RB1 gene in Merkel cell carcinoma: Hypermethylation in all tumors and concurrent heterozygous deletions in the polyomavirus-negative subgroup

APMIS

Volumn 122, Issue 12, 2014, Pages 1157-1166

  Sahi, Helka ^a,b   Savola, Suvi ^c   Sihto, Harri ^a   Koljonen, Virve ^a,b   Bohling, Tom ^a   Knuutila, Sakari ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^c MRC HOLLAND   (Netherlands)

Author keywords

Array comparative genomic hybridization; Hypermethylation; Merkel cell carcinoma; Merkel cell polyomavirus; Retinoblastoma gene; Retinoblastoma protein

Indexed keywords

RETINOBLASTOMA PROTEIN; RETINOBLASTOMA PROTEIN 1; UNCLASSIFIED DRUG; TUMOR SUPPRESSOR PROTEIN;

ADULT; AGED; ARTICLE; CANCER SURVIVAL; CHROMOSOME 11P; CLINICAL ARTICLE; CLINICAL FEATURE; COMPARATIVE GENOMIC HYBRIDIZATION; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; FEMALE; GENE AMPLIFICATION; GENE DELETION; GENE DOSAGE; GENE EXPRESSION; GENE LOCUS; GENOMIC INSTABILITY; GENOMICS; HETEROZYGOTE; HUMAN; IMMUNOHISTOCHEMISTRY; MALE; MERKEL CELL POLYOMAVIRUS; MERKEL CELL TUMOR; MULTIPLEX LIGATION DEPENDENT PROBE AMPLIFICATION; POLYOMAVIRUS INFECTION; PRIORITY JOURNAL; PROMOTER REGION; START CODON; COPY NUMBER VARIATION; GENE EXPRESSION REGULATION; GENETICS; ISOLATION AND PURIFICATION; METABOLISM; MIDDLE AGED; PATHOLOGY; POLYOMA VIRUS; VERY ELDERLY; VIROLOGY;

AGED; AGED, 80 AND OVER; CARCINOMA, MERKEL CELL; COMPARATIVE GENOMIC HYBRIDIZATION; DNA COPY NUMBER VARIATIONS; DNA METHYLATION; FEMALE; GENE DELETION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENETIC LOCI; HUMANS; MALE; MIDDLE AGED; POLYOMAVIRUS; PROMOTER REGIONS, GENETIC; RETINOBLASTOMA PROTEIN; TUMOR SUPPRESSOR PROTEINS;

EID: 84922479831     PISSN: 09034641     EISSN: 16000463     Source Type: Journal    
DOI: 10.1111/apm.12274     Document Type: Article

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