arrest
-
Giraud S, Diaz-Latoud C, Hacot S, Textoris J, Bourette RP, Diaz JJ. US11 of herpes simplex virus type 1 interacts with HIPK2 and antagonizes HIPK2-induced cell growth arrest. J Virol 2004; 78: 2984-2993.
-
(2004)
J Virol
, vol.78
, pp. 2984-2993
-
-
Giraud, S.1
Diaz-Latoud, C.2
Hacot, S.3
Textoris, J.4
Bourette, R.P.5
Diaz, J.J.6
-
13
-
-
23844433285
-
Regulation of homeodomaininteracting protein kinase 2 (HIPK2) effector function through dynamic small ubiquitin-related modifier-1 (SUMO-1) modification
-
Hofmann TG, Jaffray E, Stollberg N, Hay RT, Will H. Regulation of homeodomaininteracting protein kinase 2 (HIPK2) effector function through dynamic small ubiquitin-related modifier-1 (SUMO-1) modification. J Biol Chem 2005; 280: 29224-29232.
-
(2005)
J Biol Chem
, vol.280
, pp. 29224-29232
-
-
Hofmann, T.G.1
Jaffray, E.2
Stollberg, N.3
Hay, R.T.4
Will, H.5
-
14
-
-
33847365838
-
MDM2- regulated degradation of HIPK2 prevents p53Ser46 phosphorylation and DNA damage-induced apoptosis
-
Rinaldo C, Prodosmo A, Mancini F, Iacovelli S, Sacchi A, Moretti F et al. MDM2- regulated degradation of HIPK2 prevents p53Ser46 phosphorylation and DNA damage-induced apoptosis. Mol Cell 2007; 25: 739-750.
-
(2007)
Mol Cell
, vol.25
, pp. 739-750
-
-
Rinaldo, C.1
Prodosmo, A.2
Mancini, F.3
Iacovelli, S.4
Sacchi, A.5
Moretti, F.6
-
15
-
-
78650957031
-
Control of nuclear HIPK2 localization and function by a SUMO interaction motif
-
de la Vega L, Frobius K, Moreno R, Calzado MA, Geng H, Schmitz ML. Control of nuclear HIPK2 localization and function by a SUMO interaction motif. Biochim Biophys Acta 2011; 1813: 283-297.
-
(2011)
Biochim Biophys Acta
, vol.1813
, pp. 283-297
-
-
De La Vega, L.1
Frobius, K.2
Moreno, R.3
Calzado, M.A.4
Geng, H.5
Schmitz, M.L.6
-
16
-
-
84874332563
-
HIPK2 kinase activity depends on cis-autophosphorylation of its activation loop
-
Saul VV, de la Vega L, Milanovic M, Kruger M, Braun T, Fritz-Wolf K et al. HIPK2 kinase activity depends on cis-autophosphorylation of its activation loop. J Mol Cell Biol 2013; 5: 27-38.
-
(2013)
J Mol Cell Biol
, vol.5
, pp. 27-38
-
-
Saul, V.V.1
De La Vega, L.2
Milanovic, M.3
Kruger, M.4
Braun, T.5
Fritz-Wolf, K.6
-
17
-
-
84881558218
-
WIP1, a homeostatic regulator of the DNA damage response, is targeted by HIPK2 for phosphorylation and degradation
-
Choi DW, Na W, Kabir MH, Yi E, Kwon S, Yeom J et al. WIP1, a homeostatic regulator of the DNA damage response, is targeted by HIPK2 for phosphorylation and degradation. Mol Cell 2013; 51: 374-385.
-
(2013)
Mol Cell
, vol.51
, pp. 374-385
-
-
Choi, D.W.1
Na, W.2
Kabir, M.H.3
Yi, E.4
Kwon, S.5
Yeom, J.6
-
18
-
-
33646589651
-
Autoregulatory control of the p53 response by caspase-mediated processing of HIPK2
-
Gresko E, Roscic A, Ritterhoff S, Vichalkovski A, del Sal G, Schmitz ML. Autoregulatory control of the p53 response by caspase-mediated processing of HIPK2. EMBO J 2006; 25: 1883-1894.
-
(2006)
EMBO J
, vol.25
, pp. 1883-1894
-
-
Gresko, E.1
Roscic, A.2
Ritterhoff, S.3
Vichalkovski, A.4
Del Sal, G.5
Schmitz, M.L.6
-
19
-
-
84859589441
-
A systems approach identifies HIPK2 as a key regulator of kidney fibrosis
-
Jin Y, Ratnam K, Chuang PY, Fan Y, Zhong Y, Dai Y et al. A systems approach identifies HIPK2 as a key regulator of kidney fibrosis. Nat Med 2012; 18: 580-588.
