Antiulcer properties of fruits and vegetables: A mechanism based perspective

Food and Chemical Toxicology

Volumn 108, Issue , 2017, Pages 104-119

  Harsha, Choudhary ^a   Banik, Kishore ^a   Bordoloi, Devivasha ^a   Kunnumakkara, Ajaikumar B ^a  

^a INDIAN INSTITUTE OF TECHNOLOGY GUWAHATI   (India)

Author keywords

Antioxidant; Fruits; Gastric ulcer; Inflammation; Vegetables

Indexed keywords

AMOXICILLIN; CLARITHROMYCIN; EVODIA RUTAECARPA EXTRACT; FLAVONOID; PHENOL DERIVATIVE; PHENOLIC ACID; PLANT EXTRACT; REACTIVE OXYGEN METABOLITE; TANNIN DERIVATIVE; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANTIBACTERIAL ACTIVITY; ANTICHOLINERGIC EFFECT; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ANTISECRETORY ACTIVITY; ANTIULCER ACTIVITY; CELL PROTECTION; CRANBERRY JUICE; DIETARY INTAKE; DRUG ACTIVITY; FRUIT; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HUMAN; INTESTINE MOTILITY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; OXIDATIVE STRESS; PHYTOCHEMISTRY; REVIEW; SIGNAL TRANSDUCTION; STOMACH ACID SECRETION; STOMACH ULCER; TETRADIUM RUTICARPUM; VEGETABLE; ANIMAL; DIET;

ANIMALS; DIET; FRUIT; HUMANS; STOMACH ULCER; VEGETABLES;

EID: 85026196120     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2017.07.023     Document Type: Review

References (201)

1. Adão, C.R., da Silva, B.P., Parente, J.P., A new steroidal saponin with antiinflammatory and antiulcerogenic properties from the bulbs of Allium ampeloprasum var. porrum. Fitoterapia 82 (2011), 1175–1180.
2. Adeniyi, B.A., Anyiam, F.M., In vitro anti-Helicobacter pylori potential of methanol extract of Allium ascalonicum Linn. (Liliaceae) leaf: susceptibility and effect on urease activity. Phytother. Res. 18 (2004), 358–361.
3. Aguwa, C.N., Nwako, S.O., Preliminary studies on the root extracts of Nauclea latifolia Smith, for anti-ulcer properties. Niger. J. Pharm. Sci. 4 (1998), 16–23.
4. Ajaikumar, K.B., Asheef, M., Babu, B.H., Padikkala, J., The inhibition of gastric mucosal injury by Punicagranatum L. (pomegranate) methanolic extract. J. Ethnopharmacol. 4 (2005), 171–176.
5. Akhtar, A.H., Ahmad, K.U., Anti-ulcerogenic evaluation of the methanolic extracts of some indigenous medicinal plants of Pakistan in aspirin-ulcerated rats. J. Ethnopharmacol. 46 (1995), 1–6.
6. Al Batran, R., Al-Bayaty, F., Jamil Al-Obaidi, M.M., Abdualkader, A.M., Hadi, H.A., Ali, H.M., Abdulla, M.A., In vivo antioxidant and antiulcer activity of Parkia speciosa ethanolic leaf extract against ethanol-induced gastric ulcer in rats. PLoS One, 8, 2013, e64751.
7. Al-Howiriny, T., Alsheikh, A., Alqasoumi, S., Al-Yahya, M., ElTahir, K., Rafatullah, S., Gastric antiulcer, antisecretory and cytoprotective properties of celery (Apium graveolens) in rats. Pharm. Biol. 48 (2010), 786–793.
8. Al-Qarawi, A.A., Abdel-Rahman, H., Ali, B.H., Mousa, H.M., El-Mougy, S.A., The ameliorative effect of dates (Phoenix dactylifera L.) on ethanol-induced gastric ulcer in rats. J. Ethnopharmacol. 98 (2005), 313–317.
9. Al-Rehaily, A.J., Al-Howiriny, T.A., Al-Sohaibani, M.O., Rafatullah, S., Gastroprotective effects of ‘Amla’ Emblica officinalis on in vivo test models in rats. Phytomedicine 9 (2002), 515–522.
10. Alam, S., Asad, M., Asdaq, S.M., Prasad, V.S., Antiulcer activity of methanolic extract of Momordica charantia L. in rats. J. Ethnopharmacol. 123 (2009), 464–469.
11. Alam, M.S., Alam, M.A., Ahmad, S., Najmi, A.K., Asif, M., Jahangir, T., Protective effects of Punica granatum in experimentally-induced gastric ulcers. Toxicol. Mech. Methods 20 (2010), 572–578.
12. Alqasoumi, S., Al-Sohaibani, M., Al-Howiriny, T., Al-Yahya, M., Rafatullah, S., Rocket “Eruca sativa”: a salad herb with potential gastric anti-ulcer activity. World J. Gastroenterol. 15 (2009), 1958–1965.
13. Alvarez-Suarez, J.M., Dekanski, D., Ristić, S., Radonjić, N.V., Petronijević, N.D., Giampieri, F., Astolfi, P., González-Paramás, A.M., Santos-Buelga, C., Tulipani, S., Quiles, J.L., Mezzetti, B., Battino, M., Strawberry polyphenols attenuate ethanol-induced gastric lesions in ratsby activation of antioxidant enzymes and attenuation of MDA increase. PLoS One, 6, 2011, e25878.
14. Arawwawala, L.D., Thabrew, M.I., Arambewela, L.S., Gastroprotective activity of Trichosanthes cucumerina in rats. J. Ethnopharmacol. 127 (2010), 750–754.
15. Baananou, S., Bouftira, I., Mahmoud, A., Boukef, K., Marongiu, B., Boughattas, N.A., Antiulcerogenic and antibacterial activities of Apiumgraveolens essential oil and extract. Nat. Prod. Res. 27 (2013), 1075–1083.
16. Badanavalu Chandrashekar, K., Dharmesh, S.M., Gastro protective and H(+)K(+)-ATPase/H. pylori inhibitory properties of pectic polysaccharides from potato. Int. J. Biol. Macromol. 84 (2016), 385–393.
17. Bala, I., Bhardwaj, V., Hariharan, S., Kumar, M.N., Analytical methods for assay of Ellagic acid and its solubility studies. J. Pharmaceut. Biomed. Anal. 40 (2006), 206–210.
18. Bandyopadhyay, S.K., Pakrashi, S.C., Pakrashi, A., The role of antioxidant activity of Phyllanthus emblica fruits on prevention from indomethacin induced gastric ulcer. J. Ethnopharmacol. 70 (2000), 171–176.
19. Banerjee, D., Maity, B., Bauri, A.K., Bandyopadhyay, S.K., Chattopadhyay, S., Gastroprotective properties of Myristica malabarica against indometacin-induced stomach ulceration: aOzbakişDengizmechanistic exploration. J. Pharm. Pharmacol. 59 (2007), 1555–1565.
