11β-Hydroxysteroid dehydrogenase type 1 contributes to the regulation of 7-oxysterol levels in the arterial wall through the inter-conversion of 7-ketocholesterol and 7β-hydroxycholesterol

Biochimie

Volumn 95, Issue 3, 2013, Pages 548-555

  Mitić, Tijana ^a,b   Andrew, Ruth ^a   Walker, Brian R ^a   Hadoke, Patrick W F ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b BRISTOL ROYAL INFIRMARY   (United Kingdom)

Author keywords

11 Hydroxysteroid dehydrogenase type 1; 7 Oxysterol; Aortic function; Glucocorticoid

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 1; 7 OXOCHOLESTEROL; 7 OXYSTEROL; 7BETA HYDROXYCHOLESTEROL; OXYSTEROL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERY WALL; ARTICLE; CARDIOVASCULAR FUNCTION; CONTROLLED STUDY; ENZYME ACTIVITY; IN VITRO STUDY; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; VASCULAR RING;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; ANIMALS; AORTA; GENE DELETION; HYDROXYCHOLESTEROLS; KETOCHOLESTEROLS; MALE; MICE;

MUS;

EID: 84874111592     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2012.08.007     Document Type: Article

References (48)

1. A.J. Brown, and W. Jessup Oxysterols: sources, cellular storage and metabolism, and new insights into their roles in cholesterol homeostasis Molecular Aspects of Medicine 30 2009 111 122
2. V. Deckert, L. Persegol, L. Viens, G. Lizard, A. Athias, C. Lallemant, P. Gambert, and L. Lagrost Inhibitors of arterial relaxation among components of human oxidized low-density lipoproteins: cholesterol derivatives oxidized in position 7 are potent inhibitors of endothelium-dependent relaxation Circulation 95 1997 723 731
3. V. Deckert, A. Brunet, F. Lantoine, G. Lizard, E.M.-v. Brussel, S. Monier, L. Lagrost, M. vid-Dufilho, P. Gambert, and M.A. Devynck Inhibition by cholesterol oxides of NO release from human vascular endothelial cells Arteriosclerosis, Thrombosis, and Vascular Biology 18 1998 1054 1060
4. G. Lizard, S. Gueldry, V. Deckert, P. Gambert, and L. Lagrost Evaluation of the cytotoxic effects of some oxysterols and of cholesterol on endothelial cell growth: methodological aspects Pathologie Biologie 45 1997 281 290
5. A. Vejux, E. Kahn, F. Menetrier, T. Montange, J. Lherminier, J.M. Riedinger, and G. Lizard Cytotoxic oxysterols induce caspase-independent myelin figure formation and caspase-dependent polar lipid accumulation Histochemistry and Cell Biology 127 2007 609 624
6. J.R. Seckl, and B.R. Walker Minireview: 11β-hydroxysteroid dehydrogenase type 1 - a tissue-specific amplifier of glucocorticoid action Endocrinology 142 2001 1371 1376
7. Y. Kotelevtsev, R.W. Brown, S. Fleming, C. Kenyon, C.R.W. Edwards, J.R. Seckl, and J.J. Mullins Hypertension in mice lacking 11β-hydroxysteroid dehydrogenase type 2 Journal of Clinical Investigation 103 1999 683 689
8. M. Wamil, R. Andrew, K.E. Chapman, J. Street, N.M. Morton, and J.R. Seckl 7-Oxysterols modulate glucocorticoid activity in adipocytes through competition for 11β-hydroxysteroid dehydrogenase type 1 Endocrinology 149 2008 5909 5918
