-
1
-
-
79953726304
-
Glucocorticosteroids: current and future directions
-
Barnes, P.J., Glucocorticosteroids: current and future directions. Br. J. Pharmacol. 163 (2011), 29–43.
-
(2011)
Br. J. Pharmacol.
, vol.163
, pp. 29-43
-
-
Barnes, P.J.1
-
2
-
-
84883769810
-
Glucocorticoid receptor signaling in health and disease
-
Kadmiel, M., Cidlowski, J.A., Glucocorticoid receptor signaling in health and disease. Trends Pharmacol. Sci. 34 (2013), 518–530.
-
(2013)
Trends Pharmacol. Sci.
, vol.34
, pp. 518-530
-
-
Kadmiel, M.1
Cidlowski, J.A.2
-
3
-
-
84868140995
-
Short- and long-term effects of exposure to natural and synthetic glucocorticoids during development
-
Singh, R.R., Cuffe, J.S., Moritz, K.M., Short- and long-term effects of exposure to natural and synthetic glucocorticoids during development. Clin. Exp. Pharmacol. Physiol. 39 (2012), 979–989.
-
(2012)
Clin. Exp. Pharmacol. Physiol.
, vol.39
, pp. 979-989
-
-
Singh, R.R.1
Cuffe, J.S.2
Moritz, K.M.3
-
4
-
-
84873464631
-
Clinical pharmacokinetics and pharmacodynamics of prednisolone and prednisone in solid organ transplantation
-
Bergmann, T.K., Barraclough, K.A., Lee, K.J., Staatz, C.E., Clinical pharmacokinetics and pharmacodynamics of prednisolone and prednisone in solid organ transplantation. Clin. Pharmacokinet. 51 (2012), 711–741.
-
(2012)
Clin. Pharmacokinet.
, vol.51
, pp. 711-741
-
-
Bergmann, T.K.1
Barraclough, K.A.2
Lee, K.J.3
Staatz, C.E.4
-
5
-
-
84856335862
-
Tissue-specific modulation of mineralocorticoid receptor function by 11β-hydroxysteroid dehydrogenases: an overview
-
Odermatt, A., Kratschmar, D.V., Tissue-specific modulation of mineralocorticoid receptor function by 11β-hydroxysteroid dehydrogenases: an overview. Mol. Cell. Endocrinol. 350 (2012), 168–186.
-
(2012)
Mol. Cell. Endocrinol.
, vol.350
, pp. 168-186
-
-
Odermatt, A.1
Kratschmar, D.V.2
-
6
-
-
0000110129
-
Conversion of cortisone to compound F
-
Amelung, D., Hubener, H.J., Roka, L., Meyerheim, G., Conversion of cortisone to compound F. J. Clin. Endocrinol. Metab. 13 (1953), 1125–1126.
-
(1953)
J. Clin. Endocrinol. Metab.
, vol.13
, pp. 1125-1126
-
-
Amelung, D.1
Hubener, H.J.2
Roka, L.3
Meyerheim, G.4
-
7
-
-
0024147720
-
Corticosteroid 11β-hydroxysteroid dehydrogenase activities in vertebrate liver
-
Monder, C., Lakshmi, V., Corticosteroid 11β-hydroxysteroid dehydrogenase activities in vertebrate liver. Steroids 52 (1988), 515–528.
-
(1988)
Steroids
, vol.52
, pp. 515-528
-
-
Monder, C.1
Lakshmi, V.2
-
8
-
-
0024789306
-
Cloning and expression of rat cDNA encoding corticosteroid 11β-dehydrogenase
-
Agarwal, A.K., Monder, C., Eckstein, B., White, P.C., Cloning and expression of rat cDNA encoding corticosteroid 11β-dehydrogenase. J. Biol. Chem. 264 (1989), 18939–18943.
-
(1989)
J. Biol. Chem.
, vol.264
, pp. 18939-18943
-
-
Agarwal, A.K.1
Monder, C.2
Eckstein, B.3
White, P.C.4
-
9
-
-
0025611952
-
Expression of 11β-hydroxysteroid dehydrogenase using recombinant vaccinia virus
-
Agarwal, A.K., Tusie-Luna, M.T., Monder, C., White, P.C., Expression of 11β-hydroxysteroid dehydrogenase using recombinant vaccinia virus. Mol. Endocrinol. 4 (1990), 1827–1832.
-
(1990)
Mol. Endocrinol.
, vol.4
, pp. 1827-1832
-
-
Agarwal, A.K.1
Tusie-Luna, M.T.2
Monder, C.3
White, P.C.4
-
10
-
-
0027331415
-
Regulation of 11β-hydroxysteroid dehydrogenase by sex steroids in vivo: further evidence for the existence of a second dehydrogenase in rat kidney
-
Low, S.C., Assaad, S.N., Rajan, V., Chapman, K.E., Edwards, C.R., Seckl, J.R., Regulation of 11β-hydroxysteroid dehydrogenase by sex steroids in vivo: further evidence for the existence of a second dehydrogenase in rat kidney. J. Endocrinol. 139 (1993), 27–35.
-
(1993)
J. Endocrinol.
, vol.139
, pp. 27-35
-
-
Low, S.C.1
Assaad, S.N.2
Rajan, V.3
Chapman, K.E.4
Edwards, C.R.5
Seckl, J.R.6
-
11
-
-
0033553424
-
Targeting proteins to the lumen of endoplasmic reticulum using N-terminal domains of 11β-hydroxysteroid dehydrogenase and the 50 kDa esterase
-
Mziaut, H., Korza, G., Hand, A.R., Gerard, C., Ozols, J., Targeting proteins to the lumen of endoplasmic reticulum using N-terminal domains of 11β-hydroxysteroid dehydrogenase and the 50 kDa esterase. J. Biol. Chem. 274 (1999), 14122–14129.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 14122-14129
-
-
Mziaut, H.1
Korza, G.2
Hand, A.R.3
Gerard, C.4
Ozols, J.5
-
12
-
-
0033214482
-
The N-terminal anchor sequences of 11β-hydroxysteroid dehydrogenases determine their orientation in the endoplasmic reticulum membrane
-
Odermatt, A., Arnold, P., Stauffer, A., Frey, B.M., Frey, F.J., The N-terminal anchor sequences of 11β-hydroxysteroid dehydrogenases determine their orientation in the endoplasmic reticulum membrane. J. Biol. Chem. 274 (1999), 28762–28770.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 28762-28770
-
-
Odermatt, A.1
Arnold, P.2
Stauffer, A.3
Frey, B.M.4
Frey, F.J.5
-
13
-
-
0028899788
-
Lumenal orientation and post-translational modifications of the liver microsomal 11β-hydroxysteroid dehydrogenase
-
Ozols, J., Lumenal orientation and post-translational modifications of the liver microsomal 11β-hydroxysteroid dehydrogenase. J. Biol. Chem. 270 (1995), 2305–2312.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 2305-2312
-
-
Ozols, J.1
-
14
-
-
3342998410
-
Hexose-6-phosphate dehydrogenase determines the reaction direction of 11β-hydroxysteroid dehydrogenase type 1 as an oxoreductase
-
Atanasov, A.G., Nashev, L.G., Schweizer, R.A., Frick, C., Odermatt, A., Hexose-6-phosphate dehydrogenase determines the reaction direction of 11β-hydroxysteroid dehydrogenase type 1 as an oxoreductase. FEBS Lett. 571 (2004), 129–133.
-
(2004)
FEBS Lett.
, vol.571
, pp. 129-133
-
-
Atanasov, A.G.1
Nashev, L.G.2
Schweizer, R.A.3
Frick, C.4
Odermatt, A.5
-
15
-
-
3042595899
-
Cooperativity between 11β-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase in the lumen of the endoplasmic reticulum
-
Banhegyi, G., Benedetti, A., Fulceri, R., Senesi, S., Cooperativity between 11β-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase in the lumen of the endoplasmic reticulum. J. Biol. Chem. 279 (2004), 27017–27021.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 27017-27021
-
-
Banhegyi, G.1
Benedetti, A.2
Fulceri, R.3
Senesi, S.4
-
16
-
-
0014217345
-
Localization and characteristics of hexose 6-phosphate dehydrogenase (glucose dehydrogenase)
-
Beutler, E., Morrison, M., Localization and characteristics of hexose 6-phosphate dehydrogenase (glucose dehydrogenase). J. Biol. Chem. 242 (1967), 5289–5293.
-
(1967)
J. Biol. Chem.
, vol.242
, pp. 5289-5293
-
-
Beutler, E.1
Morrison, M.2
-
17
-
-
0028232093
-
Absence of glucose uptake by liver microsomes: an explanation for the complete latency of glucose dehydrogenase
-
Romanelli, A., St-Denis, J.F., Vidal, H., Tchu, S., van de Werve, G., Absence of glucose uptake by liver microsomes: an explanation for the complete latency of glucose dehydrogenase. Biochem. Biophys. Res. Commun. 200 (1994), 1491–1497.
