-
2
-
-
84952637494
-
Critical review about mdm2 in cancer: Possible role in malignant mesothelioma and implications for treatment
-
Jan
-
Urso L, Calabrese F, Favaretto A, Conte P, Pasello G. Critical review about mdm2 in cancer: Possible role in malignant mesothelioma and implications for treatment. Crit Rev Oncol Hematol. 2016 Jan;97:220-30.
-
(2016)
Crit Rev Oncol Hematol
, vol.97
, pp. 220-230
-
-
Urso, L.1
Calabrese, F.2
Favaretto, A.3
Conte, P.4
Pasello, G.5
-
3
-
-
84951823898
-
Mdm2 and hif1alpha expression levels in different histologic subtypes of malignant pleural mesothelioma: Correlation with pathological and clinical data
-
Pasello G, Urso L, Mencoboni M, Grosso F, Ceresoli GL, Lunardi F, Vuljan SE, Bertorelle R, Sacchetto V, Ciminale V, Rea F, Favaretto A, Conte P, Calabrese F. Mdm2 and hif1alpha expression levels in different histologic subtypes of malignant pleural mesothelioma: Correlation with pathological and clinical data. Oncotarget. 2015;6:42053-42066.
-
(2015)
Oncotarget
, vol.6
, pp. 42053-42066
-
-
Pasello, G.1
Urso, L.2
Mencoboni, M.3
Grosso, F.4
Ceresoli, G.L.5
Lunardi, F.6
Vuljan, S.E.7
Bertorelle, R.8
Sacchetto, V.9
Ciminale, V.10
Rea, F.11
Favaretto, A.12
Conte, P.13
Calabrese, F.14
-
4
-
-
84897710994
-
The regulation of mdm2 oncogene and its impact on human cancers
-
Zhao Y, Yu H, Hu W. The regulation of mdm2 oncogene and its impact on human cancers. Acta Biochim Biophys Sin (Shanghai). 2014;46:180-189.
-
(2014)
Acta Biochim Biophys Sin (Shanghai)
, vol.46
, pp. 180-189
-
-
Zhao, Y.1
Yu, H.2
Hu, W.3
-
5
-
-
0034044571
-
Mdm2 oncogene as a novel target for human cancer therapy
-
Zhang, Wang H. Mdm2 oncogene as a novel target for human cancer therapy. Curr Pharm Des. 2000;6:393-416.
-
(2000)
Curr Pharm Des
, vol.6
, pp. 393-416
-
-
Zhang, W.H.1
-
6
-
-
79551474361
-
Mdm2 and mdmx in cancer and development
-
Marine JC. Mdm2 and mdmx in cancer and development. Curr Top Dev Biol. 2011;94:45-75.
-
(2011)
Curr Top Dev Biol
, vol.94
, pp. 45-75
-
-
Marine, J.C.1
-
7
-
-
84922391218
-
Mdm2 and mdmx involvement in human cancer
-
Berberich SJ. Mdm2 and mdmx involvement in human cancer. Subcell Biochem. 2014;85:263-280.
-
(2014)
Subcell Biochem
, vol.85
, pp. 263-280
-
-
Berberich, S.J.1
-
8
-
-
60749126297
-
The p53 mrna-mdm2 interaction
-
Naski N, Gajjar M, Bourougaa K, Malbert-Colas L, Fahraeus R, Candeias MM. The p53 mrna-mdm2 interaction. Cell Cycle. 2009;8:31-34.
-
(2009)
Cell Cycle
, vol.8
, pp. 31-34
-
-
Naski, N.1
Gajjar, M.2
Bourougaa, K.3
Malbert-Colas, L.4
Fahraeus, R.5
Candeias, M.M.6
-
9
-
-
84855982133
-
The p53 mrna-mdm2 interaction controls mdm2 nuclear trafficking and is required for p53 activation following DNA damage
-
Gajjar M, Candeias MM, Malbert-Colas L, Mazars A, Fujita J, Olivares-Illana V, Fahraeus R. The p53 mrna-mdm2 interaction controls mdm2 nuclear trafficking and is required for p53 activation following DNA damage. Cancer Cell. 2012;21:25-35.
-
(2012)
Cancer Cell
, vol.21
, pp. 25-35
-
-
Gajjar, M.1
Candeias, M.M.2
Malbert-Colas, L.3
Mazars, A.4
Fujita, J.5
Olivares-Illana, V.6
Fahraeus, R.7
-
10
-
-
84899867316
-
Hdmx folds the nascent p53 mrna following activation by the atm kinase
-
Malbert-Colas L, Ponnuswamy A, Olivares-Illana V, Tournillon AS, Naski N, Fahraeus R. Hdmx folds the nascent p53 mrna following activation by the atm kinase. Mol Cell. 2014;54:500-511.
-
(2014)
Mol Cell
, vol.54
, pp. 500-511
-
-
Malbert-Colas, L.1
Ponnuswamy, A.2
Olivares-Illana, V.3
Tournillon, A.S.4
Naski, N.5
Fahraeus, R.6
-
11
-
-
51049124035
-
P53 mrna controls p53 activity by managing mdm2 functions
-
Candeias MM, Malbert-Colas L, Powell DJ, Daskalogianni C, Maslon MM, Naski N, Bourougaa K, Calvo F, Fahraeus R. P53 mrna controls p53 activity by managing mdm2 functions. Nat Cell Biol. 2008;10:1098-1105.
-
(2008)
Nat Cell Biol
, vol.10
, pp. 1098-1105
-
-
Candeias, M.M.1
Malbert-Colas, L.2
Powell, D.J.3
Daskalogianni, C.4
Maslon, M.M.5
Naski, N.6
Bourougaa, K.7
Calvo, F.8
Fahraeus, R.9
-
12
-
-
0029033861
-
The retinoblastoma protein and cell cycle control
-
Weinberg RA. The retinoblastoma protein and cell cycle control. Cell. 1995;81:323-330.
-
(1995)
Cell
, vol.81
, pp. 323-330
-
-
Weinberg, R.A.1
-
13
-
-
0035962637
-
The rb/chromatin connection and epigenetic control: Opinion
-
Ferreira R, Naguibneva I, Pritchard LL, Ait-Si-Ali S, Harel-Bellan A. The rb/chromatin connection and epigenetic control: Opinion. Oncogene. 2001;20:3128-3133.
