메뉴 건너뛰기




Volumn 21, Issue 18, 2014, Pages 2498-2514

The PTEN/NRF2 axis promotes human carcinogenesis

Author keywords

[No Author keywords available]

Indexed keywords

BETA TRANSDUCIN REPEAT CONTAINING PROTEIN; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3BETA; HEME OXYGENASE 1; KELCH LIKE ECH ASSOCIATED PROTEIN 1; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; TERT BUTYLHYDROQUINONE; TRANSCRIPTION FACTOR NRF2; NFE2L2 PROTEIN, HUMAN; PTEN PROTEIN, HUMAN;

EID: 84907929068     PISSN: 15230864     EISSN: 15577716     Source Type: Journal    
DOI: 10.1089/ars.2014.5843     Document Type: Article
Times cited : (104)

References (60)
  • 1
    • 84863027990 scopus 로고    scopus 로고
    • Guggulsterone induces heme oxygenase-1 expression through activation of Nrf2 in human mammary epithelial cells: PTEN as a putative target
    • Almazari I, Park JM, Park SA, Suh JY, Na HK, Cha YN, Surh YJ. Guggulsterone induces heme oxygenase-1 expression through activation of Nrf2 in human mammary epithelial cells: PTEN as a putative target. Carcinogenesis 33: 368-376, 2012.
    • (2012) Carcinogenesis , vol.33 , pp. 368-376
    • Almazari, I.1    Park, J.M.2    Park, S.A.3    Suh, J.Y.4    Na, H.K.5    Cha, Y.N.6    Surh, Y.J.7
  • 2
    • 84866894408 scopus 로고    scopus 로고
    • Comprehensive genomic characterization of squamous cell lung cancers
    • Cancer Genome Atlas Research Network.
    • Cancer Genome Atlas Research Network. Comprehensive genomic characterization of squamous cell lung cancers. Nature 489: 519-525, 2012.
    • (2012) Nature , vol.489 , pp. 519-525
  • 5
    • 79958063084 scopus 로고    scopus 로고
    • Induction of the Keap1/Nrf2/ARE pathway by oxidizable diphenols
    • Dinkova-Kostova AT, and Wang XJ. Induction of the Keap1/Nrf2/ARE pathway by oxidizable diphenols. Chem Biol Interact 192: 101-106, 2011.
    • (2011) Chem Biol Interact , vol.192 , pp. 101-106
    • Dinkova-Kostova, A.T.1    Wang, X.J.2
  • 6
    • 84879802004 scopus 로고    scopus 로고
    • Redox signaling via oxidative inactivation of PTEN modulates pressure-dependent myogenic tone in rat middle cerebral arteries
    • Gebremedhin D, Terashvili M, Wickramasekera N, Zhang DX, Rau N, Miura H, and Harder DR. Redox signaling via oxidative inactivation of PTEN modulates pressure-dependent myogenic tone in rat middle cerebral arteries. PLoS One 8: E68498, 2013.
    • (2013) PLoS One , vol.8 , pp. e68498
    • Gebremedhin, D.1    Terashvili, M.2    Wickramasekera, N.3    Zhang, D.X.4    Rau, N.5    Miura, H.6    Harder, D.R.7
  • 7
    • 0033057707 scopus 로고    scopus 로고
    • Sample purification and preparation technique based on nano-scale reversed-phase columns for the sensitive analysis of complex peptide mixtures by matrixassisted laser desorption/ionization mass spectrometry
    • Gobom J, Nordhoff E, Mirgorodskaya E, Ekman R, and Roepstorff P. Sample purification and preparation technique based on nano-scale reversed-phase columns for the sensitive analysis of complex peptide mixtures by matrixassisted laser desorption/ionization mass spectrometry. J Mass Spectrom 34: 105-116, 1999.
