Susceptibility to anthrax lethal toxin-induced rat death is controlled by a single chromosome 10 locus that includes rNlrp1

PLoS Pathogens

Volumn 6, Issue 5, 2010, Pages 1-8

  Newman, Zachary L ^a   Printz, Morton P ^b   Liu, Shihui ^a   Crown, Devorah ^a   Breen, Laura ^b   Miller Randolph, Sharmina ^a   Flodman, Pamela ^c   Leppla, Stephen H ^a   Moayeri, Mahtab ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID DERIVATIVE; ANTHRAX TOXIN; INFLAMMASOME; PROTEIN NLRP1; UNCLASSIFIED DRUG; BACTERIAL ANTIGEN; BACTERIAL TOXIN; NALP1 PROTEIN, RAT; NERVE PROTEIN;

ALLELE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACILLUS ANTHRACIS; CHROMOSOME 10; CONTROLLED STUDY; CYTOLYSIS; CYTOTOXICITY; DISEASE PREDISPOSITION; FEMALE; GENE FUNCTION; GENE LOCUS; GENE SEQUENCE; GENETIC POLYMORPHISM; LETHALITY; MACROPHAGE FUNCTION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; RAT; RAT STRAIN; SEQUENCE HOMOLOGY; AMINO ACID SEQUENCE; ANIMAL; ANTHRAX; BROWN NORWAY RAT; CELL CULTURE; CHEMISTRY; CHROMOSOME; CHROMOSOME MAP; CYTOLOGY; DAHL SALT SENSITIVE RAT; DISEASE MODEL; FIBROBLAST; FISCHER 344 RAT; GENETIC PREDISPOSITION; GENETICS; IMMUNOLOGY; MACROPHAGE; METABOLISM; MICROBIOLOGY; MOLECULAR GENETICS; MORTALITY; PROTEIN TERTIARY STRUCTURE; SPONTANEOUSLY HYPERTENSIVE RAT; SPRAGUE DAWLEY RAT; WISTAR KYOTO RAT;

ANIMALIA; BACILLUS ANTHRACIS; MURINAE; MUS; RATTUS;

AMINO ACID SEQUENCE; ANIMALS; ANTHRAX; ANTIGENS, BACTERIAL; BACTERIAL TOXINS; CELLS, CULTURED; CHROMOSOME MAPPING; CHROMOSOMES, MAMMALIAN; DISEASE MODELS, ANIMAL; FEMALE; FIBROBLASTS; GENETIC PREDISPOSITION TO DISEASE; MACROPHAGES; MICE; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; PROTEIN STRUCTURE, TERTIARY; RATS; RATS, INBRED BN; RATS, INBRED DAHL; RATS, INBRED F344; RATS, INBRED SHR; RATS, INBRED WKY; RATS, SPRAGUE-DAWLEY;

EID: 77954056386     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1000906     Document Type: Article

References (41)