-
(1994)
Biochem. Biophys. Res. Commun.
, vol.200
, pp. 1491-1497
-
-
Romanelli, A.1
St-Denis, J.F.2
Vidal, H.3
Tchu, S.4
van de Werve, G.5
-
18
-
-
0020082753
-
Mouse liver microsomal hexose-6-phosphate dehydrogenase. NADPH generation and utilization in monooxygenation reactions
-
Kulkarni, A.P., Hodgson, E., Mouse liver microsomal hexose-6-phosphate dehydrogenase. NADPH generation and utilization in monooxygenation reactions. Biochem. Pharmacol. 31 (1982), 1131–1137.
-
(1982)
Biochem. Pharmacol.
, vol.31
, pp. 1131-1137
-
-
Kulkarni, A.P.1
Hodgson, E.2
-
19
-
-
0033081568
-
Human hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) encoded at 1p36: coding sequence and expression
-
Mason, P.J., Stevens, D., Diez, A., Knight, S.W., Scopes, D.A., Vulliamy, T.J., Human hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) encoded at 1p36: coding sequence and expression. Blood Cells Mol. Dis. 25 (1999), 30–37.
-
(1999)
Blood Cells Mol. Dis.
, vol.25
, pp. 30-37
-
-
Mason, P.J.1
Stevens, D.2
Diez, A.3
Knight, S.W.4
Scopes, D.A.5
Vulliamy, T.J.6
-
20
-
-
84898648095
-
The SLC37 family of sugar-phosphate/phosphate exchangers
-
Chou, J.Y., Mansfield, B.C., The SLC37 family of sugar-phosphate/phosphate exchangers. Curr. Top. Membr. 73 (2014), 357–382.
-
(2014)
Curr. Top. Membr.
, vol.73
, pp. 357-382
-
-
Chou, J.Y.1
Mansfield, B.C.2
-
21
-
-
60249093534
-
11β-Hydroxysteroid dehydrogenase 1 reductase activity is dependent on a high ratio of NADPH/NADP(+) and is stimulated by extracellular glucose
-
Dzyakanchuk, A.A., Balazs, Z., Nashev, L.G., Amrein, K.E., Odermatt, A., 11β-Hydroxysteroid dehydrogenase 1 reductase activity is dependent on a high ratio of NADPH/NADP(+) and is stimulated by extracellular glucose. Mol. Cell. Endocrinol. 301 (2009), 137–141.
-
(2009)
Mol. Cell. Endocrinol.
, vol.301
, pp. 137-141
-
-
Dzyakanchuk, A.A.1
Balazs, Z.2
Nashev, L.G.3
Amrein, K.E.4
Odermatt, A.5
-
22
-
-
46549084919
-
Direct protein–protein interaction of 11β-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase in the endoplasmic reticulum lumen
-
Atanasov, A.G., Nashev, L.G., Gelman, L., Legeza, B., Sack, R., Portmann, R., Odermatt, A., Direct protein–protein interaction of 11β-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase in the endoplasmic reticulum lumen. Biochim. Biophys. Acta 1783 (2008), 1536–1543.
-
(2008)
Biochim. Biophys. Acta
, vol.1783
, pp. 1536-1543
-
-
Atanasov, A.G.1
Nashev, L.G.2
Gelman, L.3
Legeza, B.4
Sack, R.5
Portmann, R.6
Odermatt, A.7
-
23
-
-
59849120142
-
H6PDH interacts directly with 11β-HSD1: implications for determining the directionality of glucocorticoid catalysis
-
Zhang, Y.L., Zhong, X., Gjoka, Z., Li, Y., Stochaj, W., Stahl, M., Kriz, R., Tobin, J.F., Erbe, D., Suri, V., H6PDH interacts directly with 11β-HSD1: implications for determining the directionality of glucocorticoid catalysis. Arch. Biochem. Biophys. 483 (2009), 45–54.
-
(2009)
Arch. Biochem. Biophys.
, vol.483
, pp. 45-54
-
-
Zhang, Y.L.1
Zhong, X.2
Gjoka, Z.3
Li, Y.4
Stochaj, W.5
Stahl, M.6
Kriz, R.7
Tobin, J.F.8
Erbe, D.9
Suri, V.10
-
24
-
-
38549142798
-
Hexose-6-phosphate dehydrogenase and 11β-hydroxysteroid dehydrogenase-1 tissue distribution in the rat
-
Gomez-Sanchez, E.P., Romero, D.G., de Rodriguez, A.F., Warden, M.P., Krozowski, Z., Gomez-Sanchez, C.E., Hexose-6-phosphate dehydrogenase and 11β-hydroxysteroid dehydrogenase-1 tissue distribution in the rat. Endocrinology 149 (2008), 525–533.
-
(2008)
Endocrinology
, vol.149
, pp. 525-533
-
-
Gomez-Sanchez, E.P.1
Romero, D.G.2
de Rodriguez, A.F.3
Warden, M.P.4
Krozowski, Z.5
Gomez-Sanchez, C.E.6
-
25
-
-
84859029706
-
The anabolic androgenic steroid fluoxymesterone inhibits 11β-hydroxysteroid dehydrogenase 2-dependent glucocorticoid inactivation
-
Furstenberger, C., Vuorinen, A., Da Cunha, T., Kratschmar, D.V., Saugy, M., Schuster, D., Odermatt, A., The anabolic androgenic steroid fluoxymesterone inhibits 11β-hydroxysteroid dehydrogenase 2-dependent glucocorticoid inactivation. Toxicol. Sci. 126 (2012), 353–361.
-
(2012)
Toxicol. Sci.
, vol.126
, pp. 353-361
-
-
Furstenberger, C.1
Vuorinen, A.2
Da Cunha, T.3
Kratschmar, D.V.4
Saugy, M.5
Schuster, D.6
Odermatt, A.7
-
26
-
-
1142285512
-
The 11-ketosteroid 11-ketodexamethasone is a glucocorticoid receptor agonist
-
Rebuffat, A.G., Tam, S., Nawrocki, A.R., Baker, M.E., Frey, B.M., Frey, F.J., Odermatt, A., The 11-ketosteroid 11-ketodexamethasone is a glucocorticoid receptor agonist. Mol. Cell. Endocrinol. 214 (2004), 27–37.
-
(2004)
Mol. Cell. Endocrinol.
, vol.214
, pp. 27-37
-
-
Rebuffat, A.G.1
Tam, S.2
Nawrocki, A.R.3
Baker, M.E.4
Frey, B.M.5
Frey, F.J.6
Odermatt, A.7
-
27
-
-
0031008086
-
Metabolism of dexamethasone in the human kidney: nicotinamide adenine dinucleotide-dependent 11β-reduction
-
Diederich, S., Hanke, B., Oelkers, W., Bahr, V., Metabolism of dexamethasone in the human kidney: nicotinamide adenine dinucleotide-dependent 11β-reduction. J. Clin. Endocrinol. Metab. 82 (1997), 1598–1602.
-
(1997)
J. Clin. Endocrinol. Metab.
, vol.82
, pp. 1598-1602
-
-
Diederich, S.1
Hanke, B.2
Oelkers, W.3
Bahr, V.4
-
28
-
-
0036882139
-
11β-hydroxysteroid dehydrogenase types 1 and 2: an important pharmacokinetic determinant for the activity of synthetic mineralo- and glucocorticoids
-
Diederich, S., Eigendorff, E., Burkhardt, P., Quinkler, M., Bumke-Vogt, C., Rochel, M., Seidelmann, D., Esperling, P., Oelkers, W., Bahr, V., 11β-hydroxysteroid dehydrogenase types 1 and 2: an important pharmacokinetic determinant for the activity of synthetic mineralo- and glucocorticoids. J. Clin. Endocrinol. Metab. 87 (2002), 5695–5701.
-
(2002)
J. Clin. Endocrinol. Metab.
, vol.87
, pp. 5695-5701
-
-
Diederich, S.1
Eigendorff, E.2
Burkhardt, P.3
Quinkler, M.4
Bumke-Vogt, C.5
Rochel, M.6
Seidelmann, D.7
Esperling, P.8
Oelkers, W.9
Bahr, V.10
-
29
-
-
34249105475
-
Is your metabolism determined by (cell) fate?
-
Feldman, B.J., Is your metabolism determined by (cell) fate?. Pediatr. Res. 61 (2007), 636–639.
-
(2007)
Pediatr. Res.
, vol.61
, pp. 636-639
-
-
Feldman, B.J.1
-
30
-
-
0030936556
-
Does central obesity reflect Cushing's disease of the omentum?
