-
1
-
-
84960354901
-
Tissue-resident macrophage ontogeny and homeostasis
-
Ginhoux, F. & Guilliams, M. Tissue-resident macrophage ontogeny and homeostasis. Immunity 44, 439-449 (2016
-
(2016)
Immunity
, vol.44
, pp. 439-449
-
-
Ginhoux, F.1
Guilliams, M.2
-
2
-
-
84951284076
-
The development and maintenance of resident macrophages
-
Perdiguero, E. G. & Geissmann, F. The development and maintenance of resident macrophages. Nat. Immunol. 17, 2-8 (2016).
-
(2016)
Nat. Immunol
, vol.17
, pp. 2-8
-
-
Perdiguero, E.G.1
Geissmann, F.2
-
3
-
-
70049099836
-
Intestinal lamina propria dendritic cell subsets have different origin and functions
-
Varol, C. et al. Intestinal lamina propria dendritic cell subsets have different origin and functions. Immunity 31, 502-512 (2009).
-
(2009)
Immunity
, vol.31
, pp. 502-512
-
-
Varol, C.1
-
4
-
-
84960920909
-
Yolk sac macrophages, fetal liver, and adult monocytes can colonize an empty niche and develop into functional tissue-resident macrophages
-
van de Laar, L. et al. Yolk sac macrophages, fetal liver, and adult monocytes can colonize an empty niche and develop into functional tissue-resident macrophages. Immunity 44, 755-768 (2016).
-
(2016)
Immunity
, vol.44
, pp. 755-768
-
-
Van De Laar, L.1
-
5
-
-
70049098070
-
Origin of the lamina propria dendritic cell network
-
Bogunovic, M. et al. Origin of the lamina propria dendritic cell network. Immunity 31, 513-525 (2009).
-
(2009)
Immunity
, vol.31
, pp. 513-525
-
-
Bogunovic, M.1
-
6
-
-
79960829290
-
Neutrophils in the activation and regulation of innate and adaptive immunity
-
Mantovani, A., Cassatella, M. A., Costantini, C. & Jaillon, S. Neutrophils in the activation and regulation of innate and adaptive immunity. Nat. Rev. Immunol. 11, 519-531 (2011).
-
(2011)
Nat. Rev. Immunol
, vol.11
, pp. 519-531
-
-
Mantovani, A.1
Cassatella, M.A.2
Costantini, C.3
Jaillon, S.4
-
7
-
-
1542287347
-
Neutrophil extracellular traps kill bacteria
-
This study showed for the first time the release of extracellular chromatin traps by neutrophils
-
Brinkmann, V. et al. Neutrophil extracellular traps kill bacteria. Science 303, 1532-1535 (2004). This study showed for the first time the release of extracellular chromatin traps by neutrophils.
-
(2004)
Science
, vol.303
, pp. 1532-1535
-
-
Brinkmann, V.1
-
8
-
-
84876913029
-
Protective and pathological roles of mast cells and basophils
-
Voehringer, D. Protective and pathological roles of mast cells and basophils. Nat. Rev. Immunol. 13, 362-375 (2013).
-
(2013)
Nat. Rev. Immunol
, vol.13
, pp. 362-375
-
-
Voehringer, D.1
-
9
-
-
84871482550
-
Eosinophils: Changing perspectives in health and disease
-
Rosenberg, H. F., Dyer, K. D. & Foster, P. S. Eosinophils: changing perspectives in health and disease. Nat. Rev. Immunol. 13, 9-22 (2013).
-
(2013)
Nat. Rev. Immunol
, vol.13
, pp. 9-22
-
-
Rosenberg, H.F.1
Dyer, K.D.2
Foster, P.S.3
-
10
-
-
80054899779
-
Phenotypic and functional plasticity of cells of innate immunity: Macrophages, mast cells and neutrophils
-
Galli, S. J., Borregaard, N. & Wynn, T. A. Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils. Nat. Immunol. 12, 1035-1044 (2011).
-
(2011)
Nat. Immunol
, vol.12
, pp. 1035-1044
-
-
Galli, S.J.1
Borregaard, N.2
Wynn, T.A.3
-
11
-
-
84986594034
-
The long non-coding RNA Morrbid regulates Bim and short-lived myeloid cell lifespan
-
Kotzin, J. J. et al. The long non-coding RNA Morrbid regulates Bim and short-lived myeloid cell lifespan. Nature 537, 239-243 (2016).
-
(2016)
Nature
, vol.537
, pp. 239-243
-
-
Kotzin, J.J.1
-
12
-
-
0036105543
-
Differential responses of mast cell Toll-like receptors 2 and 4 in allergy and innate immunity
-
Supajatura, V. et al. Differential responses of mast cell Toll-like receptors 2 and 4 in allergy and innate immunity. J. Clin. Invest. 109, 1351-1359 (2002).
-
(2002)
J. Clin. Invest
, vol.109
, pp. 1351-1359
-
-
Supajatura, V.1
-
13
-
-
34548779804
-
Molecular mechanisms underlying the synergistic induction of CXCL10 by LPS and IFN-gamma in human neutrophils
-
Tamassia, N. et al. Molecular mechanisms underlying the synergistic induction of CXCL10 by LPS and IFN-gamma in human neutrophils. Eur. J. Immunol. 37, 2627-2634 (2007).
-
(2007)
Eur. J. Immunol
, vol.37
, pp. 2627-2634
-
-
Tamassia, N.1
-
14
-
-
84964341342
-
Epigenetic regulation of neutrophil development and function
-
Ostuni, R., Natoli, G., Cassatella, M. A. & Tamassia, N. Epigenetic regulation of neutrophil development and function. Semin. Immunol. 28, 83-93 (2016).
-
(2016)
Semin. Immunol
, vol.28
, pp. 83-93
-
-
Ostuni, R.1
Natoli, G.2
Cassatella, M.A.3
Tamassia, N.4
-
15
-
-
84865790047
-
An integrated encyclopedia of DNA elements in the human genome
-
Consortium, E. P. An integrated encyclopedia of DNA elements in the human genome. Nature 489, 57-74 (2012).
-
(2012)
Nature
, vol.489
, pp. 57-74
-
-
Consortium, E.P.1
-
16
-
-
77954928774
-
Maintaining cell identity through global control of genomic organization
-
Natoli, G. Maintaining cell identity through global control of genomic organization. Immunity 33, 12-24 (2010).
-
(2010)
Immunity
, vol.33
, pp. 12-24
-
-
Natoli, G.1
-
17
-
-
84901921616
-
Coregulation of transcription factor binding and nucleosome occupancy through DNA features of mammalian enhancers
-
Barozzi, I. et al. Coregulation of transcription factor binding and nucleosome occupancy through DNA features of mammalian enhancers. Mol. Cell 54, 844-857 (2014).
-
(2014)
Mol. Cell
, vol.54
, pp. 844-857
-
-
Barozzi, I.1
-
18
-
-
84951320292
-
Molecular control of activation and priming in macrophages
-
Glass, C. K. & Natoli, G. Molecular control of activation and priming in macrophages. Nat. Immunol. 17, 26-33 (2016).
-
(2016)
Nat. Immunol
, vol.17
, pp. 26-33
-
-
Glass, C.K.1
Natoli, G.2
-
19
-
-
0028136726
-
Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages
-
Scott, E. W., Simon, M. C., Anastasi, J. & Singh, H. Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages. Science 265, 1573-1577 (1994).