20. Banerjee, D., Bauri, A.K., Guha, R.K., Bandyopadhyay, S.K., Chattopadhyay, S., Healing properties of malabaricone B and malabaricone C, against indomethacin-induced gastric ulceration and mechanism of action. Eur. J. Pharmacol. 578 (2008), 300–312.
21. Bansal, V.K., Goel, R.K., Gastroprotective effect of Acacia nilotica young seedless pod extract: role of polyphenolic constituents. Asian Pac J. Trop. Med. 5 (2012), 523–528.
22. Basu, S., Srivastava, P.K., Heat shock proteins: the fountain head of innate and adaptive immune responses. Cell Stress Chaperon, 5, 2000, 443.
23. Berté, P.E., da Silva Lopes, J., Comandulli, N.G., Rangel, D.W., Monache, F.D., Filho, V.C., Niero, R., de Andrade, S.F., Evaluation of the gastroprotective activity of the extracts, fractions, and pure compounds obtained from aerial parts of Rubus imperialis in different experimental models. Naunyn Schmiedeb. Arch. Pharmacol. 387 (2014), 313–319.
24. Best, R., Lewis, D.A., Nasser, N., The anti-ulcerogenic activity of the unripe plantain banana (Musa species). Br. J. Pharmacol. 82 (1984), 107–116.
25. Bhatnagar, M., Sisodia, S.S., Antisecretory and antiulcer activity of Asparagus racemosus Willd. against indomethacin plus phyloric ligation-induced gastric ulcer in rats. J. Herb. Pharmacother. 6 (2006), 13–20.
26. Bhatnagar, M., Sisodia, S.S., Bhatnagar, R., Antiulcer and antioxidant activity of Asparagus racemosus Willd and Withania somnifera Dunal in rats. Ann. N. Y. Acad. Sci. 1056 (2005), 261–278.
27. Bode, C., Bode, J.C., Alcohol's role in gastrointestinal tract disorders. Alcohol Health Res. World 21 (1997), 76–83.
28. Bonamin, F., Moraes, T.M., Dos Santos, R.C., Kushima, H., Faria, F.M., Silva, M.A., Junior, I.V., Nogueira, L., Bauab, T.M., Souza Brito, A.R., da Rocha, L.R., Hiruma-Lima, C.A., The effect of a minor constituent of essential oil from Citrus aurantium: the role of β-myrcene in preventing peptic ulcer disease. ChemBiol Interact. 5 (2014), 11–19.
29. Boparai, V., Rajagopalan, J., Triadafilopoulos, G., Guide to the Use of Proton Pump Inhibitors in Adult Patients. 2008.
30. Boyacioglu, M., Kum, C., Sekkin, S., Yalinkilinc, H.S., Avci, H., Epikmen, E.T., Karademir, U., The effects of lycopene on DNA damage and oxidative stress on indomethacin-induced gastric ulcer in rats. Clin. Nutr. 35 (2016), 428–435.
31. Brzozowski, T., Konturek, P.C., Konturek, S.J., Brzozowska, I., Pawlik, T., Role of prostaglandins in gastroprotection and gastric adaptation. J. Physiol. Pharmacol. 5 (2005), 33–55.
32. Burger, O., Weiss, E., Sharon, N., Tabak, M., Neeman, I., Ofek, I., Inhibition of Helicobacter pylori adhesion to human gastric mucus by a high-molecular-weight constituent of cranberry juice. Crit. Rev. Food Sci. Nutr. 42:3 Suppl (2002), 279–284.
33. Carvalho, C.A., Fernandes, K.M., Matta, S.L., Silva, M.B., Oliveira, L.L., Fonseca, C.C., Evaluation of antiulcerogenic activity of aqueous extract of Brassica oleracea var. capitata (cabbage) on Wistar rat gastric ulceration. Arq. Gastroenterol. 48 (2011), 276–282.
34. Chandra, P., Kishore, K., Ghosh, A.K., Assessment of antisecretory, Gastroprotective,and in-vitro antacid potential of Daucus carota in experimental rats. Osong Public Health Res. Perspect. 6 (2015), 329–335.
35. Chatterjee, A., Chattopadhyay, S., Bandyopadhyay, S.K., Biphasic effect of Phyllanthus emblica L. extract on NSAID-induced ulcer: an antioxidative trail weaved with immunomodulatory effect. Evid. Based Complement. Altern. Med., 2011, 2011, 146808.
36. Chatterjee, A., Chatterjee, S., Biswas, A., Bhattacharya, S., Chattopadhyay, S., Bandyopadhyay, S.K., Gallic acid enriched fraction of Phyllanthus emblica potentiates Indomethacin-induced gastric ulcer healing via eNOS-dependent pathway. Evid. Based Complement. Altern. Med., 2012, 2012, 487380.
37. Chaudière, J., Ferrari-Iliou, R., Intracellular antioxidants: from chemical to biochemical mechanisms. Food Chem. Toxicol. 37 (1999), 949–962.
38. CHENEY, G., Rapid healing of peptic ulcers in patients receiving fresh cabbage juice. Calif. Med. 70 (1949), 10–15.
39. Chioma, A., Obiora, A., Chukwuemeka, U., Does the African garden egg offer protection against experimentally induced ulcers?. 2011 Feb Asian Pac J. Trop. Med. 4:2 (2011), 163–166, 10.1016/S1995-7645(11)60061-8 PubMed PMID: 21771445.
40. Choi, K.S., Kim, E.H., Hong, H., Ock, C.Y., Lee, J.S., Kim, J.H., Hahm, K.B., Attenuation of cysteamine-induced duodenal ulcer with Cochinchina momordica seed extract through inhibiting cytoplasmic phospholipase A2/5-lipoxygenase and activating γ-glutamylcysteine synthetase. J. Gastroenterol. Hepatol. 27:Suppl 3 (2012), 13–22.
41. Choi, Y.J., Kim, N., Lee, J.Y., Nam, R.H., Chang, H., Seo, J.H., Kang, K.K., Kim, H.J., Choi, Y.J., Lee, H.S., Lee, D.H., Protective effects of garlic extract, PMK-S005, against nonsteroidal anti-inflammatory drugs-induced acute gastric damage in rats. Dig. Dis. Sci. 59 (2014), 2927–2934.
42. Chou, S.P., An examination of the alcohol consumption and peptic ulcer association—results of a national survey. Alcohol Clin. Exp. Res., 1994, 18,149–18,153.
43. Cirak, M.Y., Akyon, Y., Megraud, F., Diagnosis of Helicobacter pylori. Helicobacter 12:Suppl. 1 (2007), 4–9.
44. Coelho, R.G., Gonzalez, F.G., Sannomiya, M., Di Stasi, L.C., Vilegas, W., Gastric anti-ulcer activity of leaf fractions obtained of polar extract from Wilbrandia ebracteata in mice. Nat. Prod. Res. 23 (2009), 51–59.
45. Coffey, R.J., Romano, M., Goldenring, J., Roles for transforming growth factor-alpha in the stomach. J. Clin. Gastroenterol. 21:Suppl 1 (1995), S36–S39.