-
Bujalska, I.J., Kumar, S., Stewart, P.M., Does central obesity reflect Cushing's disease of the omentum?. Lancet 349 (1997), 1210–1213.
-
(1997)
Lancet
, vol.349
, pp. 1210-1213
-
-
Bujalska, I.J.1
Kumar, S.2
Stewart, P.M.3
-
31
-
-
0141739647
-
Tissue-specific Cushing's syndrome, 11β-hydroxysteroid dehydrogenases and the redefinition of corticosteroid hormone action
-
Stewart, P.M., Tissue-specific Cushing's syndrome, 11β-hydroxysteroid dehydrogenases and the redefinition of corticosteroid hormone action. Eur. J. Endocrinol. 149 (2003), 163–168.
-
(2003)
Eur. J. Endocrinol.
, vol.149
, pp. 163-168
-
-
Stewart, P.M.1
-
32
-
-
23944464132
-
Genetic manipulation of 11β-hydroxysteroid dehydrogenases in mice
-
Paterson, J.M., Seckl, J.R., Mullins, J.J., Genetic manipulation of 11β-hydroxysteroid dehydrogenases in mice. Am. J. Physiol. Regul. Integr. Comp. Physiol. 289 (2005), R642–652.
-
(2005)
Am. J. Physiol. Regul. Integr. Comp. Physiol.
, vol.289
, pp. R642-652
-
-
Paterson, J.M.1
Seckl, J.R.2
Mullins, J.J.3
-
33
-
-
84882789718
-
11β-hydroxysteroid dehydrogenase 1: translational and therapeutic aspects
-
Gathercole, L.L., Lavery, G.G., Morgan, S.A., Cooper, M.S., Sinclair, A.J., Tomlinson, J.W., Stewart, P.M., 11β-hydroxysteroid dehydrogenase 1: translational and therapeutic aspects. Endocr. Rev. 34 (2013), 525–555.
-
(2013)
Endocr. Rev.
, vol.34
, pp. 525-555
-
-
Gathercole, L.L.1
Lavery, G.G.2
Morgan, S.A.3
Cooper, M.S.4
Sinclair, A.J.5
Tomlinson, J.W.6
Stewart, P.M.7
-
34
-
-
0031283178
-
11β-hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress
-
Kotelevtsev, Y., Holmes, M.C., Burchell, A., Houston, P.M., Schmoll, D., Jamieson, P., Best, R., Brown, R., Edwards, C.R., Seckl, J.R., Mullins, J.J., 11β-hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress. Proc. Natl. Acad. Sci. U. S. A. 94 (1997), 14924–14929.
-
(1997)
Proc. Natl. Acad. Sci. U. S. A.
, vol.94
, pp. 14924-14929
-
-
Kotelevtsev, Y.1
Holmes, M.C.2
Burchell, A.3
Houston, P.M.4
Schmoll, D.5
Jamieson, P.6
Best, R.7
Brown, R.8
Edwards, C.R.9
Seckl, J.R.10
Mullins, J.J.11
-
35
-
-
0035798621
-
Improved lipid and lipoprotein profile, hepatic insulin sensitivity, and glucose tolerance in 11β-hydroxysteroid dehydrogenase type 1 null mice
-
Morton, N.M., Holmes, M.C., Fievet, C., Staels, B., Tailleux, A., Mullins, J.J., Seckl, J.R., Improved lipid and lipoprotein profile, hepatic insulin sensitivity, and glucose tolerance in 11β-hydroxysteroid dehydrogenase type 1 null mice. J. Biol. Chem. 276 (2001), 41293–41300.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 41293-41300
-
-
Morton, N.M.1
Holmes, M.C.2
Fievet, C.3
Staels, B.4
Tailleux, A.5
Mullins, J.J.6
Seckl, J.R.7
-
36
-
-
12144291638
-
Novel adipose tissue-mediated resistance to diet-induced visceral obesity in 11β-hydroxysteroid dehydrogenase type 1-deficient mice
-
Morton, N.M., Paterson, J.M., Masuzaki, H., Holmes, M.C., Staels, B., Fievet, C., Walker, B.R., Flier, J.S., Mullins, J.J., Seckl, J.R., Novel adipose tissue-mediated resistance to diet-induced visceral obesity in 11β-hydroxysteroid dehydrogenase type 1-deficient mice. Diabetes 53 (2004), 931–938.
-
(2004)
Diabetes
, vol.53
, pp. 931-938
-
-
Morton, N.M.1
Paterson, J.M.2
Masuzaki, H.3
Holmes, M.C.4
Staels, B.5
Fievet, C.6
Walker, B.R.7
Flier, J.S.8
Mullins, J.J.9
Seckl, J.R.10
-
37
-
-
84888262119
-
11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors still improve metabolic phenotype in male 11β-HSD1 knockout mice suggesting off-target mechanisms
-
Harno, E., Cottrell, E.C., Yu, A., DeSchoolmeester, J., Gutierrez, P.M., Denn, M., Swales, J.G., Goldberg, F.W., Bohlooly, Y.M., Andersen, H., Wild, M.J., Turnbull, A.V., Leighton, B., White, A., 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors still improve metabolic phenotype in male 11β-HSD1 knockout mice suggesting off-target mechanisms. Endocrinology 154 (2013), 4580–4593.
-
(2013)
Endocrinology
, vol.154
, pp. 4580-4593
-
-
Harno, E.1
Cottrell, E.C.2
Yu, A.3
DeSchoolmeester, J.4
Gutierrez, P.M.5
Denn, M.6
Swales, J.G.7
Goldberg, F.W.8
Bohlooly, Y.M.9
Andersen, H.10
Wild, M.J.11
Turnbull, A.V.12
Leighton, B.13
White, A.14
-
38
-
-
0035824440
-
A transgenic model of visceral obesity and the metabolic syndrome
-
Masuzaki, H., Paterson, J., Shinyama, H., Morton, N.M., Mullins, J.J., Seckl, J.R., Flier, J.S., A transgenic model of visceral obesity and the metabolic syndrome. Science 294 (2001), 2166–2170.
-
(2001)
Science
, vol.294
, pp. 2166-2170
-
-
Masuzaki, H.1
Paterson, J.2
Shinyama, H.3
Morton, N.M.4
Mullins, J.J.5
Seckl, J.R.6
Flier, J.S.7
-
39
-
-
85047693986
-
Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice
-
Masuzaki, H., Yamamoto, H., Kenyon, C.J., Elmquist, J.K., Morton, N.M., Paterson, J.M., Shinyama, H., Sharp, M.G., Fleming, S., Mullins, J.J., Seckl, J.R., Flier, J.S., Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice. J. Clin. Investig. 112 (2003), 83–90.
-
(2003)
J. Clin. Investig.
, vol.112
, pp. 83-90
-
-
Masuzaki, H.1
Yamamoto, H.2
Kenyon, C.J.3
Elmquist, J.K.4
Morton, N.M.5
Paterson, J.M.6
Shinyama, H.7
Sharp, M.G.8
Fleming, S.9
Mullins, J.J.10
Seckl, J.R.11
Flier, J.S.12
-
40
-
-
2342510149
-
Metabolic syndrome without obesity: hepatic overexpression of 11β-hydroxysteroid dehydrogenase type 1 in transgenic mice
-
Paterson, J.M., Morton, N.M., Fievet, C., Kenyon, C.J., Holmes, M.C., Staels, B., Seckl, J.R., Mullins, J.J., Metabolic syndrome without obesity: hepatic overexpression of 11β-hydroxysteroid dehydrogenase type 1 in transgenic mice. Proc. Natl. Acad. Sci. U. S. A. 101 (2004), 7088–7093.
-
(2004)
Proc. Natl. Acad. Sci. U. S. A.
, vol.101
, pp. 7088-7093
-
-
Paterson, J.M.1
Morton, N.M.2
Fievet, C.3
Kenyon, C.J.4
Holmes, M.C.5
Staels, B.6
Seckl, J.R.7
Mullins, J.J.8
-
41
-
-
77955630861
-
The 11β-hydroxysteroid dehydrogenase type 1 inhibitor INCB13739 improves hyperglycemia in patients with type 2 diabetes inadequately controlled by metformin monotherapy
-
Rosenstock, J., Banarer, S., Fonseca, V.A., Inzucchi, S.E., Sun, W., Yao, W., Hollis, G., Flores, R., Levy, R., Williams, W.V., Seckl, J.R., Huber, R., The 11β-hydroxysteroid dehydrogenase type 1 inhibitor INCB13739 improves hyperglycemia in patients with type 2 diabetes inadequately controlled by metformin monotherapy. Diabetes Care 33 (2010), 1516–1522.
