11β-Hydroxyandrostenedione, the product of androstenedione metabolism in the adrenal, is metabolized in LNCaP cells by 5α-reductase yielding 11β-hydroxy-5α-androstanedione

Journal of Steroid Biochemistry and Molecular Biology

Volumn 138, Issue , 2013, Pages 132-142

  Swart, Amanda C ^a   Schloms, Lindie ^a   Storbeck, Karl Heinz ^a   Bloem, Liezl M ^a   Toit, Therina Du ^a   Quanson, Jonathan L ^a   Rainey, William E ^b   Swart, Pieter ^a  

^a STELLENBOSCH UNIVERSITY   (South Africa)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

17 HSD; 5 Dione; AKR1C3; Castration resistant prostate cancer; Dihydrotestosterone

Indexed keywords

11BETA HYDROXY 5ALPHA ANDROSTANEDIONE; 11BETA HYDROXYANDROSTENEDIONE; ALDOSTERONE SYNTHASE; ANDROSTANEDIONE; CORTICOSTERONE; CORTODOXONE; CYTOCHROME P450; CYTOCHROME P450 11BETA HYDROXYLASE; ETOMIDATE; FORSKOLIN; HYDROCORTISONE; STEROID 5ALPHA REDUCTASE; TESTOSTERONE; TRILOSTANE; UNCLASSIFIED DRUG;

ADRENAL GLAND; ANDROGEN SYNTHESIS; ARTICLE; CASTRATION RESISTANT PROSTATE CANCER; CELL STRAIN LNCAP; CONTROLLED STUDY; ENZYME ASSAY; HORMONE METABOLISM; LIMIT OF DETECTION; LIMIT OF QUANTITATION; PROSTATE CANCER; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

11Β-HYDROXY 5Α-ANDROSTANEDIONE; 11Β-HYDROXYANDROSTENEDIONE; 11Β-HYDROXYANDROSTERONE; 11Β-HYDROXYSTEROID DEHYDROGENASE; 11Β-HYDROXYTESTOSTERONE; 11ΒHSD; 11-KETOANDROSTENEDIONE; 11-KETOTESTOSTERONE; 11KA4; 11KT; 11OH-5Α-DIONE; 11OH-AST; 11OHA4; 11OHT; 17Β-HYDROXYSTEROID DEHYDROGENASE; 17ΒHSD; 17-HYDROXYPREGNENOLONE; 17-HYDROXYPROGESTERONE; 17OHPREG; 17OHPROG; 3Β-HYDROXYSTEROID DEHYDROGENASE; 3ΒHSD; 5Α-DIONE; A4; AKR1C3; ALDO; ALDOSTERONE; ALDOSTERONE SYNTHASE; ANDROSTENEDIONE; CASTRATION-RESISTANT PROSTATE CANCER; CORT; CORTICOSTERONE; CYP11B1; CYP11B2; CYP17A1; CYTOCHROME P450; DEHYDROEPIANDROSTENEDIONE; DEHYDROEPIANDROSTENEDIONE-SULFATE; DEOXYCORTICOSTERONE; DHEA; DHEA-S; DHT; DIHYDROTESTOSTERONE; DOC; H6PDH; HEXOSE 6-PHOSPHATE DEHYDROGENASE; P450; P450 11Β-HYDROXYLASE; P450 17-HYDROXYLASE; PREG; PREGNENOLONE; PROG; PROGESTERONE; SRD5A1; SRD5A2; STEROID 5Α-REDUCTASE TYPE 1; STEROID 5Α-REDUCTASE TYPE 2; SULFOTRANSFERASE; SULT2A1; T; TESTOSTERONE;

ADRENAL GLANDS; ANDROSTENEDIONE; ANIMALS; CELL LINE, TUMOR; CERCOPITHECUS AETHIOPS; CHOLESTENONE 5 ALPHA-REDUCTASE; COS CELLS; HUMANS; TANDEM MASS SPECTROMETRY;

EID: 84884563854     PISSN: 09600760     EISSN: 18791220     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2013.04.010     Document Type: Article

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