메뉴 건너뛰기




Volumn 76, Issue 16, 2016, Pages 4728-4740

Tumor suppressor HIPK2 regulates malignant growth via phosphorylation of NOTCH

Author keywords

[No Author keywords available]

Indexed keywords

CAMPTOTHECIN; CISPLATIN; DOXORUBICIN; ETOPOSIDE; FBW7 UBIQUITIN LIGASE; HOMEODOMAIN INTERACTING PROTEIN KINASE 2; NOTCH1 RECEPTOR; TUMOR SUPPRESSOR PROTEIN; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG; CARRIER PROTEIN; HIPK2 PROTEIN, HUMAN; NOTCH1 PROTEIN, HUMAN; PROTEIN SERINE THREONINE KINASE;

EID: 84982168624     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-15-3310     Document Type: Article
Times cited : (17)

References (32)
  • 1
    • 0033617522 scopus 로고    scopus 로고
    • Notch signaling: Cell fate control and signal integration in development
    • Artavanis-Tsakonas S, Rand MD, Lake RJ. Notch signaling: cell fate control and signal integration in development. Science 1999;284: 770-6.
    • (1999) Science , vol.284 , pp. 770-776
    • Artavanis-Tsakonas, S.1    Rand, M.D.2    Lake, R.J.3
  • 2
    • 7244250027 scopus 로고    scopus 로고
    • Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis
    • Pece S, Serresi M, Santolini E, Capra M, Hulleman E, Galimberti V, et al. Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis. J Cell Biol 2004;167:215-21.
    • (2004) J Cell Biol , vol.167 , pp. 215-221
    • Pece, S.1    Serresi, M.2    Santolini, E.3    Capra, M.4    Hulleman, E.5    Galimberti, V.6
  • 3
    • 24944506696 scopus 로고    scopus 로고
    • High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival
    • Reedijk M, Odorcic S, Chang L, Zhang H, Miller N, McCready DR, et al. High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival. Cancer Res 2005;65:8530-7.
    • (2005) Cancer Res , vol.65 , pp. 8530-8537
    • Reedijk, M.1    Odorcic, S.2    Chang, L.3    Zhang, H.4    Miller, N.5    McCready, D.R.6
  • 4
    • 32944470488 scopus 로고    scopus 로고
    • Aberrant activation of notch signaling in human breast cancer
    • Stylianou S, Clarke RB, Brennan K. Aberrant activation of notch signaling in human breast cancer. Cancer Res 2006;66:1517-25.
    • (2006) Cancer Res , vol.66 , pp. 1517-1525
    • Stylianou, S.1    Clarke, R.B.2    Brennan, K.3
  • 5
    • 48549103124 scopus 로고    scopus 로고
    • Cross-talk between notch and the estrogen receptor in breast cancer suggests novel therapeutic approaches
    • Rizzo P, Miao H, D'Souza G, Osipo C, Song LL, Yun J, et al. Cross-talk between notch and the estrogen receptor in breast cancer suggests novel therapeutic approaches. Cancer Res 2008;68:5226-35.
    • (2008) Cancer Res , vol.68 , pp. 5226-5235
    • Rizzo, P.1    Miao, H.2    D'Souza, G.3    Osipo, C.4    Song, L.L.5    Yun, J.6
  • 6
    • 0033613401 scopus 로고    scopus 로고
    • Involvement of Notch1 in the development of mouse mammary tumors
    • Dievart A, Beaulieu N, Jolicoeur P. Involvement of Notch1 in the development of mouse mammary tumors. Oncogene 1999;18: 5973-81.
    • (1999) Oncogene , vol.18 , pp. 5973-5981
    • Dievart, A.1    Beaulieu, N.2    Jolicoeur, P.3
  • 7
    • 38549148417 scopus 로고    scopus 로고
    • Notch and cancer: A double-edged sword
    • Koch U, Radtke F. Notch and cancer: a double-edged sword. Cell Mol Life Sci 2007;64:2746-62.
    • (2007) Cell Mol Life Sci , vol.64 , pp. 2746-2762
    • Koch, U.1    Radtke, F.2
  • 9
    • 34648857551 scopus 로고    scopus 로고
    • Notch emerges as new cancer drug target
    • Garber K. Notch emerges as new cancer drug target. J Natl Cancer Inst 2007;99:1284-5.
    • (2007) J Natl Cancer Inst , vol.99 , pp. 1284-1285
    • Garber, K.1
  • 10
    • 0030659821 scopus 로고    scopus 로고
    • Sel-10, a negative regulator of lin-12 activity in Caenorhabditis elegans, encodes a member of the CDC4 family of proteins
    • Hubbard EJ, Wu G, Kitajewski J, Greenwald I. sel-10, a negative regulator of lin-12 activity in Caenorhabditis elegans, encodes a member of the CDC4 family of proteins. Genes Dev 1997;11:3182-93.