-
(2010)
Diabetes Care
, vol.33
, pp. 1516-1522
-
-
Rosenstock, J.1
Banarer, S.2
Fonseca, V.A.3
Inzucchi, S.E.4
Sun, W.5
Yao, W.6
Hollis, G.7
Flores, R.8
Levy, R.9
Williams, W.V.10
Seckl, J.R.11
Huber, R.12
-
42
-
-
84894070010
-
Medicinal chemistry of inhibitors of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)
-
Scott, J.S., Goldberg, F.W., Turnbull, A.V., Medicinal chemistry of inhibitors of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). J. Med. Chem. 57 (2014), 4466–4486.
-
(2014)
J. Med. Chem.
, vol.57
, pp. 4466-4486
-
-
Scott, J.S.1
Goldberg, F.W.2
Turnbull, A.V.3
-
43
-
-
84862748339
-
Lack of significant metabolic abnormalities in mice with liver-specific disruption of 11β-hydroxysteroid dehydrogenase type 1
-
Lavery, G.G., Zielinska, A.E., Gathercole, L.L., Hughes, B., Semjonous, N., Guest, P., Saqib, K., Sherlock, M., Reynolds, G., Morgan, S.A., Tomlinson, J.W., Walker, E.A., Rabbitt, E.H., Stewart, P.M., Lack of significant metabolic abnormalities in mice with liver-specific disruption of 11β-hydroxysteroid dehydrogenase type 1. Endocrinology 153 (2012), 3236–3248.
-
(2012)
Endocrinology
, vol.153
, pp. 3236-3248
-
-
Lavery, G.G.1
Zielinska, A.E.2
Gathercole, L.L.3
Hughes, B.4
Semjonous, N.5
Guest, P.6
Saqib, K.7
Sherlock, M.8
Reynolds, G.9
Morgan, S.A.10
Tomlinson, J.W.11
Walker, E.A.12
Rabbitt, E.H.13
Stewart, P.M.14
-
44
-
-
84904309908
-
11β-Hydroxysteroid dehydrogenase-1 is involved in bile acid homeostasis by modulating fatty acid transport protein-5 in the liver of mice
-
Penno, C.A., Morgan, S.A., Rose, A.J., Herzig, S., Lavery, G.G., Odermatt, A., 11β-Hydroxysteroid dehydrogenase-1 is involved in bile acid homeostasis by modulating fatty acid transport protein-5 in the liver of mice. Mol. Metab. 3 (2014), 554–564.
-
(2014)
Mol. Metab.
, vol.3
, pp. 554-564
-
-
Penno, C.A.1
Morgan, S.A.2
Rose, A.J.3
Herzig, S.4
Lavery, G.G.5
Odermatt, A.6
-
45
-
-
33644885712
-
Why is 11β-hydroxysteroid dehydrogenase type 1 facing the endoplasmic reticulum lumen? Physiological relevance of the membrane topology of 11β-HSD1
-
Odermatt, A., Atanasov, A.G., Balazs, Z., Schweizer, R.A., Nashev, L.G., Schuster, D., Langer, T., Why is 11β-hydroxysteroid dehydrogenase type 1 facing the endoplasmic reticulum lumen? Physiological relevance of the membrane topology of 11β-HSD1. Mol. Cell. Endocrinol. 248 (2006), 15–23.
-
(2006)
Mol. Cell. Endocrinol.
, vol.248
, pp. 15-23
-
-
Odermatt, A.1
Atanasov, A.G.2
Balazs, Z.3
Schweizer, R.A.4
Nashev, L.G.5
Schuster, D.6
Langer, T.7
-
46
-
-
76749116526
-
The glucocorticoid-activating enzyme 11β-hydroxysteroid dehydrogenase type 1 has broad substrate specificity: physiological and toxicological considerations
-
Odermatt, A., Nashev, L.G., The glucocorticoid-activating enzyme 11β-hydroxysteroid dehydrogenase type 1 has broad substrate specificity: physiological and toxicological considerations. J. Steroid Biochem. Mol. Biol. 119 (2010), 1–13.
-
(2010)
J. Steroid Biochem. Mol. Biol.
, vol.119
, pp. 1-13
-
-
Odermatt, A.1
Nashev, L.G.2
-
47
-
-
0028956967
-
Sodium-retaining activity of some natural and synthetic 21-deoxysteroids
-
Burton, G., Galigniana, M., De Lavallaz, S., Brachet-Cota, A.L., Sproviero, E.M., Ghini, A.A., Lantos, C.P., Damasco, M.C., Sodium-retaining activity of some natural and synthetic 21-deoxysteroids. Mol. Pharmacol. 47 (1995), 535–543.
-
(1995)
Mol. Pharmacol.
, vol.47
, pp. 535-543
-
-
Burton, G.1
Galigniana, M.2
De Lavallaz, S.3
Brachet-Cota, A.L.4
Sproviero, E.M.5
Ghini, A.A.6
Lantos, C.P.7
Damasco, M.C.8
-
48
-
-
0030952348
-
Features of the shuttle pair 11β-hydroxyprogesterone-11-ketoprogesterone
-
Galigniana, M.D., Vicent, G.P., Burton, G., Lantos, C.P., Features of the shuttle pair 11β-hydroxyprogesterone-11-ketoprogesterone. Steroids 62 (1997), 358–364.
-
(1997)
Steroids
, vol.62
, pp. 358-364
-
-
Galigniana, M.D.1
Vicent, G.P.2
Burton, G.3
Lantos, C.P.4
-
49
-
-
0015589925
-
Biosynthesis of 11-hydroxyandrostenedione by human and baboon adrenals
-
Axelrod, L.R., Kraemer, D.C., Burdett, J. Jr., Goldzieher, J.W., Biosynthesis of 11-hydroxyandrostenedione by human and baboon adrenals. Acta Endocrinol. (Copenh.) 72 (1973), 545–550.
-
(1973)
Acta Endocrinol. (Copenh.)
, vol.72
, pp. 545-550
-
-
Axelrod, L.R.1
Kraemer, D.C.2
Burdett, J.3
Goldzieher, J.W.4
-
50
-
-
84874854402
-
Liquid chromatography–tandem mass spectrometry analysis of human adrenal vein 19-carbon steroids before and after ACTH stimulation
-
Rege, J., Nakamura, Y., Satoh, F., Morimoto, R., Kennedy, M.R., Layman, L.C., Honma, S., Sasano, H., Rainey, W.E., Liquid chromatography–tandem mass spectrometry analysis of human adrenal vein 19-carbon steroids before and after ACTH stimulation. J. Clin. Endocrinol. Metab. 98 (2013), 1182–1188.
-
(2013)
J. Clin. Endocrinol. Metab.
, vol.98
, pp. 1182-1188
-
-
Rege, J.1
Nakamura, Y.2
Satoh, F.3
Morimoto, R.4
Kennedy, M.R.5
Layman, L.C.6
Honma, S.7
Sasano, H.8
Rainey, W.E.9
-
51
-
-
84884563854
-
11β-hydroxyandrostenedione, the product of androstenedione metabolism in the adrenal, is metabolized in LNCaP cells by 5α-reductase yielding 11β-hydroxy-5α-androstanedione
-
Swart, A.C., Schloms, L., Storbeck, K.H., Bloem, L.M., Toit, T., Quanson, J.L., Rainey, W.E., Swart, P., 11β-hydroxyandrostenedione, the product of androstenedione metabolism in the adrenal, is metabolized in LNCaP cells by 5α-reductase yielding 11β-hydroxy-5α-androstanedione. J. Steroid Biochem. Mol. Biol. 138 (2013), 132–142.
-
(2013)
J. Steroid Biochem. Mol. Biol.
, vol.138
, pp. 132-142
-
-
Swart, A.C.1
Schloms, L.2
Storbeck, K.H.3
Bloem, L.M.4
Toit, T.5
Quanson, J.L.6
Rainey, W.E.7
Swart, P.8
-
52
-
-
84881260404
-
11β-Hydroxydihydrotestosterone and 11-ketodihydrotestosterone, novel C19 steroids with androgenic activity: a putative role in castration resistant prostate cancer?
-
Storbeck, K.H., Bloem, L.M., Africander, D., Schloms, L., Swart, P., Swart, A.C., 11β-Hydroxydihydrotestosterone and 11-ketodihydrotestosterone, novel C19 steroids with androgenic activity: a putative role in castration resistant prostate cancer?. Mol. Cell. Endocrinol. 377 (2013), 135–146.
-
(2013)
Mol. Cell. Endocrinol.
, vol.377
, pp. 135-146
-
-
Storbeck, K.H.1
Bloem, L.M.2
Africander, D.3
Schloms, L.4
Swart, P.5
Swart, A.C.6
-
53
-
-
0036887723
-
Steroid and sterol 7-hydroxylation: ancient pathways
-
Lathe, R., Steroid and sterol 7-hydroxylation: ancient pathways. Steroids 67 (2002), 967–977.