-
(2001)
Oncogene
, vol.20
, pp. 3128-3133
-
-
Ferreira, R.1
Naguibneva, I.2
Pritchard, L.L.3
Ait-Si-Ali, S.4
Harel-Bellan, A.5
-
14
-
-
84877246101
-
The retinoblastoma protein induces apoptosis directly at the mitochondria
-
Hilgendorf KI, Leshchiner ES, Nedelcu S, Maynard MA, Calo E, Ianari A, Walensky LD, Lees JA. The retinoblastoma protein induces apoptosis directly at the mitochondria. Genes Dev. 2013;27:1003-1015.
-
(2013)
Genes Dev
, vol.27
, pp. 1003-1015
-
-
Hilgendorf, K.I.1
Leshchiner, E.S.2
Nedelcu, S.3
Maynard, M.A.4
Calo, E.5
Ianari, A.6
Walensky, L.D.7
Lees, J.A.8
-
15
-
-
84922479831
-
Rb1 gene in merkel cell carcinoma: Hypermethylation in all tumors and concurrent heterozygous deletions in the polyomavirus-negative subgroup
-
Sahi H, Savola S, Sihto H, Koljonen V, Bohling T, Knuutila S. Rb1 gene in merkel cell carcinoma: Hypermethylation in all tumors and concurrent heterozygous deletions in the polyomavirus-negative subgroup. APMIS. 2014;122:1157-1166.
-
(2014)
APMIS
, vol.122
, pp. 1157-1166
-
-
Sahi, H.1
Savola, S.2
Sihto, H.3
Koljonen, V.4
Bohling, T.5
Knuutila, S.6
-
16
-
-
0030848575
-
Hypermethylation in the retinoblastoma gene is associated with unilateral, sporadic retinoblastoma
-
Ohtani-Fujita N, Dryja TP, Rapaport JM, Fujita T, Matsumura S, Ozasa K, Watanabe Y, Hayashi K, Maeda K, Kinoshita S, Matsumura T, Ohnishi Y, Hotta Y, et al. Hypermethylation in the retinoblastoma gene is associated with unilateral, sporadic retinoblastoma. Cancer Genet Cytogenet. 1997;98:43-49.
-
(1997)
Cancer Genet Cytogenet
, vol.98
, pp. 43-49
-
-
Ohtani-Fujita, N.1
Dryja, T.P.2
Rapaport, J.M.3
Fujita, T.4
Matsumura, S.5
Ozasa, K.6
Watanabe, Y.7
Hayashi, K.8
Maeda, K.9
Kinoshita, S.10
Matsumura, T.11
Ohnishi, Y.12
Hotta, Y.13
-
17
-
-
70349437076
-
P53 and e2f: Partners in life and death
-
Polager S, Ginsberg D. P53 and e2f: Partners in life and death. Nat Rev Cancer. 2009;9:738-748.
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 738-748
-
-
Polager, S.1
Ginsberg, D.2
-
18
-
-
84871513029
-
Deciphering the retinoblastoma protein phosphorylation code
-
Rubin SM. Deciphering the retinoblastoma protein phosphorylation code. Trends Biochem Sci. 2013;38:12-19.
-
(2013)
Trends Biochem Sci
, vol.38
, pp. 12-19
-
-
Rubin, S.M.1
-
19
-
-
84941266305
-
Regulation of the retinoblastoma-e2f pathway by the ubiquitin-proteasome system
-
Sengupta S, Henry RW. Regulation of the retinoblastoma-e2f pathway by the ubiquitin-proteasome system. Biochim Biophys Acta. 2015;1849:1289-1297.
-
(2015)
Biochim Biophys Acta
, vol.1849
, pp. 1289-1297
-
-
Sengupta, S.1
Henry, R.W.2
-
20
-
-
84947736207
-
A novel retinoblastoma protein (Rb) e3 ubiquitin ligase (nrbe3) promotes rb degradation and is transcriptionally regulated by e2f1 transcription factor
-
Wang Y, Zheng Z, Zhang J, Wang Y, Kong R, Liu J, Zhang Y, Deng H, Du X, Ke Y. A novel retinoblastoma protein (rb) e3 ubiquitin ligase (nrbe3) promotes rb degradation and is transcriptionally regulated by e2f1 transcription factor. J Biol Chem. 2015;290:28200-28213.
-
(2015)
J Biol Chem
, vol.290
, pp. 28200-28213
-
-
Wang, Y.1
Zheng, Z.2
Zhang, J.3
Wang, Y.4
Kong, R.5
Liu, J.6
Zhang, Y.7
Deng, H.8
Du, X.9
Ke, Y.10
-
21
-
-
33644770294
-
Targeting retinoblastoma protein for degradation by proteasomes
-
Ying H, Xiao ZX. Targeting retinoblastoma protein for degradation by proteasomes. Cell Cycle. 2006;5:506-508.
-
(2006)
Cell Cycle
, vol.5
, pp. 506-508
-
-
Ying, H.1
Xiao, Z.X.2
-
22
-
-
29444438631
-
Epstein-barr virus latent antigen 3c can mediate the degradation of the retinoblastoma protein through an scf cellular ubiquitin ligase
-
Knight JS, Sharma N, Robertson ES. Epstein-barr virus latent antigen 3c can mediate the degradation of the retinoblastoma protein through an scf cellular ubiquitin ligase. Proc Natl Acad Sci U S A. 2005;102:18562-18566.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 18562-18566
-
-
Knight, J.S.1
Sharma, N.2
Robertson, E.S.3
-
23
-
-
34848876774
-
Human papillomavirus type 16 e7 oncoprotein associates with the cullin 2 ubiquitin ligase complex, which contributes to degradation of the retinoblastoma tumor suppressor
-
Huh K, Zhou X, Hayakawa H, Cho JY, Libermann TA, Jin J, Harper JW, Munger K. Human papillomavirus type 16 e7 oncoprotein associates with the cullin 2 ubiquitin ligase complex, which contributes to degradation of the retinoblastoma tumor suppressor. J Virol. 2007;81:9737-9747.
-
(2007)
J Virol
, vol.81
, pp. 9737-9747
-
-
Huh, K.1
Zhou, X.2
Hayakawa, H.3
Cho, J.Y.4
Libermann, T.A.5
Jin, J.6
Harper, J.W.7
Munger, K.8
-
24
-
-
33745949757
-
Dual-site regulation of mdm2 e3-ubiquitin ligase activity
-
Wallace M, Worrall E, Pettersson S, Hupp TR, Ball KL. Dual-site regulation of mdm2 e3-ubiquitin ligase activity. Mol Cell. 2006;23:251-263.