1. Young JA, Collier RJ (2007) Anthrax toxin: receptor-binding, internalization, pore formation, and translocation. Annu Rev Biochem 76: 243-265.
2. Moayeri M, Leppla SH (2009) Cellular and systemic effects of anthrax lethal toxin and edema toxin. Mol Aspects Med 30: 439-455.
3. Boyden ED, Dietrich WF (2006) Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin. Nat Genet 38: 240-244.
4. Martinon F, Burns K, Tschopp J (2002) The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proILbeta. Mol Cell 10: 417-426.
5. Muehlbauer SM, Evering TH, Bonuccelli G, Squires RC, Ashton AW, et al. (2007) Anthrax lethal toxin kills macrophages in a strain-specific manner by apoptosis or caspase-1-mediated necrosis. Cell Cycle 6: 758-766.
6. Fink SL, Bergsbaken T, Cookson BT (2008) Anthrax lethal toxin and Salmonella elicit the common cell death pathway of caspase-1-dependent pyroptosis via distinct mechanisms. Proc Natl Acad Sci U S A 105: 4312-4317.
7. Wickliffe KE, Leppla SH, Moayeri M (2008) Anthrax lethal toxin-induced inflammasome formation and caspase-1 activation are late events dependent on ion fluxes and the proteasome. Cell Microbiol 10: 332-343.
8. Liao KC, Mogridge J (2009) Expression of Nlrp1b inflammasome components in human fibroblasts confers susceptibility to anthrax lethal toxin. Infect Immun 77: 4455-4462.
9. Nour AM, Yeung YG, Santambrogio L, Boyden ED, Stanley ER, et al. (2009) Anthrax lethal toxin triggers the formation of a membrane-associated inflammasome complex in murine macrophages. Infect Immun 77: 1262-1271.
10. Franchi L, Eigenbrod T, Munoz-Planillo R, Nunez G (2009) The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis. Nat Immunol 10: 241-247.
11. Martinon F, Mayor A, Tschopp J (2009) The inflammasomes: guardians of the body. Annu Rev Immunol 27: 229-265.
12. Beall FA, Dalldorf FG (1966) The pathogenesis of the lethal effect of anthrax toxin in the rat. J Infect Dis 116: 377-389.
13. Moayeri M, Haines D, Young HA, Leppla SH (2003) Bacillus anthracis lethal toxin induces TNF-á-independent hypoxia-mediated toxicity in mice. J Clin Invest 112: 670-682.
14. Cui X, Moayeri M, Li Y, Li X, Haley M, et al. (2004) Lethality during continuous anthrax lethal toxin infusion is associated with circulatory shock but not inflammatory cytokine or nitric oxide release in rats. Am J Physiol Regul Integr Comp Physiol 286: R699-R709.
15. Moayeri M, Martinez NW, Wiggins J, Young HA, Leppla SH (2004) Mouse susceptibility to anthrax lethal toxin is influenced by genetic factors in addition to those controlling macrophage sensitivity. Infect Immun 72: 4439-4447.
16. Terra JK, Cote CK, France B, Jenkins AL, Bozue JA, et al. (2010) Cutting edge: Resistance to Bacillus anthracis infection mediated by a lethal toxin sensitive allele of Nalp1b/Nlrp1b. J Immunol 184: 17-20.
17. Moayeri M, Webster JI, Wiggins JF, Leppla SH, Sternberg EM (2005) Endocrine perturbation increases susceptibility of mice to anthrax lethal toxin. Infect Immun 73: 4238-4244.
18. Beall FA, Taylor MJ, Thorne CB (1962) Rapid lethal effect in rats of a third component found upon fractionating the toxin of Bacillus anthracis. J Bacteriol 83: 1274-1280.
19. Ezzell JW, Ivins BE, Leppla SH (1984) Immunoelectrophoretic analysis, toxicity, and kinetics of in vitro production of the protective antigen and lethal factor components of Bacillus anthracis toxin. Infect Immun 45: 761-767.
20. Gupta PK, Moayeri M, Crown D, Fattah RJ, Leppla SH (2008) Role of Nterminal amino acids in the potency of anthrax lethal factor. PLoS ONE 3: e3130.
21. Watson LE, Kuo SR, Katki K, Dang T, Park SK, et al. (2007) Anthrax toxins induce shock in rats by depressed cardiac ventricular function. PLoS ONE 2: e466.
