Mechanisms of NLRP1-Mediated Autoinflammatory Disease in Humans and Mice

Journal of Molecular Biology

Volumn 430, Issue 2, 2018, Pages 142-152

  Yu, Chien Hsiung ^a,b   Moecking, Jonas ^c   Geyer, Matthias ^c   Masters, Seth L ^a,b  

^a WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c UNIVERSITY OF BONN   (Germany)

Author keywords

autoinflammation; caspase 1; IL 1 ; inflammasome; NLRP1

Indexed keywords

ADAPTOR PROTEIN; ADENOSINE TRIPHOSPHATE; BACTERIAL PROTEIN; INTERLEUKIN 1BETA CONVERTING ENZYME; MURAMYL DIPEPTIDE; NLRP1 PROTEIN; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR; UNCLASSIFIED DRUG; APOPTOSIS REGULATORY PROTEIN; CASPASE RECRUITMENT DOMAIN SIGNALING PROTEIN; INFLAMMASOME; INTERLEUKIN 1BETA; NALP1 PROTEIN, MOUSE; NLRP1 PROTEIN, HUMAN; PYCARD PROTEIN, HUMAN; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

AUTOINFLAMMATORY DISEASE; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; GENE MUTATION; GENETIC ASSOCIATION; GENETIC VARIABILITY; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN CLEAVAGE; PROTEIN DOMAIN; PROTEIN FUNCTION; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM; ANIMAL; AUTOIMMUNE DISEASE; CASPASE ACTIVATION AND RECRUITMENT DOMAIN; CHEMISTRY; GENETICS; IMMUNOLOGY; INFLAMMATION; MOUSE; MUTATION; PATHOLOGY; PYRIN DOMAIN;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; APOPTOSIS REGULATORY PROTEINS; AUTOIMMUNE DISEASES; CARD SIGNALING ADAPTOR PROTEINS; CASPASE 1; CASPASE ACTIVATION AND RECRUITMENT DOMAIN; HUMANS; INFLAMMASOMES; INFLAMMATION; INTERLEUKIN-1BETA; MICE; MUTATION; PYRIN DOMAIN;

EID: 85026224436     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2017.07.012     Document Type: Review

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