9. M. Hult, B. Elleby, N. Shafqat, S. Svensson, A. Rane, H. Jîrnvall, L. Abrahmsen, and U. Oppermann Human and rodent type 1 11β-hydroxysteroid dehydrogenases are 7β-hydroxycholesterol dehydrogenases involved in oxysterol metabolism Cellular and Molecular Life Sciences 61 2004 992 999
10. R.A.S. Schweizer, Z. Marcel, Z. Balazs, D. Bernhard, and A. Odermatt Rapid hepatic metabolism of 7-ketocholesterol by 11β-hydroxysteroid dehydrogenase type 1: species-specific differences between the rat, human, and hamster enzyme Journal of Biological Chemistry 279 2004 18415 18424
11. B.R. Walker, J.L. Yau, L.P. Brett, J.R. Seckl, C. Monder, B.C. Williams, and C.R. Edwards 11β-Hydroxysteroid dehydrogenase in vascular smooth muscle and heart: implications for cardiovascular responses to glucocorticoids Endocrinology 129 1991 3305 3312
12. N.M. Morton, J.M. Paterson, H. Masuzaki, M.C. Holmes, B. Staels, C. Fievet, B.R. Walker, J.S. Flier, J.J. Mullins, and J.R. Seckl Novel adipose tissue-mediated resistance to diet-induced visceral obesity in 11β-hydroxysteroid dehydrogenase type 1-deficient mice Diabetes 53 2004 931 938
13. Z. Krozowski, and Z. Chai The role of 11β-hydroxysteroid dehydrogenases in the cardiovascular system Endocrine Journal 50 2003 485 489
14. C. Christy, P.W.F. Hadoke, J.M. Paterson, J.J. Mullins, J.R. Seckl, and B.R. Walker 11β-Hydroxysteroid dehydrogenase type 2 in mouse aorta: localization and influence on response to glucocorticoids Hypertension 42 2003 580 587
15. A.R. Dover, P.W.F. Hadoke, L.J. Macdonald, E. Miller, D.E. Newby, and B.R. Walker Intra-vascular glucocorticoid metabolism during inflammation and injury in mice Endocrinology 148 2006 166 172
16. Y. Kotelevtsev, M.C. Holmes, A. Burchell, P.M. Houston, D. Schmoll, P. Jamieson, R. Best, R. Brown, C.R. Edwards, J.R. Seckl, and J.J. Mullins 11β-Hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress Proceedings of the National Academy of Sciences 94 1997 14924 14929
17. G. Lizard, S. Monier, C. Cordelet, L. Gesquiere, V. Deckert, S. Gueldry, L. Lagrost, and P. Gambert Characterization and comparison of the mode of cell death, apoptosis versus necrosis, induced by 7β-hydroxycholesterol and 7-ketocholesterol in the cells of the vascular wall Arteriosclerosis, Thrombosis, and Vascular Biology 19 1999 1190 1200
18. C.I. Seye, M.W.M. Knaapen, D. Daret, C. Desgranges, A.G. Herman, M.M. Kockx, and H. Bult 7-Ketocholesterol induces reversible cytochrome c release in smooth muscle cells in absence of mitochondrial swelling Cardiovascular Research 64 2004 144 153
19. R. Hynynen, M. Suchanek, J. Spandl, N. Back, C. Thiele, and V.M. Olkkonen OSBP-related protein 2 (ORP2) is a sterol receptor on lipid droplets that regulates the metabolism of neutral lipids Journal of Lipid Research 50 2009 1305 1315
20. P.W.F. Hadoke, C. Christy, Y.V. Kotelevtsev, B.C. Williams, C.J. Kenyon, J.R. Seckl, J.J. Mullins, and B.R. Walker Endothelial cell dysfunction in mice after transgenic knockout of type 2, but not type 1, 11β-hydroxysteroid dehydrogenase Circulation 104 2001 2832 2837
21. K. Endo, T. Oyama, A. Saiki, N. Ban, M. Ohira, N. Koide, T. Murano, H. Watanabe, M. Nishii, M. Miura, K. Sekine, Y. Miyashita, and K. Shirai Determination of serum 7-ketocholesterol concentrations and their relationships with coronary multiple risks in diabetes mellitus Diabetes Research and Clinical Practice 80 2008 63 68
