메뉴 건너뛰기




Volumn 3, Issue 2, 1999, Pages 181-193

RB regulates the stability and the apoptotic function of p53 via MDM2

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN MDM2; PROTEIN P53; RETINOBLASTOMA PROTEIN;

EID: 0033082231     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(00)80309-3     Document Type: Article
Times cited : (244)

References (40)
  • 2
    • 0029171789 scopus 로고
    • Regulation of transcription functions of the p53 tumor suppressor by the mdm2 oncogene
    • Chen, J., Lin, J., and Levine, A.J. (1995). Regulation of transcription functions of the p53 tumor suppressor by the mdm2 oncogene. Mol. Med. 1, 142-152.
    • (1995) Mol. Med. , vol.1 , pp. 142-152
    • Chen, J.1    Lin, J.2    Levine, A.J.3
  • 3
    • 0032578795 scopus 로고    scopus 로고
    • pRb phosphorylation mutants reveal role of pRb in regulating S phase completion by a mechanism independent of E2F
    • Chew, Y.P., Ellis, M., Wilkie, S., and Mittnacht, S. (1998). pRb phosphorylation mutants reveal role of pRb in regulating S phase completion by a mechanism independent of E2F. Oncogenes 17, 2177-2186.
    • (1998) Oncogenes , vol.17 , pp. 2177-2186
    • Chew, Y.P.1    Ellis, M.2    Wilkie, S.3    Mittnacht, S.4
  • 4
    • 0029762617 scopus 로고    scopus 로고
    • Domains A and B in the Rb pocket interact to form a transcriptional repressor motif
    • Chow, K.N.B., and Dean, D.C. (1996). Domains A and B in the Rb pocket interact to form a transcriptional repressor motif. Mol. Cell. Biol. 16, 7173-7181.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 7173-7181
    • Chow, K.N.B.1    Dean, D.C.2
  • 6
    • 0028131554 scopus 로고
    • Transcription activation by p53 correlates with suppression of growth but not transformation
    • Crook, T., Marston, N.J., Sara, E.A., and Vousden, K.H. (1994). Transcription activation by p53 correlates with suppression of growth but not transformation. Cell 79, 817-827.
    • (1994) Cell , vol.79 , pp. 817-827
    • Crook, T.1    Marston, N.J.2    Sara, E.A.3    Vousden, K.H.4
  • 7
    • 0030947356 scopus 로고    scopus 로고
    • High level expression of p27kip1 and cyclin D1 in some proliferating breast tumor cells: Inverse correlation with the degree of malignancy in human breast and colorectal cancers
    • Fredersdorf, S., Burns, J., Milne, A.M., Packham, G., Fallis, L., Gillett, C.E., Royds, J.A., Peston, D., Hall, P.A., Hanby, A.M., et al. (1997). High level expression of p27kip1 and cyclin D1 in some proliferating breast tumor cells: Inverse correlation with the degree of malignancy in human breast and colorectal cancers. Proc. Natl. Acad. Sci. USA 94, 6380-6385.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 6380-6385
    • Fredersdorf, S.1    Burns, J.2    Milne, A.M.3    Packham, G.4    Fallis, L.5    Gillett, C.E.6    Royds, J.A.7    Peston, D.8    Hall, P.A.9    Hanby, A.M.10
  • 8
    • 0028986133 scopus 로고
    • p53 phosphorylation mutants retain transcription activity
    • Fuchs, B., O'Connor, D., Fallis, L., Sheidtmann, K.H., and Lu, X. (1995). p53 phosphorylation mutants retain transcription activity. Oncogene 10, 789-793.
    • (1995) Oncogene , vol.10 , pp. 789-793
    • Fuchs, B.1    O'Connor, D.2    Fallis, L.3    Sheidtmann, K.H.4    Lu, X.5
  • 10
    • 0029985647 scopus 로고    scopus 로고
    • Cell type-specific inhibition of p53-mediated apoptosis by mdm2
    • Haupt, Y., Barak, Y., and Oren, M. (1996). Cell type-specific inhibition of p53-mediated apoptosis by mdm2. EMBO J. 15, 1596-1606.
    • (1996) EMBO J. , vol.15 , pp. 1596-1606
    • Haupt, Y.1    Barak, Y.2    Oren, M.3
  • 11
    • 0029820095 scopus 로고    scopus 로고
    • The retinoblastoma gene product protects E2F-1 from degradation by the ubiquitin-proteosome pathway
    • Hofmann, F., Martelli, F., Livingston, D.M., and Wang, Z. (1996). The retinoblastoma gene product protects E2F-1 from degradation by the ubiquitin-proteosome pathway. Genes Dev. 10, 2949-2959.
