11β-hydroxysteroid dehydrogenase types 1 and 2: An important pharmacokinetic determinant for the activity of synthetic mineralo- and glucocorticoids

Journal of Clinical Endocrinology and Metabolism

Volumn 87, Issue 12, 2002, Pages 5695-5701

  Diederich, Sven ^a   Eigendorff, Ekkehard ^a   Burkhardt, Patrick ^a   Quinkler, Marcus ^a   Bumke Vogt, Christiane ^a   Rochel, Marina ^a   Seidelmann, Dieter ^b   Esperling, Peter ^b   Oelkers, Wolfgang ^a   Bähr, Volker B ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b BAYER PHARMA AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; 11BETA HYDROXYSTEROID DEHYDROGENASE 1; 11BETA HYDROXYSTEROID DEHYDROGENASE 2; DEFLAZACORT; DEXAMETHASONE; FLUOCORTOLONE; GLUCOCORTICOID; HYDROCORTISONE; METHYLPREDNISOLONE; MINERALOCORTICOID; PREDNISOLONE; PREDNYLIDENE; STEROID; UNCLASSIFIED DRUG; HSD11B1 PROTEIN, HUMAN; HSD11B2 PROTEIN, HUMAN; HYDROXYSTEROID DEHYDROGENASE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVITY; EXPRESSION VECTOR; FLUORINATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; NONHUMAN; OXIDATION; PRIORITY JOURNAL; STEROID THERAPY; ANIMAL; CHO CELL; ENZYME SPECIFICITY; HAMSTER; KIDNEY CORTEX; LIVER MICROSOME; METABOLISM; MICROSOME; OXIDATION REDUCTION REACTION; SYNTHESIS;

ANIMALIA; CRICETINAE; CRICETULUS GRISEUS; VECTORS;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 2; ANIMALS; CHO CELLS; CRICETINAE; GLUCOCORTICOIDS; HUMANS; HYDROXYSTEROID DEHYDROGENASES; KIDNEY CORTEX; MICROSOMES; MICROSOMES, LIVER; MINERALOCORTICOIDS; OXIDATION-REDUCTION; SUBSTRATE SPECIFICITY; TRANSFECTION;

EID: 0036882139     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2002-020970     Document Type: Article

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