Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6

Nature

Volumn 525, Issue 7569, 2015, Pages 389-393

  Zhang, Qian ^a,b   Zhao, Kai ^a   Shen, Qicong ^b   Han, Yanmei ^b   Gu, Yan ^b   Li, Xia ^a   Zhao, Dezhi ^a   Liu, Yiqi ^b   Wang, Chunmei ^a   Zhang, Xiang ^b   Su, Xiaoping ^b   Liu, Juan ^b   Ge, Wei ^a   Levine, Ross L ^c   Li, Nan ^b   Cao, Xuetao ^a,b  

^a INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEXTRAN SULFATE; DIOXYGENASE; DNA; HISTONE; HISTONE DEACETYLASE 2; I KAPPA B KINASE EPSILON; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; TET2 PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; CHROMATIN; DNA BINDING PROTEIN; I KAPPA B; IKAPPABETA PROTEIN, MOUSE; ONCOPROTEIN; TET2 PROTEIN, HUMAN; TET2 PROTEIN, MOUSE;

CATALYSIS; CHROMOSOME; DNA; GENE EXPRESSION; IMMUNITY; METHYLATION; PHENOTYPE; POLYSACCHARIDE; PROTEIN; RODENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE MARROW CELL; BONE MARROW DERIVED MACROPHAGE; CHROMATIN; CONTROLLED STUDY; CYTOKINE PRODUCTION; DEACETYLATION; DENDRITIC CELL; DNA METHYLATION; EXPERIMENTAL COLITIS; GENE LOSS; GENE REPRESSION; GENE TARGETING; HISTONE DEACETYLATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; INNATE IMMUNITY; MEDIATOR; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; RECEPTOR UPREGULATION; SEPTIC SHOCK; TRANSCRIPTION INITIATION; WILD TYPE; ACETYLATION; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; C57BL MOUSE; CHEMISTRY; COLITIS; CYTOLOGY; DEFICIENCY; DOWN REGULATION; ENZYMOLOGY; FEMALE; GENETIC EPIGENESIS; GENETIC TRANSCRIPTION; GENETICS; HEK293 CELL LINE; IMMUNOLOGY; MACROPHAGE; MALE; METABOLISM;

MUS;

ACETYLATION; ANIMALS; CHROMATIN; COLITIS; DENDRITIC CELLS; DNA METHYLATION; DNA-BINDING PROTEINS; DOWN-REGULATION; EPIGENESIS, GENETIC; FEMALE; HEK293 CELLS; HISTONE DEACETYLASE 2; HISTONES; HUMANS; I-KAPPA B PROTEINS; INFLAMMATION; INTERLEUKIN-6; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS; TRANSCRIPTION, GENETIC;

EID: 84942050633     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature15252     Document Type: Article

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