-
(2002)
Steroids
, vol.67
, pp. 967-977
-
-
Lathe, R.1
-
54
-
-
84893318795
-
Steroid signaling: ligand-binding promiscuity, molecular symmetry, and the need for gating
-
Lathe, R., Kotelevtsev, Y., Steroid signaling: ligand-binding promiscuity, molecular symmetry, and the need for gating. Steroids 82 (2014), 14–22.
-
(2014)
Steroids
, vol.82
, pp. 14-22
-
-
Lathe, R.1
Kotelevtsev, Y.2
-
55
-
-
0037445848
-
Glucocorticoids inhibit interconversion of 7-hydroxy and 7-oxo metabolites of dehydroepiandrosterone: a role for 11β-hydroxysteroid dehydrogenases?
-
Robinzon, B., Michael, K.K., Ripp, S.L., Winters, S.J., Prough, R.A., Glucocorticoids inhibit interconversion of 7-hydroxy and 7-oxo metabolites of dehydroepiandrosterone: a role for 11β-hydroxysteroid dehydrogenases?. Arch. Biochem. Biophys. 412 (2003), 251–258.
-
(2003)
Arch. Biochem. Biophys.
, vol.412
, pp. 251-258
-
-
Robinzon, B.1
Michael, K.K.2
Ripp, S.L.3
Winters, S.J.4
Prough, R.A.5
-
56
-
-
24944502755
-
Interactions between dehydroepiandrosterone and glucocorticoid metabolism in pig kidney: nuclear and microsomal 11β-hydroxysteroid dehydrogenases
-
Robinzon, B., Prough, R.A., Interactions between dehydroepiandrosterone and glucocorticoid metabolism in pig kidney: nuclear and microsomal 11β-hydroxysteroid dehydrogenases. Arch. Biochem. Biophys. 442 (2005), 33–40.
-
(2005)
Arch. Biochem. Biophys.
, vol.442
, pp. 33-40
-
-
Robinzon, B.1
Prough, R.A.2
-
57
-
-
33746232050
-
Inter-conversion of 7α- and 7β-hydroxy-dehydroepiandrosterone by the human 11β-hydroxysteroid dehydrogenase type 1
-
Muller, C., Pompon, D., Urban, P., Morfin, R., Inter-conversion of 7α- and 7β-hydroxy-dehydroepiandrosterone by the human 11β-hydroxysteroid dehydrogenase type 1. J. Steroid Biochem. Mol. Biol. 99 (2006), 215–222.
-
(2006)
J. Steroid Biochem. Mol. Biol.
, vol.99
, pp. 215-222
-
-
Muller, C.1
Pompon, D.2
Urban, P.3
Morfin, R.4
-
58
-
-
39349102358
-
Hexose-6-phosphate dehydrogenase modulates 11β-hydroxysteroid dehydrogenase type 1-dependent metabolism of 7-keto- and 7β-hydroxy-neurosteroids
-
Nashev, L.G., Chandsawangbhuwana, C., Balazs, Z., Atanasov, A.G., Dick, B., Frey, F.J., Baker, M.E., Odermatt, A., Hexose-6-phosphate dehydrogenase modulates 11β-hydroxysteroid dehydrogenase type 1-dependent metabolism of 7-keto- and 7β-hydroxy-neurosteroids. PLoS One, 2, 2007, e561.
-
(2007)
PLoS One
, vol.2
, pp. e561
-
-
Nashev, L.G.1
Chandsawangbhuwana, C.2
Balazs, Z.3
Atanasov, A.G.4
Dick, B.5
Frey, F.J.6
Baker, M.E.7
Odermatt, A.8
-
59
-
-
74949101637
-
7α-hydroxytestosterone affects 11β-hydroxysteroid dehydrogenase 1 direction in rat Leydig cells
-
Hu, G.X., Lian, Q.Q., Chen, B.B., Prasad, P.V., Kumar, N., Zheng, Z.Q., Ge, R.S., 7α-hydroxytestosterone affects 11β-hydroxysteroid dehydrogenase 1 direction in rat Leydig cells. Endocrinology 151 (2010), 748–754.
-
(2010)
Endocrinology
, vol.151
, pp. 748-754
-
-
Hu, G.X.1
Lian, Q.Q.2
Chen, B.B.3
Prasad, P.V.4
Kumar, N.5
Zheng, Z.Q.6
Ge, R.S.7
-
60
-
-
33746214636
-
The native anti-glucocorticoid paradigm
-
Muller, C., Hennebert, O., Morfin, R., The native anti-glucocorticoid paradigm. J. Steroid Biochem. Mol. Biol. 100 (2006), 95–105.
-
(2006)
J. Steroid Biochem. Mol. Biol.
, vol.100
, pp. 95-105
-
-
Muller, C.1
Hennebert, O.2
Morfin, R.3
-
61
-
-
84884557271
-
7α-hydroxylation of dehydroepiandrosterone does not interfere with the activation of glucocorticoids by 11β-hydroxysteroid dehydrogenase in E(t)C cerebellar neurons
-
Gottfried-Blackmore, A., Jellinck, P.H., Vecchiarelli, H.A., Masheeb, Z., Kaufmann, M., McEwen, B.S., Bulloch, K., 7α-hydroxylation of dehydroepiandrosterone does not interfere with the activation of glucocorticoids by 11β-hydroxysteroid dehydrogenase in E(t)C cerebellar neurons. J. Steroid Biochem. Mol. Biol. 138 (2013), 290–297.
-
(2013)
J. Steroid Biochem. Mol. Biol.
, vol.138
, pp. 290-297
-
-
Gottfried-Blackmore, A.1
Jellinck, P.H.2
Vecchiarelli, H.A.3
Masheeb, Z.4
Kaufmann, M.5
McEwen, B.S.6
Bulloch, K.7
-
62
-
-
60249100376
-
Hexose-6-phosphate dehydrogenase modulates the effect of inhibitors and alternative substrates of 11β-hydroxysteroid dehydrogenase 1
-
Balazs, Z., Nashev, L.G., Chandsawangbhuwana, C., Baker, M.E., Odermatt, A., Hexose-6-phosphate dehydrogenase modulates the effect of inhibitors and alternative substrates of 11β-hydroxysteroid dehydrogenase 1. Mol. Cell. Endocrinol. 301 (2009), 117–122.
-
(2009)
Mol. Cell. Endocrinol.
, vol.301
, pp. 117-122
-
-
Balazs, Z.1
Nashev, L.G.2
Chandsawangbhuwana, C.3
Baker, M.E.4
Odermatt, A.5
-
63
-
-
38149005365
-
DHEA induces 11β-HSD2 by acting on CCAAT/enhancer-binding proteins
-
Balazs, Z., Schweizer, R.A., Frey, F.J., Rohner-Jeanrenaud, F., Odermatt, A., DHEA induces 11β-HSD2 by acting on CCAAT/enhancer-binding proteins. J. Am. Soc. Nephrol. 19 (2008), 92–101.
-
(2008)
J. Am. Soc. Nephrol.
, vol.19
, pp. 92-101
-
-
Balazs, Z.1
Schweizer, R.A.2
Frey, F.J.3
Rohner-Jeanrenaud, F.4
Odermatt, A.5
-
64
-
-
17444391240
-
Dehydroepiandrosterone inhibits the amplification of glucocorticoid action in adipose tissue
-
Apostolova, G., Schweizer, R.A., Balazs, Z., Kostadinova, R.M., Odermatt, A., Dehydroepiandrosterone inhibits the amplification of glucocorticoid action in adipose tissue. Am. J. Physiol. Endocrinol. Metab. 288 (2005), E957–964.
-
(2005)
Am. J. Physiol. Endocrinol. Metab.
, vol.288
, pp. E957-964
-
-
Apostolova, G.1
Schweizer, R.A.2
Balazs, Z.3
Kostadinova, R.M.4
Odermatt, A.5
-
65
-
-
84886997219
-
Dehydroepiandrosterone exerts antiglucocorticoid action on human preadipocyte proliferation, differentiation, and glucose uptake
-
McNelis, J.C., Manolopoulos, K.N., Gathercole, L.L., Bujalska, I.J., Stewart, P.M., Tomlinson, J.W., Arlt, W., Dehydroepiandrosterone exerts antiglucocorticoid action on human preadipocyte proliferation, differentiation, and glucose uptake. Am. J. Physiol. Endocrinol. Metab. 305 (2013), E1134–1144.
-
(2013)
Am. J. Physiol. Endocrinol. Metab.
