-
1
-
-
84876723158
-
RB1 in cancer: Different mechanisms of RB1 inactivation and alterations of pRb pathway in tumorigenesis
-
Di Fiore R, D'Anneo A, Tesoriere G, Vento R. RB1 in cancer: different mechanisms of RB1 inactivation and alterations of pRb pathway in tumorigenesis. J Cell Physiol 2013; 228: 1676-1687.
-
(2013)
J Cell Physiol
, vol.228
, pp. 1676-1687
-
-
Di Fiore, R.1
D'Anneo, A.2
Tesoriere, G.3
Vento, R.4
-
2
-
-
0036884829
-
The retinoblastoma tumour suppressor in development and cancer
-
Classon M, Harlow E. The retinoblastoma tumour suppressor in development and cancer. Nat Rev Cancer 2002; 2: 910-917.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 910-917
-
-
Classon, M.1
Harlow, E.2
-
4
-
-
84876808719
-
Molecular mechanisms underlying RB protein function
-
Dick FA, Rubin SM. Molecular mechanisms underlying RB protein function. Nat Rev Mol Cell Biol 2013; 14: 297-306.
-
(2013)
Nat Rev Mol Cell Biol
, vol.14
, pp. 297-306
-
-
Dick, F.A.1
Rubin, S.M.2
-
5
-
-
0037115601
-
Structural basis for the recognition of the E2F transactivation domain by the retinoblastoma tumor suppressor
-
Lee C, Chang JH, Lee HS, Cho Y. Structural basis for the recognition of the E2F transactivation domain by the retinoblastoma tumor suppressor. Genes Dev 2002; 16: 3199-3212.
-
(2002)
Genes Dev
, vol.16
, pp. 3199-3212
-
-
Lee, C.1
Chang, J.H.2
Lee, H.S.3
Cho, Y.4
-
6
-
-
0037418175
-
Crystal structure of the retinoblastoma tumor suppressor protein bound to E2F and the molecular basis of its regulation
-
Xiao B, Spencer J, Clements A, Ali-Khan N, Mittnacht S, Broceo C et al. Crystal structure of the retinoblastoma tumor suppressor protein bound to E2F and the molecular basis of its regulation. Proc Natl Acad Sci USA 2003; 100: 2363-2368.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 2363-2368
-
-
Xiao, B.1
Spencer, J.2
Clements, A.3
Ali-Khan, N.4
Mittnacht, S.5
Broceo, C.6
-
7
-
-
50149120366
-
Cellular mechanisms of tumour suppression by the retinoblastoma gene
-
Burkhart DL, Sage J. Cellular mechanisms of tumour suppression by the retinoblastoma gene. Nat Rev Cancer 2008; 8: 671-682.
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 671-682
-
-
Burkhart, D.L.1
Sage, J.2
-
8
-
-
84858055716
-
The retinoblastoma family of proteins and their regulatory functions in the mammalian cell division cycle
-
Henley SA, Dick FA. The retinoblastoma family of proteins and their regulatory functions in the mammalian cell division cycle. Cell Div 2012; 7: 10.
-
(2012)
Cell Div
, vol.7
, pp. 10
-
-
Henley, S.A.1
Dick, F.A.2
-
9
-
-
0030918714
-
Differential phosphorylation of the retinoblastoma protein by G1/S cyclin-dependent kinases
-
Zarkowska T, Mittnacht S. Differential phosphorylation of the retinoblastoma protein by G1/S cyclin-dependent kinases. J Biol Chem 1997; 272: 12738-12746.
-
(1997)
J Biol Chem
, vol.272
, pp. 12738-12746
-
-
Zarkowska, T.1
Mittnacht, S.2
-
10
-
-
0033578816
-
Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1
-
Harbour JW, Luo RX, Dei Santi A, Postigo AA, Dean DC. Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1. Cell 1999; 98: 859-869.
-
(1999)
Cell
, vol.98
, pp. 859-869
-
-
Harbour, J.W.1
Luo, R.X.2
Dei Santi, A.3
Postigo, A.A.4
Dean, D.C.5
-
11
-
-
33748047128
-
RB and cell cycle progression
-
Giacinti C, Giordano A. RB and cell cycle progression. Oncogene 2006; 25: 5220-5227.