22. Kuo SR, Willingham MC, Bour SH, Andreas EA, Park SK, et al. (2008) Anthrax toxin-induced shock in rats is associated with pulmonary edema and hemorrhage. Microb Pathog 44: 467-472.
23. Moayeri M, Crown D, Dorward DW, Gardner D, Ward JM, et al. (2009) The heart is an early target of anthrax lethal toxin in mice: a protective role for neuronal nitric oxide synthase (nNOS). PLoS Pathog 4: e1000456.
24. Nye SH, Wittenburg AL, Evans DL, O'connor JA, Roman RJ, et al. (2007) Rat survival to anthrax lethal toxin is likely controlled by a single gene. Pharmacogenomics J 8: 16-22.
25. Pravenec M, Klir P, Kren V, Zicha J, Kunes J (1989) An analysis of spontaneous hypertension in spontaneously hypertensive rats by means of new recombinant inbred strains. J Hypertens 7: 217-221.
26. Printz MP, Jirout M, Jaworski R, Alemayehu A, Kren V (2003) Genetic models in applied physiology. HXB/BXH rat recombinant inbred strain platform: a newly enhanced tool for cardiovascular, behavioral, and developmental genetics and genomics. J Appl Physiol 94: 2510-2522.
27. McAllister RD, Singh Y, Du Bois WD, Potter M, Boehm T, et al. (2003) Susceptibility to anthrax lethal toxin is controlled by three linked quantitative trait loci. Am J Pathol 163: 1735-1741.
28. Jirout M, Krenova D, Kren V, Breen L, Pravenec M, et al. (2003) A new framework marker-based linkage map and SDPs for the rat HXB/BXH strain set. Mamm Genome 14: 537-546.
29. Watters JW, Dewar K, Lehoczky J, Boyartchuk V, Dietrich WF (2001) Kif1C, a kinesin-like motor protein, mediates mouse macrophage resistance to anthrax lethal factor. Curr Biol 11: 1503-1511.
30. Jin Y, Mailloux CM, Gowan K, Riccardi SL, Laberge G, et al. (2007) NALP1 in vitiligo-associated multiple autoimmune disease. N Engl J Med 356: 1216-1225.
31. Taieb A (2007) NALP1 and the inflammasomes: challenging our perception of vitiligo and vitiligo-related autoimmune disorders. Pigment Cell Res 20: 260-262.
32. Magitta NF, Boe Wolff AS, Johansson S, Skinningsrud B, Lie BA, et al. (2009) A coding polymorphism in NALP1 confers risk for autoimmune Addison's disease and type 1 diabetes. Genes Immun 10: 120-124.
33. Hanna PC, Acosta D, Collier RJ (1993) On the role of macrophages in anthrax. Proc Natl Acad Sci U S A 90: 10198-10201.
34. Feldmeyer L, Keller M, Niklaus G, Hohl D, Werner S, et al. (2007) The inflammasome mediates UVB-induced activation and secretion of interleukin-1beta by keratinocytes. Curr Biol 17: 1140-1145.
35. de Rivero Vaccari JP, Lotocki G, Marcillo AE, Dietrich WD, Keane RW (2008) A molecular platform in neurons regulates inflammation after spinal cord injury. J Neurosci 28: 3404-3414.
36. Abulafia DP, de Rivero Vaccari JP, Lozano JD, Lotocki G, Keane RW, et al. (2009) Inhibition of the inflammasome complex reduces the inflammatory response after thromboembolic stroke in mice. J Cereb Blood Flow Metab 29: 534-544.
37. de Rivero Vaccari JP, Lotocki G, Alonso OF, Bramlett HM, Dietrich WD, et al. (2009) Therapeutic neutralization of the NLRP1 inflammasome reduces the innate immune response and improves histopathology after traumatic brain injury. J Cereb Blood Flow Metab 29: 1251-1261.
38. Park S, Leppla SH (2000) Optimized production and purification of Bacillus anthracis lethal factor. Protein Expr Purif 18: 293-302.
39. Varughese M, Chi A, Teixeira AV, Nicholls PJ, Keith JM, et al. (1998) Internalization of a Bacillus anthracis protective antigen-c-Myc fusion protein mediated by cell surface anti-c-Myc antibodies. Mol Med 4: 87-95.
40. Arora N, Klimpel KR, Singh Y, Leppla SH (1992) Fusions of anthrax toxin lethal factor to the ADP-ribosylation domain of Pseudomonas exotoxin A are potent cytotoxins which are translocated to the cytosol of mammalian cells. J Biol Chem 267: 15542-15548.
41. Manly KF, Cudmore RH, Jr., Meer JM (2001) Map Manager QTX, crossplatform software for genetic mapping. Mamm Genome 12: 930-932.