-
(2006)
Mol Cell
, vol.23
, pp. 251-263
-
-
Wallace, M.1
Worrall, E.2
Pettersson, S.3
Hupp, T.R.4
Ball, K.L.5
-
25
-
-
0027964904
-
Immunochemical analysis of the interaction of p53 with mdm2;--fine mapping of the mdm2 binding site on p53 using synthetic peptides
-
Picksley SM, Vojtesek B, Sparks A, Lane DP. Immunochemical analysis of the interaction of p53 with mdm2;--fine mapping of the mdm2 binding site on p53 using synthetic peptides. Oncogene. 1994;9:2523-2529.
-
(1994)
Oncogene
, vol.9
, pp. 2523-2529
-
-
Picksley, S.M.1
Vojtesek, B.2
Sparks, A.3
Lane, D.P.4
-
26
-
-
31944433282
-
The central region of hdm2 provides a second binding site for p53
-
Yu GW, Rudiger S, Veprintsev D, Freund S, Fernandez-Fernandez MR, Fersht AR. The central region of hdm2 provides a second binding site for p53. Proc Natl Acad Sci U S A. 2006;103:1227-1232.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 1227-1232
-
-
Yu, G.W.1
Rudiger, S.2
Veprintsev, D.3
Freund, S.4
Fernandez-Fernandez, M.R.5
Fersht, A.R.6
-
27
-
-
0034624678
-
Activity of mdm2, a ubiquitin ligase, toward p53 or itself is dependent on the ring finger domain of the ligase
-
Honda R, Yasuda H. Activity of mdm2, a ubiquitin ligase, toward p53 or itself is dependent on the ring finger domain of the ligase. Oncogene. 2000;19:1473-1476.
-
(2000)
Oncogene
, vol.19
, pp. 1473-1476
-
-
Honda, R.1
Yasuda, H.2
-
28
-
-
0031583962
-
Oncoprotein mdm2 is a ubiquitin ligase e3 for tumor suppressor p53
-
Honda R, Tanaka H, Yasuda H. Oncoprotein mdm2 is a ubiquitin ligase e3 for tumor suppressor p53. FEBS Lett. 1997;420:25-27.
-
(1997)
FEBS Lett
, vol.420
, pp. 25-27
-
-
Honda, R.1
Tanaka, H.2
Yasuda, H.3
-
29
-
-
0029028354
-
Interaction between the retinoblastoma protein and the oncoprotein mdm2
-
Xiao ZX, Chen J, Levine AJ, Modjtahedi N, Xing J, Sellers WR, Livingston DM. Interaction between the retinoblastoma protein and the oncoprotein mdm2. Nature. 1995;375:694-698.
-
(1995)
Nature
, vol.375
, pp. 694-698
-
-
Xiao, Z.X.1
Chen, J.2
Levine, A.J.3
Modjtahedi, N.4
Xing, J.5
Sellers, W.R.6
Livingston, D.M.7
-
30
-
-
11144241617
-
The central acidic domain of mdm2 is critical in inhibition of retinoblastoma-mediated suppression of e2f and cell growth
-
Sdek P, Ying H, Zheng H, Margulis A, Tang X, Tian K, Xiao ZX. The central acidic domain of mdm2 is critical in inhibition of retinoblastoma-mediated suppression of e2f and cell growth. J Biol Chem. 2004;279:53317-53322.
-
(2004)
J Biol Chem
, vol.279
, pp. 53317-53322
-
-
Sdek, P.1
Ying, H.2
Zheng, H.3
Margulis, A.4
Tang, X.5
Tian, K.6
Xiao, Z.X.7
-
31
-
-
0037115601
-
Structural basis for the recognition of the e2f transactivation domain by the retinoblastoma tumor suppressor
-
Lee C, Chang JH, Lee HS, Cho Y. Structural basis for the recognition of the e2f transactivation domain by the retinoblastoma tumor suppressor. Genes Dev. 2002;16:3199-3212.
-
(2002)
Genes Dev
, vol.16
, pp. 3199-3212
-
-
Lee, C.1
Chang, J.H.2
Lee, H.S.3
Cho, Y.4
-
32
-
-
19944431662
-
Enhanced mdm2 activity inhibits prb function via ubiquitin-dependent degradation
-
Uchida C, Miwa S, Kitagawa K, Hattori T, Isobe T, Otani S, Oda T, Sugimura H, Kamijo T, Ookawa K, Yasuda H, Kitagawa M. Enhanced mdm2 activity inhibits prb function via ubiquitin-dependent degradation. EMBO J. 2005;24:160-169.
-
(2005)
EMBO J
, vol.24
, pp. 160-169
-
-
Uchida, C.1
Miwa, S.2
Kitagawa, K.3
Hattori, T.4
Isobe, T.5
Otani, S.6
Oda, T.7
Sugimura, H.8
Kamijo, T.9
Ookawa, K.10
Yasuda, H.11
Kitagawa, M.12
-
33
-
-
0032549711
-
Arf promotes mdm2 degradation and stabilizes p53: Arf-ink4a locus deletion impairs both the rb and p53 tumor suppression pathways
-
Zhang Y, Xiong Y, Yarbrough WG. Arf promotes mdm2 degradation and stabilizes p53: Arf-ink4a locus deletion impairs both the rb and p53 tumor suppression pathways. Cell. 1998;92:725-734.
-
(1998)
Cell
, vol.92
, pp. 725-734
-
-
Zhang, Y.1
Xiong, Y.2
Yarbrough, W.G.3
-
34
-
-
0032169516
-
The alternative product from the human cdkn2a locus, p14(Arf), participates in a regulatory feedback loop with p53 and mdm2
-
Stott FJ, Bates S, James MC, McConnell BB, Starborg M, Brookes S, Palmero I, Ryan K, Hara E, Vousden KH, Peters G. The alternative product from the human cdkn2a locus, p14(arf), participates in a regulatory feedback loop with p53 and mdm2. EMBO J. 1998;17:5001-5014.
-
(1998)
EMBO J
, vol.17
, pp. 5001-5014
-
-
Stott, F.J.1
Bates, S.2
James, M.C.3
McConnell, B.B.4
Starborg, M.5
Brookes, S.6
Palmero, I.7
Ryan, K.8
Hara, E.9
Vousden, K.H.10
Peters, G.11
-
35
-
-
28444437051
-
Mdm2 promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma protein
-
Sdek P, Ying H, Chang DL, Qiu W, Zheng H, Touitou R, Allday MJ, Xiao ZX. Mdm2 promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma protein. Mol Cell. 2005;20:699-708.
