P53 isoforms gain functions

Oncogene

Volumn 29, Issue 37, 2010, Pages 5113-5119

  Olivares Illana, V ^a   Fahraeus R ^a  

^a INSERM   (France)

Author keywords

alternative gene expression; endoplasmic reticulum stress; p53; senescence

Indexed keywords

AMINO ACID; MESSENGER RNA; PROTEIN P47; PROTEIN P53; ISOPROTEIN;

APOPTOSIS; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL DIFFERENTIATION; ENDOPLASMIC RETICULUM STRESS; GENE EXPRESSION; HUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; REVIEW; RNA TRANSLATION; SENESCENCE; ANIMAL; CELL AGING; CHEMISTRY; GENETICS; PHYSIOLOGY;

ANIMALS; CELL AGING; G2 PHASE; HUMANS; PROTEIN ISOFORMS; RNA, MESSENGER; TUMOR SUPPRESSOR PROTEIN P53;

EID: 77956935083     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2010.266     Document Type: Review

References (56)

1. Adams PD. (2009). Healing and hurting: molecular mechanisms, functions, and pathologies of cellular senescence. Mol Cell 36: 2-14.
2. Bartkova J, Rezaei N, Liontos M, Karakaidos P, Kletsas D, Issaeva N et al. (2006). Oncogene-induced senescence is part of the tumori-genesis barrier imposed by DNA damage checkpoints. Nature 444: 633-637.
3. Bourdon JC, Fernandes K, Murray-Zmijewski F, Liu G, Diot A, Xirodimas DP et al. (2005). p53 isoforms can regulate p53 transcriptional activity. Genes Dev 19: 2122-2137.
4. Bourougaa K, Naski N, Boularan C, Mlynarczyk C, Candeias MM, Marullo S et al. (2010). Endoplasmic reticulum stress induces G2 cell cycle arrest via mRNA translation of the p53 isoform p53/47. Mol Cell, 2010 38: 78-88.
5. Braig M, Lee S, Loddenkemper C, Rudolph C, Peters AH, Schlegelberger B et al. (2005). Oncogene-induced senescence as an initial barrier in lymphoma development. Nature 436: 660-665.
6. Candeias MM, Malbert-Colas L, Powell DJ, Daskalogianni C, Maslon MM, Naski N et al. (2008). p53 mRNA controls p53 activity by managing Mdm2 functions. Nat Cell Biol 10: 1098-1105.
7. Candeias MM, Powell DJ, Roubalova E, Apcher S, Bourougaa K, Vojtesek B et al. (2006). Expression of p53 and p53/47 are controlled by alternative mechanisms of messenger RNA translation initiation. Oncogene 25: 6936-6947.
8. Chan TA, Hermeking H, Lengauer C, Kinzler KW, Vogelstein B. (1999). 14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage. Nature 401: 616-620.
9. Chen X, Shen J, Prywes R. (2002). The luminal domain of ATF6 senses endoplasmic reticulum (ER) stress and causes translocation of ATF6 from the ER to the Golgi. J Biol Chem 277: 13045-13052.
10. Collado M, Gil J, Efeyan A, Guerra C, Schuhmacher AJ, Barradas M et al. (2005). Tumour biology: senescence in premalignant tumours. Nature 436: 642.
11. Collado M, Serrano M. (2010). Senescence in tumours: evidence from mice and humans. Nat Rev Cancer 10: 51-57.
12. Cornelis S, Bruynooghe Y, Denecker G, Van Huffel S, Tinton S, Beyaert R. (2000). Identification and characterization of a novel cell cycle-regulated internal ribosome entry site. Mol Cell 5: 597-605.
13. Courtois S, Verhaegh G, North S, Luciani MG, Lassus P, Hibner U et al. (2002). DeltaN-p53, a natural isoform of p53 lacking the first transactivation domain, counteracts growth suppression by wild-type p53. Oncogene 21: 6722-6728.
14. dAdda di Fagagna F, Reaper PM, Clay-Farrace L, Fiegler H, Carr P, Von Zglinicki T et al. (2003). A DNA damage checkpoint response in telomere-initiated senescence. Nature 426: 194-198.
