Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2

Nature Cell Biology

Volumn 4, Issue 1, 2002, Pages 1-10

  Hofmann, Thomas G ^a,b   Möller, Andreas ^a   Sirma, Hüseyin ^b   Zentgraf, Hanswalter ^a   Taya, Yoichi ^c   Dröge, Wulf ^a   Will, Hans ^b   Lienhard Schmitz, M ^a,d  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b Department of General Virology   (Switzerland)

^c NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^d National Cancer Center Research Institute ^*  (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; HOMEODOMAIN PROTEIN; ISOPROTEIN; LYSINE; PROMYELOCYTIC LEUKEMIA PROTEIN 3; PROTEIN P53; PROTEIN SERINE THREONINE KINASE; UNCLASSIFIED DRUG;

ACETYLATION; APOPTOSIS; ARTICLE; CELL GROWTH; CELL NUCLEUS INCLUSION BODY; CELL PROLIFERATION; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; MITOSIS INHIBITION; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; REGULATORY MECHANISM; ULTRAVIOLET RADIATION;

ANIMALS; APOPTOSIS; CARRIER PROTEINS; CELL DIVISION; CELL NUCLEUS; CREB-BINDING PROTEIN; ENZYME ACTIVATION; GENES, TUMOR SUPPRESSOR; HUMANS; MICE; NEOPLASM PROTEINS; NUCLEAR PROTEINS; OLIGONUCLEOTIDES, ANTISENSE; PROTEIN BINDING; PROTEIN ISOFORMS; PROTEIN-SERINE-THREONINE KINASES; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS; ULTRAVIOLET RAYS;

EID: 0036141392     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/ncb715     Document Type: Article

References (48)

1. The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
2. Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53
3. Mdm2 promotes the rapid degradation of p53
4. Regulation of p53 stability by Mdm2
5. Regulation of the p53 tumor suppressor protein
6. Identification and classification of p53-regulated genes
7. Analysis of p53-regulated gene expression patterns using oligonucleotide arrays
8. Stress signals utilize multiple pathways to stabilize p53
9. DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2
10. Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2
11. Stress-activated kinases regulate protein stability
12. Post-translational modifications and activation of p53 by genotoxic stresses
13. DNA damage-induced activation of p53 by the checkpoint kinase Chk2
14. The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites
15. The ataxia-telangiectasia related protein ATR mediates DNA-dependent phosphorylation of p53
16. DNA-dependent protein kinase-independent activation of p53 in response to DNA damage
17. Requirement of ATM in phosphorylation of the human p53 protein at serine 15 following DNA double-strand breaks
18. E1A signaling to p53 involves the p19(ARF) tumor suppressor
19. Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation
20. p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53
21. p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage
22. p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2
23. Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain
24. DNA damage activates p53 through a phosphorylation-acetylation cascade
25. Deacetylation of p53 modulates its effect on cell growth and apoptosis
26. PML is induced by oncogenic ras and promotes premature senescence
27. Regulation of p53 activity in nuclear bodies by a specific PML isoform
28. The function of PML in p53-dependent apoptosis
29. PML regulates p53 acetylation and premature senescence induced by oncogenic Ras
30. Human homeodomain-interacting protein kinase-2 (HIPK2) is a member of the DYRK family of protein kinases and maps to chromosome 7q32-q34
31. Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors
32. Characterization of a novel serine/threonine kinase associated with nuclear bodies
33. Localization of nascent RNA and CREB binding protein with the PML-containing nuclear body
34. Modulation of CREB binding protein function by the promyelocytic (PML) oncoprotein suggests a role for nuclear bodies in hormone signaling
35. WAF1, a potential mediator of p53 tumor suppression
36. P53 and PML: New partners in tumor suppression
37. Properties and assembly mechanisms of ND10, PML bodies, or PODs
38. The transcription coactivator CBP is a dynamic component of the promyelocytic leukemia nuclear body
39. Promyelocytic leukemia (PML) nuclear bodies are protein structures that do not accumulate RNA
40. Cloning and characterization of Dlk, a novel serine/threonine kinase that is tightly associated with chromatin and phosphorylates core histones
41. A role for the p38 mitogen-activated protein kinase pathway in the transcriptional activation of p53 on genotoxic stress by chemotherapeutic agents
42. Human p53 is phosphorylated on serines 6 and 9 in response to DNA damage-inducing agents
43. Phosphorylation of serines 15 and 37 is necessary for efficient accumulation of p53 following irradiation with UV
44. PIC-1/SUMO-1-modified PML-retinoic acid receptor alpha mediates arsenic trioxide-induced apoptosis in acute promyelocytic leukemia
45. Oncogenic forms of p53 inhibit p53-regulated gene expression
46. Peroxisome proliferator-activated receptor alpha negatively regulates the vascular inflammatory gene response by negative cross-talk with transcription factors NF-κB and AP-1
47. Mixed-lineage kinase 3 delivers CD3/CD28-derived signals into the IκB kinase complex