46. Cristoni, A., Magistretti, M.J., Antiulcer and healing activity of Vaccinium myrtillus anthocyanosides. Farm. Prat. 42 (1987), 29–43.
47. D'Argenio, G., Mazzone, G., Tuccillo, C., Grandone, I., Gravina, A.G., Graziani, G., Fogliano, V., Romano, M., Apple polyphenol extracts prevent aspirin-induced damage to the rat gastric mucosa. Br. J. Nutr. 100 (2008), 1228–1236.
48. Dammann, H.G., Dau, B., Dreyer, M., Müller, P., Simon, B., H2 receptor antagonists in the therapy of peptic ulcer disease. Z Gastroenterol. 25 (1987), 136–145.
49. Das, S.K., Roy, C., The protective role of Aeglemarmelos on aspirin-induced gastro-duodenal ulceration in albino rat model: a possible involvement of antioxidants. Saudi J. Gastroenterol. 18 (2012), 188–194 Drugs, 68, 925-947.
50. Das, S.K., Vasudevan, D.M., Monitoring oxidative stress in patients with non-alcoholic and alcoholic liver diseases. Indian J. Clin. Biochem. 20 (2005), 24–28.
51. Dejana, E., Lampugnani, M.G., Giorgi, M., Gaboli, M., Federici, A.B., Ruggeri, Z.M., Marchisio, P.C., Von Willebrand factor promotes endothelial cell adhesion via an Arg-Gly-Asp-dependent mechanism. J. Cell Biol. 109 (1989), 367–375.
52. Delgado Montero, R., Flores Cortez, D., Villalobos Pacheco, E., Effect of Capsicum annum L (pucunucho, ají mono) in gastric ulcer experimentally induced in rats. Rev. Gastroenterol. Peru. 35 (2015), 141–146.
53. Devaraj, V.C., Gopala Krishna, B., Viswanatha, G.L., Satya Prasad, V., Vinay Babu, S.N., Protective effect of leaves of Raphinus sativus Linn on experimentally induced gastric ulcers in rats. Saudi Pharm. J. 19 (2011), 171–176.
54. Dharmani, P., Mishra, P.K., Maurya, R., Chauhan, V.S., Palit, G., Desmodiumgangeticum: a potent anti-ulcer agent. Indian J. Exp. Biol. 43 (2005), 517–521.
55. Dubois, R.W., Melmed, G.Y., Henning, J.M., Laine, L., Guidelines for the appropriate use of non-steroidal anti-inflammatory drugs, cyclooxygenase-2-specific inhibitors and proton pump inhibitors in patients requiring chronic anti-inflammatory therapy. Aliment. Pharmacol. Ther. 19 (2004), 197–208.
56. El-Ashmawy, N.E., Khedr, E.G., El-Bahrawy, H.A., Selim, H.M., Gastroprotective effect of garlic in indomethacin induced gastric ulcer in rats. Nutrition 32 (2016), 849–854.
57. El-Shenawy, S.M., Evaluation of some pharmacological activities of ethanol extracts of seeds, pericarp and leaves of Eugenia Jamolana in rats. Inflammopharmacology 17 (2009), 85–92.
58. Ezaki, N., Kato, M., Takizawa, N., Morimoto, S., Nonaka, G., Nishioka, I., Pharmacological studies on LinderaeumbellataeRamnusIV. Effects of condensed tannin related compounds on peptic activity and stress-induced gastric lesions in mice. Planta Med. 51 (1985), 34–38.
59. Ezike, A.C., Akah, P.A., Okoli, C.O., Ezeuchenne, N.A., Ezeugwu, S., Carica papaya (Paw-Paw) unripe fruit may be beneficial in ulcer. J. Med. Food 12 (2009), 1268–1273.
60. Fernandes, H.B., Silva, F.V., Passos, F.F., Bezerra, R.D., Chaves, M.H., Oliveira, F.A., Oliveira, R.C., Gastroprotective effect of the ethanolic extract of Parkia platycephala Benth. leaves against acute gastric lesion models in rodents. Biol. Res. 43 (2010), 451–457.
61. Ferrara, N., Vascular endothelial growth factor: basic science and clinical progress. Endocr. Rev. 25 (2004), 581–611.
62. Filocamo, A., Bisignano, C., Ferlazzo, N., Cirmi, S., Mandalari, G., Navarra, M., In vitro effect of bergamot (Citrus bergamia) juice against cagA-positive and-negative clinical isolates of Helicobacter pylori. BMC Complement. Altern. Med., 15, 2015, 256.
63. Fornai, Matteo, Antonioli, Luca, Colucci, Rocchina, Tuccori, Marco, Blandizzi, Corrado, Chai, Jianyuan, (eds.) Pathophysiology of Gastric Ulcer Development and Healing: Molecular Mechanisms and Novel Therapeutic Options, Peptic Ulcer Disease, 2011 ISBN: 978-953-307-976-9, InTech.
64. Fukai, T., Ushio-Fukai, M., Superoxide dismutases: role in redox signaling, vascular function, and diseases. Antioxid. Redox Signal 15 (2011), 1583–1606.
65. Funk, C.D., Prostaglandins and leukotrienes: advances in eicosanoid biology. Science 294 (2001), 1871–1875.
66. Galati, E.M., Mondello, M.R., Giuffrida, D., Dugo, G., Miceli, N., Pergolizzi, S., Taviano, M.F., Chemical characterization and biological effects of Sicilian Opuntia ficus indica (L.) mill. Fruit juice: antioxidant and antiulcerogenic activity. J. Agric. Food Chem. 51 (2003), 4903–4908.
67. GBD, Mortality and Causes of Death Collaborators. Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet 385:9963 (2013), 117–171 2015 Jan 10.
68. Goel, R.K., Chakrabarti, A., Sanyal, A.K., The effect of biological variables on the anti-ulcerogenic effect of vegetable plantain banana. Planta Med. 2 (1984), 85–88.
69. Goel, R.K., Gupta, S., Shankar, R., Sanyal, A.K., Anti-ulcerogenic effect of banana powder (Musa sapientum var. paradisiaca) and its effect on mucosal resistance. J. Ethnopharmacol. 18 (1986), 33–44.
70. Goel, R.K., Sairam, K., Rao, C.V., Role of gastric antioxidant and anti-Helicobactor pylori activities in antiulcerogenic activity of plantain banana (Musa sapientum var. paradisiaca). Indian J. Exp. Biol. 39 (2001), 719–722.
71. Gomathy, G., Venkatesan, D., Palani, S., Gastroprotective potentials of the ethanolic extract of Mukia maderaspatana against indomethacin-induced gastric ulcer in rats. Nat. Prod. Res. 29 (2015), 2107–2111.
72. Gonzalez, F.G., Di Stasi, L.C., Anti-ulcerogenic and analgesic activities of the leaves of Wilbrandia ebracteata in mice. Phytomedicine 9 (2002), 125–134.