15. Dankort D, Filenova E, Collado M, Serrano M, Jones K, McMahon M. (2007). A new mouse model to explore the initiation, progression, and therapy of BRAFV600E-induced lung tumors. Genes Dev 21: 379-384.
16. Efeyan A, Ortega-Molina A, Velasco-Miguel S, Herranz D, Vassilev LT, Serrano M. (2007). Induction of p53-dependent senescence by the MDM2 antagonist nutlin-3a in mouse cells of fibroblast origin. Cancer Res 67: 7350-7357.
17. el-Deiry WS, Tokino T, Velculescu VE, Levy DB, Parsons R, Trent JM et al. (1993). WAF1, a potential mediator of p53 tumor suppression. Cell 75: 817-825.
18. Feldser DM, Greider CW. (2007). Short telomeres limit tumor progression in vivo by inducing senescence. Cancer Cell 11: 461-469.
19. Fernandez J, Bode B, Koromilas A, Diehl JA, Krukovets I, Snider MD et al. (2002). Translation mediated by the internal ribosome entry site of the cat-1 mRNA is regulated by glucose availability in a PERK kinase-dependent manner. J Biol Chem 277: 11780-11787.
20. Fernandez PM, Tabbara SO, Jacobs LK, Manning FC, Tsangaris TN, Schwartz AM et al. (2000). Overexpression of the glucose-regulated stress gene GRP78 in malignant but not benign human breast lesions. Breast Cancer Res Treat 59: 15-26.
21. Fujita K, Mondal AM, Horikawa I, Nguyen GH, Kumamoto K. (2009). p53 isoforms D133p53 and p53b are endogenous regulators of replicative cellular senescence. Nat Cell Biol 11: 1135-1142.
22. Ghosh A, Stewart D, Matlashewski G. (2004). Regulation of human p53 activity and cell localization by alternative splicing. Mol Cell Biol 24: 7987-7997.
23. Grover R, Candeias MM, Fahraeus R, Das S. (2009). p53 and little brother p53/47: linking IRES activities with protein functions. Oncogene 28: 2766-2772.
24. Hansen S, Lane DP, Midgley CA. (1998). The N terminus of the murine p53 tumour suppressor is an independent regulatory domain affecting activation and thermostability. J Mol Biol 275: 575-588.
25. Harding HP, Zhang Y, Ron D. (1999). Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase. Nature 397: 271-274.
26. He L, He X, Lim LP, de Stanchina E, Xuan Z, Liang Y et al. (2007). A microRNA component of the p53 tumour suppressor network. Nature 447: 1130-1134.
27. Hermeking H, Benzinger A. (2006). 14-3-3 proteins in cell cycle regulation. Semin Cancer Biol 16: 183-192.
28. Hermeking H, Lengauer C, Polyak K, He TC, Zhang L, Thiagalingam S et al. (1997). 14-3-3 sigma is a p53-regulated inhibitor of G2/M progression. Mol Cell 1: 3-11.
29. Kim I, Xu W, Reed JC. (2008). Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities. Nat Rev Drug Discov 7: 1013-1030.
30. Koumenis C, Naczki C, Koritzinsky M, Rastani S, Diehl A, Sonenberg N et al. (2002). Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha. Mol Cell Biol 22: 7405-7416.
31. Lane DP, Cheok CF, Brown CJ, Madhumalar A, Ghadessy FJ, Verma C. (2010). The Mdm2 and p53 genes are conserved in the Arachnids. Cell Cycle 9: 748-754.
32. Ledoux S, Yang R, Friedlander G, Laouari D. (2003). Glucose depletion enhances P-glycoprotein expression in hepatoma cells: role of endoplasmic reticulum stress response. Cancer Res 63: 7284-7290.
33. Lee K, Tirasophon W, Shen X, Michalak M, Prywes R, Okada T et al. (2002). IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response. Genes Dev 16: 452-466.