    • (1999) J Mass Spectrom , vol.34 , pp. 105-116
    • Gobom, J.1    Nordhoff, E.2    Mirgorodskaya, E.3    Ekman, R.4    Roepstorff, P.5
  • 9
    • 84897421970 scopus 로고    scopus 로고
    • The Nrf2 regulatory network provides an interface between redox and intermediary metabolism
    • Hayes JD and Dinkova-Kostova AT. The Nrf2 regulatory network provides an interface between redox and intermediary metabolism. Trends Biochem Sci 39: 199-218, 2014.
    • (2014) Trends Biochem Sci , vol.39 , pp. 199-218
    • Hayes, J.D.1    Dinkova-Kostova, A.T.2
  • 10
    • 84898627378 scopus 로고    scopus 로고
    • Reactive nitrogen species and hydrogen sulfide as regulators of protein tyrosine phosphatase activity
    • Heneberg P. Reactive nitrogen species and hydrogen sulfide as regulators of protein tyrosine phosphatase activity. Antioxid Redox Signal 20: 2191-2209, 2014.
    • (2014) Antioxid Redox Signal , vol.20 , pp. 2191-2209
    • Heneberg, P.1
  • 13
    • 84885944468 scopus 로고    scopus 로고
    • The emerging role of the Nrf2-Keap1 signaling pathway in cancer
    • Jaramillo MC and Zhang DD. The emerging role of the Nrf2-Keap1 signaling pathway in cancer. Genes Dev 27: 2179-2191, 2013.
    • (2013) Genes Dev , vol.27 , pp. 2179-2191
    • Jaramillo, M.C.1    Zhang, D.D.2
  • 14
    • 77954351631 scopus 로고    scopus 로고
    • High levels of Nrf2 determine chemoresistance in type II endometrial cancer
    • Jiang T, Chen N, Zhao F, Wang XJ, Kong B, Zheng W, and Zhang DD. High levels of Nrf2 determine chemoresistance in type II endometrial cancer. Cancer Res 70: 5486-5496, 2010.
    • (2010) Cancer Res , vol.70 , pp. 5486-5496
    • Jiang, T.1    Chen, N.2    Zhao, F.3    Wang, X.J.4    Kong, B.5    Zheng, W.6    Zhang, D.D.7
  • 16
    • 84873148285 scopus 로고    scopus 로고
    • Redox regulation of tumor suppressor PTEN in cancer and aging (Review)
    • Kitagishi Y and Matsuda S. Redox regulation of tumor suppressor PTEN in cancer and aging (Review). Int J Mol Med 31: 511-515, 2013.
    • (2013) Int J Mol Med , vol.31 , pp. 511-515
    • Kitagishi, Y.1    Matsuda, S.2
  • 17
    • 9344259718 scopus 로고    scopus 로고
    • Reversible oxidation and inactivation of the tumor suppressor PTEN in cells stimulated with peptide growth factors
    • Kwon J, Lee SR, Yang KS, Ahn Y, Kim YJ, Stadtman ER, and Rhee SG. Reversible oxidation and inactivation of the tumor suppressor PTEN in cells stimulated with peptide growth factors. Proc Natl Acad Sci U S A 101: 16419-16424, 2004.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 16419-16424
    • Kwon, J.1    Lee, S.R.2    Yang, K.S.3    Ahn, Y.4    Kim, Y.J.5    Stadtman, E.R.6    Rhee, S.G.7
  • 18
    • 24944519450 scopus 로고    scopus 로고
    • Highly selective enrichment of phosphorylated peptides from peptide mixtures using titanium dioxide microcolumns
    • Larsen MR, Thingholm TE, Jensen ON, Roepstorff P, and Jorgensen TJ. Highly selective enrichment of phosphorylated peptides from peptide mixtures using titanium dioxide microcolumns. Mol Cell Proteomics 4: 873-886, 2005.
    • (2005) Mol Cell Proteomics , vol.4 , pp. 873-886
    • Larsen, M.R.1    Thingholm, T.E.2    Jensen, O.N.3    Roepstorff, P.4    Jorgensen, T.J.5
  • 20
    • 0037036358 scopus 로고    scopus 로고
    • Reversible inactivation of the tumor suppressor PTEN by H2O2
    • Lee SR, Yang KS, Kwon J, Lee C, Jeong W, and Rhee SG. Reversible inactivation of the tumor suppressor PTEN by H2O2. J Biol Chem 277: 20336-20342, 2002.
