The conformationally flexible S9-S10 linker region in the core domain of p53 contains a novel MDM2 binding site whose mutation increases ubiquitination of p53 in vivo

Journal of Biological Chemistry

Volumn 277, Issue 32, 2002, Pages 28446-28458

  Shimizu, Harumi ^a   Burch, Lindsay R ^a   Smith, Amanda J ^a   Dornan, David ^a   Wallace, Maura ^a   Ball, Kathryn L ^a   Hupp, Ted R ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; BIOASSAY; BIOCHEMISTRY; POLYPEPTIDES; PROTEINS; RNA;

HYPER-UBIQUITINATED; MUTATION; RIBONUCLEOPROTEIN; TUMOR SUPPRESSOR PROTEINS;

TUMORS;

ALANINE; LEUCINE; PEPTIDE; PHENYLALANINE; PROTEIN MDM2; PROTEIN P53; RNA; SERINE; SMALL NUCLEAR RIBONUCLEOPROTEIN; TUMOR SUPPRESSOR PROTEIN; LIGAND; MDM2 PROTEIN, HUMAN; NUCLEAR PROTEIN; ONCOPROTEIN; PEPTIDE LIBRARY; UBIQUITIN;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; BETA SHEET; BINDING AFFINITY; INDUCED MUTATION; NUCLEOTIDE BINDING SITE; PHAGE DISPLAY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN RNA BINDING; PROTEIN STABILITY; RNA ANALYSIS; RNA STABILITY; UBIQUITINATION; ALLELE; BINDING SITE; CELL CULTURE; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; GENETIC TRANSFECTION; HUMAN; IMMUNOHISTOCHEMISTRY; METABOLISM; MOLECULAR GENETICS; MUTATION; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; SEQUENCE HOMOLOGY; SERODIAGNOSIS; TRANSACTIVATION; TUMOR SUPPRESSOR GENE;

ALLELES; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; BINDING SITES; DOSE-RESPONSE RELATIONSHIP, DRUG; GENES, P53; HUMANS; IMMUNOHISTOCHEMISTRY; LEUCINE; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; NUCLEAR PROTEINS; PEPTIDE LIBRARY; PRECIPITIN TESTS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; SEQUENCE HOMOLOGY, AMINO ACID; SERINE; TRANS-ACTIVATION (GENETICS); TRANSFECTION; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITIN;

EID: 0037047345     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M202296200     Document Type: Article

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