-
(2006)
Oncogene
, vol.25
, pp. 5220-5227
-
-
Giacinti, C.1
Giordano, A.2
-
12
-
-
0141861977
-
Active localization of the retinoblastoma protein in chromatin and its response to S phase DNA damage
-
Avni D, Yang H, Martelli F, Hofmann F, ElShamy WM, Ganesan S et al. Active localization of the retinoblastoma protein in chromatin and its response to S phase DNA damage. Mol Cell 2003; 12: 735-746.
-
(2003)
Mol Cell
, vol.12
, pp. 735-746
-
-
Avni, D.1
Yang, H.2
Martelli, F.3
Hofmann, F.4
ElShamy, W.M.5
Ganesan, S.6
-
13
-
-
0038482115
-
Oxidative stress induces protein phosphatase 2A-dependent dephosphorylation of the pocket proteins pRb, p107, and p130
-
Cicchillitti L, Fasanaro P, Biglioli P, Capogrossi MC, Martelli F. Oxidative stress induces protein phosphatase 2A-dependent dephosphorylation of the pocket proteins pRb, p107, and p130. J Biol Chem 2003; 278: 19509-19517.
-
(2003)
J Biol Chem
, vol.278
, pp. 19509-19517
-
-
Cicchillitti, L.1
Fasanaro, P.2
Biglioli, P.3
Capogrossi, M.C.4
Martelli, F.5
-
15
-
-
77449101168
-
Mdm2-mediated ubiquitylation: P53 and beyond
-
Marine J-C, Lozano G. Mdm2-mediated ubiquitylation: p53 and beyond. Cell Death Differ 2010; 17: 93-102.
-
(2010)
Cell Death Differ
, vol.17
, pp. 93-102
-
-
Marine, J.-C.1
Lozano, G.2
-
16
-
-
28444437051
-
MDM2 promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma protein
-
Sdek P, Ying H, Chang DLF, Qiu W, Zheng H, Touitou R et al. MDM2 promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma protein. Mol Cell 2005; 20: 699-708.
-
(2005)
Mol Cell
, vol.20
, pp. 699-708
-
-
Sdek, P.1
Ying, H.2
Chang, D.L.F.3
Qiu Zheng, W.4
Touitou, R.5
-
17
-
-
11144241617
-
The central acidic domain of MDM2 is critical in inhibition of retinoblastoma-mediated suppression of E2F and cell growth
-
Sdek P, Ying H, Zheng H, Margulis A, Tang X, Tian K et al. The central acidic domain of MDM2 is critical in inhibition of retinoblastoma-mediated suppression of E2F and cell growth. J Biol Chem 2004; 279: 53317-53322.
-
(2004)
J Biol Chem
, vol.279
, pp. 53317-53322
-
-
Sdek, P.1
Ying, H.2
Zheng, H.3
Margulis, A.4
Tang, X.5
Tian, K.6
-
18
-
-
84873055344
-
MDM2 MDMX and p53 in oncogenesis and cancer therapy
-
Wade M, Li Y-C, Wahl GM. MDM2, MDMX and p53 in oncogenesis and cancer therapy. Nat Rev Cancer 2013; 13: 83-96.
-
(2013)
Nat Rev Cancer
, vol.13
, pp. 83-96
-
-
Wade, M.1
Li, Y.-C.2
Wahl, G.M.3
-
19
-
-
0033531252
-
Comparative study of the p53-mdm2 and p53-MDMX interfaces
-
Bottger V, Bottger A, Garcia-Echeverria C, Ramos YF, van der Eb AJ, Jochemsen AG et al. Comparative study of the p53-mdm2 and p53-MDMX interfaces. Oncogene 1999; 18: 189-199.
-
(1999)
Oncogene
, vol.18
, pp. 189-199
-
-
Bottger, V.1
Bottger, A.2
Garcia-Echeverria, C.3
Ramos, Y.F.4
Van Der Eb, A.J.5
Jochemsen, A.G.6
-
20
-
-
10144259344
-
MDMX: A novel p53-binding protein with some functional properties of MDM2
-
Shvarts A, Steegenga WT, Riteco N, van Laar T, Dekker P, Bazuine M et al. MDMX: a novel p53-binding protein with some functional properties of MDM2. EMBO J 1996; 15: 5349-5357.
-
(1996)
EMBO J
, vol.15
, pp. 5349-5357
-
-
Shvarts, A.1
Steegenga, W.T.2
Riteco, N.3
Van Laar, T.4
Dekker, P.5
Bazuine, M.6
-
21
-
-
0033621415
-
Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein
-
Sharp DA, Kratowicz SA, Sank MJ, George DL. Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein. J Biol Chem 1999; 274: 38189-38196.
