High-resolution, dual-platform aCGH analysis reveals frequent HIPK2 amplification and increased expression in pilocytic astrocytomas

Oncogene

Volumn 27, Issue 34, 2008, Pages 4745-4751

  Deshmukh, H ^a   Yeh, T H ^a,b   Yu, J ^a   Sharma, M K ^a   Perry, A ^a   Leonard, J R ^a   Watson, M A ^a   Gutmann, D H ^a   Nagarajan, R ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

Author keywords

aCGH; HIPK2 amplification; Pilocytic astrocytomas

Indexed keywords

DNA; HOMEODOMAIN INTERACTING PROTEIN KINASE 2; HOMEODOMAIN PROTEIN; MESSENGER RNA;

ADULT; ARTICLE; ASTROCYTOMA; CANCER GRADING; CEREBELLUM; CHILD; CHROMOSOME 7Q; CHROMOSOME HIGH RESOLUTION BANDING ANALYSIS; COMPARATIVE GENOMIC HYBRIDIZATION; CONTROLLED STUDY; EPENDYMOMA; FEMALE; GENE AMPLIFICATION; GENE EXPRESSION; GENE LOCUS; GENOME ANALYSIS; GLIOMA; HUMAN; HUMAN CELL; LEUKOCYTE; MAJOR CLINICAL STUDY; MALE; PILOCYTIC ASTROCYTOMA; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; QUANTITATIVE ASSAY; SINGLE NUCLEOTIDE POLYMORPHISM; TISSUE MICROARRAY;

ADOLESCENT; ASTROCYTOMA; CARRIER PROTEINS; CASE-CONTROL STUDIES; CEREBELLAR NEOPLASMS; CHILD; CHILD, PRESCHOOL; CLUSTER ANALYSIS; DNA MUTATIONAL ANALYSIS; FEMALE; GENE AMPLIFICATION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE FREQUENCY; HUMANS; MALE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN-SERINE-THREONINE KINASES; TUMOR CELLS, CULTURED; TUMOR STEM CELL ASSAY;

EID: 49149087048     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2008.110     Document Type: Article

References (33)