73. Grover, J.K., Adiga, G., Vats, V., Rathi, S.S., Extracts of Benincasa hispida prevent development of experimental ulcers. J. Ethnopharmacol. 78 (2001), 159–164.
74. Guilbert, J.J., The world health report 2002-reducing risks, promoting healthy life. Educ. Health (Abingdon), 16, 2003, 230.
75. Gürbüz, I., Akyüz, C., Yeşilada, E., Sener, B., Anti-ulcerogenic effect of Momordica charantia L. fruits on various ulcer models in rats. J. Ethnopharmacol. 71 (2000), 77–82.
76. Hamasaki, N., Ishii, E., Tominaga, K., Tezuka, Y., Nagaoka, T., Kadota, S., Kuroki, T., Yano, I., Highly selective antibacterial activity of novel alkyl quinolone alkaloids from a Chinese herbal medicine, Gosyuyu (Wu-Chu-Yu), against Helicobacter pylori in vitro. Microbiol. Immunol. 44 (2000), 9–15.
77. Hamauzu, Y., Inno, T., Kume, C., Irie, M., Hiramatsu, K., Antioxidant and antiulcerative properties of phenolics from Chinese quince, quince, and apple fruits. J. Agric. Food Chem. 54 (2006), 765–772.
78. Hanifa Moursi, S.A., Al-Khatib, I.M., Effect of Melia azedarach fruits on gipsing-restraint stress-induced ulcers in rats. Jpn. J. Pharmacol. 36 (1984), 527–533.
79. He, W., Zhang, Y., Wang, X., Guo, L., Han, L., Liu, E., Wang, T., Zhizhu decoction promotes gastric emptying and protects the gastric mucosa. J. Med. Food 16 (2013), 306–311.
80. Hernandez, D.E., Hancke, J.L., Wikman, G., Evaluation of the anti-ulcer and antisecretory activity of extracts of Aralia elata root and Schizandra chinensis fruit in the rat. J. Ethnopharmacol. 23 (1988), 109–114.
81. Hesse, C., Razmovski-Naumovski, V., Duke, C.C., Davies, N.M., Roufogalis, B.D., Phytopreventative effects of Gynostemma pentaphyllum against acute indomethacin-induced gastrointestinal and renal toxicity in rats. Phytother. Res. 21 (2007), 523–530.
82. Hiruma-Lima, A., Gracioso, J.S., Nunes, D.S., Souza Brito, A.R.M., Effects of an essential oil from the bark of Croton cajucara Benth on experimental gastric ulcer models in ratsand mice. J. Pharm. Pharmacol. 51 (1999), 341–346.
83. Hosseinzadeh, H., Karimi, G.R., Ameri, M., Effects of Anethum graveolens L. seed extracts on experimental gastric irritation models in mice. BMC Pharmacol., 19, 2002, 21.
84. Hummel, S.G., Fischer, A.J., Martin, S.M., Schafer, F.Q., Buettner, G.R., Nitric oxide as a cellular antioxidant: a little goes a long way. Free Radic. Biol. Med. 40:3 (2006), 501–506 1.
85. Hussain, L., Akash, M.S., Naseem, S., Rehman, K., Ahmed, K.Z., Anti-ulcerogenic effects of Salmalia malabarica in gastric ulceration–pilot study. Adv. Clin. Exp. Med. 24 (2015), 595–605.
86. Hwang, J.J., Lee, D.H., Lee, A.R., Yoon, H., Shin, C.M., Park, Y.S., Kim, N., Characteristics of gastric cancer in peptic ulcer patients with Helicobacter pylori infection. World J. Gastroenterol 21 (2015), 4954–4960.
87. Ibrahim, M., Khan, A.A., Tiwari, S.K., Habeeb, M.A., Khaja, M.N., Habibullah, C.M., Antimicrobial activity of Sapindus mukorossi and Rheum emodi extracts against H pylori: in vitro and in vivo studies. World J. Gastroenterol. 12 (2006), 7136–7142.
88. Ishida, K., Kojima, R., Tsuboi, M., Tsuda, Y., Ito, M., Effects of artichoke leaf extract on acute gastric mucosal injury in rats. Biol. Pharm. Bull. 33 (2010), 223–229.
89. Jainu, M., Devi, C.S., Antiulcerogenic and ulcer healing effects of Solanum nigrum (L.) on experimental ulcer models: possible mechanism for the inhibition of acid formation. J. Ethnopharmacol. 104 (2006), 156–163.
90. Jiang, X.W., Hu, J., Mian, F.I., A new therapeutic candidate for oral aphthous ulcer: Allicin. Med. Hypotheses 71 (2008), 897–899.
91. Jung, K., Chin, Y.W., Chung, Y.H., Park, Y.H., Yoo, H., Min, D.S., Lee, B., Kim, J., Anti-gastritis and wound healing effects of Momordicae Semen extract and its active component. Immunopharmacol. Immunotoxicol. 35 (2013), 126–132.
92. Kadry, H., Shoala, S., El Gindi, O., Sleem, A.A., Mosharrafa, S., Kassem, M., Chemical characterization of the lipophilic fraction of Livistona decipiens and Livistona chinensis fruit pulps (Palmae) and assessment of their anti-hyperlipidemic and anti-ulcer activities. Nat. Prod. Commun. 4 (2009), 265–270.
93. Kang, J.M., Kim, N., Kim, B., Kim, J.H., Lee, B.Y., Park, J.H., Lee, M.K., Lee, H.S., Jang, I.J., Kim, J.S., Jung, H.C., Song, I.S., Gastroprotective action of Cochinchina momordica seed extract is mediated by activation of CGRP and inhibition of cPLA(2)/5-LOX pathway. Dig. Dis. Sci. 54 (2009), 2549–2560.
94. Kang, J.M., Kim, N., Kim, B., Kim, J.H., Lee, B.Y., Park, J.H., Lee, M.K., Lee, H.S., Kim, J.S., Jung, H.C., Song, I.S., Enhancement of gastric ulcer healing and angiogenesis by Cochinchina Momordica seed extract in rats. J. Korean Med. Sci. 25 (2010), 875–881.
95. Khosla, P., Karan, R.S., Bhargava, V.K., Effect of garlic oil on ethanol induced gastric ulcers in rats. Phytother. Res. 18 (2004), 87–91.
96. Kidd, M., Modlin, I.M., A century of Helicobacter pylori: paradigms lost-paradigms regained. Digestion 59 (1998), 1–15.
97. Kim, S.J., Lee, H.J., Kim, B.S., Lee, D., Lee, S.J., Yoo, S.H., Chang, H.I., Antiulcer activity of anthocyanins from Rubus coreanus via association with regulation of the activity of matrix metalloproteinase-2. J. Agric. Food Chem. 59 (2011), 11786–11793.
98. Kim, S., Lee, H.G., Park, S.A., Kundu, J.K., Keum, Y.S., Cha, Y.N., Na, H.K., Surh, Y.J., Keap1 cysteine 288 as a potential target for diallyl trisulfide-induced Nrf2 activation. PLoS One, 9, 2014, e85984.
