The order of expression of transcription factors directs hierarchical specification of hematopoietic lineages

Genes and Development

Volumn 20, Issue 21, 2006, Pages 3010-3021

  Iwasaki, Hiromi ^a,b   Mizuno, Shin Ichi ^b   Arinobu, Yojiro ^b   Ozawa, Hidetoshi ^b   Mori, Yasuo ^a   Shigematsu, Hirokazu ^b   Takatsu, Kiyoshi ^c   Tenen, Daniel G ^b   Akashi, Koichi ^a,b  

^a KYUSHU UNIVERSITY HOSPITAL   (Japan)

^b HARVARD MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

Hematopoiesis; Hematopoietic progenitors; Transcription factor

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN ALPHA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GATA 2;

ANIMAL CELL; ARTICLE; CELL LINEAGE; CELL MATURATION; CELL POPULATION; CONTROLLED STUDY; CORRELATION ANALYSIS; EOSINOPHIL; GRANULOCYTE PRECURSOR; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; LYMPHOID CELL; MAST CELL; MONOCYTE; MOUSE; MYELOID PROGENITOR CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ANIMALS; CCAAT-ENHANCER-BINDING PROTEIN-ALPHA; CELL DIFFERENTIATION; CELL LINEAGE; GATA2 TRANSCRIPTION FACTOR; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GRANULOCYTES; HEMATOPOIESIS; HEMATOPOIETIC STEM CELLS; MAST CELLS; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; MYELOID PROGENITOR CELLS;

EID: 33751071630     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.1493506     Document Type: Article

References (53)