-
(2005)
Mol Cell
, vol.20
, pp. 699-708
-
-
Sdek, P.1
Ying, H.2
Chang, D.L.3
Qiu, W.4
Zheng, H.5
Touitou, R.6
Allday, M.J.7
Xiao, Z.X.8
-
36
-
-
34547174700
-
Apc/c(Cdc20) controls the ubiquitin-mediated degradation of p21 in prometaphase
-
Amador V, Ge S, Santamaria PG, Guardavaccaro D, Pagano M. Apc/c(cdc20) controls the ubiquitin-mediated degradation of p21 in prometaphase. Mol Cell. 2007;27:462-473.
-
(2007)
Mol Cell
, vol.27
, pp. 462-473
-
-
Amador, V.1
Ge, S.2
Santamaria, P.G.3
Guardavaccaro, D.4
Pagano, M.5
-
37
-
-
0038152755
-
Role of the scfskp2 ubiquitin ligase in the degradation of p21cip1 in s phase
-
Bornstein G, Bloom J, Sitry-Shevah D, Nakayama K, Pagano M, Hershko A. Role of the scfskp2 ubiquitin ligase in the degradation of p21cip1 in s phase. J Biol Chem. 2003;278:25752-25757.
-
(2003)
J Biol Chem
, vol.278
, pp. 25752-25757
-
-
Bornstein, G.1
Bloom, J.2
Sitry-Shevah, D.3
Nakayama, K.4
Pagano, M.5
Hershko, A.6
-
38
-
-
0346243936
-
Mdm2 promotes p21waf1/cip1 proteasomal turnover independently of ubiquitylation
-
Jin Y, Lee H, Zeng SX, Dai MS, Lu H. Mdm2 promotes p21waf1/cip1 proteasomal turnover independently of ubiquitylation. EMBO J. 2003;22:6365-6377.
-
(2003)
EMBO J
, vol.22
, pp. 6365-6377
-
-
Jin, Y.1
Lee, H.2
Zeng, S.X.3
Dai, M.S.4
Lu, H.5
-
39
-
-
51949112601
-
The crl4cdt2 ubiquitin ligase targets the degradation of p21cip1 to control replication licensing
-
Kim Y, Starostina NG, Kipreos ET. The crl4cdt2 ubiquitin ligase targets the degradation of p21cip1 to control replication licensing. Genes Dev. 2008;22:2507-2519.
-
(2008)
Genes Dev
, vol.22
, pp. 2507-2519
-
-
Kim, Y.1
Starostina, N.G.2
Kipreos, E.T.3
-
40
-
-
77449127476
-
Ubiquitin-independent p53 proteasomal degradation
-
Tsvetkov P, Reuven N, Shaul Y. Ubiquitin-independent p53 proteasomal degradation. Cell Death Differ. 2010;17:103-108.
-
(2010)
Cell Death Differ
, vol.17
, pp. 103-108
-
-
Tsvetkov, P.1
Reuven, N.2
Shaul, Y.3
-
41
-
-
84907185306
-
Chao CC. Mechanisms of p53 degradation
-
Chao CC. Mechanisms of p53 degradation. Clin Chim Acta. 2015;438:139-147.
-
(2015)
Clin Chim Acta
, vol.438
, pp. 139-147
-
-
-
42
-
-
0033082231
-
Rb regulates the stability and the apoptotic function of p53 via mdm2
-
Hsieh JK, Chan FS, O’Connor DJ, Mittnacht S, Zhong S, Lu X. Rb regulates the stability and the apoptotic function of p53 via mdm2. Mol Cell. 1999;3:181-193.
-
(1999)
Mol Cell
, vol.3
, pp. 181-193
-
-
Hsieh, J.K.1
Chan, F.S.2
O’Connor, D.J.3
Mittnacht, S.4
Zhong, S.5
Lu, X.6
-
43
-
-
79551622682
-
P38 phosphorylates rb on ser567 by a novel, cell cycle-independent mechanism that triggers rb-hdm2 interaction and apoptosis
-
Delston RB, Matatall KA, Sun Y, Onken MD, Harbour JW. P38 phosphorylates rb on ser567 by a novel, cell cycle-independent mechanism that triggers rb-hdm2 interaction and apoptosis. Oncogene. 2011;30:588-599.
-
(2011)
Oncogene
, vol.30
, pp. 588-599
-
-
Delston, R.B.1
Matatall, K.A.2
Sun, Y.3
Onken, M.D.4
Harbour, J.W.5
-
44
-
-
34247269029
-
Tao kinases mediate activation of p38 in response to DNA damage
-
Raman M, Earnest S, Zhang K, Zhao Y, Cobb MH. Tao kinases mediate activation of p38 in response to DNA damage. EMBO J. 2007;26:2005-2014.
-
(2007)
EMBO J
, vol.26
, pp. 2005-2014
-
-
Raman, M.1
Earnest, S.2
Zhang, K.3
Zhao, Y.4
Cobb, M.H.5
-
45
-
-
0033552627
-
Mdm2: A bridge over the two tumour suppressors, p53 and rb
-
Yap DB, Hsieh JK, Chan FS, Lu X. Mdm2: A bridge over the two tumour suppressors, p53 and rb. Oncogene. 1999;18:7681-7689.
-
(1999)
Oncogene
, vol.18
, pp. 7681-7689
-
-
Yap, D.B.1
Hsieh, J.K.2
Chan, F.S.3
Lu, X.4
-
46
-
-
0035203715
-
Mdmx stabilizes p53 and mdm2 via two distinct mechanisms
-
Stad R, Little NA, Xirodimas DP, Frenk R, van der Eb AJ, Lane DP, Saville MK, Jochemsen AG. Mdmx stabilizes p53 and mdm2 via two distinct mechanisms. EMBO Rep. 2001;2:1029-1034.
-
(2001)
EMBO Rep
, vol.2
, pp. 1029-1034
-
-
Stad, R.1
Little, N.A.2
Xirodimas, D.P.3
Frenk, R.4
van der Eb, A.J.5
Lane, D.P.6
Saville, M.K.7
Jochemsen, A.G.8
-
47
-
-
10144259344
-
Mdmx: A novel p53-binding protein with some functional properties of mdm2
-
Shvarts A, Steegenga WT, Riteco N, van Laar T, Dekker P, Bazuine M, van Ham RC, van der Houven van Oordt W, Hateboer G, van der Eb AJ, Jochemsen AG. Mdmx: A novel p53-binding protein with some functional properties of mdm2. EMBO J. 1996;15:5349-5357.