-
(1999)
J Biol Chem
, vol.274
, pp. 38189-38196
-
-
Sharp, D.A.1
Kratowicz, S.A.2
Sank, M.J.3
George, D.L.4
-
22
-
-
0033051322
-
MDM2 interacts with MDMX through their RING finger domains
-
Tanimura S, Ohtsuka S, Mitsui K, Shirouzu K, Yoshimura A, Ohtsubo M. MDM2 interacts with MDMX through their RING finger domains. FEBS Lett 1999; 447: 5-9.
-
(1999)
FEBS Lett
, vol.447
, pp. 5-9
-
-
Tanimura, S.1
Ohtsuka, S.2
Mitsui, K.3
Shirouzu, K.4
Yoshimura, A.5
Ohtsubo, M.6
-
23
-
-
34447123808
-
RING domainmediated interaction is a requirement for MDM2's E3 ligase activity
-
Kawai H, Lopez-Pajares V, Kim MM, Wiederschain D, Yuan Z-M. RING domainmediated interaction is a requirement for MDM2's E3 ligase activity. Cancer Res 2007; 67: 6026-6030.
-
(2007)
Cancer Res
, vol.67
, pp. 6026-6030
-
-
Kawai, H.1
Lopez-Pajares, V.2
Kim, M.M.3
Wiederschain, D.4
Yuan, Z.-M.5
-
24
-
-
0142123127
-
HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53
-
Linares LK, Hengstermann A, Ciechanover A, Muller S, Scheffner M. HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53. Proc Natl Acad Sci USA 2003; 100: 12009-12014.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 12009-12014
-
-
Linares, L.K.1
Hengstermann, A.2
Ciechanover, A.3
Muller, S.4
Scheffner, M.5
-
25
-
-
69249202241
-
Mdmx enhances p53 ubiquitination by altering the substrate preference of the Mdm2 ubiquitin ligase
-
Okamoto K, Taya Y, Nakagama H. Mdmx enhances p53 ubiquitination by altering the substrate preference of the Mdm2 ubiquitin ligase. FEBS Lett 2009; 583: 2710-2714.
-
(2009)
FEBS Lett
, vol.583
, pp. 2710-2714
-
-
Okamoto, K.1
Taya, Y.2
Nakagama, H.3
-
26
-
-
42149105590
-
Structure of the MDM2/ MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans
-
Linke K, Mace PD, Smith CA, Vaux DL, Silke J, Day CL. Structure of the MDM2/ MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans. Cell Death Differ 2008; 15: 841-848.
-
(2008)
Cell Death Differ
, vol.15
, pp. 841-848
-
-
Linke, K.1
Mace, P.D.2
Smith, C.A.3
Vaux, D.L.4
Silke, J.5
Day, C.L.6
-
27
-
-
79961076734
-
The p53 inhibitors MDM2/ MDMX complex is required for control of p53 activity in vivo
-
Huang L, Yan Z, Liao X, Li Y, Yang J, Wang Z-G et al. The p53 inhibitors MDM2/ MDMX complex is required for control of p53 activity in vivo. Proc Natl Acad Sci USA 2011; 108: 12001-12006.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 12001-12006
-
-
Huang, L.1
Yan, Z.2
Liao, X.3
Li, Y.4
Yang, J.5
Wang, Z.-G.6
-
28
-
-
79961039603
-
Heterodimerization of Mdm2 and Mdm4 is critical for regulating p53 activity during embryogenesis but dispensable for p53 and Mdm2 stability
-
Pant V, Xiong S, Iwakuma T, Quints-Cardama A, Lozano G. Heterodimerization of Mdm2 and Mdm4 is critical for regulating p53 activity during embryogenesis but dispensable for p53 and Mdm2 stability. Proc Natl Acad Sci USA 2011; 108: 11995-12000.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 11995-12000
-
-
Pant, V.1
Xiong, S.2
Iwakuma, T.3
Quints-Cardama, A.4
Lozano, G.5
-
29
-
-
0029047362
-
A biomarker that identifies senescent human cells in culture and in aging skin in vivo
-
Dimri GP, Lee X, Basile G, Acosta M, Scott G, Roskelley C et al. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci USA 1995; 92: 9363-9367.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 9363-9367
-
-
Dimri, G.P.1
Lee, X.2
Basile, G.3
Acosta, M.4
Scott, G.5
Roskelley, C.6
-
30
-
-
0030944985
-
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
-
Serrano M, Lin AW, McCurrach ME, Beach D, Lowe SW. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 1997; 88: 593-602.