, vol.305
, pp. E1134-1144
-
-
McNelis, J.C.1
Manolopoulos, K.N.2
Gathercole, L.L.3
Bujalska, I.J.4
Stewart, P.M.5
Tomlinson, J.W.6
Arlt, W.7
-
66
-
-
79957749029
-
Hepatic reduction of the secondary bile acid 7-oxolithocholic acid is mediated by 11β-hydroxysteroid dehydrogenase 1
-
Odermatt, A., Da Cunha, T., Penno, C.A., Chandsawangbhuwana, C., Reichert, C., Wolf, A., Dong, M., Baker, M.E., Hepatic reduction of the secondary bile acid 7-oxolithocholic acid is mediated by 11β-hydroxysteroid dehydrogenase 1. Biochem. J. 436 (2011), 621–629.
-
(2011)
Biochem. J.
, vol.436
, pp. 621-629
-
-
Odermatt, A.1
Da Cunha, T.2
Penno, C.A.3
Chandsawangbhuwana, C.4
Reichert, C.5
Wolf, A.6
Dong, M.7
Baker, M.E.8
-
67
-
-
33244467651
-
Bile salt biotransformations by human intestinal bacteria
-
Ridlon, J.M., Kang, D.J., Hylemon, P.B., Bile salt biotransformations by human intestinal bacteria. J. Lipid Res. 47 (2006), 241–259.
-
(2006)
J. Lipid Res.
, vol.47
, pp. 241-259
-
-
Ridlon, J.M.1
Kang, D.J.2
Hylemon, P.B.3
-
68
-
-
0019066473
-
Metabolism in man of 7-ketolithocholic acid: precursor of cheno- and ursodeoxycholic acids
-
Fromm, H., Carlson, G.L., Hofmann, A.F., Farivar, S., Amin, P., Metabolism in man of 7-ketolithocholic acid: precursor of cheno- and ursodeoxycholic acids. Am. J. Physiol. 239 (1980), G161–166.
-
(1980)
Am. J. Physiol.
, vol.239
, pp. G161-166
-
-
Fromm, H.1
Carlson, G.L.2
Hofmann, A.F.3
Farivar, S.4
Amin, P.5
-
69
-
-
0020956569
-
Formation of ursodeoxycholic acid from chenodeoxycholic acid in the human colon: studies of the role of 7-ketolithocholic acid as an intermediate
-
Fromm, H., Sarva, R.P., Bazzoli, F., Formation of ursodeoxycholic acid from chenodeoxycholic acid in the human colon: studies of the role of 7-ketolithocholic acid as an intermediate. J. Lipid Res. 24 (1983), 841–853.
-
(1983)
J. Lipid Res.
, vol.24
, pp. 841-853
-
-
Fromm, H.1
Sarva, R.P.2
Bazzoli, F.3
-
70
-
-
0019977610
-
Effect of 7-ketolithocholic acid on bile acid metabolism in humans
-
Salen, G., Verga, D., Batta, A.K., Tint, G.S., Shefer, S., Effect of 7-ketolithocholic acid on bile acid metabolism in humans. Gastroenterology 83 (1982), 341–347.
-
(1982)
Gastroenterology
, vol.83
, pp. 341-347
-
-
Salen, G.1
Verga, D.2
Batta, A.K.3
Tint, G.S.4
Shefer, S.5
-
71
-
-
0024595529
-
Reduction of 7-ketolithocholic acid by human liver enzyme preparations in vitro
-
Amuro, Y., Yamade, W., Kudo, K., Yamamoto, T., Hada, T., Higashino, K., Reduction of 7-ketolithocholic acid by human liver enzyme preparations in vitro. Am. J. Physiol. 256 (1989), G67–71.
-
(1989)
Am. J. Physiol.
, vol.256
, pp. G67-71
-
-
Amuro, Y.1
Yamade, W.2
Kudo, K.3
Yamamoto, T.4
Hada, T.5
Higashino, K.6
-
72
-
-
0022415069
-
Reduction of 7-ketolithocholic acid to chenodeoxycholic acid by rat liver preparations in vitro
-
Amuro, Y., Yamade, W., Nakano, T., Hayashi, E., Hada, T., Higashino, K., Reduction of 7-ketolithocholic acid to chenodeoxycholic acid by rat liver preparations in vitro. Biochim. Biophys. Acta 841 (1985), 229–231.
-
(1985)
Biochim. Biophys. Acta
, vol.841
, pp. 229-231
-
-
Amuro, Y.1
Yamade, W.2
Nakano, T.3
Hayashi, E.4
Hada, T.5
Higashino, K.6
-
73
-
-
84884133611
-
Impaired oxidoreduction by 11β-hydroxysteroid dehydrogenase 1 results in the accumulation of 7-oxolithocholic acid
-
Penno, C.A., Morgan, S.A., Vuorinen, A., Schuster, D., Lavery, G.G., Odermatt, A., Impaired oxidoreduction by 11β-hydroxysteroid dehydrogenase 1 results in the accumulation of 7-oxolithocholic acid. J. Lipid Res. 54 (2013), 2874–2883.
-
(2013)
J. Lipid Res.
, vol.54
, pp. 2874-2883
-
-
Penno, C.A.1
Morgan, S.A.2
Vuorinen, A.3
Schuster, D.4
Lavery, G.G.5
Odermatt, A.6
-
74
-
-
77952561299
-
Bile acids as regulators of hepatic lipid and glucose metabolism
-
Trauner, M., Claudel, T., Fickert, P., Moustafa, T., Wagner, M., Bile acids as regulators of hepatic lipid and glucose metabolism. Dig. Dis. 28 (2010), 220–224.
-
(2010)
Dig. Dis.
, vol.28
, pp. 220-224
-
-
Trauner, M.1
Claudel, T.2
Fickert, P.3
Moustafa, T.4
Wagner, M.5
-
75
-
-
0032569018
-
Purification and characterization of hamster liver microsomal 7α-hydroxycholesterol dehydrogenase. Similarity to type I 11β-hydroxysteroid dehydrogenase
-
Song, W., Chen, J., Dean, W.L., Redinger, R.N., Prough, R.A., Purification and characterization of hamster liver microsomal 7α-hydroxycholesterol dehydrogenase. Similarity to type I 11β-hydroxysteroid dehydrogenase. J. Biol. Chem. 273 (1998), 16223–16228.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 16223-16228
-
-
Song, W.1
Chen, J.2
Dean, W.L.3
Redinger, R.N.4
Prough, R.A.5
-
76
-
-
2442513350
-
Rapid hepatic metabolism of 7-ketocholesterol by 11β-hydroxysteroid dehydrogenase type 1: species-specific differences between the rat, human, and hamster enzyme
-
Schweizer, R.A., Zurcher, M., Balazs, Z., Dick, B., Odermatt, A., Rapid hepatic metabolism of 7-ketocholesterol by 11β-hydroxysteroid dehydrogenase type 1: species-specific differences between the rat, human, and hamster enzyme. J. Biol. Chem. 279 (2004), 18415–18424.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 18415-18424
-
-
Schweizer, R.A.1
Zurcher, M.2
Balazs, Z.3
Dick, B.4
Odermatt, A.5
-
77
-
-
2442614716
-
Human and rodent type 1 11β-hydroxysteroid dehydrogenases are 7β-hydroxycholesterol dehydrogenases involved in oxysterol metabolism
-
Hult, M., Elleby, B., Shafqat, N., Svensson, S., Rane, A., Jornvall, H., Abrahmsen, L., Oppermann, U., Human and rodent type 1 11β-hydroxysteroid dehydrogenases are 7β-hydroxycholesterol dehydrogenases involved in oxysterol metabolism. Cell. Mol. Life Sci. 61 (2004), 992–999.
-
(2004)
Cell. Mol. Life Sci.
, vol.61
, pp. 992-999
-
-
Hult, M.1
Elleby, B.2
Shafqat, N.3
Svensson, S.4
Rane, A.5
Jornvall, H.6
Abrahmsen, L.7
Oppermann, U.8
-
78
-
-
23844467917
-
Comparative enzymology of 11β-hydroxysteroid dehydrogenase type 1 from six species
-
Arampatzis, S., Kadereit, B., Schuster, D., Balazs, Z., Schweizer, R.A., Frey, F.J., Langer, T., Odermatt, A., Comparative enzymology of 11β-hydroxysteroid dehydrogenase type 1 from six species. J. Mol. Endocrinol. 35 (2005), 89–101.
-
(2005)
J. Mol. Endocrinol.
, vol.35
, pp. 89-101
-
-
Arampatzis, S.1
Kadereit, B.2
Schuster, D.3
Balazs, Z.4
Schweizer, R.A.5
Frey, F.J.6
Langer, T.7
Odermatt, A.8
-
79
-
-
84884308244
-
11β-Hydroxysteroid dehydrogenase type 1 contributes to the balance between 7-keto- and 7-hydroxy-oxysterols in vivo
-
Mitic, T., Shave, S., Semjonous, N., McNae, I., Cobice, D.F., Lavery, G.G., Webster, S.P., Hadoke, P.W., Walker, B.R., Andrew, R., 11β-Hydroxysteroid dehydrogenase type 1 contributes to the balance between 7-keto- and 7-hydroxy-oxysterols in vivo. Biochem. Pharmacol. 86 (2013), 146–153.