    • (2002) J Biol Chem , vol.277 , pp. 20336-20342
    • Lee, S.R.1    Yang, K.S.2    Kwon, J.3    Lee, C.4    Jeong, W.5    Rhee, S.G.6
  • 21
    • 1542335553 scopus 로고    scopus 로고
    • Regulation of heme oxygenase-1 expression through the phosphatidylinositol 3-kinase/Akt pathway and the Nrf2 transcription factor in response to the antioxidant phytochemical carnosol
    • Martin D, Rojo AI, Salinas M, Diaz R, Gallardo G, Alam J, De Galarreta CM, and Cuadrado A. Regulation of heme oxygenase-1 expression through the phosphatidylinositol 3-kinase/Akt pathway and the Nrf2 transcription factor in response to the antioxidant phytochemical carnosol. J Biol Chem 279: 8919-8929, 2004.
    • (2004) J Biol Chem , vol.279 , pp. 8919-8929
    • Martin, D.1    Rojo, A.I.2    Salinas, M.3    Diaz, R.4    Gallardo, G.5    Alam, J.6    De Galarreta, C.M.7    Cuadrado, A.8
  • 22
    • 33747728194 scopus 로고    scopus 로고
    • Dimerization of substrate adaptors can facilitate cullinmediated ubiquitylation of proteins by a " tethering mechanism: A two-site interaction model for the Nrf2-Keap1 complex
    • McMahon M, Thomas N, Itoh K, Yamamoto M, and Hayes JD. Dimerization of substrate adaptors can facilitate cullinmediated ubiquitylation of proteins by a " tethering mechanism: A two-site interaction model for the Nrf2-Keap1 complex. J Biol Chem 281: 24756-24768, 2006.
    • (2006) J Biol Chem , vol.281 , pp. 24756-24768
    • McMahon, M.1    Thomas, N.2    Itoh, K.3    Yamamoto, M.4    Hayes, J.D.5
  • 26
    • 84890940231 scopus 로고    scopus 로고
    • Oncogenic potential of Nrf2 and its principal target protein heme oxygenase-1
    • Na HK and Surh YJ. Oncogenic potential of Nrf2 and its principal target protein heme oxygenase-1. Free Radic Biol Med 67: 353-365, 2014.
    • (2014) Free Radic Biol Med , vol.67 , pp. 353-365
    • Na, H.K.1    Surh, Y.J.2
  • 27
    • 77956357506 scopus 로고    scopus 로고
    • Regulation of Nrf2-And AP-1-mediated gene expression by epigallocatechin-3-gallate and sulforaphane in prostate of Nrf2-knockout or C57BL/6J mice and PC-3 AP-1 human prostate cancer cells
    • Nair S, Barve A, Khor TO, Shen GX, Lin W, Chan JY, Cai L, and Kong AN. Regulation of Nrf2-And AP-1-mediated gene expression by epigallocatechin-3-gallate and sulforaphane in prostate of Nrf2-knockout or C57BL/6J mice and PC-3 AP-1 human prostate cancer cells. Acta Pharmacol Sin 31: 1223-1240, 2010.
    • (2010) Acta Pharmacol Sin , vol.31 , pp. 1223-1240
    • Nair, S.1    Barve, A.2    Khor, T.O.3    Shen, G.X.4    Lin, W.5    Chan, J.Y.6    Cai, L.7    Kong, A.N.8
  • 29
    • 34548154756 scopus 로고    scopus 로고
    • Regulation of PTEN activity by its carboxyl-Terminal autoinhibitory domain
    • Odriozola L, Singh G, Hoang T, and Chan AM. Regulation of PTEN activity by its carboxyl-Terminal autoinhibitory domain. J Biol Chem 282: 23306-23315, 2007.
    • (2007) J Biol Chem , vol.282 , pp. 23306-23315
    • Odriozola, L.1    Singh, G.2    Hoang, T.3    Chan, A.M.4
  • 31
    • 0034980666 scopus 로고    scopus 로고
    • Induction of senescence by oncogenic
    • Palmero I and Serrano M. Induction of senescence by oncogenic Ras. Methods Enzymol 333: 247-256, 2001.