-
(1994)
Science
, vol.265
, pp. 1573-1577
-
-
Scott, E.W.1
Simon, M.C.2
Anastasi, J.3
Singh, H.4
-
20
-
-
0242549003
-
Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities
-
McKercher, S. R. et al. Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities. EMBO J. 15, 5647-5658 (1996).
-
(1996)
EMBO J
, vol.15
, pp. 5647-5658
-
-
McKercher, S.R.1
-
21
-
-
18744416572
-
Cooperative and antagonistic interplay between PU.1 and GATA?2 in the specification of myeloid cell fates
-
Walsh, J. C. et al. Cooperative and antagonistic interplay between PU.1 and GATA?2 in the specification of myeloid cell fates. Immunity 17, 665-676 (2002).
-
(2002)
Immunity
, vol.17
, pp. 665-676
-
-
Walsh, J.C.1
-
22
-
-
84904886001
-
Transcriptional establishment of cell-type identity: Dynamics and causal mechanisms of T?Cell lineage commitment
-
Rothenberg, E. V. et al. Transcriptional establishment of cell-type identity: dynamics and causal mechanisms of T?cell lineage commitment. Cold Spring Harb. Symp. Quant. Biol. 78, 31-41 (2013).
-
(2013)
Cold Spring Harb. Symp. Quant. Biol
, vol.78
, pp. 31-41
-
-
Rothenberg, E.V.1
-
23
-
-
75949115944
-
Noncooperative interactions between transcription factors and clustered DNA binding sites enable graded transcriptional responses to environmental inputs
-
Giorgetti, L. et al. Noncooperative interactions between transcription factors and clustered DNA binding sites enable graded transcriptional responses to environmental inputs. Mol. Cell 37, 418-428 (2010).
-
(2010)
Mol. Cell
, vol.37
, pp. 418-428
-
-
Giorgetti, L.1
-
24
-
-
34447099234
-
Probing the limits to positional information
-
Gregor, T., Tank, D. W., Wieschaus, E. F. & Bialek, W. Probing the limits to positional information. Cell 130, 153-164 (2007).
-
(2007)
Cell
, vol.130
, pp. 153-164
-
-
Gregor, T.1
Tank, D.W.2
Wieschaus, E.F.3
Bialek, W.4
-
25
-
-
84881236410
-
Positive feedback between PU.1 and the cell cycle controls myeloid differentiation
-
In this study, the authors describe the post-transcriptional mechanisms that determine different concentrations of PU.1 in B lymphocytes and macrophages
-
Kueh, H. Y., Champhekar, A., Nutt, S. L., Elowitz, M. B. & Rothenberg, E. V. Positive feedback between PU.1 and the cell cycle controls myeloid differentiation. Science 341, 670-673 (2013). In this study, the authors describe the post-transcriptional mechanisms that determine different concentrations of PU.1 in B lymphocytes and macrophages.
-
(2013)
Science
, vol.341
, pp. 670-673
-
-
Kueh, H.Y.1
Champhekar, A.2
Nutt, S.L.3
Elowitz, M.B.4
Rothenberg, E.V.5
-
26
-
-
0142124320
-
Regulation of macrophage and neutrophil cell fates by the PU.1:C/EBPalpha ratio and granulocyte colony-stimulating factor
-
Dahl, R. et al. Regulation of macrophage and neutrophil cell fates by the PU.1:C/EBPalpha ratio and granulocyte colony-stimulating factor. Nat. Immunol. 4, 1029-1036 (2003).
-
(2003)
Nat. Immunol
, vol.4
, pp. 1029-1036
-
-
Dahl, R.1
-
27
-
-
0037100304
-
Granulocyte inducer C/EBPalpha inactivates the myeloid master regulator PU.1: Possible role in lineage commitment decisions
-
Reddy, V. A. et al. Granulocyte inducer C/EBPalpha inactivates the myeloid master regulator PU.1: possible role in lineage commitment decisions. Blood 100, 483-490 (2002).
-
(2002)
Blood
, vol.100
, pp. 483-490
-
-
Reddy, V.A.1
-
28
-
-
77953282048
-
The transcription factor PU.1 controls dendritic cell development and Flt3 cytokine receptor expression in a dose-dependent manner
-
Carotta, S. et al. The transcription factor PU.1 controls dendritic cell development and Flt3 cytokine receptor expression in a dose-dependent manner. Immunity 32, 628-641 (2010).
-
(2010)
Immunity
, vol.32
, pp. 628-641
-
-
Carotta, S.1
-
29
-
-
42649114059
-
The IRF family transcription factors in immunity and oncogenesis
-
Tamura, T., Yanai, H., Savitsky, D. & Taniguchi, T. The IRF family transcription factors in immunity and oncogenesis. Annu. Rev. Immunol. 26, 535-584 (2008).
-
(2008)
Annu. Rev. Immunol
, vol.26
, pp. 535-584
-
-
Tamura, T.1
Yanai, H.2
Savitsky, D.3
Taniguchi, T.4
-
30
-
-
0033680746
-
ICSBP directs bipotential myeloid progenitor cells to differentiate into mature macrophages
-
Tamura, T., Nagamura-Inoue, T., Shmeltzer, Z., Kuwata, T. & Ozato, K. ICSBP directs bipotential myeloid progenitor cells to differentiate into mature macrophages. Immunity 13, 155-165 (2000).
-
(2000)
Immunity
, vol.13
, pp. 155-165
-
-
Tamura, T.1
Nagamura-Inoue, T.2
Shmeltzer, Z.3
Kuwata, T.4
Ozato, K.5
-
31
-
-
84920973718
-
Transcription factor IRF8 plays a critical role in the development of murine basophils and mast cells
-
Sasaki, H. et al. Transcription factor IRF8 plays a critical role in the development of murine basophils and mast cells. Blood 125, 358-369 (2015).
-
(2015)
Blood
, vol.125
, pp. 358-369
-
-
Sasaki, H.1
-
32
-
-
84922998982
-
A dual cis-regulatory code links IRF8 to constitutive and inducible gene expression in macrophages
-
Mancino, A. et al. A dual cis-regulatory code links IRF8 to constitutive and inducible gene expression in macrophages. Genes Dev. 29, 394-408 (2015).
-
(2015)
Genes Dev
, vol.29
, pp. 394-408
-
-
Mancino, A.1
-
33
-
-
77956640232
-
Autocrine purinergic receptor signaling is essential for macrophage chemotaxis
-
Kronlage, M. et al. Autocrine purinergic receptor signaling is essential for macrophage chemotaxis. Sci. Signal. 3, ra55 (2010).
-
(2010)
Sci. Signal
, vol.3
, pp. ra55
-
-
Kronlage, M.1
-
34
-
-
80053100071
-
P2 receptors and extracellular ATP: A novel homeostatic pathway in inflammation
-
Bours, M. J., Dagnelie, P. C., Giuliani, A. L., Wesselius, A. & Di Virgilio, F. P2 receptors and extracellular ATP: a novel homeostatic pathway in inflammation. Front. Biosci. (Schol. Ed.) 3, 1443-1456 (2011).
-
(2011)
Front. Biosci. (Schol. Ed.)
