A Tumor Suppressor Function for Notch Signaling in Forebrain Tumor Subtypes

Cancer Cell

Volumn 28, Issue 6, 2015, Pages 730-742

  Giachino, Claudio ^a   Boulay, Jean Louis ^b   Ivanek, Robert ^a   Alvarado, Alvaro ^c   Tostado, Cristobal ^b   Lugert, Sebastian ^a   Tchorz, Jan ^a   Coban, Mustafa ^a   Mariani, Luigi ^b   Bettler, Bernhard ^a   Lathia, Justin ^c   Frank, Stephan ^a   Pfister, Stefan ^d   Kool, Marcel ^d   Taylor, Verdon ^a  

^a UNIVERSITY OF BASEL   (Switzerland)

^b UNIVERSITY HOSPITAL BASEL   (Switzerland)

^c LERNER RESEARCH INSTITUTE   (United States)

^d GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

Brain tumor; Glioma; Hes5; Notch signaling; Primitive neuroectodermal tumor

Indexed keywords

CRE RECOMBINASE; NOTCH RECEPTOR; NOTCH1 RECEPTOR; NOTCH2 RECEPTOR; PLATELET DERIVED GROWTH FACTOR; PROTEIN P53; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; HES5 PROTEIN, MOUSE; IMMUNOGLOBULIN J RECOMBINATION SIGNAL SEQUENCE BINDING PROTEIN; NOTCH1 PROTEIN, MOUSE; NOTCH2 PROTEIN, MOUSE; PLATELET DERIVED GROWTH FACTOR B; PLATELET-DERIVED GROWTH FACTOR A; RBPJ PROTEIN, MOUSE; RECOMBINANT PROTEIN; REPRESSOR PROTEIN; TUMOR SUPPRESSOR PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN TUMOR; CANCER INHIBITION; CANCER PROGNOSIS; CARCINOGENESIS; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE COURSE; FOREBRAIN; GENE DOSAGE; GENE INACTIVATION; GENOTYPE; GLIOMA CELL; GLIOMA STEM CELL; HUMAN; HUMAN TISSUE; LATENT PERIOD; MITOSIS; NEURAL STEM CELL; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SUBVENTRICULAR ZONE; TUMOR GROWTH; ANIMAL; CANCER GRADING; CANCER STEM CELL; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE TRANSFER; GENETIC DATABASE; GENETICS; GLIOMA; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; KAPLAN MEIER METHOD; KNOCKOUT MOUSE; METABOLISM; MORTALITY; PATHOLOGY; PHENOTYPE; TIME FACTOR; TUMOR VOLUME;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BRAIN NEOPLASMS; CELL PROLIFERATION; DATABASES, GENETIC; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE TRANSFER TECHNIQUES; GLIOMA; HUMANS; IMMUNOGLOBULIN J RECOMBINATION SIGNAL SEQUENCE-BINDING PROTEIN; INFUSIONS, INTRAVENTRICULAR; KAPLAN-MEIER ESTIMATE; MICE, KNOCKOUT; NEOPLASM GRADING; NEOPLASTIC STEM CELLS; NEURAL STEM CELLS; PHENOTYPE; PLATELET-DERIVED GROWTH FACTOR; PROSENCEPHALON; PROTO-ONCOGENE PROTEINS C-SIS; RECEPTOR, NOTCH1; RECEPTOR, NOTCH2; RECEPTORS, NOTCH; RECOMBINANT PROTEINS; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; TIME FACTORS; TUMOR BURDEN; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS;

EID: 84959134029     PISSN: 15356108     EISSN: 18783686     Source Type: Journal    
DOI: 10.1016/j.ccell.2015.10.008     Document Type: Article

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