1. Akashi, K., Traver, D., Miyamoto, T., and Weissman, I.L. 2000. A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Nature 404: 193-197.
2. Arinobu, Y., Iwasaki, H., Gurish, M.F., Mizuno, S.I., Shigematsu, H., Ozawa, H., Tenen, D.G., Austen, K.F., and Akashi, K. 2005. Developmental checkpoints of the basophil/mast cell lineages in adult murine hematopoiesis. Proc. Natl. Acad. Sci. 102: 18105-18110.
3. Baba, Y., Garrett, K.P., and Kincade, P.W. 2005. Constitutively active β-catenin confers multilineage differentiation potential on lymphoid and myeloid progenitors. Immunity 23: 599-609.
4. Boyce, J.A., Friend, D., Matsumoto, R., Austen, K.F., and Owen, W.F. 1995. Differentiation in vitro of hybrid eosinophil/basophil granulocytes: Autocrine function of an eosinophil developmental intermediate. J. Exp. Med. 182: 49-57.
5. Brummelkamp, T.R., Bernards, R., and Agami, R. 2002. A system for stable expression of short interfering RNAs in mammalian cells. Science 296: 550-553.
6. Dahl, R., Walsh, J.C., Lancki, D., Laslo, P., Iyer, S.R., Singh, H., and Simon, M.C. 2003. Regulation of macrophage and neutrophil cell fates by the PU.1:C/EBPα ratio and granulocyte colony-stimulating factor. Nat. Immunol. 4: 1029-1036.
7. DeKoter, R.P. and Singh, H. 2000. Regulation of B lymphocyte and macrophage development by graded expression of PU.1. Science 288: 1439-1441.
8. Elbashir, S.M., Lendeckel, W., and Tuschl, T. 2001. RNA interference is mediated by 21- and 22-nucleotide RNAs. Genes & Dev. 15: 188-200.
9. Fujiwara, Y., Browne, C.P., Cunniff, K., Goff, S.C., and Orkin, S.H. 1996. Arrested development of embryonic red cell precursors in mouse embryos lacking transcription factor GATA-1. Proc. Natl. Acad. Sci. 93: 12355-12358.
10. Galli, S.J. 2000. Mast cells and basophils. Curr. Opin. Hematol. 7: 32-39.
11. Harigae, H., Takahashi, S., Suwabe, N., Ohtsu, H., Gu, L., Yang, Z., Tsai, F.Y., Kitamura, Y., Engel, J.D., and Yamamoto, M. 1998. Differential roles of GATA-1 and GATA-2 in growth and differentiation of mast cells. Genes Cells 3: 39-50.
12. Heyworth, C., Pearson, S., May, G., and Enver, T. 2002. Transcription factor-mediated lineage switching reveals plasticity in primary committed progenitor cells. EMBO J. 21: 3770-3781.
13. Hirasawa, R., Shimizu, R., Takahashi, S., Osawa, M., Takayanagi, S., Kato, Y., Onodera, M., Minegishi, N., Yamamoto, M., Fukao, K., et al. 2002. Essential and instructive roles of GATA factors in eosinophil development. J. Exp. Med. 195: 1379-1386.
14. Iwasaki, H., Mizuno, S., Wells, R.A., Cantor, A.B., Watanabe, S., and Akashi, K. 2003. GATA-1 converts lymphoid and myelomonocytic progenitors into the megakaryocyte/erythrocyte lineages. Immunity 19: 451-462.
15. Iwasaki, H., Mizuno, S., Mayfield, R., Shigematsu, H., Arinobu, Y., Seed, B., Gurish, M.F., Takatsu, K., and Akashi, K. 2005. Identification of eosinophil lineage-committed progenitors in the murine bone marrow. J. Exp. Med. 201: 1891-1897.
16. Iwasaki-Arai, J., Iwasaki, H., Miyamoto, T., Watanabe, S., and Akashi, K. 2003. Enforced granulocyte/macrophage colony-stimulating factor signals do not support lymphopoiesis, but instruct lymphoid to myelomonocytic lineage conversion. J. Exp. Med. 197: 1311-1322.
17. Jippo, T., Mizuno, H., Xu, Z., Nomura, S., Yamamoto, M., and Kitamura, Y. 1996. Abundant expression of transcription factor GATA-2 in proliferating but not in differentiated mast cells in tissues of mice: Demonstration by in situ hybridization. Blood 87: 993-998.
18. Kondo, M., Weissman, I.L., and Akashi, K. 1997. Identification of clonogenic common lymphoid progenitors in mouse bone marrow. Cell 91: 661-672.
19. Kondo, M., Scherer, D.C., Miyamoto, T., King, A.G., Akashi, K., Sugamura, K., and Weissman, I.L. 2000. Cell-fate conversion of lymphoid-committed progenitors by instructive actions of cytokines. Nature 407: 383-386.
20. Kulessa, H., Frampton, J., and Graf, T. 1995. GATA-1 reprograms avian myelomonocytic cell lines into eosinophils, thromboblasts, and erythroblasts. Genes & Dev. 9: 1250-1262.
21. Manz, M.G., Miyamoto, T., Akashi, K., and Weissman, I.L. 2002. Prospective isolation of human clonogenic common myeloid progenitors. Proc. Natl. Acad. Sci. 99: 11872-11877.
22. Martin, D.I., Zon, L.I., Mutter, G., and Orkin, S.H. 1990. Expression of an erythroid transcription factor in megakaryocytic and mast cell lineages. Nature 344: 444-447.
23. McNagny, K. and Graf, T. 2002. Making eosinophils through subtle shifts in transcription factor expression. J. Exp. Med. 195: F43-F47.
24. Migliaccio, A.R., Rana, R.A., Sanchez, M., Lorenzini, R., Centurione, L., Bianchi, L., Vannucchi, A.M., Migliaccio, G., and Orkin, S.H. 2003. GATA-1 as a regulator of mast cell differentiation revealed by the phenotype of the GATA-1low mouse mutant. J. Exp. Med. 197: 281-296.
25. Nerlov, C. 2004. C/EBPα mutations in acute myeloid leukaemias. Nat. Rev. Cancer 4: 394-400.
26. Nerlov, C. and Graf, T. 1998. PU.1 induces myeloid lineage commitment in multipotent hematopoietic progenitors. Genes & Dev. 12: 2403-2412.
27. Nerlov, C., McNagny, K.M., Doderlein, G., Kowenz-Leutz, E., and Graf, T. 1998. Distinct C/EBP functions are required for eosinophil lineage commitment and maturation. Genes & Dev. 12: 2413-2423.