, vol.3
, pp. 1443-1456
-
-
Bours, M.J.1
Dagnelie, P.C.2
Giuliani, A.L.3
Wesselius, A.4
Di Virgilio, F.5
-
35
-
-
77954886436
-
P2X4 receptors mediate PGE2 release by tissue-resident macrophages and initiate inflammatory pain
-
Ulmann, L., Hirbec, H. & Rassendren, F. P2X4 receptors mediate PGE2 release by tissue-resident macrophages and initiate inflammatory pain. EMBO J. 29, 2290-2300 (2010).
-
(2010)
EMBO J
, vol.29
, pp. 2290-2300
-
-
Ulmann, L.1
Hirbec, H.2
Rassendren, F.3
-
36
-
-
79960219807
-
IRF8 mutations and human dendritic-cell immunodeficiency
-
Hambleton, S. et al. IRF8 mutations and human dendritic-cell immunodeficiency. N. Engl. J. Med. 365, 127-138 (2011).
-
(2011)
N. Engl. J. Med
, vol.365
, pp. 127-138
-
-
Hambleton, S.1
-
37
-
-
84918783058
-
A negative feedback loop of transcription factors specifies alternative dendritic cell chromatin states
-
Bornstein, C. et al. A negative feedback loop of transcription factors specifies alternative dendritic cell chromatin states. Mol. Cell 56, 749-762 (2014).
-
(2014)
Mol. Cell
, vol.56
, pp. 749-762
-
-
Bornstein, C.1
-
38
-
-
84857724877
-
IRF?8 extinguishes neutrophil production and promotes dendritic cell lineage commitment in both myeloid and lymphoid mouse progenitors
-
Becker, A. M. et al. IRF?8 extinguishes neutrophil production and promotes dendritic cell lineage commitment in both myeloid and lymphoid mouse progenitors. Blood 119, 2003-2012 (2012).
-
(2012)
Blood
, vol.119
, pp. 2003-2012
-
-
Becker, A.M.1
-
39
-
-
0031029557
-
Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein alpha-deficient mice
-
Zhang, D. E. et al. Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein alpha-deficient mice. Proc. Natl Acad. Sci. USA 94, 569-574 (1997).
-
(1997)
Proc. Natl Acad. Sci. USA
, vol.94
, pp. 569-574
-
-
Zhang, D.E.1
-
40
-
-
34547133494
-
The C/EBP family of transcription factors: A paradigm for interaction between gene expression and proliferation control
-
Nerlov, C. The C/EBP family of transcription factors: a paradigm for interaction between gene expression and proliferation control. Trends Cell Biol. 17, 318-324 (2007).
-
(2007)
Trends Cell Biol
, vol.17
, pp. 318-324
-
-
Nerlov, C.1
-
41
-
-
84994059846
-
An autonomous CEBPA enhancer specific for myeloid-lineage priming and neutrophilic differentiation
-
Avellino, R. et al. An autonomous CEBPA enhancer specific for myeloid-lineage priming and neutrophilic differentiation. Blood 127, 2991-3003 (2016).
-
(2016)
Blood
, vol.127
, pp. 2991-3003
-
-
Avellino, R.1
-
42
-
-
84950290139
-
Transcriptional heterogeneity and lineage commitment in myeloid progenitors
-
This study revisits the developmental trajectories in the myeloid lineage, combining single-cell RNA sequencing with index sorting
-
Paul, F. et al. Transcriptional heterogeneity and lineage commitment in myeloid progenitors. Cell 163, 1663-1677 (2015). This study revisits the developmental trajectories in the myeloid lineage, combining single-cell RNA sequencing with index sorting.
-
(2015)
Cell
, vol.163
, pp. 1663-1677
-
-
Paul, F.1
-
43
-
-
0037090244
-
C/EBP beta gene inactivation causes both impaired and enhanced gene expression and inverse regulation of IL?12 p40 and p35 mRNAs in macrophages
-
Gorgoni, B., Maritano, D., Marthyn, P., Righi, M. & Poli, V. C/EBP beta gene inactivation causes both impaired and enhanced gene expression and inverse regulation of IL?12 p40 and p35 mRNAs in macrophages. J. Immunol. 168, 4055-4062 (2002).
-
(2002)
J. Immunol
, vol.168
, pp. 4055-4062
-
-
Gorgoni, B.1
Maritano, D.2
Marthyn, P.3
Righi, M.4
Poli, V.5
-
44
-
-
0029024113
-
Lymphoproliferative disorder and imbalanced T?Helper response in C/EBP beta-deficient mice
-
Screpanti, I. et al. Lymphoproliferative disorder and imbalanced T?helper response in C/EBP beta-deficient mice. EMBO J. 14, 1932-1941 (1995).
-
(1995)
EMBO J
, vol.14
, pp. 1932-1941
-
-
Screpanti, I.1
-
45
-
-
0028853334
-
Targeted disruption of the NF?IL6 gene discloses its essential role in bacteria killing and tumor cytotoxicity by macrophages
-
Tanaka, T. et al. Targeted disruption of the NF?IL6 gene discloses its essential role in bacteria killing and tumor cytotoxicity by macrophages. Cell 80, 353-361 (1995).
-
(1995)
Cell
, vol.80
, pp. 353-361
-
-
Tanaka, T.1
-
46
-
-
0030659176
-
Impaired granulopoiesis, myelodysplasia, and early lethality in CCAAT/enhancer binding protein epsilon-deficient mice
-
Yamanaka, R. et al. Impaired granulopoiesis, myelodysplasia, and early lethality in CCAAT/enhancer binding protein epsilon-deficient mice. Proc. Natl Acad. Sci. USA 94, 13187-13192 (1997).
-
(1997)
Proc. Natl Acad. Sci. USA
, vol.94
, pp. 13187-13192
-
-
Yamanaka, R.1
-
47
-
-
0038757823
-
Mutations in proto-oncogene GFI1 cause human neutropenia and target ELA2
-
Person, R. E. et al. Mutations in proto-oncogene GFI1 cause human neutropenia and target ELA2. Nat. Genet. 34, 308-312 (2003).
-
(2003)
Nat. Genet
, vol.34
, pp. 308-312
-
-
Person, R.E.1
-
48
-
-
33749510883
-
LEF?1 is crucial for neutrophil granulocytopoiesis and its expression is severely reduced in congenital neutropenia
-
Skokowa, J. et al. LEF?1 is crucial for neutrophil granulocytopoiesis and its expression is severely reduced in congenital neutropenia. Nat. Med. 12, 1191-1197 (2006).
-
(2006)
Nat. Med
, vol.12
, pp. 1191-1197
-
-
Skokowa, J.1
-
49
-
-
33845921855
-
Distinct and shared transcriptomes are regulated by microphthalmia-associated transcription factor isoforms in mast cells
-
Shahlaee, A. H., Brandal, S., Lee, Y. N., Jie, C. & Takemoto, C. M. Distinct and shared transcriptomes are regulated by microphthalmia-associated transcription factor isoforms in mast cells. J. Immunol. 178, 378-388 (2007).
-
(2007)
J. Immunol
, vol.178
, pp. 378-388
-
-
Shahlaee, A.H.1
Brandal, S.2
Lee, Y.N.3
Jie, C.4
Takemoto, C.M.5
-
50
-
-
84880728627
-
Antagonistic regulation by the transcription factors C/EBPalpha and MITF specifies basophil and mast cell fates
-
Qi, X. et al. Antagonistic regulation by the transcription factors C/EBPalpha and MITF specifies basophil and mast cell fates. Immunity 39, 97-110 (2013).