-
(2012)
Nat Med
, vol.18
, pp. 580-588
-
-
Jin, Y.1
Ratnam, K.2
Chuang, P.Y.3
Fan, Y.4
Zhong, Y.5
Dai, Y.6
-
20
-
-
46449125390
-
Control of HIPK2 stability by ubiquitin ligase Siah-1 and checkpoint kinases ATM and ATR
-
Winter M, Sombroek D, Dauth I, Moehlenbrink J, Scheuermann K, Crone J et al. Control of HIPK2 stability by ubiquitin ligase Siah-1 and checkpoint kinases ATM and ATR. Nat Cell Biol 2008; 10: 812-824.
-
(2008)
Nat Cell Biol
, vol.10
, pp. 812-824
-
-
Winter, M.1
Sombroek, D.2
Dauth, I.3
Moehlenbrink, J.4
Scheuermann, K.5
Crone, J.6
-
21
-
-
0036141392
-
Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2
-
Hofmann TG, Moller A, Sirma H, Zentgraf H, Taya Y, Droge W et al. Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2. Nat Cell Biol 2002; 4: 1-10.
-
(2002)
Nat Cell Biol
, vol.4
, pp. 1-10
-
-
Hofmann, T.G.1
Moller, A.2
Sirma, H.3
Zentgraf, H.4
Taya, Y.5
Droge, W.6
-
22
-
-
84933053342
-
Homeodomaininteracting protein kinase 2 regulates DNA damage response through interacting with heterochromatin protein 1gamma
-
Akaike Y, Kuwano Y, Nishida K, Kurokawa K, Kajita K, Kano S et al. Homeodomaininteracting protein kinase 2 regulates DNA damage response through interacting with heterochromatin protein 1gamma. Oncogene 2015; 34: 3463-3473.
-
(2015)
Oncogene
, vol.34
, pp. 3463-3473
-
-
Akaike, Y.1
Kuwano, Y.2
Nishida, K.3
Kurokawa, K.4
Kajita, K.5
Kano, S.6
-
23
-
-
44849135825
-
Expression of HIPK2 in cervical cancer: Correlation with clinicopathology and prognosis
-
Al-Beiti MA, Lu X. Expression of HIPK2 in cervical cancer: correlation with clinicopathology and prognosis. Aust N Z J Obstet Gynaecol 2008; 48: 329-336.
-
(2008)
Aust N Z J Obstet Gynaecol
, vol.48
, pp. 329-336
-
-
Al-Beiti, M.A.1
Lu, X.2
-
24
-
-
84978985708
-
Microarray expression data identify DCC as a candidate gene for early meningioma progression
-
Schulten HJ, Hussein D, Al-Adwani F, Karim S, Al-Maghrabi J, Al-Sharif M et al. Microarray expression data identify DCC as a candidate gene for early meningioma progression. PLoS One 2016; 11: e0153681.
-
(2016)
PLoS One
, vol.11
, pp. e0153681
-
-
Schulten, H.J.1
Hussein, D.2
Al-Adwani, F.3
Karim, S.4
Al-Maghrabi, J.5
Al-Sharif, M.6
-
25
-
-
49149087048
-
High-resolution, dual-platform aCGH analysis reveals frequent HIPK2 amplification and increased expression in pilocytic astrocytomas
-
Deshmukh H, Yeh TH, Yu J, Sharma MK, Perry A, Leonard JR et al. High-resolution, dual-platform aCGH analysis reveals frequent HIPK2 amplification and increased expression in pilocytic astrocytomas. Oncogene 2008; 27: 4745-4751.
-
(2008)
Oncogene
, vol.27
, pp. 4745-4751
-
-
Deshmukh, H.1
Yeh, T.H.2
Yu, J.3
Sharma, M.K.4
Perry, A.5
Leonard, J.R.6
-
26
-
-
84876008551
-
A genome-wide RNA interference screen identifies new regulators of androgen receptor function in prostate cancer cells
-
Imberg-Kazdan K, Ha S, Greenfield A, Poultney CS, Bonneau R, Logan SK et al. A genome-wide RNA interference screen identifies new regulators of androgen receptor function in prostate cancer cells. Genome Res 2013; 23: 581-591.