-
(2013)
Biochem. Pharmacol.
, vol.86
, pp. 146-153
-
-
Mitic, T.1
Shave, S.2
Semjonous, N.3
McNae, I.4
Cobice, D.F.5
Lavery, G.G.6
Webster, S.P.7
Hadoke, P.W.8
Walker, B.R.9
Andrew, R.10
-
80
-
-
84874111592
-
11β-Hydroxysteroid dehydrogenase type 1 contributes to the regulation of 7-oxysterol levels in the arterial wall through the inter-conversion of 7-ketocholesterol and 7β-hydroxycholesterol
-
Mitic, T., Andrew, R., Walker, B.R., Hadoke, P.W., 11β-Hydroxysteroid dehydrogenase type 1 contributes to the regulation of 7-oxysterol levels in the arterial wall through the inter-conversion of 7-ketocholesterol and 7β-hydroxycholesterol. Biochimie 95 (2013), 548–555.
-
(2013)
Biochimie
, vol.95
, pp. 548-555
-
-
Mitic, T.1
Andrew, R.2
Walker, B.R.3
Hadoke, P.W.4
-
81
-
-
79955535643
-
Macrophages in the pathogenesis of atherosclerosis
-
Moore, K.J., Tabas, I., Macrophages in the pathogenesis of atherosclerosis. Cell 145 (2011), 341–355.
-
(2011)
Cell
, vol.145
, pp. 341-355
-
-
Moore, K.J.1
Tabas, I.2
-
82
-
-
0035399825
-
11β-hydroxysteroid dehydrogenase type 1 is induced in human monocytes upon differentiation to macrophages
-
Thieringer, R., Le Grand, C.B., Carbin, L., Cai, T.Q., Wong, B., Wright, S.D., Hermanowski-Vosatka, A., 11β-hydroxysteroid dehydrogenase type 1 is induced in human monocytes upon differentiation to macrophages. J. Immunol. 167 (2001), 30–35.
-
(2001)
J. Immunol.
, vol.167
, pp. 30-35
-
-
Thieringer, R.1
Le Grand, C.B.2
Carbin, L.3
Cai, T.Q.4
Wong, B.5
Wright, S.D.6
Hermanowski-Vosatka, A.7
-
83
-
-
23944493717
-
11β-HSD1 inhibition ameliorates metabolic syndrome and prevents progression of atherosclerosis in mice
-
Hermanowski-Vosatka, A., Balkovec, J.M., Cheng, K., Chen, H.Y., Hernandez, M., Koo, G.C., Le Grand, C.B., Li, Z., Metzger, J.M., Mundt, S.S., Noonan, H., Nunes, C.N., Olson, S.H., Pikounis, B., Ren, N., Robertson, N., Schaeffer, J.M., Shah, K., Springer, M.S., Strack, A.M., Strowski, M., Wu, K., Wu, T., Xiao, J., Zhang, B.B., Wright, S.D., Thieringer, R., 11β-HSD1 inhibition ameliorates metabolic syndrome and prevents progression of atherosclerosis in mice. J. Exp. Med. 202 (2005), 517–527.
-
(2005)
J. Exp. Med.
, vol.202
, pp. 517-527
-
-
Hermanowski-Vosatka, A.1
Balkovec, J.M.2
Cheng, K.3
Chen, H.Y.4
Hernandez, M.5
Koo, G.C.6
Le Grand, C.B.7
Li, Z.8
Metzger, J.M.9
Mundt, S.S.10
Noonan, H.11
Nunes, C.N.12
Olson, S.H.13
Pikounis, B.14
Ren, N.15
Robertson, N.16
Schaeffer, J.M.17
Shah, K.18
Springer, M.S.19
Strack, A.M.20
Strowski, M.21
Wu, K.22
Wu, T.23
Xiao, J.24
Zhang, B.B.25
Wright, S.D.26
Thieringer, R.27
more..
-
84
-
-
84872185794
-
11β-HSD1 inhibition reduces atherosclerosis in mice by altering proinflammatory gene expression in the vasculature
-
Luo, M.J., Thieringer, R., Springer, M.S., Wright, S.D., Hermanowski-Vosatka, A., Plump, A., Balkovec, J.M., Cheng, K., Ding, G.J., Kawka, D.W., Koo, G.C., Grand, C.B., Luo, Q., Maletic, M.M., Malkowitz, L., Shah, K., Singer, I., Waddell, S.T., Wu, K.K., Yuan, J., Zhu, J., Stepaniants, S., Yang, X., Lum, P.Y., Wang, I.M., 11β-HSD1 inhibition reduces atherosclerosis in mice by altering proinflammatory gene expression in the vasculature. Physiol. Genomics 45 (2013), 47–57.
-
(2013)
Physiol. Genomics
, vol.45
, pp. 47-57
-
-
Luo, M.J.1
Thieringer, R.2
Springer, M.S.3
Wright, S.D.4
Hermanowski-Vosatka, A.5
Plump, A.6
Balkovec, J.M.7
Cheng, K.8
Ding, G.J.9
Kawka, D.W.10
Koo, G.C.11
Grand, C.B.12
Luo, Q.13
Maletic, M.M.14
Malkowitz, L.15
Shah, K.16
Singer, I.17
Waddell, S.T.18
Wu, K.K.19
Yuan, J.20
Zhu, J.21
Stepaniants, S.22
Yang, X.23
Lum, P.Y.24
Wang, I.M.25
more..
-
85
-
-
84875719517
-
11β-hydroxysteroid dehydrogenase type 1 deficiency in bone marrow-derived cells reduces atherosclerosis
-
Kipari, T., Hadoke, P.W., Iqbal, J., Man, T.Y., Miller, E., Coutinho, A.E., Zhang, Z., Sullivan, K.M., Mitic, T., Livingstone, D.E., Schrecker, C., Samuel, K., White, C.I., Bouhlel, M.A., Chinetti-Gbaguidi, G., Staels, B., Andrew, R., Walker, B.R., Savill, J.S., Chapman, K.E., Seckl, J.R., 11β-hydroxysteroid dehydrogenase type 1 deficiency in bone marrow-derived cells reduces atherosclerosis. FASEB J. 27 (2013), 1519–1531.
-
(2013)
FASEB J.
, vol.27
, pp. 1519-1531
-
-
Kipari, T.1
Hadoke, P.W.2
Iqbal, J.3
Man, T.Y.4
Miller, E.5
Coutinho, A.E.6
Zhang, Z.7
Sullivan, K.M.8
Mitic, T.9
Livingstone, D.E.10
Schrecker, C.11
Samuel, K.12
White, C.I.13
Bouhlel, M.A.14
Chinetti-Gbaguidi, G.15
Staels, B.16
Andrew, R.17
Walker, B.R.18
Savill, J.S.19
Chapman, K.E.20
Seckl, J.R.21
more..
-
86
-
-
84893213752
-
Carbonyl reduction pathways in drug metabolism
-
Malatkova, P., Wsol, V., Carbonyl reduction pathways in drug metabolism. Drug Metab. Rev. 46 (2014), 96–123.
-
(2014)
Drug Metab. Rev.
, vol.46
, pp. 96-123
-
-
Malatkova, P.1
Wsol, V.2
-
87
-
-
33847083503
-
Carbonyl reductases and pluripotent hydroxysteroid dehydrogenases of the short-chain dehydrogenase/reductase superfamily
-
Hoffmann, F., Maser, E., Carbonyl reductases and pluripotent hydroxysteroid dehydrogenases of the short-chain dehydrogenase/reductase superfamily. Drug Metab. Rev. 39 (2007), 87–144.
-
(2007)
Drug Metab. Rev.
, vol.39
, pp. 87-144
-
-
Hoffmann, F.1
Maser, E.2
-
88
-
-
84888584531
-
Biochemical properties of human dehydrogenase/reductase (SDR family) member 7
-
Stambergova, H., Skarydova, L., Dunford, J.E., Wsol, V., Biochemical properties of human dehydrogenase/reductase (SDR family) member 7. Chem. Biol. Interact. 207 (2014), 52–57.
-
(2014)
Chem. Biol. Interact.
, vol.207
, pp. 52-57
-
-
Stambergova, H.1
Skarydova, L.2
Dunford, J.E.3
Wsol, V.4
-
89
-
-
0024422513
-
Purification and properties of a metyrapone-reducing enzyme from mouse liver microsomes—this ketone is reduced by an aldehyde reductase
-
Maser, E., Netter, K.J., Purification and properties of a metyrapone-reducing enzyme from mouse liver microsomes—this ketone is reduced by an aldehyde reductase. Biochem. Pharmacol. 38 (1989), 3049–3054.