    • (1997) Genes Dev , vol.11 , pp. 3182-3193
    • Hubbard, E.J.1    Wu, G.2    Kitajewski, J.3    Greenwald, I.4
  • 11
    • 0035860804 scopus 로고    scopus 로고
    • Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor
    • Gupta-Rossi N, Le Bail O, GonenH, BrouC, Logeat F, Six E, et al. Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor. J Biol Chem 2001;276:34371-8.
    • (2001) J Biol Chem , vol.276 , pp. 34371-34378
    • Gupta-Rossi, N.1    Le Bail, O.2    Gonen, H.3    Brou, C.4    Logeat, F.5    Six, E.6
  • 12
    • 34547780475 scopus 로고    scopus 로고
    • FBW7mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors
    • O'Neil J, Grim J, Strack P, Rao S, Tibbitts D, Winter C, et al.FBW7mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors. J Exp Med 2007;204:1813-24.
    • (2007) J Exp Med , vol.204 , pp. 1813-1824
    • O'Neil, J.1    Grim, J.2    Strack, P.3    Rao, S.4    Tibbitts, D.5    Winter, C.6
  • 15
    • 79251474710 scopus 로고    scopus 로고
    • Inhibition of Notch1 signaling by Runx2 during osteoblast differentiation
    • Ann EJ, Kim HY, Choi YH, Kim MY, MoJS, Jung J, et al. Inhibition of Notch1 signaling by Runx2 during osteoblast differentiation. J Bone Miner Res 2011;26:317-30.
    • (2011) J Bone Miner Res , vol.26 , pp. 317-330
    • Ann, E.J.1    Kim, H.Y.2    Choi, Y.H.3    Kim, M.Y.4    Mo, J.S.5    Jung, J.6
  • 16
    • 78651104178 scopus 로고    scopus 로고
    • Serum-and glucocorticoid-inducible kinase 1 (SGK1) controls Notch1 signaling by downregulation of protein stability through Fbw7 ubiquitin ligase
    • Mo JS, Ann EJ, Yoon JH, Jung J, Choi YH, Kim HY, et al. Serum-and glucocorticoid-inducible kinase 1 (SGK1) controls Notch1 signaling by downregulation of protein stability through Fbw7 ubiquitin ligase. J Cell Sci 2011;124:100-12.
    • (2011) J Cell Sci , vol.124 , pp. 100-112
    • Mo, J.S.1    Ann, E.J.2    Yoon, J.H.3    Jung, J.4    Choi, Y.H.5    Kim, H.Y.6
  • 17
    • 41949130508 scopus 로고    scopus 로고
    • Ubiquitination and degradation of homeodomain-interacting protein kinase 2 by WD40 repeat/SOCS box protein WSB-1
    • Choi DW, Seo YM, Kim EA, Sung KS, Ahn JW, Park SJ, et al. Ubiquitination and degradation of homeodomain-interacting protein kinase 2 by WD40 repeat/SOCS box protein WSB-1. J Biol Chem 2008;283:4682-9.
    • (2008) J Biol Chem , vol.283 , pp. 4682-4689
    • Choi, D.W.1    Seo, Y.M.2    Kim, E.A.3    Sung, K.S.4    Ahn, J.W.5    Park, S.J.6
  • 18
    • 38549086019 scopus 로고    scopus 로고
    • FBW7 ubiquitin ligase: A tumour suppressor at the crossroads of cell division, growth and differentiation
    • Welcker M, Clurman BE. FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation. Nat Rev Cancer 2008;8:83-93.
    • (2008) Nat Rev Cancer , vol.8 , pp. 83-93
    • Welcker, M.1    Clurman, B.E.2
  • 19
    • 67650447715 scopus 로고    scopus 로고
    • The human protein kinase HIPK2 phosphorylates and downregulates the methyl-binding transcription factor ZBTB4
    • Yamada D, Perez-Torrado R, Filion G, Caly M, Jammart B, Devignot V, et al. The human protein kinase HIPK2 phosphorylates and downregulates the methyl-binding transcription factor ZBTB4. Oncogene 2009;28:2535-44.
    • (2009) Oncogene , vol.28 , pp. 2535-2544
    • Yamada, D.1    Perez-Torrado, R.2    Filion, G.3    Caly, M.4    Jammart, B.5    Devignot, V.6
  • 20
    • 34548740091 scopus 로고    scopus 로고
    • HIPK2 represses betacatenin-mediated transcription, epidermal stem cell expansion, and skin tumorigenesis
    • Wei G, Ku S, Ma GK, Saito S, Tang AA, Zhang J, et al. HIPK2 represses betacatenin-mediated transcription, epidermal stem cell expansion, and skin tumorigenesis. Proc Natl Acad Sci U S A 2007;104:13040-5.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 13040-13045
    • Wei, G.1    Ku, S.2    Ma, G.K.3    Saito, S.4    Tang, A.A.5    Zhang, J.6
  • 21
    • 78651330430 scopus 로고    scopus 로고
    • COSMIC: Mining complete cancer genomes in the catalogue of somatic mutations in cancer