-
(2013)
Genome Res
, vol.23
, pp. 581-591
-
-
Imberg-Kazdan, K.1
Ha, S.2
Greenfield, A.3
Poultney, C.S.4
Bonneau, R.5
Logan, S.K.6
-
27
-
-
84927741187
-
Kinome-wide screening of HER2+ breast cancer cells for molecules that mediate cell proliferation or sensitize cells to trastuzumab therapy
-
Lapin V, Shirdel EA, Wei X, Mason JM, Jurisica I, Mak TW. Kinome-wide screening of HER2+ breast cancer cells for molecules that mediate cell proliferation or sensitize cells to trastuzumab therapy. Oncogenesis 2014; 3: e133.
-
(2014)
Oncogenesis
, vol.3
, pp. e133
-
-
Lapin, V.1
Shirdel, E.A.2
Wei, X.3
Mason, J.M.4
Jurisica, I.5
Mak, T.W.6
-
28
-
-
0031577292
-
An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements
-
Itoh K, Chiba T, Takahashi S, Ishii T, Igarashi K, Katoh Y et al. An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. Biochem Biophys Res Commun 1997; 236: 313-322.
-
(1997)
Biochem Biophys Res Commun
, vol.236
, pp. 313-322
-
-
Itoh, K.1
Chiba, T.2
Takahashi, S.3
Ishii, T.4
Igarashi, K.5
Katoh, Y.6
-
29
-
-
0037763721
-
Regulatory mechanisms controlling gene expression mediated by the antioxidant response element
-
Nguyen T, Sherratt PJ, Pickett CB. Regulatory mechanisms controlling gene expression mediated by the antioxidant response element. Annu Rev Pharmacol Toxicol 2003; 43: 233-260.
-
(2003)
Annu Rev Pharmacol Toxicol
, vol.43
, pp. 233-260
-
-
Nguyen, T.1
Sherratt, P.J.2
Pickett, C.B.3
-
30
-
-
0032953192
-
Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
-
Itoh K, Wakabayashi N, Katoh Y, Ishii T, Igarashi K, Engel JD et al. Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. Genes Dev 1999; 13: 76-86.
-
(1999)
Genes Dev
, vol.13
, pp. 76-86
-
-
Itoh, K.1
Wakabayashi, N.2
Katoh, Y.3
Ishii, T.4
Igarashi, K.5
Engel, J.D.6
-
31
-
-
0037821802
-
Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression
-
McMahon M, Itoh K, Yamamoto M, Hayes JD. Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression. J Biol Chem 2003; 278: 21592-21600.
-
(2003)
J Biol Chem
, vol.278
, pp. 21592-21600
-
-
McMahon, M.1
Itoh, K.2
Yamamoto, M.3
Hayes, J.D.4
-
32
-
-
1942455887
-
Molecular mechanism activating Nrf2-Keap1 pathway in regulation of adaptive response to electrophiles
-
Itoh K, Tong KI, Yamamoto M. Molecular mechanism activating Nrf2-Keap1 pathway in regulation of adaptive response to electrophiles. Free Radic Biol Med 2004; 36: 1208-1213.
-
(2004)
Free Radic Biol Med
, vol.36
, pp. 1208-1213
-
-
Itoh, K.1
Tong, K.I.2
Yamamoto, M.3
-
33
-
-
37549032763
-
An auto-regulatory loop between stress sensors INrf2 and Nrf2 controls their cellular abundance
-
Lee OH, Jain AK, Papusha V, Jaiswal AK. An auto-regulatory loop between stress sensors INrf2 and Nrf2 controls their cellular abundance. J Biol Chem 2007; 282: 36412-36420.
-
(2007)
J Biol Chem
, vol.282
, pp. 36412-36420
-
-
Lee, O.H.1
Jain, A.K.2
Papusha, V.3
Jaiswal, A.K.4
-
34
-
-
84880038672
-
Feedback loop between p66 (Shc) and Nrf2 promotes lung cancer progression
-
Du W, Jiang Y, Zheng Z, Zhang Z, Chen N, Ma Z et al. Feedback loop between p66 (Shc) and Nrf2 promotes lung cancer progression. Cancer Lett 2013; 337: 58-65.
-
(2013)
Cancer Lett
, vol.337
, pp. 58-65
-
-
Du, W.1
Jiang, Y.2
Zheng, Z.3
Zhang, Z.4
Chen, N.5
Ma, Z.6
-
35
-
-
77954599053
-
P62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription
-
Jain A, Lamark T, Sjottem E, Larsen KB, Awuh JA, Overvatn A et al. p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription. J Biol Chem 2010; 285: 22576-22591.