99. Konturek, P.C., Brzozowski, T., Konturek, S.J., Pajdo, R., Konturek, J.E., Kwiecień, S., Taut, A., Hahn, E.G., Apoptosis in gastric mucosa with stress-induced gastric ulcers. J. Physiology and Pharmacol. Official J. Pol. Physiological Soc., 50, 1999, 211.
100. Konturek, S.J., Konturek, P.C., Konturek, J.W., Plonka, M., Czesnikiewicz-Guzik, M., Brzozowski, T., Bielanski, W., Helicobacter pylori and its involvement in gastritis and peptic ulcer formation. J. Physiol. Pharmacol. 57:Suppl 3 (2006), 29–50.
101. Krylova, S.G., Vymyatnina, Z.K., Zueva, E.P., Amosova, E.N., Razina, T.G., Litvinenko, V.I., Effects of Cichorium intybus L. root extract on secretory activity of the stomach in health and ulcer disease. Bull. Exp. Biol. Med. 159 (2015), 638–641.
102. Kunnumakkara, A.B., Anticancer Properties of Fruits and Vegetables: A Scientific Review. 2015, World Scientific, New Jersey.
103. Kunnumakkara, A.B., Harikumar, K.B., Anand, P., Sung, B., Ahn, K.S., Lai, S., Tharakan, S., Aggarwal, B.B., Targeting inflammation for prevention of cancer by food and food factors. J. Clin. Biochem. Nutr. 43 (2008), 1–10.
104. Lai, S., Zhou, Q., Zhang, Y., Shang, J., Yu, T., Effects of pomegranate tannins on experimental gastric damages. Zhongguo Zhong Yao Za Zhi 34 (2009), 1290–1294.
105. Lakshmi, V., Singh, N., Shrivastva, S., Mishra, S.K., Dharmani, P., Mishra, V., Palit, G., Gedunin and photogedunin of Xylocarpus granatum show significant anti-secretory effects and protect the gastric mucosa of peptic ulcer in rats. Phytomedicine 17 (2010), 569–574.
106. Lakshmi, V., Mishra, V., Palit, G., A new gastroprotective effect of limonoid compounds xyloccensins x and y from xylocarpus molluccensis in rats. Nat. Prod. Bioprospect 4 (2014), 277–283.
107. Lanas, A., Role of nitric oxide in the gastrointestinal tract. Arthritis Res. Ther., 10(Suppl 2), 2008, S4.
108. Lee, J.H., Lee, S.H., Kim, Y.S., Jeong, C.S., Protective effects of neohesperidin and poncirin isolated from the fruits of Poncirus trifoliata on potential gastric disease. Phytother. Res. 23 (2009), 1748–1753.
109. Lemos, M., Santin, J.R., Júnior, L.C., Niero, R., Andrade, S.F., Gastroprotective activity of hydroalcoholic extract obtained from the leaves of Brassica oleracea var. acephala DC in different animal models. J. Ethnopharmacol. 138 (2011), 503–507.
110. Levenstein, S., Stress and peptic ulcer: life beyond helicobacter. Br. Med. J. 316 (1998), 538–541.
111. Lewis, D.A., Fields, W.N., Shaw, G.P., A natural flavonoid present in unripe plantain banana pulp (Musa sapientum L. var. paradisiaca) protects the gastric mucosa from aspirin-induced erosions. J. Ethnopharmacol. 65 (1999), 283–288.
112. Li, M.K., Sung, J.J., Woo, K.S., Sanderson, J., Leung, N.W., Yu, L.M., Tsui, C.P., Chung, S.C., Leung, F.W., Somatostatin reduces gastric mucosal blood flow in patients with portal hypertensive gastropathy: a randomized, double-blind crossover study. Dig. Dis. Sci. 41 (1996), 2440–2446.
113. Li, N.S., Luo, X.J., Dai, Z., Liu, B., Zhang, Y.S., Yang, Z.C., Peng, J., Beneficial effects of capsiate on ethanol-induced mucosal injury in ratsare related to stimulation of calcitonin gene-related Peptide release. Planta Med. 78 (2012), 24–30.
114. Lim, J.H., Kim, J.H., Kim, N., Lee, B.H., Seo, P.J., Kang, J.M., Jo, S.Y., Park, J.H., Nam, R.H., Chang, H., Kwon, J.W., Lee, D.H., Gastroprotective effect of Cochinchina momordica seed extract in nonsteroidal anti-inflammatory drug-induced acute gastric damage in a rat model. Gut Liver 8 (2014), 49–57.
115. Lima, Z.P., Severi, J.A., Pellizzon, C.H., Brito, A.R., Solis, P.N., Cáceres, A., Girón, L.M., Vilegas, W., Hiruma-Lima, C.A., Can the aqueous decoction of mango flowers be used as an antiulcer agent?. J. Ethnopharmacol. 106 (2006), 29–37.
116. Livingston Raja, N.R., Sundar, K., Psidium guajava Linn confers gastro protective effects on rats. Eur. Rev. Med. Pharmacol. Sci. 16 (2012), 151–156.
117. Mahendran, P., Vanisree, A.J., Shyamala Devi, C.S., The antiulcer activity of Garcinia cambogia extract against indomethacin-induced gastric ulcer in rats. Phytother Res. 16 (2002), 80–83.
118. Maity, B., Banerjee, D., Bandyopadhyay, S.K., Chattopadhyay, S., Myristica malabarica heals stomach ulceration by increasing prostaglandin synthesis and angiogenesis. Planta Med. 74 (2008), 1774–1778.
119. Marshall, B.J., Armstrong, J.A., McGechie, D.B., Glancy, R.J., Attempt to fulfil Koch's postulates for pyloric campylobacter. Med. J. Aust. 142 (1985), 436–439.
120. Martel-Pelletier, J., Lajeunesse, D., Reboul, P., Pelletier, J.P., Therapeutic role of dual inhibitors of 5-LOX and COX, selective and non-selective non-steroidal anti-inflammatory drugs. Ann. Rheum. Dis. 62 (2003), 501–509.
121. Martins, D.T., Lima, J.C., Rao, V.S., The acetone soluble fraction from bark extract of Stryphnodendron adstringens (Mart.) coville inhibits gastric acid secretion and experimental gastric ulceration in rats. Phytother. Res. 16 (2002), 427–431.
122. Matsumoto, M., Hara, H., Chiji, H., Kasai, T., Gastroprotective effect of red pigments in black chokeberry fruit (Aronia melanocarpa Elliot) on acute gastric hemorrhagic lesions in rats. J. Agric. Food Chem. 52 (2004), 2226–2229.
123. Mayer, M.P., Bukau, B., Hsp70 chaperones: cellular functions and molecular mechanism. Cell Mol. Life Sci. 62 (2005), 670–684.
124. Megala, J., Geetha, A., Antiulcerogenic activity of hydroalcoholic fruit extract of Pithecellobium dulce in different experimental ulcer models in rats. J. Ethnopharmacol. 142 (2012), 415–421.