    • (1996) Genes Dev. , vol.10 , pp. 2949-2959
    • Hofmann, F.1    Martelli, F.2    Livingston, D.M.3    Wang, Z.4
  • 12
    • 0032537851 scopus 로고    scopus 로고
    • E2F-1-induced p53-independent apoptosis in transgenic mice
    • Holmberg, C., Helin, K., Sehested, M., and Karlstrom, O. (1998). E2F-1-induced p53-independent apoptosis in transgenic mice. Oncogene 17, 143-155.
    • (1998) Oncogene , vol.17 , pp. 143-155
    • Holmberg, C.1    Helin, K.2    Sehested, M.3    Karlstrom, O.4
  • 13
    • 0030850752 scopus 로고    scopus 로고
    • E2F1 induced apoptosis requires DNA binding but not transcriptional activity and is inhibited by the retinoblastoma protein through direct interaction
    • Hsieh, J.-K., Fredersdorf, S., Kauzarides, T., Martin, K., and Lu, X. (1997). E2F1 induced apoptosis requires DNA binding but not transcriptional activity and is inhibited by the retinoblastoma protein through direct interaction. Genes Dev. 11, 1840-1852.
    • (1997) Genes Dev. , vol.11 , pp. 1840-1852
    • Hsieh, J.-K.1    Fredersdorf, S.2    Kauzarides, T.3    Martin, K.4    Lu, X.5
  • 14
    • 0029027040 scopus 로고
    • Two distinct signaling pathways activate the latent DNA binding function of p53 in a casein kinase II-independent manner
    • Hupp, T.R., and Lane, D.P. (1995). Two distinct signaling pathways activate the latent DNA binding function of p53 in a casein kinase II-independent manner. J. Biol. Chem. 270, 18165-18174.
    • (1995) J. Biol. Chem. , vol.270 , pp. 18165-18174
    • Hupp, T.R.1    Lane, D.P.2
  • 15
    • 0026448672 scopus 로고
    • Regulation of the specific DNA binding function of p53
    • Hupp, T.R., Meek, D.W., Midgley, C.A., and Lane, D.P. (1992). Regulation of the specific DNA binding function of p53. Cell 71, 875-886.
    • (1992) Cell , vol.71 , pp. 875-886
    • Hupp, T.R.1    Meek, D.W.2    Midgley, C.A.3    Lane, D.P.4
  • 16
    • 0030463947 scopus 로고    scopus 로고
    • The tumorigenic potential and cell growth characteristics of p53-deficient cells are equivalent in the presence or absence of Mdm2
    • Jones, S.N., Sands, A.T., Hancock, A.R., Vogel, H., Donehower, L.A., Linke, S.P., Wahl, G.M., and Bradley, A. (1996). The tumorigenic potential and cell growth characteristics of p53-deficient cells are equivalent in the presence or absence of Mdm2. Proc. Natl. Acad. Sci. USA 93, 14106-14111.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 14106-14111
    • Jones, S.N.1    Sands, A.T.2    Hancock, A.R.3    Vogel, H.4    Donehower, L.A.5    Linke, S.P.6    Wahl, G.M.7    Bradley, A.8
  • 17
    • 0028859541 scopus 로고
    • Bax-deficient mice with lymphoid hyperplasia and male germ cell death
    • Knudson, M.K., Tung, K., Tourtellotte, G., Brown, G.A.J., and Korsmmer, S.J. (1995). Bax-deficient mice with lymphoid hyperplasia and male germ cell death. Science 270, 96-98.
    • (1995) Science , vol.270 , pp. 96-98
    • Knudson, M.K.1    Tung, K.2    Tourtellotte, G.3    Brown, G.A.J.4    Korsmmer, S.J.5
  • 18
    • 0029972806 scopus 로고    scopus 로고
    • p53: Puzzle and paradigm
    • Ko, L.J., and Prives, C. (1996). p53: Puzzle and paradigm. Genes Dev. 10, 1054-1072.
    • (1996) Genes Dev. , vol.10 , pp. 1054-1072
    • Ko, L.J.1    Prives, C.2
  • 19
    • 0030965946 scopus 로고    scopus 로고
    • Regulation of p53 stability by mdm2
    • Kubbutat, M.H., Jones, S.N., and Vousden, K.H. (1997). Regulation of p53 stability by mdm2. Nature 387, 299-303.
    • (1997) Nature , vol.387 , pp. 299-303
    • Kubbutat, M.H.1    Jones, S.N.2    Vousden, K.H.3
  • 20
    • 0030941458 scopus 로고    scopus 로고
    • p53, the cellular gatekeeper for growth and division
    • Levine, A.J. (1997). p53, the cellular gatekeeper for growth and division. Cell 88, 323-331.
