Carbonyl reduction of triadimefon by human and rodent 11β- hydroxysteroid dehydrogenase 1

Biochemical Pharmacology

Volumn 85, Issue 9, 2013, Pages 1370-1378

  Meyer, Arne ^a   Vuorinen, Anna ^b   Zielinska, Agnieszka E ^c   Da Cunha, Thierry ^a   Strajhar, Petra ^a   Lavery, Gareth G ^c   Schuster, Daniela ^b   Odermatt, Alex ^a  

^a UNIVERSITY OF BASEL   (Switzerland)

^b UNIVERSITY OF INNSBRUCK   (Austria)

^c UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

11 Hydroxysteroid dehydrogenase; Azole fungicide; Liver microsomes; Metabolism; Molecular docking; Triadimefon

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 1; CARBONYL DERIVATIVE; CORTISONE; GLUCOCORTICOID; ISOENZYME; OXIDOREDUCTASE INHIBITOR; RECOMBINANT ENZYME; TRIADIMEFON; TRIADIMENOL;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL LEVEL; CELL STRESS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME SUBSTRATE COMPLEX; HUMAN; HUMAN CELL; IC 50; LIVER MICROSOME; METABOLISM; MOLECULAR DOCKING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REDUCTION; SPECIES DIFFERENCE;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 2; ANIMALS; CORTISONE; FUNGICIDES, INDUSTRIAL; HEK293 CELLS; HUMANS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROSOMES, LIVER; MODELS, MOLECULAR; OXIDATION-REDUCTION; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; SPECIES SPECIFICITY; TRIAZINES; TRIAZOLES;

EID: 84875750549     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2013.02.014     Document Type: Article

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