-
(2013)
Immunity
, vol.39
, pp. 97-110
-
-
Qi, X.1
-
51
-
-
29144472957
-
Developmental checkpoints of the basophil/mast cell lineages in adult murine hematopoiesis
-
Arinobu, Y. et al. Developmental checkpoints of the basophil/mast cell lineages in adult murine hematopoiesis. Proc. Natl Acad. Sci. USA 102, 18105-18110 (2005).
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 18105-18110
-
-
Arinobu, Y.1
-
52
-
-
84964963496
-
TET2 regulates mast cell differentiation and proliferation through catalytic and non-catalytic activities
-
Montagner, S. et al. TET2 regulates mast cell differentiation and proliferation through catalytic and non-catalytic activities. Cell Rep. 15, 1566-1579 (2016).
-
(2016)
Cell Rep
, vol.15
, pp. 1566-1579
-
-
Montagner, S.1
-
53
-
-
33751071630
-
The order of expression of transcription factors directs hierarchical specification of hematopoietic lineages
-
Iwasaki, H. et al. The order of expression of transcription factors directs hierarchical specification of hematopoietic lineages. Genes Dev. 20, 3010-3021 (2006).
-
(2006)
Genes Dev
, vol.20
, pp. 3010-3021
-
-
Iwasaki, H.1
-
54
-
-
0030926190
-
Transcription factor GATA?2 is required for proliferation/survival of early hematopoietic cells and mast cell formation, but not for erythroid and myeloid terminal differentiation
-
Tsai, F. Y. & Orkin, S. H. Transcription factor GATA?2 is required for proliferation/survival of early hematopoietic cells and mast cell formation, but not for erythroid and myeloid terminal differentiation. Blood 89, 3636-3643 (1997).
-
(1997)
Blood
, vol.89
, pp. 3636-3643
-
-
Tsai, F.Y.1
Orkin, S.H.2
-
55
-
-
84965019138
-
Expression profiling of constitutive mast cells reveals a unique identity within the immune system
-
Immunological Genome Project Consortium
-
Dwyer, D. F., Barrett, N. A., Austen, K. F. & Immunological Genome Project Consortium. Expression profiling of constitutive mast cells reveals a unique identity within the immune system. Nat. Immunol. 17, 878-887 (2016).
-
(2016)
Nat. Immunol
, vol.17
, pp. 878-887
-
-
Dwyer, D.F.1
Barrett, N.A.2
Austen, K.F.3
-
56
-
-
84989962489
-
Single-cell analysis of mixed-lineage states leading to a binary cell fate choice
-
In this study, the authors used single-cell RNA sequencing to characterize the mechanisms that control the differentiation of myeloid precursors into neutrophils or macrophages
-
Olsson, A. et al. Single-cell analysis of mixed-lineage states leading to a binary cell fate choice. Nature 537, 698-702 (2016). In this study, the authors used single-cell RNA sequencing to characterize the mechanisms that control the differentiation of myeloid precursors into neutrophils or macrophages.
-
(2016)
Nature
, vol.537
, pp. 698-702
-
-
Olsson, A.1
-
57
-
-
84962050673
-
Distinct myeloid progenitor-differentiation pathways identified through single-cell RNA sequencing
-
Drissen, R. et al. Distinct myeloid progenitor-differentiation pathways identified through single-cell RNA sequencing. Nat. Immunol. 17, 666-676 (2016).
-
(2016)
Nat. Immunol
, vol.17
, pp. 666-676
-
-
Drissen, R.1
-
58
-
-
85015748301
-
High constitutive activity of a broad panel of housekeeping and tissue-specific cis-regulatory elements depends on a subset of ETS proteins
-
Curina, A. et al. High constitutive activity of a broad panel of housekeeping and tissue-specific cis-regulatory elements depends on a subset of ETS proteins. Genes Dev. 31, 399-412 (2017).
-
(2017)
Genes Dev
, vol.31
, pp. 399-412
-
-
Curina, A.1
-
59
-
-
80455144479
-
Pioneer transcription factors: Establishing competence for gene expression
-
Zaret, K. S. & Carroll, J. S. Pioneer transcription factors: establishing competence for gene expression. Genes Dev. 25, 2227-2241 (2011).
-
(2011)
Genes Dev
, vol.25
, pp. 2227-2241
-
-
Zaret, K.S.1
Carroll, J.S.2
-
60
-
-
84855286273
-
Mechanisms establishing TLR4?Responsive activation states of inflammatory response genes
-
Escoubet-Lozach, L. et al. Mechanisms establishing TLR4?responsive activation states of inflammatory response genes. PLoS Genet. 7, e1002401 (2011).
-
(2011)
PLoS Genet
, vol.7
, pp. e1002401
-
-
Escoubet-Lozach, L.1
-
61
-
-
84877787762
-
M?CSF instructs myeloid lineage fate in single haematopoietic stem cells
-
Mossadegh-Keller, N. et al. M?CSF instructs myeloid lineage fate in single haematopoietic stem cells. Nature 497, 239-243 (2013).
-
(2013)
Nature
, vol.497
, pp. 239-243
-
-
Mossadegh-Keller, N.1
-
62
-
-
77952567987
-
Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities
-
Heinz, S. et al. Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. Mol. Cell 38, 576-589 (2010).
-
(2010)
Mol. Cell
, vol.38
, pp. 576-589
-
-
Heinz, S.1
-
63
-
-
84975784410
-
A stringent systems approach uncovers gene-specific mechanisms regulating inflammation
-
In this work, the authors combined genomic and genetic approaches to dissect the specific regulatory requirements of individual inducible genes in the macrophage response to LPS
-
Tong, A. J. et al. A stringent systems approach uncovers gene-specific mechanisms regulating inflammation. Cell 165, 165-179 (2016). In this work, the authors combined genomic and genetic approaches to dissect the specific regulatory requirements of individual inducible genes in the macrophage response to LPS.
-
(2016)
Cell
, vol.165
, pp. 165-179
-
-
Tong, A.J.1
-
64
-
-
85011337838
-
Genome-wide association between transcription factor expression and chromatin accessibility reveals regulators of chromatin accessibility
-
Lamparter, D., Marbach, D., Rueedi, R., Bergmann, S. & Kutalik, Z. Genome-wide association between transcription factor expression and chromatin accessibility reveals regulators of chromatin accessibility. PLoS Comput. Biol. 13, e1005311 (2017).
-
(2017)
PLoS Comput. Biol
, vol.13
, pp. e1005311
-
-
Lamparter, D.1
Marbach, D.2
Rueedi, R.3
Bergmann, S.4
Kutalik, Z.5
-
65
-
-
0036144048
-
DNA methylation patterns and epigenetic memory
-
Bird, A. DNA methylation patterns and epigenetic memory. Genes Dev. 16, 6-21 (2002).
-
(2002)
Genes Dev
, vol.16
, pp. 6-21
-
-
Bird, A.1
-
66
-
-
84863986133
-
Functions of DNA methylation: Islands, start sites, gene bodies and beyond
-
Jones, P. A. Functions of DNA methylation: islands, start sites, gene bodies and beyond. Nat. Rev. Genet. 13, 484-492 (2012).
