메뉴 건너뛰기




Volumn 25, Issue 9, 2006, Pages 1883-1894

Autoregulatory control of the p53 response by caspase-mediated processing of HIPK2

Author keywords

Apoptosis; Caspases; HIPK2; p53

Indexed keywords

CASPASE; DNA; HOMEODOMAIN INTERACTING PROTEIN KINASE 2; PROTEIN P53; PROTEIN SERINE THREONINE KINASE;

EID: 33646589651     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/sj.emboj.7601077     Document Type: Article
Times cited : (67)

References (53)
  • 1
    • 20744432450 scopus 로고    scopus 로고
    • Mutations in proline 82 of p53 impair its activation by Pin1 and Chk2 in response to DNA damage
    • Berger M, Stahl N, Del Sal G, Haupt Y (2005) Mutations in proline 82 of p53 impair its activation by Pin1 and Chk2 in response to DNA damage. Mol Cell Biol 25: 5380-5388
    • (2005) Mol Cell Biol , vol.25 , pp. 5380-5388
    • Berger, M.1    Stahl, N.2    Del Sal, G.3    Haupt, Y.4
  • 2
    • 0037134020 scopus 로고    scopus 로고
    • A system for stable expression of short interfering RNAs in mammalian cells
    • Brummelkamp TR, Bernards R, Agami R (2002) A system for stable expression of short interfering RNAs in mammalian cells. Science 296: 550-553
    • (2002) Science , vol.296 , pp. 550-553
    • Brummelkamp, T.R.1    Bernards, R.2    Agami, R.3
  • 3
    • 0033598754 scopus 로고    scopus 로고
    • Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage
    • Chehab NH, Malikzay A, Stavridi ES, Halazonetis TD (1999) Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage. Proc Natl Acad Sci USA 96: 13777-13782
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 13777-13782
    • Chehab, N.H.1    Malikzay, A.2    Stavridi, E.S.3    Halazonetis, T.D.4
  • 5
    • 0036565878 scopus 로고    scopus 로고
    • Caspase-catalyzed cleavage and activation of Mst1 correlates with eosinophil but not neutrophil apoptosis
    • de Souza PM, Kankaanranta H, Michael A, Barnes PJ, Giembycz MA, Lindsay MA (2002) Caspase-catalyzed cleavage and activation of Mst1 correlates with eosinophil but not neutrophil apoptosis. Blood 99: 3432-3438
    • (2002) Blood , vol.99 , pp. 3432-3438
    • De Souza, P.M.1    Kankaanranta, H.2    Michael, A.3    Barnes, P.J.4    Giembycz, M.A.5    Lindsay, M.A.6
  • 6
    • 3142682521 scopus 로고    scopus 로고
    • HIPK2 neutralizes MDM2 inhibition rescuing p53 transcriptional activity and apoptotic function
    • Di Stefano V, Blandino G, Sacchi A, Soddu S, D'Orazi G (2004) HIPK2 neutralizes MDM2 inhibition rescuing p53 transcriptional activity and apoptotic function. Oncogene 23: 5185-5192
    • (2004) Oncogene , vol.23 , pp. 5185-5192
    • Di Stefano, V.1    Blandino, G.2    Sacchi, A.3    Soddu, S.4    D'Orazi, G.5
  • 8
    • 0037372005 scopus 로고    scopus 로고
    • The codon 72 polymorphic variants of p53 have markedly different apoptotic potential
    • Dumont P, Leu JI, Della III PA, George DL, Murphy M (2003) The codon 72 polymorphic variants of p53 have markedly different apoptotic potential. Nat Genet 33: 357-355
    • (2003) Nat Genet , vol.33 , pp. 357-1355
    • Dumont, P.1    Leu, J.I.2    Della III, P.A.3    George, D.L.4    Murphy, M.5
  • 9
    • 0037305847 scopus 로고    scopus 로고
    • Homeodomain-interacting protein kinase 1 modulates Daxx localization, phosphorylation, and transcriptional activity
    • Ecsedy JA, Michaelson JS, Leder P (2003) Homeodomain-interacting protein kinase 1 modulates Daxx localization, phosphorylation, and transcriptional activity. Mol Cell Biol 23: 950-960
    • (2003) Mol Cell Biol , vol.23 , pp. 950-960
    • Ecsedy, J.A.1    Michaelson, J.S.2    Leder, P.3
  • 10
    • 2942543339 scopus 로고    scopus 로고
    • p53-mediated transcriptional activation: From test tube to cell