125. Mejia, A., Kraft, W.K., Acid peptic diseases: pharmacological approach to treatment. Expert Rev. Clin. Pharmacol. 2 (2009), 295–314.
126. Mello, V.J., Gomes, M.T., Lemos, F.O., Delfino, J.L., Andrade, S.P., Lopes, M.T., Salas, C.E., The gastric ulcer protective and healing role of cysteine proteinases from Carica candamarcensis. Phytomedicine 15 (2008), 237–244.
127. Meyer Albiero, A.L., Aboin Sertié, J.A., Bacchi, E.M., Antiulcer activity of Sapindus saponaria L. in the rat. J. Ethnopharmacol. 82 (2002), 41–44.
128. Meyre-Silva, C., Petry, C.M., Berté, T.E., Becker, R.G., Zanatta, F., Delle-Monache, F., Cechinel-Filho, V., Andrade, S.F., Phytochemical analyses and gastroprotective effects of Eugenia umbelliflora (Myrtaceae) on experimental gastric ulcers. Nat. Prod. Commun. 4 (2009), 911–916.
129. Moghadamtousi, S.Z., Rouhollahi, E., Karimian, H., Fadaeinasab, M., Abdulla, M.A., Kadir, H.A., Gastroprotective activity of Annona muricata leaves against ethanol-induced gastric injury in ratsvia Hsp70/Bax involvement. Drug Des. devel. Ther. 8 (2014), 2099–2110.
130. Moraes, T.M., Rozza, A.L., Kushima, H., Pellizzon, C.H., Rocha, L.R., Hiruma-Lima, C.A., Healing actions of essential oils from Citrus aurantium and d-limonene in the gastric mucosa: the roles of VEGF, PCNA, and COX-2 in cell proliferation. J. Med. Food 16 (2013), 1162–1167.
131. Nam, J.H., Jung, H.J., Choi, J., Lee, K.T., Park, H.J., The anti-gastropathic and anti-rheumatic effect of niga-ichigoside F1 and 23-hydroxytormentic acid isolated from the unripe fruits of Rubus coreanus in a rat model. Biol. Pharm. Bull. 29 (2006), 967–970.
132. Nassar, M.I., Mohamed, T.K., Elshamy, A.I., El-Toumy, S.A., Abdel Lateef, A.M., Farrag, A.R., Chemical constituents and anti-ulcerogenic potential of the scales of Cynara scolymus (artichoke) heads. J. Sci. Food Agric. 93 (2013), 2494–2501.
133. Nathan, C., Inducible nitric oxide synthase: what difference does it make?. J. Clin. Invest 100 (1997), 2417–2423.
134. Niero, R., Dal Molin, M.M., Silva, S., Damian, N.S., Maia, L.O., Delle Monache, F., Cechinel Filho, V., de Andrade, S.F., Gastroprotective effects of extracts and guttiferone A isolated from Garcinia achachairu Rusby (Clusiaceae) against experimentally induced gastric lesions in mice. Naunyn Schmiedebergs Arch. Pharmacol. 385 (2012), 1103–1109.
135. Nneli, R.O., Woyike, O.A., Antiulcerogenic effects of coconut (Cocos nucifera) extract in rats. Phytother. Res. 22 (2008), 970–972.
136. Nwafor, P.A., Okwuasaba, F.K., Binda, L.G., Antidiarrhoeal and antiulcerogenic effects of methanolic extract of Asparagus pubescens root in rats. J. Ethnopharmacol. 72 (2000), 421–427.
137. O'Connor, A., Gisbert, J.P., O'Morain, C., Ladas, S., Treatment of Helicobacter pylori infection. Helicobacter 1 (2015), 54–61.
138. O'Reilly, M.S., Boehm, T., Shing, Y., Fukai, N., Vasios, G., Lane, W.S., Flynn, E., Birkhead, J.R., Olsen, B.R., Folkman, J., Endostatin: an endogenous. inhibitor of angiogenesis and tumour growth. Cell 88 (1997), 277–285.
139. Obidike, I.C., Emeje, M.O., Microencapsulation enhances the anti-ulcerogenic properties of Entada africana leaf extract. J. Ethnopharmacol. 137 (2011), 553–561.
140. Odobasic, D., Kitching, A.R., Holdsworth, S.R., Neutrophil-mediated regulation of innate and adaptive immunity: the role of myeloperoxidase. J. Immunol. Res., 2016, 2016, 2349817.
141. Oloyede, H.O., Adaja, M.C., Ajiboye, T.O., Salawu, M.O., Anti-ulcerogenic activity of aqueous extract of Carica papaya seed on indomethacin-induced peptic ulcer in male albino rats. J. Integr. Med. 13 (2015), 105–114.
142. Onasanwo, S.A., Singh, N., Saba, A.B., Oyagbemi, A.A., Oridupa, O.A., Palit, G., Anti-ulcerogenic and in vitro antioxidant activities of Lagenaria breviflora (LB) whole fruit ethanolic extract in laboratory animals. Pharmacogn. Res. 3 (2011), 2–8.
143. OzbakişDengiz, G., Gürsan, N., Effects of Momordica charantia L. (Cucurbitaceae) on indomethacin-induced ulcer model in rats. Turk. J. Gastroenterol. 16 (2005), 85–88.
144. Pakrashi, A., Pandit, S., Bandyopadhyay, S.K., Pakrashi, S.C., Antioxidant effect of Phyllanthus emblica fruits on healing of indomethacin induced gastric ulcer in rats. Indian J. Clin. Biochem. 18 (2003), 15–21.
145. Pannangpetch, P., Vuttivirojana, A., Kularbkaew, C., Tesana, S., Kongyingyoes, B., Kukongviriyapan, V., The antiulcerative effect of Thai Musa species in rats. Phytother. Res. 15 (2001), 407–410.
146. Parasher, G., Eastwood, G.L., Smoking and peptic ulcer in the Helicobacter pylori era. Eur. J. Gastroenterol. Hepatol. 12 (2000), 843–853.
147. Paturi, G., Butts, C.A., Bentley-Hewitt, K.L., McGhie, T.K., Saleh, Z.S., McLeod, A., Apple polyphenol extracts protect against aspirin-induced gastric mucosal damage in rats. Phytother Res. 28 (2014), 1846–1854.
148. Pinto, L.A., Cordeiro, K.W., Carrasco, V., Carollo, C.A., Cardoso, C.A., Argadoña, E.J., Freitas Kde, C., Antiulcerogenic activity of Carica papaya seed in rats. Naunyn Schmiedeb. Arch. Pharmacol. 388 (2015), 305–317.
149. Polewski, K., Kniat, S., Slawinska, D., Gallic acid, a natural antioxidant, in aqueous and micellar environment: spectroscopic studies. Curr. Top. Biophysics 26 (2002), 217–227.