-
(2012)
Nat. Rev. Genet
, vol.13
, pp. 484-492
-
-
Jones, P.A.1
-
67
-
-
84923330509
-
Genomic profiling of DNA methyltransferases reveals a role for DNMT3B in genic methylation
-
Baubec, T. et al. Genomic profiling of DNA methyltransferases reveals a role for DNMT3B in genic methylation. Nature 520, 243-247 (2015).
-
(2015)
Nature
, vol.520
, pp. 243-247
-
-
Baubec, T.1
-
68
-
-
85014546354
-
Intragenic DNA methylation prevents spurious transcription initiation
-
Neri, F. et al. Intragenic DNA methylation prevents spurious transcription initiation. Nature 543, 72-77 (2017).
-
(2017)
Nature
, vol.543
, pp. 72-77
-
-
Neri, F.1
-
69
-
-
0037372003
-
Epigenetic regulation of gene expression: How the genome integrates intrinsic and environmental signals
-
Jaenisch, R. & Bird, A. Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat. Genet. 33 (Suppl.), 245-254 (2003).
-
(2003)
Nat. Genet
, vol.33
, pp. 245-254
-
-
Jaenisch, R.1
Bird, A.2
-
70
-
-
70350654370
-
DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction
-
Broske, A. M. et al. DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction. Nat. Genet. 41, 1207-1215 (2009).
-
(2009)
Nat. Genet
, vol.41
, pp. 1207-1215
-
-
Broske, A.M.1
-
71
-
-
84925116257
-
Dnmt3a and Dnmt3b have overlapping and distinct functions in hematopoietic stem cells
-
Challen, G. A. et al. Dnmt3a and Dnmt3b have overlapping and distinct functions in hematopoietic stem cells. Cell Stem Cell 15, 350-364 (2014).
-
(2014)
Cell Stem Cell
, vol.15
, pp. 350-364
-
-
Challen, G.A.1
-
72
-
-
85013391402
-
Dnmt3a restrains mast cell inflammatory responses
-
This study shows that DNA methylation-related processes are crucial to restrain mast cell acute and chronic inflammatory responses in vivo and in vitro
-
Leoni, C. et al. Dnmt3a restrains mast cell inflammatory responses. Proc. Natl Acad. Sci. USA 114, E1490-E1499 (2017). This study shows that DNA methylation-related processes are crucial to restrain mast cell acute and chronic inflammatory responses in vivo and in vitro.
-
(2017)
Proc. Natl Acad. Sci. USA
, vol.114
, pp. E1490-E1499
-
-
Leoni, C.1
-
73
-
-
84928175766
-
Methyl-CpG binding protein 2 regulates microglia and macrophage gene expression in response to inflammatory stimuli
-
Cronk, J. C. et al. Methyl-CpG binding protein 2 regulates microglia and macrophage gene expression in response to inflammatory stimuli. Immunity 42, 679-691 (2015).
-
(2015)
Immunity
, vol.42
, pp. 679-691
-
-
Cronk, J.C.1
-
74
-
-
84975709184
-
Epigenetics of T lymphocytes in health and disease
-
Leoni, C., Vincenzetti, L., Emming, S. & Monticelli, S. Epigenetics of T lymphocytes in health and disease. Swiss Med. Wkly 145, w14191 (2015).
-
(2015)
Swiss Med. Wkly
, vol.145
, pp. w14191
-
-
Leoni, C.1
Vincenzetti, L.2
Emming, S.3
Monticelli, S.4
-
75
-
-
80052461558
-
Tet proteins can convert 5?Methylcytosine to 5?Formylcytosine and 5?Carboxylcytosine
-
Ito, S. et al. Tet proteins can convert 5?methylcytosine to 5?formylcytosine and 5?carboxylcytosine. Science 333, 1300-1303 (2011).
-
(2011)
Science
, vol.333
, pp. 1300-1303
-
-
Ito, S.1
-
76
-
-
66149146320
-
Conversion of 5?Methylcytosine to 5?Hydroxymethylcytosine in mammalian DNA by MLL partner TET1
-
Tahiliani, M. et al. Conversion of 5?methylcytosine to 5?hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science 324, 930-935 (2009).
-
(2009)
Science
, vol.324
, pp. 930-935
-
-
Tahiliani, M.1
-
77
-
-
84874771985
-
Dynamic readers for 5-(hydroxy)methylcytosine and its oxidized derivatives
-
Spruijt, C. G. et al. Dynamic readers for 5-(hydroxy)methylcytosine and its oxidized derivatives. Cell 152, 1146-1159 (2013).
-
(2013)
Cell
, vol.152
, pp. 1146-1159
-
-
Spruijt, C.G.1
-
78
-
-
80052284526
-
Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice
-
Ko, M. et al. Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice. Proc. Natl Acad. Sci. USA 108, 14566-14571 (2011).
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 14566-14571
-
-
Ko, M.1
-
79
-
-
79960064353
-
Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation
-
Moran-Crusio, K. et al. Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation. Cancer Cell 20, 11-24 (2011).
-
(2011)
Cancer Cell
, vol.20
, pp. 11-24
-
-
Moran-Crusio, K.1
-
80
-
-
80052285127
-
Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies
-
Li, Z. et al. Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies. Blood 118, 4509-4518 (2011).
-
(2011)
Blood
, vol.118
, pp. 4509-4518
-
-
Li, Z.1
-
81
-
-
79960062301
-
TET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesis
-
Quivoron, C. et al. TET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesis. Cancer Cell 20, 25-38 (2011).
-
(2011)
Cancer Cell
, vol.20
, pp. 25-38
-
-
Quivoron, C.1
-
82
-
-
84948446391
-
Acute loss of TET function results in aggressive myeloid cancer in mice
-
An, J. et al. Acute loss of TET function results in aggressive myeloid cancer in mice. Nat. Commun. 6, 10071 (2015).
-
(2015)
Nat. Commun
, vol.6
, pp. 10071
-
-
An, J.1
-
83
-
-
84942050633
-
Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL?6
-
Zhang, Q. et al. Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL?6. Nature 525, 389-393 (2015).
-
(2015)
Nature
, vol.525
, pp. 389-393
-
-
Zhang, Q.1
-
84
-
-
85005995773
-
Tet2 and Tet3 cooperate with B?Lineage transcription factors to regulate DNA modification and chromatin accessibility
-
Lio, C. W. et al. Tet2 and Tet3 cooperate with B?lineage transcription factors to regulate DNA modification and chromatin accessibility. eLife 5, e18290 (2016).
-
(2016)
ELife
, vol.5
, pp. e18290
-
-
Lio, C.W.1
-
85
-
-
84883685078
-
PU.1 target genes undergo Tet2?Coupled demethylation and DNMT3b?Mediated methylation in monocyte-to?Osteoclast differentiation
-
de la Rica, L. et al. PU.1 target genes undergo Tet2?coupled demethylation and DNMT3b?mediated methylation in monocyte-to?osteoclast differentiation. Genome Biol. 14, R99 (2013).
-
(2013)
Genome Biol
, vol.14
, pp. R99
-
-
De La Rica, L.1
-
86
-
-
77955902024
-
The widespread regulation of microRNA biogenesis, function and decay
-
Krol, J., Loedige, I. & Filipowicz, W. The widespread regulation of microRNA biogenesis, function and decay. Nat. Rev. Genet. 11, 597-610 (2010).