    • Fingerman IM, Briggs SD (2004) p53-mediated transcriptional activation: from test tube to cell. Cell 117: 690-691
    • (2004) Cell , vol.117 , pp. 690-691
    • Fingerman, I.M.1    Briggs, S.D.2
  • 11
    • 1542353401 scopus 로고    scopus 로고
    • Control of apoptosis by p53
    • Fridman JS, Lowe SW (2003) Control of apoptosis by p53. Oncogene 22: 9030-9040
    • (2003) Oncogene , vol.22 , pp. 9030-9040
    • Fridman, J.S.1    Lowe, S.W.2
  • 12
    • 17644377920 scopus 로고    scopus 로고
    • Covalent modification of human homeodomain interacting protein kinase 2 by SUMO-1 at lysine 25 affects its stability
    • Gresko E, Möller A, Roscic A, Schmitz ML (2005) Covalent modification of human homeodomain interacting protein kinase 2 by SUMO-1 at lysine 25 affects its stability. Biochem Biophys Res Commun 329: 1293-1299
    • (2005) Biochem Biophys Res Commun , vol.329 , pp. 1293-1299
    • Gresko, E.1    Möller, A.2    Roscic, A.3    Schmitz, M.L.4
  • 13
    • 18344377030 scopus 로고    scopus 로고
    • The p53 pathway: Positive and negative feedback loops
    • Harris SL, Levine AJ (2005) The p53 pathway: positive and negative feedback loops. Oncogene 24: 2899-2908
    • (2005) Oncogene , vol.24 , pp. 2899-2908
    • Harris, S.L.1    Levine, A.J.2
  • 14
    • 0030905284 scopus 로고    scopus 로고
    • Mdm2 promotes the rapid degradation of p53
    • Haupt Y, Maya R, Kazaz A, Oren M (1997) Mdm2 promotes the rapid degradation of p53. Nature 387: 296-299
    • (1997) Nature , vol.387 , pp. 296-299
    • Haupt, Y.1    Maya, R.2    Kazaz, A.3    Oren, M.4
  • 15
    • 0034534759 scopus 로고    scopus 로고
    • Human homeodomain-interacting protein kinase-2 (HIPK2) is a member of the DYRK family of protein kinases and maps to chromosome 7q32-q34
    • Hofmann TG, Mincheva A, Lichter P, Droge W, Schmitz ML (2000) Human homeodomain-interacting protein kinase-2 (HIPK2) is a member of the DYRK family of protein kinases and maps to chromosome 7q32-q34. Biochimie 82: 1123-1127
    • (2000) Biochimie , vol.82 , pp. 1123-1127
    • Hofmann, T.G.1    Mincheva, A.2    Lichter, P.3    Droge, W.4    Schmitz, M.L.5
  • 17
    • 0345734277 scopus 로고    scopus 로고
    • HIPK2 regulates transforming growth factor-beta-induced c-Jun NH(2)-terminal kinase activation and apoptosis in human hepatoma cells
    • Hofmann TG, Stollberg N, Schmitz ML, Will H (2003) HIPK2 regulates transforming growth factor-beta-induced c-Jun NH(2)-terminal kinase activation and apoptosis in human hepatoma cells. Cancer Res 63: 8271-8277
    • (2003) Cancer Res , vol.63 , pp. 8271-8277
    • Hofmann, T.G.1    Stollberg, N.2    Schmitz, M.L.3    Will, H.4
  • 20
    • 0037200042 scopus 로고    scopus 로고
    • Identification and characterization of HIPK2 interacting with p73 and modulating functions of the p53 family in vivo
    • Kim EJ, Park JS, Um SJ (2002) Identification and characterization of HIPK2 interacting with p73 and modulating functions of the p53 family in vivo. J Biol Chem 277: 32020-32028
    • (2002) J Biol Chem , vol.277 , pp. 32020-32028
    • Kim, E.J.1    Park, J.S.2    Um, S.J.3
  • 22
  • 25
    • 0033214236 scopus 로고    scopus 로고
    • Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis
    • Lin Y, Devin A, Rodriguez Y, Liu ZG (1999) Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis. Genes Dev 13: 2514-2526
    • (1999) Genes Dev , vol.13 , pp. 2514-2526
    • Lin, Y.1    Devin, A.2    Rodriguez, Y.3    Liu, Z.G.4
  • 26
    • 0037047157 scopus 로고    scopus 로고
    • Apoptotic threshold is lowered by p53 transactivation of caspase-6
    • MacLachlan TK, El Deiry WS (2002) Apoptotic threshold is lowered by p53 transactivation of caspase-6. Proc Natl Acad Sci USA 99: 9492-9497