    • (1997) Cell , vol.88 , pp. 323-331
    • Levine, A.J.1
  • 21
    • 0029788135 scopus 로고    scopus 로고
    • Discordance between accumulated p53 protein level and its transcriptional activity in response to UV radiation
    • Lu, X., Burbidge, S.A., Griffin, S., and Smith, H.M. (1996). Discordance between accumulated p53 protein level and its transcriptional activity in response to UV radiation. Oncogene 13, 413-418.
    • (1996) Oncogene , vol.13 , pp. 413-418
    • Lu, X.1    Burbidge, S.A.2    Griffin, S.3    Smith, H.M.4
  • 22
    • 0029910628 scopus 로고    scopus 로고
    • Loss of Rb activates both p53-dependent and independent cell death pathways in the developing mouse nervous system
    • Macleod, K.F., Hu, Y., and Jacks, T. (1996). Loss of Rb activates both p53-dependent and independent cell death pathways in the developing mouse nervous system. EMBO J. 15, 6178-6188.
    • (1996) EMBO J. , vol.15 , pp. 6178-6188
    • Macleod, K.F.1    Hu, Y.2    Jacks, T.3
  • 24
    • 0031935648 scopus 로고    scopus 로고
    • Control of Rb phosphorylation
    • Mittnacht, S. (1998). Control of Rb phosphorylation. Curr. Opin. Genet. Dev. 8, 21-27.
    • (1998) Curr. Opin. Genet. Dev. , vol.8 , pp. 21-27
    • Mittnacht, S.1
  • 25
    • 0027934570 scopus 로고
    • p53-dependent apoptosis produced by Rb-deficiency in the eye
    • Morgenbesser, S.D., Williams, B.O., Jacks, T., and Depino, R.A. (1994). p53-dependent apoptosis produced by Rb-deficiency in the eye. Nature 371, 72-74.
    • (1994) Nature , vol.371 , pp. 72-74
    • Morgenbesser, S.D.1    Williams, B.O.2    Jacks, T.3    Depino, R.A.4
  • 26
    • 0029615315 scopus 로고
    • Physical and functional interactions between p53 and cell cycle co-operating transcription factors, E2F1 and DP1
    • O'Connor, D.J., Lam, E.W.-F., Griffin, S., Zhong, S., Leighton, L.C., Burbidge, S.A., and Lu, X. (1995). Physical and functional interactions between p53 and cell cycle co-operating transcription factors, E2F1 and DP1. EMBO 14, 6184-6192.
    • (1995) EMBO , vol.14 , pp. 6184-6192
    • O'Connor, D.J.1    Lam, E.W.-F.2    Griffin, S.3    Zhong, S.4    Leighton, L.C.5    Burbidge, S.A.6    Lu, X.7
  • 27
    • 0032160407 scopus 로고    scopus 로고
    • Key roles for E2F1 in signaling p53-dependent apoptosis and cell division within developing tumors
    • Pan, H., Yin, C., Dyson, N.J., Harlow, E., Yamasaki, L., and Van Dyke, T. (1998). Key roles for E2F1 in signaling p53-dependent apoptosis and cell division within developing tumors. Mol. Cell 2, 283-292.
    • (1998) Mol. Cell , vol.2 , pp. 283-292
    • Pan, H.1    Yin, C.2    Dyson, N.J.3    Harlow, E.4    Yamasaki, L.5    Van Dyke, T.6
  • 28
    • 0032475878 scopus 로고    scopus 로고
    • Signaling to p53: Breaking the mdm2-p53 circuit
    • Prives, C. (1998). Signaling to p53: Breaking the mdm2-p53 circuit. Cell 95, 5-8.
    • (1998) Cell , vol.95 , pp. 5-8
    • Prives, C.1
  • 29
    • 0030021748 scopus 로고    scopus 로고
    • Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant
    • Rowan, S., Ludwig, R.L., Haupt, Y., Bates, S., Lu, X., Oren, M., and Vousden, K.H. (1996). Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant. EMBO 15, 827-838.
    • (1996) EMBO , vol.15 , pp. 827-838
    • Rowan, S.1    Ludwig, R.L.2    Haupt, Y.3    Bates, S.4    Lu, X.5    Oren, M.6    Vousden, K.H.7
  • 30
    • 0030997647 scopus 로고    scopus 로고
    • Interleukin 1b converting enzyme-like proteases are essential for p53-mediated transcriptionally dependent apoptosis
    • Sabbatini, P., Han, J., Chiou, S.-K., Nicholson, D.W., and White, E. (1997). Interleukin 1b converting enzyme-like proteases are essential for p53-mediated transcriptionally dependent apoptosis. Cell Growth Differ. 8, 643-653.