-
(1997)
Cell
, vol.88
, pp. 593-602
-
-
Serrano, M.1
Lin, A.W.2
McCurrach, M.E.3
Beach, D.4
Lowe, S.W.5
-
31
-
-
0034624678
-
Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase
-
Honda R, Yasuda H. Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase. Oncogene 2000; 19: 1473-1476.
-
(2000)
Oncogene
, vol.19
, pp. 1473-1476
-
-
Honda, R.1
Yasuda, H.2
-
32
-
-
0037205454
-
Mutual dependence of MDM2 and MDMX in their functional inactivation of p53
-
Gu J, Kawai H, Nie L, Kitao H, Wiederschain D, Jochemsen AG et al. Mutual dependence of MDM2 and MDMX in their functional inactivation of p53. J Biol Chem 2002; 277: 19251-19254.
-
(2002)
J Biol Chem
, vol.277
, pp. 19251-19254
-
-
Gu, J.1
Kawai, H.2
Nie, L.3
Kitao, H.4
Wiederschain, D.5
Jochemsen, A.G.6
-
33
-
-
65549120715
-
Modes of p53 regulation
-
Kruse JP, Gu W. Modes of p53 regulation. Cell 2009; 137: 609-622.
-
(2009)
Cell
, vol.137
, pp. 609-622
-
-
Kruse, J.P.1
Gu, W.2
-
34
-
-
0037377060
-
Ubiquitination, phosphorylation and acetylation: The molecular basis for p53 regulation
-
Brooks CL, Gu W. Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation. Curr Opin Cell Biol 2003; 15: 164-171.
-
(2003)
Curr Opin Cell Biol
, vol.15
, pp. 164-171
-
-
Brooks, C.L.1
Gu, W.2
-
35
-
-
0030881590
-
Differential regulation of the p21/WAF-1 and mdm2 genes after high-dose UV irradiation: P53-dependent and p53-independent regulation of the mdm2 gene
-
Wu L, Levine AJ. Differential regulation of the p21/WAF-1 and mdm2 genes after high-dose UV irradiation: p53-dependent and p53-independent regulation of the mdm2 gene. Molecular medicine 1997; 3: 441-451.
-
(1997)
Molecular Medicine
, vol.3
, pp. 441-451
-
-
Wu, L.1
Levine, A.J.2
-
36
-
-
0030748598
-
Differential activation of p53 targets in cells treated with ultraviolet radiation that undergo both apoptosis and growth arrest
-
Reinke V, Lozano G. Differential activation of p53 targets in cells treated with ultraviolet radiation that undergo both apoptosis and growth arrest. Radiation research 1997; 148: 115-122.
-
(1997)
Radiation Research
, vol.148
, pp. 115-122
-
-
Reinke, V.1
Lozano, G.2
-
37
-
-
58749094954
-
Targeting Mdm2 and Mdmx in cancer therapy: Better living through medicinal chemistry?
-
Wade M, Wahl GM. Targeting Mdm2 and Mdmx in cancer therapy: better living through medicinal chemistry? Mol Cancer Res 2009; 7: 1-11.
-
(2009)
Mol Cancer Res
, vol.7
, pp. 1-11
-
-
Wade, M.1
Wahl, G.M.2
-
38
-
-
38949093780
-
MDMX promotes proteasomal turnover of p21 at G1 and early S phases independently of, but in cooperation with, MDM2
-
Jin Y, Zeng SX, Sun X-X, Lee H, Blattner C, Xiao Z et al. MDMX promotes proteasomal turnover of p21 at G1 and early S phases independently of, but in cooperation with, MDM2. Mol Cell Biol 2008; 28: 1218-1229.
-
(2008)
Mol Cell Biol
, vol.28
, pp. 1218-1229
-
-
Jin, Y.1
Zeng, S.X.2
Sun, X.-X.3
Lee, H.4
Blattner, C.5
Xiao, Z.6
-
39
-
-
33644917708
-
Effects of MdmX on Mdm2-mediated downregulation of pRB
-
Uchida C, Miwa S, Isobe T, Kitagawa K, Hattori T, Oda T et al. Effects of MdmX on Mdm2-mediated downregulation of pRB. FEBS Lett 2006; 580: 1753-1758.