150. Polo, C.M., Moraes, T.M., Pellizzon, C.H., Marques, M.O., Rocha, L.R., Hiruma-Lima, C.A., Gastric ulcers in middle-aged rats: the healing effect of essential oil from Citrus aurantium L. (Rutaceae). Evid based complement. Altern. Med., 2012, 2012, 509451.
151. Prabha, P., Karpagam, T., Varalakshmi, B., Packiavathy, A.S., Indigenous anti-ulcer activity of Musa sapientum on peptic ulcer. Pharmacogn. Res. 3 (2011), 232–238.
152. Priya, T.T., Sabu, M.C., Jolly, C.I., Role of Mangifera indica bark polyphenols on rat gastric mucosa against ethanol and cold-restraint stress. Nat. Prod. Res. 25 (2011), 815–826.
153. Rao, C.V., Verma, A.R., Vijayakumar, M., Rastogi, S., Gastroprotective effect of standardized extract of Ficus glomerata fruit on experimental gastric ulcers in rats. J. Ethnopharmacol. 115 (2008), 323–326.
154. Reuter, S., Gupta, S.C., Chaturvedi, M.M., Aggarwal, B.B., Oxidative stress, inflammation, and cancer: how are they linked?. Free Radic. Biol. Med. 49 (2010), 1603–1616.
155. Roberts, D.M., Chronic gastritis, alcohol, and non-ulcer dyspepsia. Gut 13 (1972), 768–774.
156. Rodrigues Orsi, P., Bonamin, F., AparecidaSeveri, J., Cássia Santos, R., Vilegas, W., Hiruma-Lima, C.A., Stasi, L.C., Hymenaea stigonocarpa Mart. ex Hayne: a Brazilian medicinal plant with gastric and duodenal anti-ulcer and antidiarrheal effects in experimental rodent models. J. Ethnopharmacol. 143 (2012), 81–90.
157. Rosenstock, S., Jørgensen, T., Bonnevie, O., Andersen, L., Risk factors for peptic ulcer disease: a population based prospective cohort study comprising 2416 Danish adults. Gut 52 (2003), 186–193.
158. 2. Chem. Biol. Interact. 189 (2011), 82–89.
159. Rujjanawate, C., Kanjanapothi, D., Amornlerdpison, D., The anti-gastric ulcer effect of Gynostemma pentaphyllum Makino. Phytomedicine 11 (2004), 431–435.
160. Sairam, K., Rao, ChV., Babu, M.D., Kumar, K.V., Agrawal, V.K., K Goel, R.K., Antiulcerogenic effect of methanolic extract of Emblica officinalis: an experimental study. J. Ethnopharmacol. 82 (2002), 1–9.
161. Sairam, K., Priyambada, S., Aryya, N.C., Goel, R.K., Gastroduodenal ulcer protective activity of Asparagus racemosus: an experimental, biochemical and histological study. J. Ethnopharmacol. 86 (2003), 1–10.
162. Salih, B.A., Abasiyanik, F.M., Does regular garlic intake affect the prevalence of Helicobacter pylori in asymptomatic subjects?. Saudi Med. J. 24 (2003), 842–845.
163. Sangiovanni, E., Vrhovsek, U., Rossoni, G., Colombo, E., Brunelli, C., Brembati, L., Trivulzio, S., Gasperotti, M., Mattivi, F., Bosisio, E., Dell'Agli, M., Ellagitannins from Rubus berries for the control of gastric inflammation: in vitro and in vivo studies. PLoS One, 8, 2013, e71762.
164. Sannomiya, M., Fonseca, V.B., da Silva, M.A., Rocha, L.R., Dos Santos, L.C., Hiruma-Lima, C.A., SouzaBrito, A.R., Vilegas, W., Flavonoids and antiulcerogenic activity from Byrsonimacrassa leaves extracts. J. Ethnopharmacol. 97 (2005), 1–6.
165. Sarkar, S., Buha, D., Effect of ripe fruit pulp extract of Cucurbita pepo Linn. in aspirin induced gastric and duodenal ulcer in rats. Indian J. Exp. Biol. 46 (2008), 639–645.
166. Sen, T., Basu, A., Chaudhuri, A.K., Studies on the possible mechanism of the gastric mucosal protection by Calotropis procera–involvement of 5-lipoxygenase pathway. Fundam. Clin. Pharmacol. 12 (1998), 82–87.
167. Severi, J.A., Lima, Z.P., Kushima, H., Brito, A.R., Santos, L.C., Vilegas, W., Hiruma-Lima, C.A., Polyphenols with antiulcerogenic action from aqueous decoction of mango leaves (Mangifera indica L.). Molecules 14 (2009), 1098–1110.
168. Shaker, E., Mahmoud, H., Mnaa, S., Anti-inflammatory and anti-ulcer activity of the extract from Alhagi maurorum (camelthorn). Food Chem. Toxicol. 48 (2010), 2785–2790.
169. Sharma, S., Dave, V., Paliwal, S., Dwivedi, J., Jain, S., Gastroprotective activity of reconstituted red fruit pulp concentrate of Citrullus lanatus in rats. Anc. Sci. Life 34 (2014), 103–108.
170. Shetty, B.V., Arjuman, A., Jorapur, A., Samanth, R., Yadav, S.K., Valliammai, N., Tharian, A.D., Sudha, K., Rao, G.M., Effect of extract of Benincasa hispida on oxidative stress in ratswith indomethacin induced gastric ulcers. Indian J. Physiol. Pharmacol. 52 (2008), 178–182.
171. Sidahmed, H.M., Hashim, N.M., Amir, J., Abdulla, M.A., Hadi, A.H., Abdelwahab, S.I., Taha, M.M., Hassandarvish, P., The, X., Loke, M.F., Vadivelu, J., Rahmani, M., Mohan, S., Pyranocycloartobiloxanthone A, a novel gastroprotective compound from Artocarpus obtusus Jarret, against ethanol-induced acute gastric ulcer in vivo. Phytomedicine 20 (2013), 834–843.
172. Siddaraju, M.N., Dharmesh, S.M., Inhibition of gastric H(+),K(+)-ATPase and Helicobacter pylori growth by phenolic antioxidants of Curcuma amada. J. Agric. Food Chem. 55 (2007), 7377–7386.
173. Singh, V.P., Patil, C.S., Kulkarni, S.K., Effect of licofelone against NSAIDs-induced gastrointestinal ulceration and inflammation. Indian J. Exp. Biol. 43 (2005), 247–253.
174. Söderholm Johan, D., Perdue, M.H., Stress and the Gastrointestinal Tract. II. Stress and intestinal barrier function. Am. J. Physiol. Gastrointest. Liver Physiol. 280 (2001), 7–13.
175. Suadicani, P., Hein, H.O., Gyntelberg, F., Genetic and life-style determinants of peptic ulcer. A study of 3387 men aged 54 to 74 years: the Copenhagen Male Study. Scand J. Gastroenterology 34 (1999), 12–17.
176. Sumbul, S., Ahmad, M.A., Asif, M., Saud, I., Akhtar, M., Evaluation of myrtus communis Linn. Berries (common myrtle) in experimental ulcer models in rats. Hum. Exp. Toxicol. 29 (2010), 935–944.
