Metabolism of dexamethasone in the human kidney: Nicotinamide adenine dinucleotide-dependent 11β-reduction

Journal of Clinical Endocrinology and Metabolism

Volumn 82, Issue 5, 1997, Pages 1598-1602

  Diederich, Sven ^a   Hanke, Bert ^a   Oelkers, Wolfgang ^a   Bähr, Volker ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; DEXAMETHASONE; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; FEMALE; HUMAN; HUMAN TISSUE; KIDNEY METABOLISM; MALE; MICHAELIS CONSTANT; MOLECULAR CLONING; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL;

EID: 0031008086     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jcem.82.5.3936     Document Type: Article

References (25)

1. Edwards CR, Stewart PM, Burt D, et al. 1988 Localisation of 11 beta-hydroxysteroid dehydrogenase-tissue specific protector of the mineralocorticoid receptor. Lancet. 2:986-989.
2. Funder JW, Pearce PT, Smith R, Smith AI. 1988 Mineralocorticoid action: target tissue specificity is enzyme, not receptor, mediated. Science. 242:583-585.
3. Bush IE. 1962 Chemical and biological factors in the activity of adrenocortical steroids. Pharmacol Rev. 14:317-445.
4. Frey FJ, Escher G, Frey BM. 1994 Pharmacology of 11 beta-hydroxysteroid dehydrogenase. Steroids. 59:74-79.
5. Ballard PL, Carter JP, Graham BS, Baxter JD. 1975 A radioreceptor assay for evaluation of the plasma glucocorticoid activity of natural and synthetic steroids in man. J Clin Endocrinol Metab. 41:290-304.
6. Funder JW. 1989 How can aldosterone act as a mineralocorticoid? Endocr Res. 15:227-238.
7. Tannin GM, Agarwal AK, Monder C, New MI, White PC. 1991 The human gene for 11 beta-hydroxysteroid dehydrogenase. Structure, tissue distribution, and chromosomal localization. J Biol Chem. 266:16653-16658.
8. Albiston AL, Obeyesekere VR, Smith RE, Krozowski ZS. 1994 Cloning and tissue distribution of the human 11β-hydroxysteroid dehydrogenase type 2 enzyme. Mol Cell Endocrinol 105:R11-R17.
9. Seckl JR. 1993 11 beta-hydroxysteroid dehydrogenase isoforms and their implications for blood pressure regulation. Eur J Clin Invest. 23:589-601.
10. Stewart PM, Murry BA, Mason JI. 1994 Human kidney 11 beta-hydroxysteroid dehydrogenase is a high affinity nicotinamide adenine dinucleotide-dependent enzyme and differs from the cloned type I isoform. J Clin Endocrinol Metab. 79:480-484.
11. Arriza JL, Weinberger C, Cerelli G, et al. 1987 Cloning of human mineralocorticoid receptor complementary DNA: structural and functional kinship with the glucocorticoid receptor. Science. 237:268-275.
12. Bush IE, Hunter SA, Meigs RA. 1968 Metabolism of 11-oxygenated steroids. Metabolism in vitro by preparations of liver. Biochem J. 107:239-258.
13. Bush IE, Hunter SA, Meigs RA, Mahesh VB. 1964 Metabolism of 11-oxygenated steroids. III. Some 1-dehydro and 9 alpha-fluoro steroids. Biochem J. 93:236-255.
14. Oelkers W, Buchen S, Diederich S, Krain J, Muhme S, Schöneshöfer M. 1994 Impaired renal 11 beta-oxidation of 9 alpha-fluorocortisol: an explanation for its mineralocorticoid potency. J Clin Endocrinol Metab. 78:928-932.
15. Siebe H, Baude G, Lichtenstein I, et al. 1993 Metabolism of dexamethasone: sites and activity in mammalian tissues. Renal Physiol Biochem. 16:79-88.
16. Gaignage P, Lognay G, Marlier M, Severin M, Dreze P. 1989 Applications of chromatographic and spectometric techniques to the study of dexamethasone related compounds. Chromatographia. 28:623-630.
17. Diederich S, Quinkler M, Miller K, Heilmann P, Schöneshöfer M, Oelkers W. 1996 Human kidney 11beta-hydroxysteroid dehydrogenase: regulation by adrenocorticotropin? Eur J Endocrinol. 134:301-307.
18. Lakshmi V, Monder C. 1988 Purification and characterization of the corticosteroid 11 beta-dehydrogenase component of the rat liver 11 beta-hydroxysteroid dehydrogenase complex. Endocrinology. 123:2390-2398.
19. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. 1951 Protein Measurement with the Folin Phenol Reagent. J Biol Chem. 193:265-275.
20. Agarwal AK, Tusie Luna MT, Monder C, White PC. 1990 Expression of 11 beta-hydroxysteroid dehydrogenase using recombinant vaccinia virus. Mol Endocrinol. 4:1827-1832.
21. Atkins GL, Nimmo IA. 1974 A comparison of seven methods for fitting the Michaelis-Menten equation. Biochem J. 149:775-777.
22. Houston JB. 1994 Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance. Biochem Pharmacol. 47:1469-1479.
23. Whorwood CB, Mason JI, Ricketts ML, Howie AJ, Stewart PM. 1995 Detection of human 11b-hydroxysteroid dehydrogenase isoforms using reverse-transcriptase-polymerase chain reaction and localization of the type 2 isoform to renal collecting ducts. Mol Cell Endocrinol. 110:R7-R12.
24. Ferrari P, Smith RE, Funder JW, Krozowski ZS. 1996 Substrate and inhibitor specificity of the cloned human 11β-hydroxysteroid dehydrogenase type 2 isoform. Am J Physiol 270:E900-E904.
25. Brown RW, Chapman KE, Kotelvtsev Y, et al. 1996 Cloning and production of antisera to human placental 11β-hydroxysteroid dehydrogenase type 2. Biochem J. 313:1007-1017.