The biophysical characterisation and SAXS analysis of human NLRP1 uncover a new level of complexity of NLR proteins

PLoS ONE

Volumn 11, Issue 10, 2016, Pages

  Martino, Luigi ^a   Holland, Louise ^a,b   Christodoulou, Evangelos ^a   Kunzelmann, Simone ^a   Esposito, Diego ^a   Rittinger, Katrin ^a  

^a THE FRANCIS CRICK INSTITUTE   (United Kingdom)

^b Immunocore Limited   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; INFLAMMASOME; MURAMYL DIPEPTIDE; PROTEIN NLRP1; UNCLASSIFIED DRUG; APOPTOSIS REGULATORY PROTEIN; N ACETYLMURAMYLALANYL DEXTRO ISOGLUTAMINE; NLRP1 PROTEIN, HUMAN; NUCLEOTIDE; PROTEIN BINDING; RECOMBINANT PROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BIOCHEMICAL ANALYSIS; BIOPHYSICS; CALCULATION; CONTROLLED STUDY; HYDROLYSIS; NONHUMAN; NUCLEOTIDE BINDING SITE; OLIGOMERIZATION; PROTEIN CONFORMATION; PROTEIN DETERMINATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SEQUENCE ANALYSIS; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY; ANIMAL; BIOSYNTHESIS; CHEMISTRY; CIRCULAR DICHROISM; GENETICS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; ISOLATION AND PURIFICATION; METABOLISM; MOLECULAR GENETICS; MOUSE; PROTEIN TERTIARY STRUCTURE; RAT; SEQUENCE ALIGNMENT; SMALL ANGLE SCATTERING; X RAY DIFFRACTION;

ACETYLMURAMYL-ALANYL-ISOGLUTAMINE; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADENOSINE TRIPHOSPHATE; AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS REGULATORY PROTEINS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CIRCULAR DICHROISM; HUMANS; MICE; MOLECULAR SEQUENCE DATA; NUCLEOTIDES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RATS; RECOMBINANT PROTEINS; SCATTERING, SMALL ANGLE; SEQUENCE ALIGNMENT; X-RAY DIFFRACTION;

EID: 84991516778     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0164662     Document Type: Article

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