-
(2010)
Nat. Rev. Genet
, vol.11
, pp. 597-610
-
-
Krol, J.1
Loedige, I.2
Filipowicz, W.3
-
87
-
-
84926193978
-
Dicer is indispensable for the development of murine mast cells
-
Forster, A. et al. Dicer is indispensable for the development of murine mast cells. J. Allergy Clin. Immunol. 135, 1077-1080.e4 (2015).
-
(2015)
J. Allergy Clin. Immunol
, vol.135
, pp. 1077e4-1077e4
-
-
Forster, A.1
-
88
-
-
84976516808
-
Suppression of microRNA activity amplifies IFN-gamma-induced macrophage activation and promotes anti-tumour immunity
-
Baer, C. et al. Suppression of microRNA activity amplifies IFN-gamma-induced macrophage activation and promotes anti-tumour immunity. Nat. Cell Biol. 18, 790-802 (2016).
-
(2016)
Nat. Cell Biol
, vol.18
, pp. 790-802
-
-
Baer, C.1
-
89
-
-
34247483919
-
An evolutionarily conserved mechanism for microRNA?223 expression revealed by microRNA gene profiling
-
Fukao, T. et al. An evolutionarily conserved mechanism for microRNA?223 expression revealed by microRNA gene profiling. Cell 129, 617-631 (2007).
-
(2007)
Cell
, vol.129
, pp. 617-631
-
-
Fukao, T.1
-
90
-
-
39849096995
-
Regulation of progenitor cell proliferation and granulocyte function by microRNA?223
-
Using mir?223?deleted mice, this study revealed a key role for miR?223 in the regulation of granulocyte differentiation and activation
-
Johnnidis, J. B. et al. Regulation of progenitor cell proliferation and granulocyte function by microRNA?223. Nature 451, 1125-1129 (2008). Using mir?223?deleted mice, this study revealed a key role for miR?223 in the regulation of granulocyte differentiation and activation.
-
(2008)
Nature
, vol.451
, pp. 1125-1129
-
-
Johnnidis, J.B.1
-
91
-
-
84929494421
-
Down-regulation of microRNA?223 promotes degranulation via the PI3K/Akt pathway by targeting IGF?1R in mast cells
-
Wang, Q. et al. Down-regulation of microRNA?223 promotes degranulation via the PI3K/Akt pathway by targeting IGF?1R in mast cells. PLoS ONE 10, e0123575 (2015).
-
(2015)
PLoS ONE
, vol.10
, pp. e0123575
-
-
Wang, Q.1
-
92
-
-
33747608638
-
NF?KappaB-dependent induction of microRNA MIR?146, an inhibitor targeted to signaling proteins of innate immune responses
-
Taganov, K. D., Boldin, M. P., Chang, K. J. & Baltimore, D. NF?kappaB-dependent induction of microRNA miR?146, an inhibitor targeted to signaling proteins of innate immune responses. Proc. Natl Acad. Sci. USA 103, 12481-12486 (2006).
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 12481-12486
-
-
Taganov, K.D.1
Boldin, M.P.2
Chang, K.J.3
Baltimore, D.4
-
93
-
-
33846845071
-
MicroRNA?155 is induced during the macrophage inflammatory response
-
O'Connell, R. M., Taganov, K. D., Boldin, M. P., Cheng, G. & Baltimore, D. MicroRNA?155 is induced during the macrophage inflammatory response. Proc. Natl Acad. Sci. USA 104, 1604-1609 (2007).
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 1604-1609
-
-
O'Connell, R.M.1
Taganov, K.D.2
Boldin, M.P.3
Cheng, G.4
Baltimore, D.5
-
94
-
-
65249131826
-
Induction and regulatory function of MIR?9 in human monocytes and neutrophils exposed to proinflammatory signals
-
Bazzoni, F. et al. Induction and regulatory function of miR?9 in human monocytes and neutrophils exposed to proinflammatory signals. Proc. Natl Acad. Sci. USA 106, 5282-5287 (2009).
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 5282-5287
-
-
Bazzoni, F.1
-
95
-
-
79958257077
-
MIR?146a is a significant brake on autoimmunity, myeloproliferation, and cancer in mice
-
Boldin, M. P. et al. miR?146a is a significant brake on autoimmunity, myeloproliferation, and cancer in mice. J. Exp. Med. 208, 1189-1201 (2011).
-
(2011)
J. Exp. Med
, vol.208
, pp. 1189-1201
-
-
Boldin, M.P.1
-
96
-
-
84868689316
-
MIR?146a and NF?KappaB1 regulate mast cell survival and T lymphocyte differentiation
-
Rusca, N. et al. MiR?146a and NF?kappaB1 regulate mast cell survival and T lymphocyte differentiation. Mol. Cell. Biol. 32, 4432-4444 (2012).
-
(2012)
Mol. Cell. Biol
, vol.32
, pp. 4432-4444
-
-
Rusca, N.1
-
97
-
-
84866354593
-
MIR?146a controls the resolution of T cell responses in mice
-
Yang, L. et al. miR?146a controls the resolution of T cell responses in mice. J. Exp. Med. 209, 1655-1670 (2012).
-
(2012)
J. Exp. Med
, vol.209
, pp. 1655-1670
-
-
Yang, L.1
-
98
-
-
66349137358
-
Inositol phosphatase SHIP1 is a primary target of MIR?155
-
O'Connell, R. M., Chaudhuri, A. A., Rao, D. S. & Baltimore, D. Inositol phosphatase SHIP1 is a primary target of miR?155. Proc. Natl Acad. Sci. USA 106, 7113-7118 (2009).
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 7113-7118
-
-
O'Connell, R.M.1
Chaudhuri, A.A.2
Rao, D.S.3
Baltimore, D.4
-
99
-
-
34247584465
-
Requirement of bic/microRNA?155 for normal immune function
-
Rodriguez, A. et al. Requirement of bic/microRNA?155 for normal immune function. Science 316, 608-611 (2007).
-
(2007)
Science
, vol.316
, pp. 608-611
-
-
Rodriguez, A.1
-
100
-
-
77949977555
-
Identification and characterization of enhancers controlling the inflammatory gene expression program in macrophages
-
This study, together with reference 62, provided the first characterization and rational understanding of the macrophage repertoire of enhancers
-
Ghisletti, S. et al. Identification and characterization of enhancers controlling the inflammatory gene expression program in macrophages. Immunity 32, 317-328 (2010). This study, together with reference 62, provided the first characterization and rational understanding of the macrophage repertoire of enhancers.
-
(2010)
Immunity
, vol.32
, pp. 317-328
-
-
Ghisletti, S.1
-
101
-
-
0033748023
-
Selective requirement for c?Rel during IL?12 P40 gene induction in macrophages
-
Sanjabi, S., Hoffmann, A., Liou, H. C., Baltimore, D. & Smale, S. T. Selective requirement for c?Rel during IL?12 P40 gene induction in macrophages. Proc. Natl Acad. Sci. USA 97, 12705-12710 (2000).