    • (2001) Ras Methods Enzymol , vol.333 , pp. 247-256
    • Palmero, I.1    Serrano, M.2
  • 32
    • 77957221943 scopus 로고    scopus 로고
    • Synthetic triterpenoids attenuate cytotoxic retinal injury: Cross-Talk between Nrf2 and PI3K/AKT signaling through inhibition of the lipid phosphatase PTEN
    • Pitha-Rowe I, Liby K, Royce D, and Sporn M. Synthetic triterpenoids attenuate cytotoxic retinal injury: Cross-Talk between Nrf2 and PI3K/AKT signaling through inhibition of the lipid phosphatase PTEN. Invest Ophthalmol Vis Sci 50: 5339-5347, 2009.
    • (2009) Invest Ophthalmol Vis Sci , vol.50 , pp. 5339-5347
    • Pitha-Rowe, I.1    Liby, K.2    Royce, D.3    Sporn, M.4
  • 33
    • 79952256187 scopus 로고    scopus 로고
    • SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner
    • Rada P, Rojo AI, Chowdhry S, McMahon M, Hayes JD, and Cuadrado A. SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner. Mol Cell Biol 31: 1121-1133, 2011.
    • (2011) Mol Cell Biol , vol.31 , pp. 1121-1133
    • Rada, P.1    Rojo, A.I.2    Chowdhry, S.3    McMahon, M.4    Hayes, J.D.5    Cuadrado, A.6
  • 37
    • 84855458875 scopus 로고    scopus 로고
    • Signaling pathways activated by the phytochemical nordihydroguaiaretic acid contribute to a Keap1-independent regulation of Nrf2 stability: Role of glycogen synthase kinase-3
    • Rojo AI, Medina-Campos ON, Rada P, Zuniga-Toala A, Lopez-Gazcon A, Espada S, Pedraza-Chaverri J, and Cuadrado A. Signaling pathways activated by the phytochemical nordihydroguaiaretic acid contribute to a Keap1-independent regulation of Nrf2 stability: Role of glycogen synthase kinase-3. Free Radic Biol Med 52: 473-487, 2012.
    • (2012) Free Radic Biol Med , vol.52 , pp. 473-487
    • Rojo, A.I.1    Medina-Campos, O.N.2    Rada, P.3    Zuniga-Toala, A.4    Lopez-Gazcon, A.5    Espada, S.6    Pedraza-Chaverri, J.7    Cuadrado, A.8
  • 38
    • 49749117926 scopus 로고    scopus 로고
    • Functional interference between glycogen synthase kinase-3 beta and the transcription factor Nrf2 in protection against kainate-induced hippocampal cell death
    • Rojo AI, Rada P, Egea J, Rosa AO, Lopez MG, and Cuadrado A. Functional interference between glycogen synthase kinase-3 beta and the transcription factor Nrf2 in protection against kainate-induced hippocampal cell death. Mol Cell Neurosci 39: 125-132, 2008.
    • (2008) Mol Cell Neurosci , vol.39 , pp. 125-132
    • Rojo, A.I.1    Rada, P.2    Egea, J.3    Rosa, A.O.4    Lopez, M.G.5    Cuadrado, A.6
  • 39
    • 41149134840 scopus 로고    scopus 로고
    • GSK-3beta downregulates the transcription factor Nrf2 after oxidant damage: Relevance to exposure of neuronal cells to oxidative stress
    • Rojo AI, Sagarra MR, and Cuadrado A. GSK-3beta downregulates the transcription factor Nrf2 after oxidant damage: Relevance to exposure of neuronal cells to oxidative stress. J Neurochem 105: 192-202, 2008.