-
(1996)
EMBO J
, vol.15
, pp. 5349-5357
-
-
Shvarts, A.1
Steegenga, W.T.2
Riteco, N.3
van Laar, T.4
Dekker, P.5
Bazuine, M.6
van Ham, R.C.7
van der Houven van Oordt, W.8
Hateboer, G.9
van der Eb, A.J.10
Jochemsen, A.G.11
-
48
-
-
0033621415
-
Stabilization of the mdm2 oncoprotein by interaction with the structurally related mdmx protein
-
Sharp DA, Kratowicz SA, Sank MJ, George DL. Stabilization of the mdm2 oncoprotein by interaction with the structurally related mdmx protein. J Biol Chem. 1999;274:38189-38196.
-
(1999)
J Biol Chem
, vol.274
, pp. 38189-38196
-
-
Sharp, D.A.1
Kratowicz, S.A.2
Sank, M.J.3
George, D.L.4
-
49
-
-
0037205454
-
Mutual dependence of mdm2 and mdmx in their functional inactivation of p53
-
Gu J, Kawai H, Nie L, Kitao H, Wiederschain D, Jochemsen AG, Parant J, Lozano G, Yuan ZM. Mutual dependence of mdm2 and mdmx in their functional inactivation of p53. J Biol Chem. 2002;277:19251-19254.
-
(2002)
J Biol Chem
, vol.277
, pp. 19251-19254
-
-
Gu, J.1
Kawai, H.2
Nie, L.3
Kitao, H.4
Wiederschain, D.5
Jochemsen, A.G.6
Parant, J.7
Lozano, G.8
Yuan, Z.M.9
-
50
-
-
79959881127
-
Mdmx protein is essential for mdm2 protein-mediated p53 polyubiquitination
-
Wang X, Wang J, Jiang X. Mdmx protein is essential for mdm2 protein-mediated p53 polyubiquitination. J Biol Chem. 2011;286:23725-23734.
-
(2011)
J Biol Chem
, vol.286
, pp. 23725-23734
-
-
Wang, X.1
Wang, J.2
Jiang, X.3
-
51
-
-
42149105590
-
Structure of the mdm2/mdmx ring domain heterodimer reveals dimerization is required for their ubiquitylation in trans
-
Linke K, Mace PD, Smith CA, Vaux DL, Silke J, Day CL. Structure of the mdm2/mdmx ring domain heterodimer reveals dimerization is required for their ubiquitylation in trans. Cell Death Differ. 2008;15:841-848.
-
(2008)
Cell Death Differ
, vol.15
, pp. 841-848
-
-
Linke, K.1
Mace, P.D.2
Smith, C.A.3
Vaux, D.L.4
Silke, J.5
Day, C.L.6
-
52
-
-
0033051322
-
Mdm2 interacts with mdmx through their ring finger domains
-
Tanimura S, Ohtsuka S, Mitsui K, Shirouzu K, Yoshimura A, Ohtsubo M. Mdm2 interacts with mdmx through their ring finger domains. FEBS Lett. 1999;447:5-9.
-
(1999)
FEBS Lett
, vol.447
, pp. 5-9
-
-
Tanimura, S.1
Ohtsuka, S.2
Mitsui, K.3
Shirouzu, K.4
Yoshimura, A.5
Ohtsubo, M.6
-
53
-
-
84982853982
-
De la Mora-de la Mora I, Oria-Hernandez J, Millot G, Fahraeus R, Reyes-Vivas H, Sampedro JG, Olivares-Illana V. Allosteric interactions by p53 mrna governs hdm2 e3 ubiquitin ligase specificity under different conditions
-
Medina-Medina I, Garcia-Beltran P, de la Mora-de la Mora I, Oria-Hernandez J, Millot G, Fahraeus R, Reyes-Vivas H, Sampedro JG, Olivares-Illana V. Allosteric interactions by p53 mrna governs hdm2 e3 ubiquitin ligase specificity under different conditions. Mol Cell Biol. 2016
-
(2016)
Mol Cell Biol
-
-
Medina-Medina, I.1
Garcia-Beltran, P.2
-
54
-
-
33644917708
-
Effects of mdmx on mdm2-mediated downregulation of prb
-
Uchida C, Miwa S, Isobe T, Kitagawa K, Hattori T, Oda T, Yasuda H, Kitagawa M. Effects of mdmx on mdm2-mediated downregulation of prb. FEBS Lett. 2006;580:1753-1758.
-
(2006)
FEBS Lett
, vol.580
, pp. 1753-1758
-
-
Uchida, C.1
Miwa, S.2
Isobe, T.3
Kitagawa, K.4
Hattori, T.5
Oda, T.6
Yasuda, H.7
Kitagawa, M.8
-
55
-
-
84946499653
-
Mdmx exerts its oncogenic activity via suppression of retinoblastoma protein
-
Zhang H, Hu L, Qiu W, Deng T, Zhang Y, Bergholz J, Xiao ZX. Mdmx exerts its oncogenic activity via suppression of retinoblastoma protein. Oncogene. 2015;34:5560-5569.
-
(2015)
Oncogene
, vol.34
, pp. 5560-5569
-
-
Zhang, H.1
Hu, L.2
Qiu, W.3
Deng, T.4
Zhang, Y.5
Bergholz, J.6
Xiao, Z.X.7
-
56
-
-
85040666063
-
Mdm2/mdmx: Master negative regulators for p53 and rb
-
Hu L, Zhang H, Bergholz J, Sun S, Xiao ZX. Mdm2/mdmx: Master negative regulators for p53 and rb. Mol Cell Oncol. 2016;3:e1106635.
-
(2016)
Mol Cell Oncol
, vol.3
-
-
Hu, L.1
Zhang, H.2
Bergholz, J.3
Sun, S.4
Xiao, Z.X.5
-
57
-
-
4043181214
-
Cancer genes and the pathways they control
-
Vogelstein B, Kinzler KW. Cancer genes and the pathways they control. Nat Med. 2004;10:789-799.
-
(2004)
Nat Med
, vol.10
, pp. 789-799
-
-
Vogelstein, B.1
Kinzler, K.W.2
-
58
-
-
84942193819
-
Concomitant inactivation of the p53-and prb-functional pathways predicts resistance to DNA damaging drugs in breast cancer in vivo
-
Knappskog S, Berge EO, Chrisanthar R, Geisler S, Staalesen V, Leirvaag B, Yndestad S, de Faveri E, Karlsen BO, Wedge DC, Akslen LA, Lilleng PK, Lokkevik E, et al. Concomitant inactivation of the p53-and prb-functional pathways predicts resistance to DNA damaging drugs in breast cancer in vivo. Mol Oncol. 2015;9:1553-1564.