-
(2006)
FEBS Lett
, vol.580
, pp. 1753-1758
-
-
Uchida, C.1
Miwa, S.2
Isobe, T.3
Kitagawa, K.4
Hattori, T.5
Oda, T.6
-
41
-
-
33646794425
-
Keeping p53 in check: Essential and synergistic functions of Mdm2 and Mdm4
-
Marine J-C, Francoz S, Maetens M, Wahl G, Toledo F, Lozano G. Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4. Cell Death Differ 2006; 13: 927-934.
-
(2006)
Cell Death Differ
, vol.13
, pp. 927-934
-
-
Marine, J.-C.1
Francoz, S.2
Maetens, M.3
Wahl, G.4
Toledo, F.5
Lozano, G.6
-
42
-
-
33750590095
-
Inactivation of the p53 pathway in retinoblastoma
-
Laurie NA, Donovan SL, Shih C-S, Zhang J, Mills N, Fuller C et al. Inactivation of the p53 pathway in retinoblastoma. Nature 2006; 444: 61-66.
-
(2006)
Nature
, vol.444
, pp. 61-66
-
-
Laurie, N.A.1
Donovan, S.L.2
Shih, C.-S.3
Zhang, J.4
Mills, N.5
Fuller, C.6
-
43
-
-
0030598937
-
Loss of heterozygosity on chromosome 17 and mutation of the p53 gene in retinoblastoma
-
Kato MV, Shimizu T, Ishizaki K, Kaneko A, Yandell DW, Toguchida J et al. Loss of heterozygosity on chromosome 17 and mutation of the p53 gene in retinoblastoma. Cancer Lett 1996; 106: 75-82.
-
(1996)
Cancer Lett
, vol.106
, pp. 75-82
-
-
Kato, M.V.1
Shimizu, T.2
Ishizaki, K.3
Kaneko, A.4
Yandell, D.W.5
Toguchida, J.6
-
44
-
-
0028098165
-
Molecular abnormalities of mdm2 and p53 genes in adult soft tissue sarcomas
-
Cordon-Cardo C, Latres E, Drobnjak M, Oliva MR, Pollack D, Woodruff JM et al. Molecular abnormalities of mdm2 and p53 genes in adult soft tissue sarcomas. Cancer Res 1994; 54: 794-799.
-
(1994)
Cancer Res
, vol.54
, pp. 794-799
-
-
Cordon-Cardo, C.1
Latres, E.2
Drobnjak, M.3
Oliva, M.R.4
Pollack, D.5
Woodruff, J.M.6
-
45
-
-
79955809584
-
Rare MDM4 gene amplification in colorectal cancer: The principle of a mutually exclusive relationship between MDM alteration and TP53 inactivation is not applicable
-
Suda T, Yoshihara M, Nakamura Y, Sekiguchi H, Godai T-I, Sugano N et al. Rare MDM4 gene amplification in colorectal cancer: The principle of a mutually exclusive relationship between MDM alteration and TP53 inactivation is not applicable. Oncol Rep 2011; 26: 49-54.
-
(2011)
Oncol Rep
, vol.26
, pp. 49-54
-
-
Suda, T.1
Yoshihara, M.2
Nakamura, Y.3
Sekiguchi, H.4
Godai, T.-I.5
Sugano, N.6
-
46
-
-
0028081261
-
The MDM2 oncogene overexpression in chronic lymphocytic leukemia and low-grade lymphoma of B-cell origin
-
Watanabe T, Hotta T, Ichikawa A, Kinoshita T, Nagai H, Uchida T et al. The MDM2 oncogene overexpression in chronic lymphocytic leukemia and low-grade lymphoma of B-cell origin. Blood 1994; 84: 3158-3165.
-
(1994)
Blood
, vol.84
, pp. 3158-3165
-
-
Watanabe, T.1
Hotta, T.2
Ichikawa, A.3
Kinoshita, T.4
Nagai, H.5
Uchida, T.6
-
47
-
-
0029028354
-
Interaction between the retinoblastoma protein and the oncoprotein MDM2
-
Xiao ZX, Chen J, Levine AJ, Modjtahedi N, Xing J, Sellers WR et al. Interaction between the retinoblastoma protein and the oncoprotein MDM2. Nature 1995; 375: 694-698.
-
(1995)
Nature
, vol.375
, pp. 694-698
-
-
Xiao, Z.X.1
Chen, J.2
Levine, A.J.3
Modjtahedi, N.4
Xing, J.5
Sellers, W.R.6
|