Down-regulation of MicroRNA-223 promotes degranulation via the PI3K/Akt pathway by targeting IGF-1R in mast cells

PLoS ONE

Volumn 10, Issue 4, 2015, Pages

  Wang, Quan ^a   Zhao, De Yu ^a   Xu, Hong ^a   Zhou, Hui ^b   Yang, Qian Yuan ^a   Liu, Feng ^a   Zhou, Guo Ping ^c  

^a CHILDREN S HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

^b WOMEN S HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

^c NANJING MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

I KAPPA B ALPHA; IMMUNOGLOBULIN E; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MICRORNA 223; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SOMATOMEDIN C RECEPTOR; 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE; CHROMONE DERIVATIVE; MICRORNA; MORPHOLINE DERIVATIVE; PROTEIN KINASE INHIBITOR;

ARTICLE; CELL ACTIVATION; CELL ASSAY; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME PHOSPHORYLATION; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION; GENE FUNCTION; GENE IDENTIFICATION; MAST CELL DEGRANULATION; MOLECULAR DYNAMICS; PROTEIN FUNCTION; PROTEIN TARGETING; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; CELL LINE; DEGRANULATION; DRUG EFFECTS; ENZYMOLOGY; MAST CELL; METABOLISM; PHYSIOLOGY; RAT;

ANIMALS; CELL DEGRANULATION; CELL LINE; CHROMONES; DOWN-REGULATION; IMMUNOGLOBULIN E; MAST CELLS; MICRORNAS; MORPHOLINES; PHOSPHATIDYLINOSITOL 3-KINASES; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RECEPTOR, IGF TYPE 1; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 84929494421     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0123575     Document Type: Article

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