-
(2000)
Proc. Natl Acad. Sci. USA
, vol.97
, pp. 12705-12710
-
-
Sanjabi, S.1
Hoffmann, A.2
Liou, H.C.3
Baltimore, D.4
Smale, S.T.5
-
102
-
-
24944466828
-
A c?Rel subdomain responsible for enhanced DNA-binding affinity and selective gene activation
-
Sanjabi, S. et al. A c?Rel subdomain responsible for enhanced DNA-binding affinity and selective gene activation. Genes Dev. 19, 2138-2151 (2005).
-
(2005)
Genes Dev
, vol.19
, pp. 2138-2151
-
-
Sanjabi, S.1
-
103
-
-
84874223081
-
Cutting edge: An inactive chromatin configuration at the IL?10 locus in human neutrophils
-
Tamassia, N. et al. Cutting edge: an inactive chromatin configuration at the IL?10 locus in human neutrophils. J. Immunol. 190, 1921-1925 (2013).
-
(2013)
J. Immunol
, vol.190
, pp. 1921-1925
-
-
Tamassia, N.1
-
104
-
-
84893075305
-
Regulation of type i interferon responses
-
Ivashkiv, L. B. & Donlin, L. T. Regulation of type I interferon responses. Nat. Rev. Immunol. 14, 36-49 (2014).
-
(2014)
Nat. Rev. Immunol
, vol.14
, pp. 36-49
-
-
Ivashkiv, L.B.1
Donlin, L.T.2
-
105
-
-
78649375771
-
Neutrophils, from marrow to microbes
-
Borregaard, N. Neutrophils, from marrow to microbes. Immunity 33, 657-670 (2010).
-
(2010)
Immunity
, vol.33
, pp. 657-670
-
-
Borregaard, N.1
-
106
-
-
0033532546
-
Neutrophil-specific granule deficiency results from a novel mutation with loss of function of the transcription factor CCAAT/enhancer binding protein epsilon
-
Lekstrom-Himes, J. A., Dorman, S. E., Kopar, P., Holland, S. M. & Gallin, J. I. Neutrophil-specific granule deficiency results from a novel mutation with loss of function of the transcription factor CCAAT/enhancer binding protein epsilon. J. Exp. Med. 189, 1847-1852 (1999).
-
(1999)
J. Exp. Med
, vol.189
, pp. 1847-1852
-
-
Lekstrom-Himes, J.A.1
Dorman, S.E.2
Kopar, P.3
Holland, S.M.4
Gallin, J.I.5
-
107
-
-
27744584107
-
Chromatin-based regulation of cytokine transcription in Th2 cells and mast cells
-
Monticelli, S., Lee, D. U., Nardone, J., Bolton, D. L. & Rao, A. Chromatin-based regulation of cytokine transcription in Th2 cells and mast cells. Int. Immunol. 17, 1513-1524 (2005).
-
(2005)
Int. Immunol
, vol.17
, pp. 1513-1524
-
-
Monticelli, S.1
Lee, D.U.2
Nardone, J.3
Bolton, D.L.4
Rao, A.5
-
108
-
-
4344647601
-
Basophils produce IL?4 and accumulate in tissues after infection with a Th2?Inducing parasite
-
Min, B. et al. Basophils produce IL?4 and accumulate in tissues after infection with a Th2?inducing parasite. J. Exp. Med. 200, 507-517 (2004).
-
(2004)
J. Exp. Med
, vol.200
, pp. 507-517
-
-
Min, B.1
-
109
-
-
84900397775
-
Basophil-derived interleukin?4 controls the function of natural helper cells, a member of ILC2s, in lung inflammation
-
Motomura, Y. et al. Basophil-derived interleukin?4 controls the function of natural helper cells, a member of ILC2s, in lung inflammation. Immunity 40, 758-771 (2014).
-
(2014)
Immunity
, vol.40
, pp. 758-771
-
-
Motomura, Y.1
-
110
-
-
84875464279
-
Extracellular DNA traps in allergic, infectious, and autoimmune diseases
-
Simon, D., Simon, H. U. & Yousefi, S. Extracellular DNA traps in allergic, infectious, and autoimmune diseases. Allergy 68, 409-416 (2013).
-
(2013)
Allergy
, vol.68
, pp. 409-416
-
-
Simon, D.1
Simon, H.U.2
Yousefi, S.3
-
111
-
-
84983348004
-
Antimicrobial activity of mast cells: Role and relevance of extracellular DNA traps
-
Mollerherm, H., von Kockritz-Blickwede, M. & Branitzki-Heinemann, K. Antimicrobial activity of mast cells: role and relevance of extracellular DNA traps. Front. Immunol. 7, 265 (2016).
-
(2016)
Front. Immunol
, vol.7
, pp. 265
-
-
Mollerherm, H.1
Von Kockritz-Blickwede, M.2
Branitzki-Heinemann, K.3
-
112
-
-
42449155517
-
Phagocytosis-independent antimicrobial activity of mast cells by means of extracellular trap formation
-
von Kockritz-Blickwede, M. et al. Phagocytosis-independent antimicrobial activity of mast cells by means of extracellular trap formation. Blood 111, 3070-3080 (2008).
-
(2008)
Blood
, vol.111
, pp. 3070-3080
-
-
Von Kockritz-Blickwede, M.1
-
113
-
-
51349135381
-
Catapult-like release of mitochondrial DNA by eosinophils contributes to antibacterial defense
-
Yousefi, S. et al. Catapult-like release of mitochondrial DNA by eosinophils contributes to antibacterial defense. Nat. Med. 14, 949-953 (2008).
-
(2008)
Nat. Med
, vol.14
, pp. 949-953
-
-
Yousefi, S.1
-
114
-
-
0141958218
-
Expression and function of Toll-like receptors in eosinophils: Activation by Toll-like receptor 7 ligand
-
Nagase, H. et al. Expression and function of Toll-like receptors in eosinophils: activation by Toll-like receptor 7 ligand. J. Immunol. 171, 3977-3982 (2003).
-
(2003)
J. Immunol
, vol.171
, pp. 3977-3982
-
-
Nagase, H.1
-
115
-
-
0036569658
-
Toll-like receptor (TLR)2 and TLR4 in human peripheral blood granulocytes: A critical role for monocytes in leukocyte lipopolysaccharide responses
-
Sabroe, I., Jones, E. C., Usher, L. R., Whyte, M. K. & Dower, S. K. Toll-like receptor (TLR)2 and TLR4 in human peripheral blood granulocytes: a critical role for monocytes in leukocyte lipopolysaccharide responses. J. Immunol. 168, 4701-4710 (2002).
-
(2002)
J. Immunol
, vol.168
, pp. 4701-4710
-
-
Sabroe, I.1
Jones, E.C.2
Usher, L.R.3
Whyte, M.K.4
Dower, S.K.5
-
116
-
-
2942731608
-
TLR3-, TLR7-, and TLR9?Mediated production of proinflammatory cytokines and chemokines from murine connective tissue type skin-derived mast cells but not from bone marrow-derived mast cells
-
Matsushima, H., Yamada, N., Matsue, H. & Shimada, S. TLR3-, TLR7-, and TLR9?mediated production of proinflammatory cytokines and chemokines from murine connective tissue type skin-derived mast cells but not from bone marrow-derived mast cells. J. Immunol. 173, 531-541 (2004).