22. H.N. Hodis, S. Hashimoto, W.J. Mack, and A. Sevanian Probucol reduces oxysterol formation in hypertensive rabbits Hypertension 36 2000 436 441
23. W. Siems, S. Quast, D. Peter, W. Augustin, F. Carluccio, T. Grune, A. Sevanian, H. Hampl, and I. Wiswedel Oxysterols are increased in plasma of end-stage renal disease patients Kidney and Blood Pressure Research 28 2005 302 306
24. A.J. Brown, S. Leong, R.T. Dean, and W. Jessup 7-Hydroxycholesterol and its products in oxidized low density lipoprotein and human atherosclerotic plaque Journal of Lipid Research 38 1997 1730 1745
25. H.N. Hodis, D.W. Crawford, and A. Sevanian Cholesterol feeding increases plasma and aortic tissue cholesterol oxide levels in parallel: further evidence for the role of cholesterol oxidation in atherosclerosis Atherosclerosis 89 1991 117 126
26. N. Freeman, A. Rusinol, M. Linton, D. Hachey, S. Fazio, M. Sinensky, and D. Thewke Acyl-coenzyme A:cholesterol acyltransferase promotes oxidized LDL/oxysterol-induced apoptosis in macrophages Journal of Lipid Research 46 2005 1933 1943
27. G.R. Small, P.W.F. Hadoke, I. Sharif, A.R. Dover, D. Armour, C.J. Kenyon, G.A. Gray, and B.R. Walker Preventing local regeneration of glucocorticoids by 11β-hydroxysteroid dehydrogenase type 1 enhances angiogenesis Proceedings of the National Academy of Sciences 102 2005 12165 12170
28. R. Best, S.M. Nelson, and B.R. Walker Dexamethasone and 11-dehydrodexamethasone as tools to investigate the isozymes of 11β-hydroxysteroid dehydrogenase in vitro and in vivo Journal of Endocrinology 153 1997 41 48
29. S. Dzeletovic, A. Babiker, E. Lund, and U. Diczfalusy Time course of oxysterol formation during in vitro oxidation of low density lipoprotein Chemistry and Physics of Lipids 78 1995 119 128
30. S. Dzeletovic, O. Breuer, E. Lund, and U. Diczfalusy Determination of cholesterol oxidation products in human plasma by isotope dilution-mass spectrometry Analytical Biochemistry 225 1995 73 80
31. Z. Krozowski, S. Stuchberry, P.C. White, C. Monder, and J.W. Funder Characterisation of 11β-hydroxysteroid dehydrogenase gene expression: identification of multiple unique forms of messenger ribonucleic acid in the rat kidney Endocrinology 127 1990 3009 3013
32. V. Deckert, L. Duverneuil, S. Poupon, S. Monier, N. Le Guern, G. Lizard, D. Masson, and L. Lagrost The impairment of endothelium-dependent arterial relaxation by 7-ketocholesterol is associated with an early activation of protein kinase C British Journal of Pharmacology 137 2002 655 662
33. G. Lizard, M. Moisant, C. Cordelet, S. Monier, P. Gambert, and L. Lagrost Induction of similar features of apoptosis in human and bovine vascular endothelial cells treated by 7-ketocholesterol The Journal of Pathology 183 2006 330 338
34. V. Deckert Impairment of endothelium-dependent arterial relaxation by high-fat feeding in ApoE-deficient mice Circulation 100 1999 1230 1235
35. W. Martinet, D.M. Schrijvers, J.-P. Timmermans, and H. Bult Interactions between cell death induced by statins and 7-ketocholesterol in rabbit aorta smooth muscle cells British Journal of Pharmacology 154 2008 1236 1246