-
(2015)
Mol Oncol
, vol.9
, pp. 1553-1564
-
-
Knappskog, S.1
Berge, E.O.2
Chrisanthar, R.3
Geisler, S.4
Staalesen, V.5
Leirvaag, B.6
Yndestad, S.7
de Faveri, E.8
Karlsen, B.O.9
Wedge, D.C.10
Akslen, L.A.11
Lilleng, P.K.12
Lokkevik, E.13
-
59
-
-
0034802430
-
Combined analysis of p53 and rb pathways in epithelial ovarian cancer
-
Hashiguchi Y, Tsuda H, Yamamoto K, Inoue T, Ishiko O, Ogita S. Combined analysis of p53 and rb pathways in epithelial ovarian cancer. Hum Pathol. 2001;32:988-996.
-
(2001)
Hum Pathol
, vol.32
, pp. 988-996
-
-
Hashiguchi, Y.1
Tsuda, H.2
Yamamoto, K.3
Inoue, T.4
Ishiko, O.5
Ogita, S.6
-
60
-
-
77956453807
-
The e2f1/rb and p53/mdm2 pathways in DNA repair and apoptosis: Understanding the crosstalk to develop novel strategies for prostate cancer radiotherapy
-
Udayakumar T, Shareef MM, Diaz DA, Ahmed MM, Pollack A. The e2f1/rb and p53/mdm2 pathways in DNA repair and apoptosis: Understanding the crosstalk to develop novel strategies for prostate cancer radiotherapy. Semin Radiat Oncol. 2010;20:258-266.
-
(2010)
Semin Radiat Oncol
, vol.20
, pp. 258-266
-
-
Udayakumar, T.1
Shareef, M.M.2
Diaz, D.A.3
Ahmed, M.M.4
Pollack, A.5
-
61
-
-
0033637120
-
Deregulation of the rb and p53 pathways in uveal melanoma
-
Brantley MA, Jr., Harbour JW. Deregulation of the rb and p53 pathways in uveal melanoma. Am J Pathol. 2000;157:1795-1801.
-
(2000)
Am J Pathol
, vol.157
, pp. 1795-1801
-
-
Brantley, M.A.1
Harbour, J.W.2
-
62
-
-
79959522156
-
P16ink4a and p14arf tumor suppressor pathways are deregulated in malignant rhabdoid tumors
-
Venneti S, Le P, Martinez D, Eaton KW, Shyam N, Jordan-Sciutto KL, Pawel B, Biegel JA, Judkins AR. P16ink4a and p14arf tumor suppressor pathways are deregulated in malignant rhabdoid tumors. J Neuropathol Exp Neurol. 2011;70:596-609.
-
(2011)
J Neuropathol Exp Neurol
, vol.70
, pp. 596-609
-
-
Venneti, S.1
Le, P.2
Martinez, D.3
Eaton, K.W.4
Shyam, N.5
Jordan-Sciutto, K.L.6
Pawel, B.7
Biegel, J.A.8
Judkins, A.R.9
-
63
-
-
34247227439
-
Tp53 and rb tumor suppressor pathways collaborate in retinoblastoma genesis
-
Ayrault O, Zindy F, Roussel MF. [tp53 and rb tumor suppressor pathways collaborate in retinoblastoma genesis]. Med Sci (Paris). 2007;23:356-358.
-
(2007)
Med Sci (Paris)
, vol.23
, pp. 356-358
-
-
Ayrault, O.1
Zindy, F.2
Roussel, M.F.3
-
64
-
-
84929456514
-
Rb loss contributes to aggressive tumor phenotypes in myc-driven triple negative breast cancer
-
Knudsen ES, McClendon AK, Franco J, Ertel A, Fortina P, Witkiewicz AK. Rb loss contributes to aggressive tumor phenotypes in myc-driven triple negative breast cancer. Cell Cycle. 2015;14:109-122.
-
(2015)
Cell Cycle
, vol.14
, pp. 109-122
-
-
Knudsen, E.S.1
McClendon, A.K.2
Franco, J.3
Ertel, A.4
Fortina, P.5
Witkiewicz, A.K.6
-
66
-
-
84899434901
-
Signaling through cyclin d-dependent kinases
-
Choi YJ, Anders L. Signaling through cyclin d-dependent kinases. Oncogene. 2014;33:1890-1903.
-
(2014)
Oncogene
, vol.33
, pp. 1890-1903
-
-
Choi, Y.J.1
Anders, L.2
-
67
-
-
50949109786
-
Expression of p14arf, mdm2, and mdm4 in human retinoblastoma
-
Guo Y, Pajovic S, Gallie BL: Expression of p14arf, mdm2, and mdm4 in human retinoblastoma. Biochem Biophys Res Commun. 2008;375:1-5.
-
(2008)
Biochem Biophys Res Commun
, vol.375
, pp. 1-5
-
-
Guo, Y.1
Pajovic, S.2
Gallie, B.L.3
-
68
-
-
33750590095
-
Inactivation of the p53pathway in retinoblastoma
-
Laurie NA, Donovan SL, Shih CS, Zhang J, Mills N, Fuller C, Teunisse A, Lam S, Ramos Y, Mohan A, Johnson D, Wilson M, Rodriguez-Galindo C, et al. Inactivation of the p53pathway in retinoblastoma. Nature. 2006;444:61-66.
-
(2006)
Nature
, vol.444
, pp. 61-66
-
-
Laurie, N.A.1
Donovan, S.L.2
Shih, C.S.3
Zhang, J.4
Mills, N.5
Fuller, C.6
Teunisse, A.7
Lam, S.8
Ramos, Y.9
Mohan, A.10
Johnson, D.11
Wilson, M.12
Rodriguez-Galindo, C.13
-
70
-
-
84865187027
-
Analysis of mdm2 and mdm4 single nucleotide polymorphisms, mrna splicing and protein expression in retinoblastoma
-
McEvoy J, Ulyanov A, Brennan R, Wu G, Pounds S, Zhang J, Dyer MA. Analysis of mdm2 and mdm4 single nucleotide polymorphisms, mrna splicing and protein expression in retinoblastoma. PLoS One. 2012;7:e42739.
-
(2012)
Plos One
, vol.7
-
-
McEvoy, J.1
Ulyanov, A.2
Brennan, R.3
Wu, G.4
Pounds, S.5
Zhang, J.6
Dyer, M.A.7
-
71
-
-
0032589744
-
Mechanisms of inactivation of p14arf, p15ink4b, and p16ink4a genes in human esophageal squamous cell carcinoma
-
Xing EP, Nie Y, Song Y, Yang GY, Cai YC, Wang LD, Yang CS. Mechanisms of inactivation of p14arf, p15ink4b, and p16ink4a genes in human esophageal squamous cell carcinoma. Clin Cancer Res. 1999;5:2704-2713.