-
(2010)
J Biol Chem
, vol.285
, pp. 22576-22591
-
-
Jain, A.1
Lamark, T.2
Sjottem, E.3
Larsen, K.B.4
Awuh, J.A.5
Overvatn, A.6
-
37
-
-
66149168685
-
Nrf2 enhances cell proliferation and resistance to anticancer drugs in human lung cancer
-
Homma S, Ishii Y, Morishima Y, Yamadori T, Matsuno Y, Haraguchi N et al. Nrf2 enhances cell proliferation and resistance to anticancer drugs in human lung cancer. Clin Cancer Res 2009; 15: 3423-3432.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 3423-3432
-
-
Homma, S.1
Ishii, Y.2
Morishima, Y.3
Yamadori, T.4
Matsuno, Y.5
Haraguchi, N.6
-
38
-
-
76749106638
-
Oncogenic NRF2 mutations in squamous cell carcinomas of oesophagus and skin
-
Kim YR, Oh JE, Kim MS, Kang MR, Park SW, Han JY et al. Oncogenic NRF2 mutations in squamous cell carcinomas of oesophagus and skin. J Pathol 2010; 220: 446-451.
-
(2010)
J Pathol
, vol.220
, pp. 446-451
-
-
Kim, Y.R.1
Oh, J.E.2
Kim, M.S.3
Kang, M.R.4
Park, S.W.5
Han, J.Y.6
-
39
-
-
40449107193
-
Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth
-
Ohta T, Iijima K, Miyamoto M, Nakahara I, Tanaka H, Ohtsuji M et al. Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth. Cancer Res 2008; 68: 1303-1309.
-
(2008)
Cancer Res
, vol.68
, pp. 1303-1309
-
-
Ohta, T.1
Iijima, K.2
Miyamoto, M.3
Nakahara, I.4
Tanaka, H.5
Ohtsuji, M.6
-
40
-
-
84863764614
-
Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming
-
Mitsuishi Y, Taguchi K, Kawatani Y, Shibata T, Nukiwa T, Aburatani H et al. Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming. Cancer Cell 2012; 22: 66-79.
-
(2012)
Cancer Cell
, vol.22
, pp. 66-79
-
-
Mitsuishi, Y.1
Taguchi, K.2
Kawatani, Y.3
Shibata, T.4
Nukiwa, T.5
Aburatani, H.6
-
41
-
-
84892833777
-
Discovery and saturation analysis of cancer genes across 21 tumour types
-
Lawrence MS, Stojanov P, Mermel CH, Robinson JT, Garraway LA, Golub TR et al. Discovery and saturation analysis of cancer genes across 21 tumour types. Nature 2014; 505: 495-501.
-
(2014)
Nature
, vol.505
, pp. 495-501
-
-
Lawrence, M.S.1
Stojanov, P.2
Mermel, C.H.3
Robinson, J.T.4
Garraway, L.A.5
Golub, T.R.6
-
42
-
-
53049105119
-
Genetic alteration of Keap1 confers constitutive Nrf2 activation and resistance to chemotherapy in gallbladder cancer
-
Shibata T, Kokubu A, Gotoh M, Ojima H, Ohta T, Yamamoto M et al. Genetic alteration of Keap1 confers constitutive Nrf2 activation and resistance to chemotherapy in gallbladder cancer. Gastroenterology 2008; 135: 1358-1368, 1368.e1-4.
-
(2008)
Gastroenterology
, vol.135
, Issue.1358-1368
, pp. 1368e1-1368e4
-
-
Shibata, T.1
Kokubu, A.2
Gotoh, M.3
Ojima, H.4
Ohta, T.5
Yamamoto, M.6
-
43
-
-
77954695549
-
Nrf2 and Keap1 abnormalities in non-small cell lung carcinoma and association with clinicopathologic features
-
Solis LM, Behrens C, Dong W, Suraokar M, Ozburn NC, Moran CA et al. Nrf2 and Keap1 abnormalities in non-small cell lung carcinoma and association with clinicopathologic features. Clin Cancer Res 2010; 16: 3743-3753.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 3743-3753
-
-
Solis, L.M.1
Behrens, C.2
Dong, W.3
Suraokar, M.4
Ozburn, N.C.5
Moran, C.A.6
-
44
-
-
84876136899
-
Genotype analysis of the NRF2 gene mutation in lung cancer
-
Sasaki H, Suzuki A, Shitara M, Hikosaka Y, Okuda K, Moriyama S et al. Genotype analysis of the NRF2 gene mutation in lung cancer. Int J Mol Med 2013; 31: 1135-1138.
