7α-hydroxytestosterone affects 11β-hydroxysteroid dehydrogenase 1 direction in rat leydig cells

Endocrinology

Volumn 151, Issue 2, 2010, Pages 748-754

  Hu, Guo Xin ^a,b   Lian, Qing Quan ^b   Chen, Bing Bing ^b   Prasad, Pramod V ^a   Kumar, Narender ^a   Zheng, Zhi Qiang ^b   Ge, Ren Shan ^a,b  

^a POPULATION COUNCIL   (United States)

^b WENZHOU MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 1; 7ALPHA HYDROXYTESTOSTERONE; CORTICOSTERONE; CYTOCHROME P450 2A1; MESSENGER RNA; TESTOSTERONE DERIVATIVE; UNCLASSIFIED DRUG; 4,17 BETA DIHYDROXY 4 ANDROSTENE 3 ONE; 4,17 BETA-DIHYDROXY-4-ANDROSTENE-3-ONE; CYP2A1 PROTEIN, RAT; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; STEROID MONOOXYGENASE; UNSPECIFIC MONOOXYGENASE;

ANIMAL CELL; ARTICLE; CELL MATURATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; LEYDIG CELL; MALE; MICROSOME; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; STEM CELL; TESTIS; ANIMAL; CELL SEPARATION; CYTOLOGY; DRUG EFFECT; ENZYMOLOGY; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; NEWBORN; PHYSIOLOGY; POLYMERASE CHAIN REACTION; REGENERATION;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; ANIMALS; ANIMALS, NEWBORN; ARYL HYDROCARBON HYDROXYLASES; CELL SEPARATION; HYDROXYTESTOSTERONES; LEYDIG CELLS; MALE; NADP; POLYMERASE CHAIN REACTION; RATS; REGENERATION; RNA, MESSENGER; STEROID HYDROXYLASES; TESTIS;

EID: 74949101637     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2009-0917     Document Type: Article

References (29)

