Enhanced Mdm2 activity inhibits pRB function via ubiquitin-dependent degradation

EMBO Journal

Volumn 24, Issue 1, 2005, Pages 160-169

  Uchida, Chiharu ^a   Miwa, Seiichi ^a   Kitagawa, Kyoko ^a   Hattori, Takayuki ^a   Isobe, Tomoyasu ^a   Otani, Sunao ^a   Oda, Toshiaki ^a   Sugimura, Haruhiko ^a   Kamijo, Takehiko ^b   Ookawa, Keizou ^c   Yasuda, Hideyo ^d   Kitagawa, Masatoshi ^a  

^a HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b SHINSHU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c HIROSAKI UNIVERSITY   (Japan)

^d Kanagawa 243 0041   (Japan)

Author keywords

Mdm2; p53; RB protein; Tumor suppressor; Ubiquitin ligase

Indexed keywords

GENE PRODUCT; MUTANT PROTEIN; PROTEIN MDM2; PROTEIN P53; RETINOBLASTOMA PROTEIN; UBIQUITIN; UBIQUITIN PROTEIN LIGASE;

AMINO ACID SUBSTITUTION; ARTICLE; BIOACCUMULATION; CANCER INHIBITION; CARCINOGENESIS; CELL CYCLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DOWN REGULATION; ENZYME ACTIVITY; GENE CONTROL; GENE FUNCTION; HUMAN; HUMAN CELL; HUMAN TISSUE; LUNG CANCER; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STABILITY; REGULATORY MECHANISM; UBIQUITINATION; WILD TYPE;

ANIMALS; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE; CELL SHAPE; HUMANS; LUNG NEOPLASMS; MICE; NUCLEAR PROTEINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; RECOMBINANT FUSION PROTEINS; RETINOBLASTOMA PROTEIN; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P14ARF; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITINS;

EID: 19944431662     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.emboj.7600486     Document Type: Article

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