-
(2013)
Int J Mol Med
, vol.31
, pp. 1135-1138
-
-
Sasaki, H.1
Suzuki, A.2
Shitara, M.3
Hikosaka, Y.4
Okuda, K.5
Moriyama, S.6
-
45
-
-
79953181992
-
KEAP1 gene mutations and NRF2 activation are common in pulmonary papillary adenocarcinoma
-
Li QK, Singh A, Biswal S, Askin F, Gabrielson E. KEAP1 gene mutations and NRF2 activation are common in pulmonary papillary adenocarcinoma. J Hum Genet 2011; 56: 230-234.
-
(2011)
J Hum Genet
, vol.56
, pp. 230-234
-
-
Li, Q.K.1
Singh, A.2
Biswal, S.3
Askin, F.4
Gabrielson, E.5
-
46
-
-
79960060305
-
Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis
-
DeNicola GM, Karreth FA, Humpton TJ, Gopinathan A, Wei C, Frese K et al. Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis. Nature 2011; 475: 106-109.
-
(2011)
Nature
, vol.475
, pp. 106-109
-
-
DeNicola, G.M.1
Karreth, F.A.2
Humpton, T.J.3
Gopinathan, A.4
Wei, C.5
Frese, K.6
-
47
-
-
84907929068
-
The PTEN/NRF2 axis promotes human carcinogenesis
-
Rojo AI, Rada P, Mendiola M, Ortega-Molina A, Wojdyla K, Rogowska-Wrzesinska A et al. The PTEN/NRF2 axis promotes human carcinogenesis. Antioxid Redox Signal 2014; 21: 2498-2514.
-
(2014)
Antioxid Redox Signal
, vol.21
, pp. 2498-2514
-
-
Rojo, A.I.1
Rada, P.2
Mendiola, M.3
Ortega-Molina, A.4
Wojdyla, K.5
Rogowska-Wrzesinska, A.6
-
48
-
-
77951938173
-
Nox1 is involved in p53 deacetylation and suppression of its transcriptional activity and apoptosis
-
Puca R, Nardinocchi L, Starace G, Rechavi G, Sacchi A, Givol D et al. Nox1 is involved in p53 deacetylation and suppression of its transcriptional activity and apoptosis. Free Radic Biol Med 2010; 48: 1338-1346.
-
(2010)
Free Radic Biol Med
, vol.48
, pp. 1338-1346
-
-
Puca, R.1
Nardinocchi, L.2
Starace, G.3
Rechavi, G.4
Sacchi, A.5
Givol, D.6
-
49
-
-
78649726635
-
Transcriptional regulation of ferritin and antioxidant genes by HIPK2 under genotoxic stress
-
Hailemariam K, Iwasaki K, Huang BW, Sakamoto K, Tsuji Y. Transcriptional regulation of ferritin and antioxidant genes by HIPK2 under genotoxic stress. J Cell Sci 2010; 123: 3863-3871.
-
(2010)
J Cell Sci
, vol.123
, pp. 3863-3871
-
-
Hailemariam, K.1
Iwasaki, K.2
Huang, B.W.3
Sakamoto, K.4
Tsuji, Y.5
-
50
-
-
33750885385
-
Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer
-
Singh A, Misra V, Thimmulappa RK, Lee H, Ames S, Hoque MO et al. Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer. PLoS Med 2006; 3: e420.
-
(2006)
PLoS Med
, vol.3
, pp. e420
-
-
Singh, A.1
Misra, V.2
Thimmulappa, R.K.3
Lee, H.4
Ames, S.5
Hoque, M.O.6
-
51
-
-
51649130168
-
Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy
-
Shibata T, Ohta T, Tong KI, Kokubu A, Odogawa R, Tsuta K et al. Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy. Proc Natl Acad Sci USA 2008; 105: 13568-13573.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 13568-13573
-
-
Shibata, T.1
Ohta, T.2
Tong, K.I.3
Kokubu, A.4
Odogawa, R.5
Tsuta, K.6
-
52
-
-
77957237159
-
Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis
-
Malhotra D, Portales-Casamar E, Singh A, Srivastava S, Arenillas D, Happel C et al. Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis. Nucleic Acids Res 2010; 38: 5718-5734.