    • (1997) Cell Growth Differ. , vol.8 , pp. 643-653
    • Sabbatini, P.1    Han, J.2    Chiou, S.-K.3    Nicholson, D.W.4    White, E.5
  • 31
    • 0029849620 scopus 로고    scopus 로고
    • Cancer cell cycle
    • Sherr, C.J. (1996). Cancer cell cycle. Science 274, 1672-1677.
    • (1996) Science , vol.274 , pp. 1672-1677
    • Sherr, C.J.1
  • 32
    • 0030860911 scopus 로고    scopus 로고
    • Repression of p53-mediated transcription by MDM2: A dual mechanism
    • Thut, C., Goodrich, J.A., and Tjian, R. (1997). Repression of p53-mediated transcription by MDM2: A dual mechanism. Genes Dev. 11, 1974-1986.
    • (1997) Genes Dev. , vol.11 , pp. 1974-1986
    • Thut, C.1    Goodrich, J.A.2    Tjian, R.3
  • 33
    • 0032159103 scopus 로고    scopus 로고
    • Mutation of E2f-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos
    • Tsai, K.Y., Hu, Y., Macleod, K.F., Crowley, D., Yamasaki, L., and Jacks, T. (1998). Mutation of E2f-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos. Mol. Cell 2, 293-304.
    • (1998) Mol. Cell , vol.2 , pp. 293-304
    • Tsai, K.Y.1    Hu, Y.2    Macleod, K.F.3    Crowley, D.4    Yamasaki, L.5    Jacks, T.6
  • 34
    • 0029033861 scopus 로고
    • The retinoblastoma protein and cell cycle control
    • Weinberg, R.A. (1995). The retinoblastoma protein and cell cycle control. Cell 81, 323-330.
    • (1995) Cell , vol.81 , pp. 323-330
    • Weinberg, R.A.1
  • 35
    • 0029043782 scopus 로고
    • Mechanism of active transcriptional repression by the retinoblastoma protein
    • Weintraub, S.J., Chow, K.N.B., Luo, R.X., Zhang, S., He, S., and Dean, D.C. (1995). Mechanism of active transcriptional repression by the retinoblastoma protein. Nature 375, 812-815.
    • (1995) Nature , vol.375 , pp. 812-815
    • Weintraub, S.J.1    Chow, K.N.B.2    Luo, R.X.3    Zhang, S.4    He, S.5    Dean, D.C.6
  • 36
    • 0027429964 scopus 로고
    • A c-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle
    • Welch, P.J., and Wang, J.Y.J. (1993). A c-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle. Cell 75, 779-790.
    • (1993) Cell , vol.75 , pp. 779-790
    • Welch, P.J.1    Wang, J.Y.J.2
  • 37
    • 0028222124 scopus 로고
    • p53 and E2F-1 cooperate to mediate apoptosis
    • Wu, X., and Levine, A.J. (1994). p53 and E2F-1 cooperate to mediate apoptosis. Proc. Natl. Acad. Sci. USA 91, 3602-3606.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 3602-3606
    • Wu, X.1    Levine, A.J.2
  • 39
    • 0028198531 scopus 로고
    • Altered retinoblastoma protein expression and prognosis in early-stage non-small-cell lung carcinoma
    • Xu, H.J., Quinlan, D.C., Davidson, A.G., Hu, S.X., Summers, C.L., and Benedict, W.F. (1994). Altered retinoblastoma protein expression and prognosis in early-stage non-small-cell lung carcinoma. J. Natl. Cancer Inst. 86, 695-699.
    • (1994) J. Natl. Cancer Inst. , vol.86 , pp. 695-699
    • Xu, H.J.1    Quinlan, D.C.2    Davidson, A.G.3    Hu, S.X.4    Summers, C.L.5    Benedict, W.F.6
  • 40
    • 0029992389 scopus 로고
    • Altered retinoblastoma and p53 protein status in non-small cell carcinoma of the lung: Potential synergistic effects on prognosis
    • Xu, H.-J., Cagle, P.T., Hu, S.-X., Li, J., and Benedict, W.F. (1995). Altered retinoblastoma and p53 protein status in non-small cell carcinoma of the lung: Potential synergistic effects on prognosis. Clin. Cancer Res. 2, 1169-1176.
    • (1995) Clin. Cancer Res. , vol.2 , pp. 1169-1176
    • Xu, H.-J.1    Cagle, P.T.2    Hu, S.-X.3    Li, J.4    Benedict, W.F.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.