1. Smals AG, Kloppenborg PW, Benraad TJ 1977 Plasma testosterone profiles in Cushing's syndrome. J Clin Endocrinol Metab 45:240-245
2. Monder C, Miroff Y, Marandici A, Hardy MP 1994 11β-Hydroxysteroid dehydrogenase alleviates glucocorticoid-mediated inhibition of steroidogenesis in rat Leydig cells. Endocrinology 134:1199-1204
3. Martin LJ, Tremblay JJ 2009 The nuclear receptors NUR77 and SF1 play additive roles with c-JUN through distinct elements on the mouse Star promoter. J Mol Endocrinol 42:119-129
4. Monder C 1993 The forms and functions of 11β-hydroxysteroid dehydrogenase. J Steroid Biochem Mol Biol 45:161-165
5. Agarwal AK, Mune T, Monder C, White PC 1994 NAD(+)-dependent isoform of 11β-hydroxysteroid dehydrogenase. Cloning and characterization of cDNA from sheep kidney. J Biol Chem 269: 25959-25962
6. Holmes MC, Kotelevtsev Y, Mullins JJ, Seckl JR 2001 Phenotypic analysis of mice bearing targeted deletions of 11β-hydroxysteroid dehydrogenases 1 and 2 genes. Mol Cell Endocrinol 171:15-20
7. Atanasov AG, Nashev LG, Schweizer RA, Frick C, Odermatt A 2004 Hexose-6-phosphate dehydrogenase determines the reaction direction of 11β-hydroxysteroid dehydrogenase type 1 as an oxoreductase. FEBS Lett 571:129-133
8. Banhegyi G, Csala M, Benedetti A 2009 Hexose-6-phosphate dehydrogenase: linking endocrinology and metabolism in the endoplasmic reticulum. J Mol Endocrinol 42:283-289
9. Ge RS, Dong Q, Niu EM, Sottas CM, Hardy DO, Catterall JF, Latif SA, Morris DJ, Hardy MP 2005 11β-Hydroxysteroid dehydrogenase 2 in rat Leydig cells: its role in blunting glucocorticoid action at physiological levels of substrate. Endocrinology 146:2657-2664
10. Seng JE, Leakey JE, Arlotto MP, Parkinson A, Gandy J 1991 Cellular localization of cytochrome P450IIA1 in testes of mature Sprague-Dawley rats. Biol Reprod 45:876-882
11. Eechaute W, Lacroix E, Leusen I 1974 The conversion of testosterone to 7α-hydroxy-testosterone by incubated rat testes. Steroids 24:753-764
12. Muller C, Pompon D, Urban P, Morfin R 2006 Inter-conversion of 7α- and 7β-hydroxy-dehydroepiandrosterone by the human 11β-hydroxysteroid dehydrogenase type 1. J Steroid Biochem Mol Biol 99:215-222
13. Teerds K, Rijntjes E 2007 Dynamics of Leydig cell regeneration after EDS. In: Payne AH, Hardy MP, eds. The Leydig cell in health and disease. Totowa, NJ: Humana Press; 91-116
14. Lakshmi V, Monder C 1985 Extraction of 11β-hydroxysteroid dehydrogenase from rat liver microsomes by detergents. J Steroid Biochem 22:331-340
15. Salva A, Klinefelter GR, Hardy MP 2001 Purification of rat Leydig cells: increased yields after unit-gravity sedimentation of collagenase- dispersed interstitial cells. J Androl 22:665-671
16. Shan LX, Hardy MP 1992 Developmental changes in levels of luteinizing hormone receptor and androgen receptor in rat Leydig cells. Endocrinology 131:1107-1114
17. Payne AH, Wong KL, Vega MM 1980 Differential effects of single and repeated administrations of gonadotropins on luteinizing hormone receptors and testosterone synthesis in two populations of Leydig cells. J Biol Chem 255:7118-7122
18. Ge RS, Gao HB, Nacharaju VL, Gunsalus GL, Hardy MP 1997 Identification of a kinetically distinct activity of 11β-hydroxysteroid dehydrogenase in rat Leydig cells. Endocrinology 138: 2435-2442
19. Hu GX, Zhou HY, Li XW, Chen BB, Xiao YC, Lian QQ, Liang G, Kim HH, Zheng ZQ, Hardy DO, Ge RS 2009 The (+)- and (-)-gossypols potently inhibit both 3β-hydroxysteroid dehydrogenase and 17β-hydroxysteroid dehydrogenase 3 in human and rat testes. J Steroid Biochem Mol Biol 115:14-19
20. Gibon Y, Larher F 1997 Cycling assay for nicotinamide adenine dinucleotides: NaCl precipitation and ethanol solubilization of the reduced tetrazolium. Anal Biochem 251:153-157
21. Phillips DM, Lakshmi V, Monder C 1989 Corticosteroid 11β-dehydrogenase in rat testis. Endocrinology 125:209-216
22. Hewitt KN, Walker EA, Stewart PM 2005 Minireview: hexose-6-phosphate dehydrogenase and redox control of 11β-hydroxysteroid dehydrogenase type 1 activity. Endocrinology 146: 2539-2543
23. Lavery GG, Walker EA, Turan N, Rogoff D, Ryder JW, Shelton JM, Richardson JA, Falciani F, White PC, Stewart PM, Parker KL, McMillan DR 2008 Deletion of hexose-6-phosphate dehydrogenase activates the unfolded protein response pathway and induces skeletal myopathy. J Biol Chem 283:8453-8461
24. Imaoka S, Hashizume T, Funae Y 2005 Localization of rat cytochrome P450 in various tissues and comparison of arachidonic acid metabolism by rat P450 with that by human P450 orthologs. Drug Metab Pharmacokinet 20:478-484
25. Sriraman V, Niu E, Matias JR, Donahoe PK, MacLaughlin DT, Hardy MP, Lee MM 2001 Mullerian inhibiting substance inhibits testosterone synthesis in adult rats. J Androl 22:750-758
26. Rosness PA, Sunde A, Eik-Nes KB 1977 Production and effects of 7α-hydroxytestosterone on testosterone and dihydrotestosterone metabolism in rat testis. Biochim Biophys Acta 488:55-68
27. Tannin GM, Agarwal AK, Monder C, New MI, White PC 1991 The human gene for 11β-hydroxysteroid dehydrogenase. Structure, tissue distribution, and chromosomal localization. J Biol Chem 266: 16653-16658
28. Hennebert O, Pernelle C, Ferroud C, Morfin R 2007 7α- and 7β-hydroxy-epiandrosterone as substrates and inhibitors for thehuman 11β-hydroxysteroid dehydrogenase type 1. J Steroid Biochem Mol Biol 105:159-165
29. Hennebert O, Chalbot S, Alran S, Morfin R 2007 Dehydroepiandrosterone 7α-hydroxylation in human tissues: possible interference with type 1 11β-hydroxysteroid dehydrogenase-mediated processes. J Steroid Biochem Mol Biol 104:326-333