-
(2010)
Nucleic Acids Res
, vol.38
, pp. 5718-5734
-
-
Malhotra, D.1
Portales-Casamar, E.2
Singh, A.3
Srivastava, S.4
Arenillas, D.5
Happel, C.6
-
53
-
-
0034646646
-
Cyclopentenone prostaglandins as potential inducers of phase II detoxification enzymes 15-deoxy-delta (12-14)-prostaglandin j2-induced expression of glutathione S-transferases
-
Kawamoto Y, Nakamura Y, Naito Y, Torii Y, Kumagai T, Osawa T et al. Cyclopentenone prostaglandins as potential inducers of phase II detoxification enzymes. 15-deoxy-delta(12,14)-prostaglandin j2-induced expression of glutathione S-transferases. J Biol Chem 2000; 275: 11291-11299.
-
(2000)
J Biol Chem
, vol.275
, pp. 11291-11299
-
-
Kawamoto, Y.1
Nakamura, Y.2
Naito, Y.3
Torii, Y.4
Kumagai, T.5
Osawa, T.6
-
54
-
-
79952811165
-
Tricyclic compounds containing nonenolizable cyano enones. A novel class of highly potent anti-inflammatory and cytoprotective agents
-
Honda T, Yoshizawa H, Sundararajan C, David E, Lajoie MJ, Favaloro FG Jr. et al. Tricyclic compounds containing nonenolizable cyano enones. A novel class of highly potent anti-inflammatory and cytoprotective agents. J Med Chem 2011; 54: 1762-1778.
-
(2011)
J Med Chem
, vol.54
, pp. 1762-1778
-
-
Honda, T.1
Yoshizawa, H.2
Sundararajan, C.3
David, E.4
Lajoie, M.J.5
Favaloro, F.G.6
-
55
-
-
84866445766
-
Highly potent activation of Nrf2 by topical tricyclic bis(cyano enone): Implications for protection against UV radiation during thiopurine therapy
-
Kalra S, Knatko EV, Zhang Y, Honda T, Yamamoto M, Dinkova-Kostova AT. Highly potent activation of Nrf2 by topical tricyclic bis(cyano enone): implications for protection against UV radiation during thiopurine therapy. Cancer Prev Res (Phila) 2012; 5: 973-981.
-
(2012)
Cancer Prev Res (Phila)
, vol.5
, pp. 973-981
-
-
Kalra, S.1
Knatko, E.V.2
Zhang, Y.3
Honda, T.4
Yamamoto, M.5
Dinkova-Kostova, A.T.6
-
56
-
-
70349978982
-
1-Cyano-2,3-epithiopropane is a novel plant-derived chemopreventive agent which induces cytoprotective genes that afford resistance against the genotoxic alpha, beta-unsaturated aldehyde acrolein
-
Kelleher MO, McMahon M, Eggleston IM, Dixon MJ, Taguchi K, Yamamoto M et al. 1-Cyano-2,3-epithiopropane is a novel plant-derived chemopreventive agent which induces cytoprotective genes that afford resistance against the genotoxic alpha, beta-unsaturated aldehyde acrolein. Carcinogenesis 2009; 30: 1754-1762.
-
(2009)
Carcinogenesis
, vol.30
, pp. 1754-1762
-
-
Kelleher, M.O.1
McMahon, M.2
Eggleston, I.M.3
Dixon, M.J.4
Taguchi, K.5
Yamamoto, M.6
-
57
-
-
84919608289
-
Identification of a functional antioxidant response element within the eighth intron of the human ABCC3 gene
-
Canet MJ, Merrell MD, Harder BG, Maher JM, Wu T, Lickteig AJ et al. Identification of a functional antioxidant response element within the eighth intron of the human ABCC3 gene. Drug Metab Dispos 2015; 43: 93-99.
-
(2015)
Drug Metab Dispos
, vol.43
, pp. 93-99
-
-
Canet, M.J.1
Merrell, M.D.2
Harder, B.G.3
Maher, J.M.4
Wu, T.5
Lickteig, A.J.6
-
58
-
-
84876961787
-
Transcriptional corepressors HIPK1 and HIPK2 control angiogenesis via TGF-beta-TAK1- dependent mechanism
-
Shang Y, Doan CN, Arnold TD, Lee S, Tang AA, Reichardt LF et al. Transcriptional corepressors HIPK1 and HIPK2 control angiogenesis via TGF-beta-TAK1- dependent mechanism. PLoS Biol 2013; 11: e1001527.