36. L. Kiss, M. Chen, D. Gero, K. Modis, Z. Lacza, and C. Szabo Effects of 7-ketocholesterol on the activity of endothelial poly(ADP-ribose) polymerase and on endothelium-dependent relaxant function International Journal of Molecular Medicine 18 2006 1113 1117
37. W. Jessup, P. Wilson, K. Gaus, and L. Kritharides Oxidized lipoproteins and macrophages Vascular Pharmacology 38 2002 239 248
38. A. Hermanowski-Vosatka, J.M. Balkovec, K. Cheng, H.Y. Chen, M. Hernandez, G.C. Koo, C.B. Le Grand, Z. Li, J.M. Metzger, S.S. Mundt, H. Noonan, C.N. Nunes, S.H. Olson, B. Pikounis, N. Ren, N. Robertson, J.M. Schaeffer, K. Shah, M.S. Springer, A.M. Strack, M. Strowski, K. Wu, T. Wu, J. Xiao, B.B. Zhang, S.D. Wright, and R. Thieringer 11β-HSD1 inhibition ameliorates metabolic syndrome and prevents progression of atherosclerosis in mice The Journal of Experimental Medicine 202 2005 517 527
39. H. Larsson, Y. Bottiger, L. Iuliano, and U. Diczfalusy In vivo interconversion of 7β-hydroxycholesterol and 7-ketocholesterol, potential surrogate markers for oxidative stress Free Radical Biology and Medicine 43 2007 695 701
40. W. Song, J. Chen, W.L. Dean, R.N. Redinger, and R.A. Prough Purification and characterization of hamster liver microsomal 7α-hydroxycholesterol dehydrogenase, similarity to type I 11β-hydroxysteroid dehydrogenase (11βHSD1) Journal of Biological Chemistry 273 1998 16223 16228
41. Y. Maeda, H. Nagatomo, F. Uchiyama, J. Nagatomo, M. Yamada, H. Shiotsuki, Y. Ohta, S. Sato, M.H. Kai, and K.H. Kondo A comparative study of the conversion of 7-hydroxycholesterol in rabbit, guinea pig, rat, hamster, and chicken Steroids 67 2002 703 708
42. C.D. DuSell, M. Umetani, P.W. Shaul, D.J. Mangelsdorf, and D.P. McDonnell 27-Hydroxycholesterol is an endogenous selective estrogen receptor modulator Molecular Endocrinology 22 2008 65 77
43. T. Mitić, S. Shave, S.P. Webster, I. McNae, D.F. Cobice, N. Semjonous, R.E. Dakin, K.E. Chapman, G.G. Lavery, P.W.F. Hadoke, B.R. Walker, R. Andrew, The role of 7-oxysterols to inhibit dehydrogenation of glucocorticoids by 11β-hydroxysteroid dehydrogenase type 1, submitted for publication.
44. M.E. Ullian Cardiovascular Research 41 1999 55 64
45. D.G. Johns, A.M. Dorrance, N.L. Tramontini, and R.C. Webb Glucocorticoids inhibit tetrahydrobiopterin-dependent endothelial function Experimental Biology and Medicine 226 2001 27 31
46. M. Noshiro, E. Usui, T. Kawamoto, H. Kubo, K. Fujimoto, M. Furukawa, S. Honma, M. Makishima, K.-i. Honma, and Y. Kato Multiple mechanisms regulate circadian expression of the gene for cholesterol 7α-hydroxylase (cyp7a), a key enzyme in hepatic bile acid biosynthesis Journal of Biological Rhythms 22 2007 299 311
47. D.F. Reilly, E.J. Westgate, and G.A. FitzGerald Peripheral circadian clocks in the vasculature Arteriosclerosis, Thrombosis, and Vascular Biology 27 2007 1694 1705
48. J. Rosenstock, S.E. Inzucchi, J. Seufert, P.R. Fleck, C.A. Wilson, and Q. Mekki Initial combination therapy with alogliptin and pioglitazone in drug-naïve patients with type 2 diabetes Diabetes Care 33 2010 2406 2408