34. Levine AJ, Oren M. (2009). The first 30 years of p53: growing ever more complex. Nat Rev Cancer 9: 749-758.
35. Mandic A, Hansson J, Linder S, Shoshan MC. (2003). Cisplatin induces endoplasmic reticulum stress and nucleus-independent apoptotic signaling. J Biol Chem 278: 9100-9106.
36. Marechal V, Elenbaas B, Piette J, Nicolas JC, Levine AJ. (1994). The ribosomal L5 protein is associated with mdm-2 and mdm-2-p53 complexes. Mol Cell Biol 14: 7414-7420.
37. Moll UM, Slade N. (2004). p63 and p73: roles in development and tumor formation. Mol Cancer Res 2: 371-386.
38. Peng CY, Graves PR, Thoma RS, Wu Z, Shaw AS, Piwnica-Worms H. (1997). Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216. Science 277: 1501-1505.
39. Pomerantz J, Schreiber-Agus N, Liegeois NJ, Silverman A, Alland L, Chin L et al. (1998). The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2s inhibition of p53. Cell 92: 713-723.
40. Powell DJ, Hrstka R, Candeias M, Bourougaa K, Vojtesek B, Fahraeus R. (2008). Stress-dependent changes in the properties of p53 complexes by the alternative translation product p53/47. Cell Cycle 7: 950-959.
41. Pyronnet S, Pradayrol L, Sonenberg N. (2000). A cell cycle-dependent internal ribosome entry site. Mol Cell 5: 607-616.
42. Rajagopalan S, Jaulent AM, Wells M, Veprintsev DB, Fersht AR. (2008). 14-3-3 activation of DNA binding of p53 by enhancing its association into tetramers. Nucleic Acids Res 36: 5983-5991.
43. Ray PS, Grover R, Das S. (2006). Two internal ribosome entry sites mediate the translation of p53 isoforms. EMBO Rep 7: 404-410.
44. Ron D, Walter P. (2007). Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol 8: 519-529.
45. Schroder M, Kaufman RJ. (2005). ER stress and the unfolded protein response. Mutat Res 569: 29-63.
46. Rosenbluth M, Pietenpol A. (2008). The jury is in: p73 is a tumor suppressor after all. Genes Dev 22: 2591-2595.
47. Shen J, Chen X, Hendershot L, Prywes R. (2002). ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals. Dev Cell 3: 99-111.
48. Sivan G, Elroy-Stein O. (2008). Regulation of mRNA translation during cellular division. Cell Cycle 7: 741-744.
49. Urano F, Bertolotti A, Ron D. (2000). IRE1 and efferent signaling from the endoplasmic reticulum. J Cell Sci 113(Part 21): 3697-3702.
50. Vattem KM, Wek RC. (2004). Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells. Proc Natl Acad Sci USA 101: 11269-11274.
51. Vogelstein B, Lane D, Levine AJ. (2000). Surfing the p53 network. Nature 408: 307-310.
52. Vousden KH, Prives C. (2009). Blinded by the light: the growing complexity of p53. Cell 137: 413-431.
53. Xiao ZX, Chen J, Levine AJ, Modjtahedi N, Xing J, Sellers WR et al. (1995). Interaction between the retinoblastoma protein and the oncoprotein MDM2. Nature 375: 694-698.
54. Yin Y, Stephen CW, Luciani MG, Fahraeus R. (2002). p53 Stability and activity is regulated by Mdm2-mediated induction of alternative p53 translation products. Nat Cell Biol 4: 462-467.
55. Yoshida H, Matsui T, Yamamoto A, Okada T, Mori K. (2001). XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Cell 107: 881-891.
56. Zhu J, Zhou W, Jiang J, Chen X. (1998). Identification of a novel p53 functional domain that is necessary for mediating apoptosis. J Biol Chem 273: 13030-13036.