-
(1989)
Biochem. Pharmacol.
, vol.38
, pp. 3049-3054
-
-
Maser, E.1
Netter, K.J.2
-
90
-
-
0028175803
-
11β-Hydroxysteroid dehydrogenase mediates reductive metabolism of xenobiotic carbonyl compounds
-
Maser, E., Bannenberg, G., 11β-Hydroxysteroid dehydrogenase mediates reductive metabolism of xenobiotic carbonyl compounds. Biochem. Pharmacol. 47 (1994), 1805–1812.
-
(1994)
Biochem. Pharmacol.
, vol.47
, pp. 1805-1812
-
-
Maser, E.1
Bannenberg, G.2
-
91
-
-
0028872766
-
Cloning and primary structure of murine 11β-hydroxysteroid dehydrogenase/microsomal carbonyl reductase
-
Oppermann, U.C., Netter, K.J., Maser, E., Cloning and primary structure of murine 11β-hydroxysteroid dehydrogenase/microsomal carbonyl reductase. Eur. J. Biochem. 227 (1995), 202–208.
-
(1995)
Eur. J. Biochem.
, vol.227
, pp. 202-208
-
-
Oppermann, U.C.1
Netter, K.J.2
Maser, E.3
-
92
-
-
0035969827
-
Novel enzymological profiles of human 11β-hydroxysteroid dehydrogenase type 1
-
Hult, M., Nobel, C.S., Abrahmsen, L., Nicoll-Griffith, D.A., Jornvall, H., Oppermann, U.C., Novel enzymological profiles of human 11β-hydroxysteroid dehydrogenase type 1. Chem. Biol. Interact. 130–132 (2001), 805–814.
-
(2001)
Chem. Biol. Interact.
, vol.130-132
, pp. 805-814
-
-
Hult, M.1
Nobel, C.S.2
Abrahmsen, L.3
Nicoll-Griffith, D.A.4
Jornvall, H.5
Oppermann, U.C.6
-
93
-
-
0345073742
-
Stereochemical aspects of carbonyl reduction of the original anticancer drug oracin by mouse liver microsomes and purified 11β-hydroxysteroid dehydrogenase type 1
-
Wsol, V., Szotakova, B., Skalova, L., Maser, E., Stereochemical aspects of carbonyl reduction of the original anticancer drug oracin by mouse liver microsomes and purified 11β-hydroxysteroid dehydrogenase type 1. Chem. Biol. Interact. 143–144 (2003), 459–468.
-
(2003)
Chem. Biol. Interact.
, vol.143-144
, pp. 459-468
-
-
Wsol, V.1
Szotakova, B.2
Skalova, L.3
Maser, E.4
-
94
-
-
1642323738
-
The novel anticancer drug oracin: different stereospecificity and cooperativity for carbonyl reduction by purified human liver 11β-hydroxysteroid dehydrogenase type 1
-
Wsol, V., Szotakova, B., Skalova, L., Maser, E., The novel anticancer drug oracin: different stereospecificity and cooperativity for carbonyl reduction by purified human liver 11β-hydroxysteroid dehydrogenase type 1. Toxicology 197 (2004), 253–261.
-
(2004)
Toxicology
, vol.197
, pp. 253-261
-
-
Wsol, V.1
Szotakova, B.2
Skalova, L.3
Maser, E.4
-
95
-
-
0037325532
-
Purification characterization and NNK carbonyl reductase activities of 11β-hydroxysteroid dehydrogenase type 1 from human liver: enzyme cooperativity and significance in the detoxification of a tobacco-derived carcinogen
-
Maser, E., Friebertshauser, J., Volker, B., Purification characterization and NNK carbonyl reductase activities of 11β-hydroxysteroid dehydrogenase type 1 from human liver: enzyme cooperativity and significance in the detoxification of a tobacco-derived carcinogen. Chem. Biol. Interact. 143–144 (2003), 435–448.
-
(2003)
Chem. Biol. Interact.
, vol.143-144
, pp. 435-448
-
-
Maser, E.1
Friebertshauser, J.2
Volker, B.3
-
96
-
-
0033983383
-
Carbonyl reduction of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) by cytosolic enzymes in human liver and lung
-
Maser, E., Stinner, B., Atalla, A., Carbonyl reduction of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) by cytosolic enzymes in human liver and lung. Cancer Lett. 148 (2000), 135–144.
-
(2000)
Cancer Lett.
, vol.148
, pp. 135-144
-
-
Maser, E.1
Stinner, B.2
Atalla, A.3
-
97
-
-
55949087107
-
Mechanistic investigation of the noncytochrome P450-mediated metabolism of triadimefon to triadimenol in hepatic microsomes
-
Kenneke, J.F., Mazur, C.S., Ritger, S.E., Sack, T.J., Mechanistic investigation of the noncytochrome P450-mediated metabolism of triadimefon to triadimenol in hepatic microsomes. Chem. Res. Toxicol. 21 (2008), 1997–2004.
-
(2008)
Chem. Res. Toxicol.
, vol.21
, pp. 1997-2004
-
-
Kenneke, J.F.1
Mazur, C.S.2
Ritger, S.E.3
Sack, T.J.4
-
98
-
-
84875750549
-
Carbonyl reduction of triadimefon by human and rodent 11β-hydroxysteroid dehydrogenase 1
-
Meyer, A., Vuorinen, A., Zielinska, A.E., Da Cunha, T., Strajhar, P., Lavery, G.G., Schuster, D., Odermatt, A., Carbonyl reduction of triadimefon by human and rodent 11β-hydroxysteroid dehydrogenase 1. Biochem. Pharmacol. 85 (2013), 1370–1378.
-
(2013)
Biochem. Pharmacol.
, vol.85
, pp. 1370-1378
-
-
Meyer, A.1
Vuorinen, A.2
Zielinska, A.E.3
Da Cunha, T.4
Strajhar, P.5
Lavery, G.G.6
Schuster, D.7
Odermatt, A.8
-
99
-
-
84882764500
-
Formation of threohydrobupropion from bupropion is dependent on 11β-hydroxysteroid dehydrogenase 1
-
Meyer, A., Vuorinen, A., Zielinska, A.E., Strajhar, P., Lavery, G.G., Schuster, D., Odermatt, A., Formation of threohydrobupropion from bupropion is dependent on 11β-hydroxysteroid dehydrogenase 1. Drug Metab. Dispos. 41 (2013), 1641–1648.
-
(2013)
Drug Metab. Dispos.
, vol.41
, pp. 1641-1648
-
-
Meyer, A.1
Vuorinen, A.2
Zielinska, A.E.3
Strajhar, P.4
Lavery, G.G.5
Schuster, D.6
Odermatt, A.7
-
100
-
-
84900438381
-
Deeper insight into the reducing biotransformation of bupropion in the human liver
-
Skarydova, L., Tomanova, R., Havlikova, L., Stambergova, H., Solich, P., Wsol, V., Deeper insight into the reducing biotransformation of bupropion in the human liver. Drug Metab. Pharmacokinet. 29 (2014), 177–184.
-
(2014)
Drug Metab. Pharmacokinet.
, vol.29
, pp. 177-184
-
-
Skarydova, L.1
Tomanova, R.2
Havlikova, L.3
Stambergova, H.4
Solich, P.5
Wsol, V.6
-
101
-
-
84924105171
-
Emerging drugs of abuse: current perspectives on substituted cathinones
-
Paillet-Loilier, M., Cesbron, A., Le Boisselier, R., Bourgine, J., Debruyne, D., Emerging drugs of abuse: current perspectives on substituted cathinones. Subst. Abuse Rehabil. 5 (2014), 37–52.
-
(2014)
Subst. Abuse Rehabil.
, vol.5
, pp. 37-52
-
-
Paillet-Loilier, M.1
Cesbron, A.2
Le Boisselier, R.3
Bourgine, J.4
Debruyne, D.5
-
102
-
-
84929510029
-
Main metabolic pathways of TAK-802, a novel drug candidate for voiding dysfunction, in humans: the involvement of carbonyl reduction by 11β-hydroxysteroid dehydrogenase 1
-
Nishihara, M., Takahashi, J., Kondo, T., Mouri, K., Asahi, S., Main metabolic pathways of TAK-802, a novel drug candidate for voiding dysfunction, in humans: the involvement of carbonyl reduction by 11β-hydroxysteroid dehydrogenase 1. Drug Res. (Stuttg.), 2013.
-
(2013)
Drug Res. (Stuttg.)
-
-
Nishihara, M.1
Takahashi, J.2
Kondo, T.3
Mouri, K.4
Asahi, S.5
|