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 9492-9497
    • MacLachlan, T.K.1    El Deiry, W.S.2
  • 28
    • 0035078659 scopus 로고    scopus 로고
    • Neurodegenerative disorders and ischemic brain diseases
    • Mattson MP, Duan W, Pedersen WA, Culmsee C (2001) Neurodegenerative disorders and ischemic brain diseases. Apoptosis 6: 69-81
    • (2001) Apoptosis , vol.6 , pp. 69-81
    • Mattson, M.P.1    Duan, W.2    Pedersen, W.A.3    Culmsee, C.4
  • 29
    • 22544433198 scopus 로고    scopus 로고
    • Phosphorylation of human p53 at serine 46 determines promoter selection and whether apoptosis is attenuated or amplified
    • Mayo LD, Rok SY, Jackson MW, Smith ML, Rivera Jr G, Korgaonkar CK, Donner DB (2005) Phosphorylation of human p53 at serine 46 determines promoter selection and whether apoptosis is attenuated or amplified. J Biol Chem 280: 25953-25959
    • (2005) J Biol Chem , vol.280 , pp. 25953-25959
    • Mayo, L.D.1    Rok, S.Y.2    Jackson, M.W.3    Smith, M.L.4    Rivera Jr., G.5    Korgaonkar, C.K.6    Donner, D.B.7
  • 31
    • 0028883179 scopus 로고
    • Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
    • Miyashita T, Reed JC (1995) Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 80: 293-299
    • (1995) Cell , vol.80 , pp. 293-299
    • Miyashita, T.1    Reed, J.C.2
  • 32
    • 0035265686 scopus 로고    scopus 로고
    • PUMA, a novel proapoptotic gene, is induced by p53
    • Nakano K, Vousden KH (2001) PUMA, a novel proapoptotic gene, is induced by p53. Mol Cell 7: 683-694
    • (2001) Mol Cell , vol.7 , pp. 683-694
    • Nakano, K.1    Vousden, K.H.2
  • 33
    • 2342459790 scopus 로고    scopus 로고
    • DNA damage-induced apoptosis
    • Norbury CJ, Zhivotovsky B (2004) DNA damage-induced apoptosis. Oncogene 23: 2797-2808
    • (2004) Oncogene , vol.23 , pp. 2797-2808
    • Norbury, C.J.1    Zhivotovsky, B.2
  • 36
    • 0038075338 scopus 로고    scopus 로고
    • Decision making by p53: Life, death and cancer
    • Oren M (2003) Decision making by p53: life, death and cancer. Cell Death Differ 10: 431-442
    • (2003) Cell Death Differ , vol.10 , pp. 431-442
    • Oren, M.1
  • 37
    • 4444344019 scopus 로고    scopus 로고
    • Caspase 10 levels are increased following DNA damage in a p53-dependent manner
    • Rikhof B, Corn PG, El Deiry WS (2003) Caspase 10 levels are increased following DNA damage in a p53-dependent manner. Cancer Biol Ther 2: 707-712
    • (2003) Cancer Biol Ther , vol.2 , pp. 707-712
    • Rikhof, B.1    Corn, P.G.2    El Deiry, W.S.3
  • 38
    • 0347624644 scopus 로고    scopus 로고
    • Critical loss of CBP/p300 histone acetylase activity by caspase-6 during neurodegeneration
    • Rouaux C, Jokic N, Mbebi C, Boutillier S, Loeffler JP, Boutillier AL (2003) Critical loss of CBP/p300 histone acetylase activity by caspase-6 during neurodegeneration. EMBO J 22: 6537-6549
    • (2003) EMBO J , vol.22 , pp. 6537-6549
    • Rouaux, C.1    Jokic, N.2    Mbebi, C.3    Boutillier, S.4    Loeffler, J.P.5    Boutillier, A.L.6
  • 40
    • 0030667702 scopus 로고    scopus 로고
    • DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2
    • Shieh SY, Ikeda M, Taya Y, Prives C (1997) DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2. Cell 91: 325-334
    • (1997) Cell , vol.91 , pp. 325-334
    • Shieh, S.Y.1    Ikeda, M.2    Taya, Y.3    Prives, C.4
  • 41
    • 0035298087 scopus 로고    scopus 로고
    • Comprehensive studies on subcellular localizations and cell death-inducing activities of eight GFP-tagged apoptosis-related caspases