1. Agamanolis DP, Malone JM. (1995). Chromosomal abnormalities in 47 pediatric brain tumors. Cancer Genet Cytogenet 81: 125-134.
2. Albertson DG. (2006). Gene amplification in cancer. Trends Genet 22: 447-455.
3. Arjona D, Rey JA, Taylor SM. (2006). Early genetic changes involved in low-grade astrocytic tumor development. Curr Mol Med 6: 645-650.
4. Calzado MA, Renner F, Roscic A, Schmitz ML. (2007). HIPK2: a versatile switchboard regulating the transcription machinery and cell death. Cell Cycle 6: 139-143.
5. Cheng Y, Pang JC, Ng HK, Ding M, Zhang SF, Zheng J et al. (2000). Pilocytic astrocytomas do not show most of the genetic changes commonly seen in diffuse astrocytomas. Histopathology 37: 437-444.
6. D'Orazi G, Cecchinelli B, Bruno T, Manni I, Higashimoto Y, Saito S et al. (2002). Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis. Nat Cell Biol 4: 11-19.
7. Harada J, Kokura K, Kanei-Ishii C, Nomura T, Khan MM, Kim Y et al. (2003). Requirementof the co-repressor homeodomain-interacting protein kinase 2 for ski-mediated inhibition of bone morphogenetic protein-induced transcriptional activation. J Biol Chem 278: 38998-39005.
8. Hayes VM, Dirven CM, Dam A, Verlind E, Molenaar WM, Mooij JJ et al. (1999). High frequency of TP53 mutations in juvenile pilocytic astrocytomas indicates role of TP53 in the development of these tumors. Brain Pathol 9: 463-467.
9. Ishii N, Sawamura Y, Tada M, Daub DM, Janzer RC, Meagher-Villemure M et al. (1998). Absence of p53 gene mutations in a tumor panel representative of pilocytic astrocytoma diversity using a p53 functional assay. Int J Cancer 76: 797-800.
10. Jenkins RB, Kimmel DW, Moertel CA, Schultz CG, Scheithauer BW, Kelly PJ et al. (1989). A cytogenetic study of 53 human gliomas. Cancer Genet Cytogenet 39: 253-279.
11. Jones DT, Ichimura K, Liu L, Pearson DM, Plant K, Collins VP. (2006). Genomic analysis of pilocytic astrocytomas at 0.97Mb resolution shows an increasing tendency toward chromosomal copy number change with age. J Neuropathol Exp Neurol 65: 1049-1058.
12. Kim YH, Choi CY, Lee SJ, Conti MA, Kim Y. (1998). Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors. J Biol Chem 273: 25875-25879.
13. Konigshoff M, Wilhelm J, Bohle RM, Pingoud A, Hahn M. (2003). HER-2/neu gene copy number quantified by real-time PCR: comparison of gene amplification, heterozygosity, and immunohistochemical status in breast cancer tissue. Clin Chem 49: 219-229.
14. Koschny R, Koschny T, Froster UG, Krupp W, Zuber MA. (2002). Comparative genomic hybridization in glioma: a meta-analysis of 509 cases. Cancer Genet Cytogenet 135: 147-159.
15. Lin M, Wei LJ, Sellers WR, Lieberfarb M, Wong WH, Li C. (2004). dChipSNP: significance curve and clustering of SNP-array-based loss-of-heterozygosity data. Bioinformatics 20: 1233-1240.
16. Nannya Y, Sanada M, Nakazaki K, Hosoya N, Wang L, Hangaishi A et al. (2005). A robust algorithm for copy number detection using high-density oligonucleotide single nucleotide polymorphism genotyping arrays. Cancer Res 65: 6071-6079.
17. Ohgaki H. (2005). Genetic pathways to glioblastomas. Neuropathology 25: 1-7.
18. Ohgaki H, Dessen P, Jourde B, Horstmann S, Nishikawa T, Di Patre PL et al. (2004). Genetic pathways to glioblastoma: a population-based study. Cancer Res 64: 6892-6899.
19. Pierantoni GM, Bulfone A, Pentimalli F, Fedele M, Iuliano R, Santoro M et al. (2002). The homeodomain-interacting protein kinase 2 gene is expressed late in embryogenesis and preferentially in retina, muscle, and neural tissues. Biochem Biophys Res Commun 290: 942-947.
20. Sanoudou D, Tingby O, Ferguson-Smith MA, Collins VP, Coleman N. (2000). Analysis of pilocytic astrocytoma by comparative genomic hybridization. Br J Cancer 82: 1218-1222.
21. Schmidt MC, Antweiler S, Urban N, Mueller W, Kuklik A, Meyer-Puttlitz B et al. (2002). Impactof genotype and morphology on the prognosis of glioblastoma. J Neuropathol Exp Neurol 61: 321-328.
22. Sebat J, Lakshmi B, Troge J, Alexander J, Young J, Lundin P et al. (2004). Large-scale copy number polymorphism in the human genome. Science 305: 525-528.
23. Sharma MK, Watson MA, Lyman M, Perry A, Aldape KD, Deak F et al. (2006). Matrilin-2 expression distinguishes clinically relevant subsets of pilocytic astrocytoma. Neurology 66: 127-130.
24. Tada K, Kochi M, Saya H, Kuratsu J, Shiraishi S, Kamiryo T et al. (2003). Preliminary observations on genetic alterations in pilocytic astrocytomas associated with neurofibromatosis 1. Neuro Oncol 5: 228-234.
25. Thiel G, Losanowa T, Kintzel D, Nisch G, Martin H, Vorpahl K et al. (1992). Karyotypes in 90 human gliomas. Cancer Genet Cytogenet 58: 109-120.
26. Venkatraman ES, Olshen AB. (2007). A faster circular binary segmentation algorithm for the analysis of array CGH data. Bioinformatics 23: 657-663.
27. von Deimling A, Fimmers R, Schmidt MC, Bender B, Fassbender F, Nagel J et al. (2000). Comprehensive allelotype and genetic anaysis of 466 human nervous system tumors. J Neuropathol Exp Neurol 59: 544-558.
28. Wei G, Ku S, Ma GK, Saito S, Tang AA, Zhang J et al. (2007). HIPK2 represses beta-catenin-mediated transcription, epidermal stem cell expansion, and skin tumorigenesis. Proc Natl Acad Sci USA 104: 13040-13045.
29. Wemmert S , Romeike BF, Ketter R, Steudel WI, Zang KD, Urbschat S. (2006). Intratumoral genetic heterogeneity in pilocytic astrocytomas revealed by CGH-analysis of microdissected tumor cells and FISH on tumor tissue sections. Int J Oncol 28: 353-360.
30. White FV, Anthony DC, Yunis EJ, Tarbell NJ, Scott RM, Schofield DE. (1995). Nonrandom chromosomal gains in pilocytic astrocytomas of childhood. Hum Pathol 26: 979-986.
31. Wiggins AK, Wei G, Doxakis E, Wong C, Tang AA, Zang K et al. (2004). Interaction of Brn3a and HIPK2 mediates transcriptional repression of sensory neuron survival. J Cell Biol 167: 257-267.
32. Zattara-Cannoni H, Gambarelli D, Lena G, Dufour H, Choux M, Grisoli F et al. (1998). Are juvenile pilocytic astrocytomas benign tumors? A cytogenetic study in 24 cases. Cancer Genet Cytogenet 104: 157-160.
33. Zhang J, Pho V, Bonasera SJ, Holtzman J, Tang AT, Hellmuth J et al. (2007). Essential function of HIPK2 in TGFbeta-dependent survival of midbrain dopamine neurons. Nat Neurosci 10: 77-86.