    • Forbes SA, Bindal N, Bamford S, Cole C, Kok CY, Beare D, et al. COSMIC: mining complete cancer genomes in the catalogue of somatic mutations in cancer. Nucleic Acids Res 2011;39(Database issue): D945-50.
    • (2011) Nucleic Acids Res , vol.39 , pp. D945-D950
    • Forbes, S.A.1    Bindal, N.2    Bamford, S.3    Cole, C.4    Kok, C.Y.5    Beare, D.6
  • 22
    • 68749088356 scopus 로고    scopus 로고
    • NOTCH inhibition and glucocorticoid therapy in T-cell acute lymphoblastic leukemia
    • Real PJ, Ferrando AA. NOTCH inhibition and glucocorticoid therapy in T-cell acute lymphoblastic leukemia. Leukemia 2009;23:1374-7.
    • (2009) Leukemia , vol.23 , pp. 1374-1377
    • Real, P.J.1    Ferrando, A.A.2
  • 23
    • 33645049305 scopus 로고    scopus 로고
    • Downregulation of notch-1 inhibits invasion by inactivation of nuclear factorkappaB, vascular endothelial growth factor, and matrix metalloproteinase-9 in pancreatic cancer cells
    • Wang Z, Banerjee S, Li Y, Rahman KM, Zhang Y, Sarkar FH. Downregulation of notch-1 inhibits invasion by inactivation of nuclear factorkappaB, vascular endothelial growth factor, and matrix metalloproteinase-9 in pancreatic cancer cells. Cancer Res 2006;66:2778-84.
    • (2006) Cancer Res , vol.66 , pp. 2778-2784
    • Wang, Z.1    Banerjee, S.2    Li, Y.3    Rahman, K.M.4    Zhang, Y.5    Sarkar, F.H.6
  • 24
    • 34948910811 scopus 로고    scopus 로고
    • HIPK2: A multitalented partner for transcription factors in DNA damage response and development
    • Rinaldo C, Prodosmo A, Siepi F, Soddu S. HIPK2: a multitalented partner for transcription factors in DNA damage response and development. Biochem Cell Biol 2007;85:411-8.
    • (2007) Biochem Cell Biol , vol.85 , pp. 411-418
    • Rinaldo, C.1    Prodosmo, A.2    Siepi, F.3    Soddu, S.4
  • 25
    • 18244379872 scopus 로고    scopus 로고
    • Homeodomain-interacting protein kinase-2 phosphorylates p53 at ser 46 and mediates apoptosis
    • D'Orazi G, Cecchinelli B, Bruno T, Manni I, Higashimoto Y, Saito S, et al. Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis. Nat Cell Biol 2002;4:11-9.
    • (2002) Nat Cell Biol , vol.4 , pp. 11-19
    • D'Orazi, G.1    Cecchinelli, B.2    Bruno, T.3    Manni, I.4    Higashimoto, Y.5    Saito, S.6
  • 26
    • 0036141392 scopus 로고    scopus 로고
    • Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2
    • Hofmann TG, Moller A, Sirma H, Zentgraf H, Taya Y, Droge W, et al. Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2. Nat Cell Biol 2002;4:1-10.
    • (2002) Nat Cell Biol , vol.4 , pp. 1-10
    • Hofmann, T.G.1    Moller, A.2    Sirma, H.3    Zentgraf, H.4    Taya, Y.5    Droge, W.6
  • 27
    • 33947273628 scopus 로고    scopus 로고
    • Homeodomain-interacting protein kinase 2 is the ionizing radiation-activated p53 serine 46 kinase and is regulated by ATM
    • Dauth I, Kruger J, Hofmann TG. Homeodomain-interacting protein kinase 2 is the ionizing radiation-activated p53 serine 46 kinase and is regulated by ATM. Cancer Res 2007;67:2274-9.
    • (2007) Cancer Res , vol.67 , pp. 2274-2279
    • Dauth, I.1    Kruger, J.2    Hofmann, T.G.3
  • 31
    • 0035929669 scopus 로고    scopus 로고
    • The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog
    • Oberg C, Li J, Pauley A, Wolf E, Gurney M, Lendahl U. The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog. J Biol Chem 2001;276:35847-53.
    • (2001) J Biol Chem , vol.276 , pp. 35847-35853
    • Oberg, C.1    Li, J.2    Pauley, A.3    Wolf, E.4    Gurney, M.5    Lendahl, U.6
  • 32
    • 0034791336 scopus 로고    scopus 로고
    • SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation
    • WuG, Lyapina S, Das I, Li J, Gurney M, Pauley A, et al. SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation. Mol Cell Biol 2001;21:7403-15.
    • (2001) Mol Cell Biol , vol.21 , pp. 7403-7415
    • Wu, G.1    Lyapina, S.2    Das, I.3    Li, J.4    Gurney, M.5    Pauley, A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.