    • Shikama Y, Mami U, Miyashita T, Yamada M (2001) Comprehensive studies on subcellular localizations and cell death-inducing activities of eight GFP-tagged apoptosis-related caspases. Exp Cell Res 264: 315-325
    • (2001) Exp Cell Res , vol.264 , pp. 315-325
    • Shikama, Y.1    Mami, U.2    Miyashita, T.3    Yamada, M.4
  • 42
    • 1642564569 scopus 로고    scopus 로고
    • Regulation of p53 by Mdm2: Fate is in the numbers
    • Shmueli A, Oren M (2004) Regulation of p53 by Mdm2: fate is in the numbers. Mol Cell 13: 4-5
    • (2004) Mol Cell , vol.13 , pp. 4-5
    • Shmueli, A.1    Oren, M.2
  • 44
    • 2442453730 scopus 로고    scopus 로고
    • The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress
    • Tinel A, Tschopp J (2004) The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress. Science 304: 843-846
    • (2004) Science , vol.304 , pp. 843-846
    • Tinel, A.1    Tschopp, J.2
  • 45
    • 3042858915 scopus 로고    scopus 로고
    • Caspase-mediated cleavage and activation of LIM-kinase 1 and its role in apoptotic membrane blebbing
    • Tomiyoshi G, Horita Y, Nishita M, Ohashi K, Mizuno K (2004) Caspase-mediated cleavage and activation of LIM-kinase 1 and its role in apoptotic membrane blebbing. Genes Cells 9: 591-600
    • (2004) Genes Cells , vol.9 , pp. 591-600
    • Tomiyoshi, G.1    Horita, Y.2    Nishita, M.3    Ohashi, K.4    Mizuno, K.5
  • 46
    • 0037325522 scopus 로고    scopus 로고
    • Modulation of multidrug resistance-associated protein 1 (MRP1) by p53 mutant in Saos-2 cells
    • Tsang WP, Chau SP, Fung KP, Kong SK, Kwok TT (2003) Modulation of multidrug resistance-associated protein 1 (MRP1) by p53 mutant in Saos-2 cells. Cancer Chemother Pharmacol 51: 161-166
    • (2003) Cancer Chemother Pharmacol , vol.51 , pp. 161-166
    • Tsang, W.P.1    Chau, S.P.2    Fung, K.P.3    Kong, S.K.4    Kwok, T.T.5
  • 47
    • 0034703742 scopus 로고    scopus 로고
    • p53: Death star
    • Vousden KH (2000) p53: death star. Cell 103: 691-694
    • (2000) Cell , vol.103 , pp. 691-694
    • Vousden, K.H.1
  • 48
    • 0030448650 scopus 로고    scopus 로고
    • Identification of a novel p53 functional domain that is necessary for efficient growth suppression
    • Walker KK, Levine AJ (1996) Identification of a novel p53 functional domain that is necessary for efficient growth suppression. Proc Natl Acad Sci USA 93: 15335-15340
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 15335-15340
    • Walker, K.K.1    Levine, A.J.2
  • 49
    • 2542500783 scopus 로고    scopus 로고
    • HIPK2 overexpression leads to stabilization of p53 protein and increased p53 transcriptional activity by decreasing Mdm2 protein levels
    • Wang Y, Debatin KM, Hug H (2001) HIPK2 overexpression leads to stabilization of p53 protein and increased p53 transcriptional activity by decreasing Mdm2 protein levels. BMC Mol Biol 2: 8
    • (2001) BMC Mol Biol , vol.2 , pp. 8
    • Wang, Y.1    Debatin, K.M.2    Hug, H.3
  • 51
    • 24644457314 scopus 로고    scopus 로고
    • Complicating the complexity of p53
    • Yee KS, Vousden KH (2005) Complicating the complexity of p53. Carcinogenesis 26: 1317-1322
    • (2005) Carcinogenesis , vol.26 , pp. 1317-1322
    • Yee, K.S.1    Vousden, K.H.2
  • 53
    • 14544297432 scopus 로고    scopus 로고
    • Homeodomain-interacting protein kinase-2 mediates CtBP phosphorylation and degradation in UV-triggered apoptosis
    • Zhang Q, Nottke A, Goodman RH (2005) Homeodomain-interacting protein kinase-2 mediates CtBP phosphorylation and degradation in UV-triggered apoptosis. Proc Natl Acad Sci USA 102: 2802-2807
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 2802-2807
    • Zhang, Q.1    Nottke, A.2    Goodman, R.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.