-
(2013)
PLoS Biol
, vol.11
, pp. e1001527
-
-
Shang, Y.1
Doan, C.N.2
Arnold, T.D.3
Lee, S.4
Tang, A.A.5
Reichardt, L.F.6
-
59
-
-
84955557574
-
Homeodomaininteracting protein kinase (HPK-1) regulates stress responses and ageing in C. Elegans
-
Berber S, Wood M, Llamosas E, Thaivalappil P, Lee K, Liao BM et al. Homeodomaininteracting protein kinase (HPK-1) regulates stress responses and ageing in C. elegans. Sci Rep 2016; 6: 19582.
-
(2016)
Sci Rep
, vol.6
, pp. 19582
-
-
Berber, S.1
Wood, M.2
Llamosas, E.3
Thaivalappil, P.4
Lee, K.5
Liao, B.M.6
-
60
-
-
84880048347
-
Nrf2 prevents initiation but accelerates progression through the Kras signaling pathway during lung carcinogenesis
-
Satoh H, Moriguchi T, Takai J, Ebina M, Yamamoto M. Nrf2 prevents initiation but accelerates progression through the Kras signaling pathway during lung carcinogenesis. Cancer Res 2013; 73: 4158-4168.
-
(2013)
Cancer Res
, vol.73
, pp. 4158-4168
-
-
Satoh, H.1
Moriguchi, T.2
Takai, J.3
Ebina, M.4
Yamamoto, M.5
-
61
-
-
84982168624
-
Tumor suppressor HIPK2 regulates malignant growth via phosphorylation of Notch1
-
Ann EJ, Kim MY, Yoon JH, Ahn JS, Jo EH, Lee HJ et al. Tumor suppressor HIPK2 regulates malignant growth via phosphorylation of Notch1. Cancer Res 2016; 76: 4728-4740.
-
(2016)
Cancer Res
, vol.76
, pp. 4728-4740
-
-
Ann, E.J.1
Kim, M.Y.2
Yoon, J.H.3
Ahn, J.S.4
Jo, E.H.5
Lee, H.J.6
-
62
-
-
50849104230
-
Notch tumor suppressor function
-
Dotto GP. Notch tumor suppressor function. Oncogene 2008; 27: 5115-5123.
-
(2008)
Oncogene
, vol.27
, pp. 5115-5123
-
-
Dotto, G.P.1
-
63
-
-
84959134029
-
A tumor suppressor function for Notch signaling in forebrain tumor subtypes
-
Giachino C, Boulay JL, Ivanek R, Alvarado A, Tostado C, Lugert S et al. A tumor suppressor function for Notch signaling in forebrain tumor subtypes. Cancer Cell 2015; 28: 730-742.
-
(2015)
Cancer Cell
, vol.28
, pp. 730-742
-
-
Giachino, C.1
Boulay, J.L.2
Ivanek, R.3
Alvarado, A.4
Tostado, C.5
Lugert, S.6
-
64
-
-
84901837657
-
Notch signaling: Switching an oncogene to a tumor suppressor
-
Lobry C, Oh P, Mansour MR, Look AT, Aifantis I. Notch signaling: switching an oncogene to a tumor suppressor. Blood 2014; 123: 2451-2459.
-
(2014)
Blood
, vol.123
, pp. 2451-2459
-
-
Lobry, C.1
Oh, P.2
Mansour, M.R.3
Look, A.T.4
Aifantis, I.5
-
65
-
-
0142259346
-
The role of Notch in tumorigenesis: Oncogene or tumour suppressor?
-
Radtke F, Raj K. The role of Notch in tumorigenesis: oncogene or tumour suppressor? Nat Rev Cancer 2003; 3: 756-767.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 756-767
-
-
Radtke, F.1
Raj, K.2
-
66
-
-
84907833439
-
Improved genome editing in human cell lines using the CRISPR method
-
Munoz IM, Szyniarowski P, Toth R, Rouse J, Lachaud C. Improved genome editing in human cell lines using the CRISPR method. PLoS ONE 2014; 9: e109752.