    • (2008) J Neurochem , vol.105 , pp. 192-202
    • Rojo, A.I.1    Sagarra, M.R.2    Cuadrado, A.3
  • 40
    • 7244243873 scopus 로고    scopus 로고
    • Regulation of Cu/Zn-superoxide dismutase expression via the phosphatidylinositol 3 kinase/Akt pathway and nuclear factor-kappaB
    • Rojo AI, Salinas M, Martin D, Perona R, and Cuadrado A. Regulation of Cu/Zn-superoxide dismutase expression via the phosphatidylinositol 3 kinase/Akt pathway and nuclear factor-kappaB. J Neurosci 24: 7324-7334, 2004.
    • (2004) J Neurosci , vol.24 , pp. 7324-7334
    • Rojo, A.I.1    Salinas, M.2    Martin, D.3    Perona, R.4    Cuadrado, A.5
  • 41
    • 65249123199 scopus 로고    scopus 로고
    • Role of the tumor suppressor PTEN in antioxidant responsive element-mediated transcription and associated histone modifications
    • Sakamoto K, Iwasaki K, Sugiyama H, and Tsuji Y. Role of the tumor suppressor PTEN in antioxidant responsive element-mediated transcription and associated histone modifications. Mol Biol Cell 20: 1606-1617, 2009.
    • (2009) Mol Biol Cell , vol.20 , pp. 1606-1617
    • Sakamoto, K.1    Iwasaki, K.2    Sugiyama, H.3    Tsuji, Y.4
  • 42
    • 33744950387 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3beta inhibits the xenobiotic and antioxidant cell response by direct phosphorylation and nuclear exclusion of the transcription factor Nrf2
    • Salazar M, Rojo AI, Velasco D, de Sagarra RM, and Cuadrado A. Glycogen synthase kinase-3beta inhibits the xenobiotic and antioxidant cell response by direct phosphorylation and nuclear exclusion of the transcription factor Nrf2. J Biol Chem 281: 14841-14851, 2006.
    • (2006) J Biol Chem , vol.281 , pp. 14841-14851
    • Salazar, M.1    Rojo, A.I.2    Velasco, D.3    De Sagarra, R.M.4    Cuadrado, A.5
  • 44
    • 84880048347 scopus 로고    scopus 로고
    • Nrf2 prevents initiation but accelerates progression through the Kras signaling pathway during lung carcinogenesis
    • Satoh H, Moriguchi T, Takai J, Ebina M, and Yamamoto M. Nrf2 prevents initiation but accelerates progression through the Kras signaling pathway during lung carcinogenesis. Cancer Res 73: 4158-4168, 2013.
    • (2013) Cancer Res , vol.73 , pp. 4158-4168
    • Satoh, H.1    Moriguchi, T.2    Takai, J.3    Ebina, M.4    Yamamoto, M.5
  • 45
    • 0029927505 scopus 로고    scopus 로고
    • Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels
    • Shevchenko A, Wilm M, Vorm O, and Mann M. Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels. Anal Chem 68: 850-858, 1996.
    • (1996) Anal Chem , vol.68 , pp. 850-858
    • Shevchenko, A.1    Wilm, M.2    Vorm, O.3    Mann, M.4
  • 47
    • 0035835824 scopus 로고    scopus 로고
    • PTEN: Life as a tumor suppressor
    • Simpson L and Parsons R. PTEN: Life as a tumor suppressor. Exp Cell Res 264: 29-41, 2001.
    • (2001) Exp Cell Res , vol.264 , pp. 29-41
    • Simpson, L.1    Parsons, R.2
  • 49
    • 79958155946 scopus 로고    scopus 로고
    • Post-Translational modifications of PTEN and their potential therapeutic implications
    • Singh G and Chan AM. Post-Translational modifications of PTEN and their potential therapeutic implications. Curr Cancer Drug Targets 11: 536-547, 2011.
    • (2011) Curr Cancer Drug Targets , vol.11 , pp. 536-547
    • Singh, G.1    Chan, A.M.2
  • 51
    • 84864348569 scopus 로고    scopus 로고
    • NRF2 and cancer: The good, the bad and the importance of context
    • Sporn MB and Liby KT. NRF2 and cancer: The good, the bad and the importance of context. Nat Rev Cancer 12: 564-571, 2012.