-
(1999)
Clin Cancer Res
, vol.5
, pp. 2704-2713
-
-
Xing, E.P.1
Nie, Y.2
Song, Y.3
Yang, G.Y.4
Cai, Y.C.5
Wang, L.D.6
Yang, C.S.7
-
72
-
-
0031310665
-
14-3-3 sigma is a p53-regulated inhibitor of g2/m progression
-
Hermeking H, Lengauer C, Polyak K, He TC, Zhang L, Thiagalingam S, Kinzler KW, Vogelstein B. 14-3-3 sigma is a p53-regulated inhibitor of g2/m progression. Mol Cell. 1997;1:3-11.
-
(1997)
Mol Cell
, vol.1
, pp. 3-11
-
-
Hermeking, H.1
Lengauer, C.2
Polyak, K.3
He, T.C.4
Zhang, L.5
Thiagalingam, S.6
Kinzler, K.W.7
Vogelstein, B.8
-
73
-
-
84923279273
-
Endoplasmic reticulum stress sensitizes cells to DNA damage-induced apoptosis through p53-dependent suppression of p21(Cdkn1a
-
Mlynarczyk C, Fahraeus R: Endoplasmic reticulum stress sensitizes cells to DNA damage-induced apoptosis through p53-dependent suppression of p21(cdkn1a). Nat Commun. 2014;5:5067.
-
(2014)
Nat Commun
, vol.5
, pp. 5067
-
-
Mlynarczyk, C.1
Fahraeus, R.2
-
74
-
-
0842278331
-
Direct activation of bax by p53 mediates mitochondrial membrane permeabilization and apoptosis
-
Chipuk JE, Kuwana T, Bouchier-Hayes L, Droin NM, Newmeyer DD, Schuler M, Green DR. Direct activation of bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science. 2004;303:1010-1014.
-
(2004)
Science
, vol.303
, pp. 1010-1014
-
-
Chipuk, J.E.1
Kuwana, T.2
Bouchier-Hayes, L.3
Droin, N.M.4
Newmeyer, D.D.5
Schuler, M.6
Green, D.R.7
-
75
-
-
0029028353
-
Stimulation of e2f1/dp1 transcriptional activity by mdm2 oncoprotein
-
Martin K, Trouche D, Hagemeier C, Sorensen TS, La Thangue NB, Kouzarides T. Stimulation of e2f1/dp1 transcriptional activity by mdm2 oncoprotein. Nature. 1995;375:691-694.
-
(1995)
Nature
, vol.375
, pp. 691-694
-
-
Martin, K.1
Trouche, D.2
Hagemeier, C.3
Sorensen, T.S.4
la Thangue, N.B.5
Kouzarides, T.6
-
76
-
-
27944478688
-
Stabilization of e2f1 protein by mdm2 through the e2f1 ubiquitination pathway
-
Zhang Z, Wang H, Li M, Rayburn ER, Agrawal S, Zhang R. Stabilization of e2f1 protein by mdm2 through the e2f1 ubiquitination pathway. Oncogene 2005;24:7238-7247.
-
(2005)
Oncogene
, vol.24
, pp. 7238-7247
-
-
Zhang, Z.1
Wang, H.2
Li, M.3
Rayburn, E.R.4
Agrawal, S.5
Zhang, R.6
-
77
-
-
77957756784
-
E2f1 inhibits mdm2 expression in a p53-dependent manner
-
Tian X, Chen Y, Hu W, Wu M. E2f1 inhibits mdm2 expression in a p53-dependent manner. Cell Signal. 2011;23:193-200.
-
(2011)
Cell Signal
, vol.23
, pp. 193-200
-
-
Tian, X.1
Chen, Y.2
Hu, W.3
Wu, M.4
-
78
-
-
0037441475
-
The e2f-1 transcription factor is negatively regulated by its interaction with the mdmx protein
-
Strachan GD, Jordan-Sciutto KL, Rallapalli R, Tuan RS, Hall DJ: The e2f-1 transcription factor is negatively regulated by its interaction with the mdmx protein. J Cell Biochem. 2003;88:557-568.
-
(2003)
J Cell Biochem
, vol.88
, pp. 557-568
-
-
Strachan, G.D.1
Jordan-Sciutto, K.L.2
Rallapalli, R.3
Tuan, R.S.4
Hall, D.J.5
-
80
-
-
0035824686
-
A transcriptionally inactive e2f-1 targets the mdm family of proteins for proteolytic degradation
-
Strachan GD, Rallapalli R, Pucci B, Lafond TP, Hall DJ: A transcriptionally inactive e2f-1 targets the mdm family of proteins for proteolytic degradation. J Biol Chem. 2001;276:45677-45685.
-
(2001)
J Biol Chem
, vol.276
, pp. 45677-45685
-
-
Strachan, G.D.1
Rallapalli, R.2
Pucci, B.3
Lafond, T.P.4
Hall, D.J.5
-
81
-
-
0029615315
-
Functional interactions between p53 and cell cycle co-operating transcription factors
-
O’Connor DJ, Lam EW, Griffin S, Zhong S, Leighton LC, Burbidge SA, Lu X. Physical and functional interactions between p53 and cell cycle co-operating transcription factors, e2f1 and dp1. EMBO J. 1995;14:6184-6192.
-
(1995)
E2f1 and Dp1. EMBO J
, vol.14
, pp. 6184-6192
-
-
O’Connor, D.J.1
Lam, E.W.2
Griffin, S.3
Zhong, S.4
Leighton, L.C.5
Burbidge, S.A.6
Physical, L.X.7
-
82
-
-
78651306147
-
Mef/elf4 transactivation by e2f1 is inhibited by p53
-
Taura M, Suico MA, Fukuda R, Koga T, Shuto T, Sato T, Morino-Koga S, Okada S, Kai H. Mef/elf4 transactivation by e2f1 is inhibited by p53. Nucleic Acids Res. 2011;39:76-88.