-
(2004)
J. Immunol
, vol.173
, pp. 531-541
-
-
Matsushima, H.1
Yamada, N.2
Matsue, H.3
Shimada, S.4
-
117
-
-
85006744615
-
Loss of bladder epithelium induced by cytolytic mast cell granules
-
Choi, H. W. et al. Loss of bladder epithelium induced by cytolytic mast cell granules. Immunity 45, 1258-1269 (2016).
-
(2016)
Immunity
, vol.45
, pp. 1258-1269
-
-
Choi, H.W.1
-
118
-
-
85015062618
-
Opposing macrophage polarization programs show extensive epigenomic and transcriptional cross-talk
-
Piccolo, V. et al. Opposing macrophage polarization programs show extensive epigenomic and transcriptional cross-talk. Nat. Immunol. 18, 530-540 (2017).
-
(2017)
Nat. Immunol
, vol.18
, pp. 530-540
-
-
Piccolo, V.1
-
119
-
-
84995793039
-
Glucan reverses the epigenetic state of LPS-induced immunological tolerance
-
Novakovic, B. et al. Glucan reverses the epigenetic state of LPS-induced immunological tolerance. Cell 167, 1354-1368.e14 (2016).
-
(2016)
Cell
, vol.167
, pp. 1354e14-1354e14
-
-
Novakovic, B.1
-
120
-
-
33846622099
-
Transcription factors in myeloid development: Balancing differentiation with transformation
-
Rosenbauer, F. & Tenen, D. G. Transcription factors in myeloid development: balancing differentiation with transformation. Nat. Rev. Immunol. 7, 105-117 (2007).
-
(2007)
Nat. Rev. Immunol
, vol.7
, pp. 105-117
-
-
Rosenbauer, F.1
Tenen, D.G.2
-
121
-
-
84954097140
-
Enhancer turnover is associated with a divergent transcriptional response to glucocorticoid in mouse and human macrophages
-
Jubb, A. W., Young, R. S., Hume, D. A. & Bickmore, W. A. Enhancer turnover is associated with a divergent transcriptional response to glucocorticoid in mouse and human macrophages. J. Immunol. 196, 813-822 (2016).
-
(2016)
J. Immunol
, vol.196
, pp. 813-822
-
-
Jubb, A.W.1
Young, R.S.2
Hume, D.A.3
Bickmore, W.A.4
-
122
-
-
46249106990
-
Mapping and quantifying mammalian transcriptomes by RNA-Seq
-
Mortazavi, A., Williams, B. A., McCue, K., Schaeffer, L. & Wold, B. Mapping and quantifying mammalian transcriptomes by RNA-Seq. Nat. Methods 5, 621-628 (2008).
-
(2008)
Nat. Methods
, vol.5
, pp. 621-628
-
-
Mortazavi, A.1
Williams, B.A.2
McCue, K.3
Schaeffer, L.4
Wold, B.5
-
123
-
-
84893905629
-
Massively parallel single-cell RNA-seq for marker-free decomposition of tissues into cell types
-
Jaitin, D. A. et al. Massively parallel single-cell RNA-seq for marker-free decomposition of tissues into cell types. Science 343, 776-779 (2014).
-
(2014)
Science
, vol.343
, pp. 776-779
-
-
Jaitin, D.A.1
-
124
-
-
84864251757
-
Transcript dynamics of proinflammatory genes revealed by sequence analysis of subcellular RNA fractions
-
Bhatt, D. M. et al. Transcript dynamics of proinflammatory genes revealed by sequence analysis of subcellular RNA fractions. Cell 150, 279-290 (2012).
-
(2012)
Cell
, vol.150
, pp. 279-290
-
-
Bhatt, D.M.1
-
125
-
-
57849109058
-
Nascent RNA sequencing reveals widespread pausing and divergent initiation at human promoters
-
Core, L. J., Waterfall, J. J. & Lis, J. T. Nascent RNA sequencing reveals widespread pausing and divergent initiation at human promoters. Science 322, 1845-1848 (2008).
-
(2008)
Science
, vol.322
, pp. 1845-1848
-
-
Core, L.J.1
Waterfall, J.J.2
Lis, J.T.3
-
126
-
-
84908207355
-
Identifying and mitigating bias in next-generation sequencing methods for chromatin biology
-
Meyer, C. A. & Liu, X. S. Identifying and mitigating bias in next-generation sequencing methods for chromatin biology. Nat. Rev. Genet. 15, 709-721 (2014).
-
(2014)
Nat. Rev. Genet
, vol.15
, pp. 709-721
-
-
Meyer, C.A.1
Liu, X.S.2
-
127
-
-
84888877924
-
Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position
-
Buenrostro, J. D., Giresi, P. G., Zaba, L. C., Chang, H. Y. & Greenleaf, W. J. Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position. Nat. Methods 10, 1213-1218 (2013).
-
(2013)
Nat. Methods
, vol.10
, pp. 1213-1218
-
-
Buenrostro, J.D.1
Giresi, P.G.2
Zaba, L.C.3
Chang, H.Y.4
Greenleaf, W.J.5
-
128
-
-
84878011578
-
Exploring the three-dimensional organization of genomes: Interpreting chromatin interaction data
-
Dekker, J., Marti-Renom, M. A. & Mirny, L. A. Exploring the three-dimensional organization of genomes: interpreting chromatin interaction data. Nat. Rev. Genet. 14, 390-403 (2013).
-
(2013)
Nat. Rev. Genet
, vol.14
, pp. 390-403
-
-
Dekker, J.1
Marti-Renom, M.A.2
Mirny, L.A.3
-
129
-
-
84885012678
-
Oxidative bisulfite sequencing of 5?Methylcytosine and 5?Hydroxymethylcytosine
-
Booth, M. J. et al. Oxidative bisulfite sequencing of 5?methylcytosine and 5?hydroxymethylcytosine. Nat. Protoc. 8, 1841-1851 (2013).
-
(2013)
Nat. Protoc
, vol.8
, pp. 1841-1851
-
-
Booth, M.J.1
-
130
-
-
85006488344
-
Perturb-Seq: Dissecting molecular circuits with scalable single-cell RNA profiling of pooled genetic screens
-
Dixit, A. et al. Perturb-Seq: dissecting molecular circuits with scalable single-cell RNA profiling of pooled genetic screens. Cell 167, 1853-1866e.17 (2016).
-
(2016)
Cell
, vol.167
, pp. 1853e17-1866e17
-
-
Dixit, A.1
-
131
-
-
85006345820
-
A multiplexed single-cell CRISPR screening platform enables systematic dissection of the unfolded protein response
-
Adamson, B. et al. A multiplexed single-cell CRISPR screening platform enables systematic dissection of the unfolded protein response. Cell 167, 1867-1882.e21 (2016).
-
(2016)
Cell
, vol.167
, pp. 1867e21-1867e21
-
-
Adamson, B.1
-
132
-
-
85006269827
-
Dissecting immune circuits by linking CRISPR-pooled screens with single-cell RNA-Seq
-
References 130-132 combined CRISPR-Cas9?mediated screening with single-cell transcriptomics
-
Jaitin, D. A. et al. Dissecting immune circuits by linking CRISPR-pooled screens with single-cell RNA-Seq. Cell 167, 1883-1896.e15 (2016). References 130-132 combined CRISPR-Cas9?mediated screening with single-cell transcriptomics.
-
(2016)
Cell
, vol.167
, pp. 1883e15-1883e15
-
-
Jaitin, D.A.1
|