    • (2012) Nat Rev Cancer , vol.12 , pp. 564-571
    • Sporn, M.B.1    Liby, K.T.2
  • 52
    • 34548430536 scopus 로고    scopus 로고
    • Proteomic study of caveolae and rafts isolated from human endothelial cells
    • Sprenger RR and Horrevoets AJ. Proteomic study of caveolae and rafts isolated from human endothelial cells. Methods Mol Biol 357: 199-213, 2007.
    • (2007) Methods Mol Biol , vol.357 , pp. 199-213
    • Sprenger, R.R.1    Horrevoets, A.J.2
  • 54
    • 84878572136 scopus 로고    scopus 로고
    • Toward clinical application of the Keap1-Nrf2 pathway
    • Suzuki T, Motohashi H, and Yamamoto M. Toward clinical application of the Keap1-Nrf2 pathway. Trends Pharmacol Sci 34: 340-346, 2013.
    • (2013) Trends Pharmacol Sci , vol.34 , pp. 340-346
    • Suzuki, T.1    Motohashi, H.2    Yamamoto, M.3
  • 56
    • 0030761409 scopus 로고    scopus 로고
    • Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies
    • Tashiro H, Blazes MS, Wu R, Cho KR, Bose S, Wang SI, Li J, Parsons R, and Ellenson LH. Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies. Cancer Res 57: 3935-3940, 1997.
    • (1997) Cancer Res , vol.57 , pp. 3935-3940
    • Tashiro, H.1    Blazes, M.S.2    Wu, R.3    Cho, K.R.4    Bose, S.5    Wang, S.I.6    Li, J.7    Parsons, R.8    Ellenson, L.H.9
  • 58
    • 75449091854 scopus 로고    scopus 로고
    • Activation of the NRF2 signaling pathway by copper-mediated redox cycling of para-And orthohydroquinones
    • Wang XJ, Hayes JD, Higgins LG, Wolf CR, and Dinkova-Kostova AT. Activation of the NRF2 signaling pathway by copper-mediated redox cycling of para-And orthohydroquinones. Chem Biol 17: 75-85, 2010.
    • (2010) Chem Biol , vol.17 , pp. 75-85
    • Wang, X.J.1    Hayes, J.D.2    Higgins, L.G.3    Wolf, C.R.4    Dinkova-Kostova, A.T.5
  • 59
    • 33748358379 scopus 로고    scopus 로고
    • Mechanism of action of isothiocyanates: The induction of ARE-regulated genes is associated with activation of ERK and JNK and the phosphorylation and nuclear translocation of Nrf2
    • Xu C, Yuan X, Pan Z, Shen G, Kim JH, Yu S, Khor TO, Li W, Ma J, and Kong AN. Mechanism of action of isothiocyanates: The induction of ARE-regulated genes is associated with activation of ERK and JNK and the phosphorylation and nuclear translocation of Nrf2. Mol Cancer Ther 5: 1918-1926, 2006.
    • (2006) Mol Cancer Ther , vol.5 , pp. 1918-1926
    • Xu, C.1    Yuan, X.2    Pan, Z.3    Shen, G.4    Kim, J.H.5    Yu, S.6    Khor, T.O.7    Li, W.8    Ma, J.9    Kong, A.N.10
  • 60
    • 76649089973 scopus 로고    scopus 로고
    • Loss of Kelch-like ECH-Associated protein 1 function in prostate cancer cells causes chemoresistance and radioresistance and promotes tumor growth
    • Zhang P, Singh A, Yegnasubramanian S, Esopi D, Kombairaju P, Bodas M, Wu H, Bova SG, and Biswal S. Loss of Kelch-like ECH-Associated protein 1 function in prostate cancer cells causes chemoresistance and radioresistance and promotes tumor growth. Mol Cancer Ther 9: 336-346, 2010.
    • (2010) Mol Cancer Ther , vol.9 , pp. 336-346
    • Zhang, P.1    Singh, A.2    Yegnasubramanian, S.3    Esopi, D.4    Kombairaju, P.5    Bodas, M.6    Wu, H.7    Bova, S.G.8    Biswal, S.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.