177. Sung, J.J., Kuipers, E.J., El-Serag, H.B., Systematic review: the global incidence and prevalence of peptic ulcer disease. Aliment. Pharmacol. Ther. 29 (2009), 938–946.
178. Tadić, V.M., Dobrić, S., Marković, G.M., Dordević, S.M., Arsić, I.A., Menković, N.R., Stević, T., Anti-inflammatory, gastroprotective, free-radical-scavenging, and antimicrobial activities of hawthorn berries ethanol extract. J. Agric. Food Chem. 56 (2008), 7700–7709.
179. Takano, F., Yoshizaki, F., Suzuki, K., Suya, N., Ando, T., Hisamichi, S., Anti-ulcer effects of Trichosanthes fruits. Chem. Pharm. Bull. (Tokyo) 38 (1990), 1313–1316.
180. Tamura, M., Matsui, H., Kaneko, T., Hyodo, I., Alcohol is an oxidative stressor for gastric epithelial cells: detection of superoxide in living cells. J. Clin. Biochem. and Nutr. 53 (2013), 75–80.
181. Toma, W., Hiruma-Lima C.A., Guerrero R.O., Brito A.R., Preliminary studies of Mammea americana L. (Guttiferae) bark/latex extract point to an effective antiulcer effect on gastric ulcer models in mice. Phytomedicine 12 (2005), 345–350.
182. Tovey, F.I., Hobsley, M., Segal, I., Jayaraj, A.P., Duodenal ulcer in South Africa: home-pounded versus milled maize. J. Gastroenterol. Hepatol. 20 (2005), 1008–1011.
183. Tsuda, T., The role of anthocyanins as an antioxidant under oxidative stress in rats. Biofactors 13 (2000), 133–139.
184. Valcheva-Kuzmanova, S., Marazova, K., Krasnaliev, I., Galunska, B., Borisova, P., Belcheva, A., Effect of Aronia melanocarpa fruit juice on indomethacin-induced gastric mucosal damage and oxidative stress in rats. Exp. Toxicol. Pathol. 56 (2005), 385–392.
185. Vane, J.R., Bakhle, Y.S., Botting, R.M., Cyclooxygenases 1 and 2. Annu. Rev. Pharmacol. Toxicol 38 (1998), 97–120.
186. Viana, A.F., Fernandes, H.B., Silva, F.V., Oliveira, I.S., Freitas, F.F., Machado, F.D., Costa, C.L., Arcanjo, D.D., Chaves, M.H., Oliveira, F.A., Oliveira, R.C., Gastroprotective activity of Cenostigma macrophyllum Tul. var. acuminate Teles Freire leaves on experimental ulcer models. J. Ethnopharmacol. 150 (2013), 316–323.
187. Vijayakumar, M., Eswaran, M.B., Ojha, S.K., Rao, ChV., Rawat, A.K., Antiulcer activity of hydroalchol extract of Momordica dioica roxb. Fruit. Indian J. Pharm. Sci. 73 (2011), 572–577.
188. Vinagre, R.M., Vilar-e-Silva, A., Fecury, A.A., Martins, L.C., Role of Helicobacter pylori infection and lifestyle habits in the development of gastroduodenal diseases in a population from the Brazilian Amazon. Arq. Gastroenterol. 50 (2013), 170–174.
189. Wahida, B., Abderrahman, B., Nabil, C., Antiulcerogenic activity of Zizyphus lotus (L.) extracts. J. Ethnopharmacol. 112 (2007), 228–231.
190. Wallace, J.L., How do NSAIDs cause ulcer disease?. Baillieres Best. Pract. Res. Clin. Gastroenterol. 14 (2000), 147–159.
191. Warren, J.R., Unidentified curved bacilli on gastric epithelium in active chronic gastritis. Lancet 1 (1983), 1273–1275.
192. Wink, D.A., Miranda, K.M., Espey, M.G., Pluta, R.M., Hewett, S.J., Colton, C., Vitek, M., Feelisch, M., Grisham, M.B., Mechanisms of the antioxidant effects of nitric oxide. Antioxid. Redox Signal 3 (2001), 203–213.
193. Wu, H., Jing, Z., Tang, X., Wang, X., Zhang, S., Yu, Y., Wang, Z., Cao, H., Huang, L., Yu, Y., Wang, Y., To compare the efficacy of two kinds of Zhizhu pills in the treatment of functional dyspepsia of spleen-deficiency and qi-stagnation syndrome: a randomized group sequential comparative trial. BMC Gastroenterol., 11, 2011, 81.
194. Yadav, D.K., Singh, N., Dev, K., Sharma, R., Sahai, M., Palit, G., Maurya, R., Anti-ulcer constituents of Annona squamosal twigs. Fitoterapia 82 (2011), 666–675.
195. Yamaguchi, N., Anand-Apte, B., Lee, M., Sasaki, T., Fukai, N., Shapiro, R., Que, I., Lowik, C., Timpl, R., Olsen, B.R., Endostatin inhibits VEGF-induced endothelial cell migration and tumor growth independently of zinc binding. EMBO J. 18 (1999), 4414–4423.
196. Yamaguchi, F., Saito, M., Ariga, T., Yoshimura, Y., Nakazawa, H., Free radical scavenging activity and antiulcer activity of garcinol from Garcinia indica fruit rind. J. Agric. Food Chem. 48 (2000), 2320–2325.
197. Yeoh, K.G., Kang, J.Y., Yap, I., Guan, R., Tan, C.C., Wee, A., Teng, C.H., Chili protects against aspirin-induced gastroduodenal mucosal injury in humans. Dig. Dis. Sci. 40 (1995), 580–583.
198. Yokota, T., Ohami, H., Ohishi, H., Hattori, T., Watanabe, K., Repression of acute gastric mucosal lesions by antioxidant-containing fraction from fermented products of okara (bean-curd residue). J. Nutr. Sci. Vitaminol. (Tokyo) 42 (1996), 167–172.
199. Zakaria, Z.A., Balan, T., Azemi, A.K., Omar, M.H., Mohtarrudin, N., Ahmad, Z., Abdullah, M.N., Desa, M.N., The, L.K., Salleh, M.Z., Mechanism(s) of action underlying the gastroprotective effect of ethyl acetate fraction obtained from the crude methanolic leaves extract of Muntingia calabura. BMC Complement. Altern. Med., 16, 2016, 78.
200. Zhang, L., Ma, J., Pan, K., Go, V.L., Chen, J., You, W.C., Efficacy of cranberry juice on Helicobacter pylori infection: a double-blind, randomized placebo-controlled trial. Helicobacter 10 (2005), 139–145.
201. Zhou, H., Jiao, D., 312 cases of gastric and duodenal ulcer bleeding treated with 3 kinds of alcoholic extract rhubarb tablets. Zhong Xi Yi Jie He Za Zhi 10 (1990), 150–151 131-132.