-
(2011)
Nucleic Acids Res
, vol.39
, pp. 76-88
-
-
Taura, M.1
Suico, M.A.2
Fukuda, R.3
Koga, T.4
Shuto, T.5
Sato, T.6
Morino-Koga, S.7
Okada, S.8
Kai, H.9
-
83
-
-
0036132647
-
Novel function of the cyclin a binding site of e2f in regulating p53-induced apoptosis in response to DNA damage
-
Hsieh JK, Yap D, O’Connor DJ, Fogal V, Fallis L, Chan F, Zhong S, Lu X. Novel function of the cyclin a binding site of e2f in regulating p53-induced apoptosis in response to DNA damage. Mol Cell Biol. 2002;22:78-93.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 78-93
-
-
Hsieh, J.K.1
Yap, D.2
O’Connor, D.J.3
Fogal, V.4
Fallis, L.5
Chan, F.6
Zhong, S.7
Lu, X.8
-
84
-
-
0026740449
-
Amplification of a gene encoding a p53-associated protein in human sarcomas
-
Oliner JD, Kinzler KW, Meltzer PS, George DL, Vogelstein B. Amplification of a gene encoding a p53-associated protein in human sarcomas. Nature. 1992;358:80-83.
-
(1992)
Nature
, vol.358
, pp. 80-83
-
-
Oliner, J.D.1
Kinzler, K.W.2
Meltzer, P.S.3
George, D.L.4
Vogelstein, B.5
-
85
-
-
33645769536
-
A mouse p53 mutant lacking the proline-rich domain rescues mdm4 deficiency and provides insight into the mdm2-mdm4-p53 regulatory network
-
Toledo F, Krummel KA, Lee CJ, Liu CW, Rodewald LW, Tang M, Wahl GM. A mouse p53 mutant lacking the proline-rich domain rescues mdm4 deficiency and provides insight into the mdm2-mdm4-p53 regulatory network. Cancer Cell. 2006;9:273-285.
-
(2006)
Cancer Cell
, vol.9
, pp. 273-285
-
-
Toledo, F.1
Krummel, K.A.2
Lee, C.J.3
Liu, C.W.4
Rodewald, L.W.5
Tang, M.6
Wahl, G.M.7
-
86
-
-
67349166210
-
P53 controls cancer cell invasion by inducing the mdm2-mediated degradation of slug
-
Wang SP, Wang WL, Chang YL, Wu CT, Chao YC, Kao SH, Yuan A, Lin CW, Yang SC, Chan WK, Li KC, Hong TM, Yang PC. P53 controls cancer cell invasion by inducing the mdm2-mediated degradation of slug. Nat Cell Biol. 2009;11:694-704.
-
(2009)
Nat Cell Biol
, vol.11
, pp. 694-704
-
-
Wang, S.P.1
Wang, W.L.2
Chang, Y.L.3
Wu, C.T.4
Chao, Y.C.5
Kao, S.H.6
Yuan, A.7
Lin, C.W.8
Yang, S.C.9
Chan, W.K.10
Li, K.C.11
Hong, T.M.12
Yang, P.C.13
-
87
-
-
77952543499
-
The p53 orchestra: Mdm2 and mdmx set the tone
-
Wade M, Wang YV, Wahl GM: The p53 orchestra: Mdm2 and mdmx set the tone. Trends Cell Biol. 2010;20:299-309.
-
(2010)
Trends Cell Biol
, vol.20
, pp. 299-309
-
-
Wade, M.1
Wang, Y.V.2
Wahl, G.M.3
-
88
-
-
0343819885
-
Amplification and overexpression of the mdm4 (Mdmx) gene from 1q32 in a subset of malignant gliomas without tp53 mutation or mdm2 amplification
-
Riemenschneider MJ, Buschges R, Wolter M, Reifenberger J, Bostrom J, Kraus JA, Schlegel U, Reifenberger G. Amplification and overexpression of the mdm4 (mdmx) gene from 1q32 in a subset of malignant gliomas without tp53 mutation or mdm2 amplification. Cancer Res. 1999;59:6091-6096.
-
(1999)
Cancer Res
, vol.59
, pp. 6091-6096
-
-
Riemenschneider, M.J.1
Buschges, R.2
Wolter, M.3
Reifenberger, J.4
Bostrom, J.5
Kraus, J.A.6
Schlegel, U.7
Reifenberger, G.8
-
89
-
-
0026649648
-
The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
-
Momand J, Zambetti GP, Olson DC, George D, Levine AJ. The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell. 1992;69:1237-1245.
-
(1992)
Cell
, vol.69
, pp. 1237-1245
-
-
Momand, J.1
Zambetti, G.P.2
Olson, D.C.3
George, D.4
Levine, A.J.5
-
90
-
-
0037047345
-
The conformationally flexible s9-s10 linker region in the core domain of p53 contains a novel mdm2 binding site whose mutation increases ubiquitination of p53 in vivo
-
Shimizu H, Burch LR, Smith AJ, Dornan D, Wallace M, Ball KL, Hupp TR. The conformationally flexible s9-s10 linker region in the core domain of p53 contains a novel mdm2 binding site whose mutation increases ubiquitination of p53 in vivo. J Biol Chem. 2002;277:28446-28458.
-
(2002)
J Biol Chem
, vol.277
, pp. 28446-28458
-
-
Shimizu, H.1
Burch, L.R.2
Smith, A.J.3
Dornan, D.4
Wallace, M.5
Ball, K.L.6
Hupp, T.R.7
-
91
-
-
0036606416
-
Mdmx is a negative regulator of p53 activity in vivo
-
Finch RA, Donoviel DB, Potter D, Shi M, Fan A, Freed DD, Wang CY, Zambrowicz BP, Ramirez-Solis R, Sands AT, Zhang N. Mdmx is a negative regulator of p53 activity in vivo. Cancer Res. 2002;62:3221-3225.
-
(2002)
Cancer Res
, vol.62
, pp. 3221-3225
-
-
Finch, R.A.1
Donoviel, D.B.2
Potter, D.3
Shi, M.4
Fan, A.5
Freed, D.D.6
Wang, C.Y.7
Zambrowicz, B.P.8
Ramirez-Solis, R.9
Sands, A.T.10
Zhang, N.11
-
92
-
-
84966446989
-
Secondary interaction between mdmx and p53 core domain inhibits p53 DNA binding
-
Wei X, Wu S, Song T, Chen L, Gao M, Borcherds W, Daughdrill GW, Chen J. Secondary interaction between mdmx and p53 core domain inhibits p53 DNA binding. Proc Natl Acad Sci U S A. 2016;113:E2558-2563.
-
(2016)
Proc Natl Acad Sci U S A
, vol.113
, pp. E2558-E2563
-
-
Wei, X.1
Wu, S.2
Song, T.3
Chen, L.4
Gao, M.5
Borcherds, W.6
Daughdrill, G.W.7
Chen, J.8
|