-
(2014)
PLoS ONE
, vol.9
, pp. e109752
-
-
Munoz, I.M.1
Szyniarowski, P.2
Toth, R.3
Rouse, J.4
Lachaud, C.5
-
67
-
-
0034651240
-
Chemoprevention of aflatoxin B1 hepatocarcinogenesis by coumarin, a natural benzopyrone that is a potent inducer of aflatoxin B1-aldehyde reductase, the glutathione S-transferase A5 and P1 subunits, and NAD(P)H:quinone oxidoreductase in rat liver
-
Kelly VP, Ellis EM, Manson MM, Chanas SA, Moffat GJ, McLeod R et al. Chemoprevention of aflatoxin B1 hepatocarcinogenesis by coumarin, a natural benzopyrone that is a potent inducer of aflatoxin B1-aldehyde reductase, the glutathione S-transferase A5 and P1 subunits, and NAD(P)H:quinone oxidoreductase in rat liver. Cancer Res 2000; 60: 957-969.
-
(2000)
Cancer Res
, vol.60
, pp. 957-969
-
-
Kelly, V.P.1
Ellis, E.M.2
Manson, M.M.3
Chanas, S.A.4
Moffat, G.J.5
McLeod, R.6
-
69
-
-
84866283856
-
Structural and functional characterization of Nrf2 degradation by the glycogen synthase kinase 3/beta-TrCP axis
-
Rada P, Rojo AI, Evrard-Todeschi N, Innamorato NG, Cotte A, Jaworski T et al. Structural and functional characterization of Nrf2 degradation by the glycogen synthase kinase 3/beta-TrCP axis. Mol Cell Biol 2012; 32: 3486-3499.
-
(2012)
Mol Cell Biol
, vol.32
, pp. 3486-3499
-
-
Rada, P.1
Rojo, A.I.2
Evrard-Todeschi, N.3
Innamorato, N.G.4
Cotte, A.5
Jaworski, T.6
-
70
-
-
34248593492
-
Molecular mechanism of human Nrf2 activation and degradation: Role of sequential phosphorylation by protein kinase CK2
-
Pi J, Bai Y, Reece JM, Williams J, Liu D, Freeman ML et al. Molecular mechanism of human Nrf2 activation and degradation: role of sequential phosphorylation by protein kinase CK2. Free Radic Biol Med 2007; 42: 1797-1806.
-
(2007)
Free Radic Biol Med
, vol.42
, pp. 1797-1806
-
-
Pi, J.1
Bai, Y.2
Reece, J.M.3
Williams, J.4
Liu, D.5
Freeman, M.L.6
-
71
-
-
84867317004
-
Identification of novel NRF2-regulated genes by ChIP-Seq: Influence on retinoid X receptor alpha
-
Chorley BN, Campbell MR, Wang X, Karaca M, Sambandan D, Bangura F et al. Identification of novel NRF2-regulated genes by ChIP-Seq: influence on retinoid X receptor alpha. Nucleic Acids Res 2012; 40: 7416-7429.
-
(2012)
Nucleic Acids Res
, vol.40
, pp. 7416-7429
-
-
Chorley, B.N.1
Campbell, M.R.2
Wang, X.3
Karaca, M.4
Sambandan, D.5
Bangura, F.6
-
72
-
-
84988336071
-
Heat shock factor 1 is a substrate for p38 mitogen-activated protein kinases
-
Dayalan Naidu S, Sutherland C, Zhang Y, Risco A, de la Vega L, Caunt CJ et al. Heat shock factor 1 is a substrate for p38 mitogen-activated protein kinases. Mol Cell Biol 2016; 36: 2403-2417.
-
(2016)
Mol Cell Biol
, vol.36
, pp. 2403-2417
-
-
Dayalan Naidu, S.1
Sutherland, C.2
Zhang, Y.3
Risco, A.4
De La Vega, L.5
Caunt, C.J.6
-
73
-
-
0023930873
-
Direct measurement of NAD(P)H:quinone reductase from cells cultured in microtiter wells: A screening assay for anticarcinogenic enzyme inducers
-
Prochaska HJ, Santamaria AB. Direct measurement of NAD(P)H:quinone reductase from cells cultured in microtiter wells: a screening assay for anticarcinogenic enzyme inducers. Anal Biochem 1988; 169: 328-336.
-
(1988)
Anal Biochem
, vol.169
, pp. 328-336
-
-
Prochaska, H.J.1
Santamaria, A.B.2
-
74
-
-
34547145165
-
G∗Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences
-
Faul F, Erdfelder E, Lang A-G, Buchner A. G∗Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods 2007; 39: 175-191.
-
(2007)
Behav Res Methods
, vol.39
, pp. 175-191
-
-
Faul, F.1
Erdfelder, E.2
Lang, A.-G.3
Buchner, A.4
|