28. Nerlov, C., Querfurth, E., Kulessa, H., and Graf, T. 2000. GATA-1 interacts with the myeloid PU.1 transcription factor and represses PU.1-dependent transcription. Blood 95: 2543-2551.
29. Orkin, S.H. 2000. Diversification of haematopoietic stem cells to specific lineages. Nat. Rev. Genet. 1: 57-64.
30. Querfurth, E., Schuster, M., Kulessa, H., Crispino, J.D., Doderlein, G., Orkin, S.H., Graf, T., and Nerlov, C. 2000. Antagonism between C/EBPβ and FOG in eosinophil lineage commitment of multipotent hematopoietic progenitors. Genes & Dev. 14: 2515-2525.
31. Reddy, V.A., Iwama, A., Iotzova, G., Schulz, M., Elsasser, A., Vangala, R.K., Tenen, D.G., Hiddemann, W., and Behre, G. 2002. Granulocyte inducer C/EBPα inactivates the myeloid master regulator PU.1: Possible role in lineage commitment decisions. Blood 100: 483-490.
32. Rekhtman, N., Radparvar, F., Evans, T., and Skoultchi, A.I. 1999. Direct interaction of hematopoietic transcription factors PU.1 and GATA-1: Functional antagonism in erythroid cells. Genes & Dev. 13: 1398-1411.
33. Rothenberg, M.E. 1998. Eosinophilia. N. Engl. J. Med. 338: 1592-1600.
34. Scott, E.W., Simon, M.C., Anastasi, J., and Singh, H. 1994. Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages. Science 265: 1573-1577.
35. Sieweke, M.H. and Graf, T. 1998. A transcription factor party during blood cell differentiation. Curr. Opin. Genet. Dev. 8: 545-551.
36. Takahashi, S., Shimizu, R., Suwabe, N., Kuroha, T., Yoh, K., Ohta, J., Nishimura, S., Lim, K.C., Engel, J.D., and Yamamoto, M. 2000. GATA factor transgenes under GATA-1 locus control rescue germline GATA-1 mutant deficiencies. Blood 96: 910-916.
37. Tenen, D.G., Hromas, R., Licht, J.D., and Zhang, D.E. 1997. Transcription factors, normal myeloid development, and leukemia. Blood 90: 489-519.
38. Traver, D., Akashi, K., Manz, M., Merad, M., Miyamoto, T., Engleman, E.G., and Weissman, I.L. 2000. Development of CD8α-positive dendritic cells from a common myeloid progenitor. Science 290: 2152-2154.
39. Tsai, F.Y. and Orkin, S.H. 1997. Transcription factor GATA-2 is required for proliferation/survival of early hematopoietic cells and mast cell formation, but not for erythroid and myeloid terminal differentiation. Blood 89: 3636-3643.
40. Tsai, F.Y., Browne, C.P., and Orkin, S.H. 1998. Knock-in mutation of transcription factor GATA-3 into the GATA-1 locus: Partial rescue of GATA-1 loss of function in erythroid cells. Dev. Biol. 196: 218-227.
41. Tsang, A.P., Visvader, J.E., Turner, C.A., Fujiwara, Y., Yu, C., Weiss, M.J., Crossley, M., and Orkin, S.H. 1997. FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation. Cell 90: 109-119.
42. Tsang, A.P., Fujiwara, Y., Hom, D.B., and Orkin, S.H. 1998. Failure of megakaryopoiesis and arrested erythropoiesis in mice lacking the GATA-1 transcriptional cofactor FOG. Genes & Dev. 12: 1176-1188.
43. Walsh, J.C., DeKoter, R.P., Lee, H.J., Smith, E.D., Lancki, D.W., Gurish, M.F., Friend, D.S., Stevens, R.L., Anastasi, J., and Singh, H. 2002. Cooperative and antagonistic interplay between PU.1 and GATA-2 in the specification of myeloid cell fates. Immunity 17: 665-676.
44. Wedemeyer, J., Tsai, M., and Galli, S.J. 2000. Roles of mast cells and basophils in innate and acquired immunity. Curr. Opin. Immunol. 12: 624-631.
45. Weil, S.C. and Hrisinko, M.A. 1987. A hybrid eosinophilic-basophilic granulocyte in chronic granulocytic leukemia. Am. J. Clin. Pathol. 87: 66-70.
46. Xie, H., Ye, M., Feng, R., and Graf, T. 2004. Stepwise reprogramming of B cells into macrophages. Cell 117: 663-676.
47. Yamaguchi, N., Hitoshi, Y., Mita, S., Hosoya, Y., Murata, Y., Kikuchi, Y., Tominaga, A., and Takatsu, K. 1990. Characterization of the murine interleukin 5 receptor by using a monoclonal antibody. Int. Immunol. 2: 181-187.
48. Yuan, B., Latek, R., Hossbach, M., Tuschl, T., and Lewitter, F. 2004. siRNA Selection Server: An automated siRNA oligonucleotide prediction server. Nucleic Acids Res. 32: W130-W134.
49. Zhang, D.E., Zhang, P., Wang, N.D., Hetherington, C.J., Darlington, G.J., and Tenen, D.G. 1997. Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein α-deficient mice. Proc. Natl. Acad. Sci. 94: 569-574.
50. Zhang, P., Behre, G., Pan, J., Iwama, A., Wara-Aswapati, N., Radomska, H.S., Auron, P.E., Tenen, D.G., and Sun, Z. 1999. Negative cross-talk between hematopoietic regulators: GATA proteins repress PU.1. Proc. Natl. Acad. Sci. 96: 8705-8710.
51. Zhang, P., Zhang, X., Iwama, A., Yu, C., Smith, K.A., Mueller, B.U., Narravula, S., Torbett, B.E., Orkin, S.H., and Tenen, D.G. 2000. PU.1 inhibits GATA-1 function and erythroid differentiation by blocking GATA-1DNAbinding. Blood 96: 2641-2648.
52. Zhang, P., Iwasaki-Arai, J., Iwasaki, H., Fenyus, M.L., Dayaram, T., Owens, B.M., Shigematsu, H., Levantini, E., Huettner, C.S., Lekstrom-Himes, J.A., et al. 2004. Enhancement of hematopoietic stem cell repopulating capacity and self-renewal in the absence of the transcription factor C/EBP α. Immunity 21: 853-863.
53. Zon, L.I., Yamaguchi, Y., Yee, K., Albee, E.A., Kimura, A., Bennett, J.C., Orkin, S.H., and Ackerman, S.J. 1993. Expression of mRNA for the GATA-binding proteins in human eosinophils and basophils: Potential role in gene transcription. Blood 81: 3234-3241.