Phytochemical analyses and gastroprotective effects of Eugenia umbelliflora (Myrtaceae) on experimental gastric ulcers

Natural Product Communications

Volumn 4, Issue 7, 2009, Pages 911-916

  Meyre Silva, Christiane ^a   Petry, Cristiane Maes ^a   Berté, Talita Elisa ^a   Becker, Renan Gandolfi ^a   Zanatta, Francielle ^a   Delle Monache, Franco ^a   Cechinel Filho, Valdir ^a   Andrade, Sérgio Faloni ^a  

^a UNIVERSIDADE DO VALE DO ITAJAÍ   (Brazil)

Author keywords

Eugenia umbelliflora; Gastroprotective effects; Phytochemical analyses; Triterpenes

Indexed keywords

ALCOHOL; ALPHA AMYRIN; BETHANECHOL; BETULIC ACID; BETULIN; CIMETIDINE; ELLAGIC ACID; EUGENIA UMBELLIFLORA EXTRACT; FAMOTIDINE; INDOMETACIN; METHANOL; NONSTEROID ANTIINFLAMMATORY AGENT; OMEPRAZOLE; PLANT EXTRACT; RANITIDINE; TARAXEROL; TRIMETHOXY ELLAGIC ACID; TRITERPENE DERIVATIVE; UNCLASSIFIED DRUG; ANTIULCER AGENT; CENTRAL DEPRESSANT AGENT; CHOLINERGIC RECEPTOR STIMULATING AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHEMICAL COMPOSITION; CHOLINERGIC ACTIVITY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG INDUCED DISEASE; DRUG ISOLATION; EUGENIA; EUGENIA UMBELLIFLORA; FRUIT; HISTAMINE RELEASE; IMMOBILIZATION STRESS; INDUCED HYPOTHERMIA; MALE; MOUSE; MYRTACEAE; NONHUMAN; PHYTOCHEMISTRY; PLANT LEAF; STOMACH MUCOSA; STOMACH ULCER; ULCEROGENESIS; ANIMAL; BAGG ALBINO MOUSE; CHEMICALLY INDUCED DISORDER; CHEMISTRY; COLD; EXERCISE; MENTAL STRESS; THIN LAYER CHROMATOGRAPHY;

MUS; MYRTACEAE;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTI-ULCER AGENTS; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CHOLINERGIC AGENTS; CHROMATOGRAPHY, THIN LAYER; CIMETIDINE; COLD TEMPERATURE; ETHANOL; EUGENIA; FRUIT; INDOMETHACIN; MALE; MICE; MICE, INBRED BALB C; OMEPRAZOLE; PLANT EXTRACTS; PLANT LEAVES; RESTRAINT, PHYSICAL; STOMACH ULCER; STRESS, PSYCHOLOGICAL;

EID: 70349563905     PISSN: 1934578X     EISSN: 15559475     Source Type: Journal    
DOI: 10.1177/1934578x0900400706     Document Type: Article

References (38)

1. Silva C, Bilia DAC, Barbedo CJ. (2005) Fracionamento e germinação de sementes de Eugenia. Revista Brasileira de Sementes, 27, 86-92.
2. Cronquist A. (1981) An Integrated System of Classification of Flowering Plants. Columbia University Press, New York.
3. Gu JQ, Park EJ, Luyengi L, Hawthorne ME, Mehta RG, Farnsworth NR, Pezzuto JM, Kinghorn AD. (2001) Constituents of Eugenia sandwicensis with potential cancer chemopreventive activity. Phytochemistry, 58, 121-127. (Pubitemid 32750857)
4. Almeida CE, Karnikowski MG, Foleto R, Baldisserotto B. (1995) Analysis of antidiarrhoeic effect of plants used in popular medicine. Revista de Saúde Pública, 29, 428-433. (Pubitemid 26090032)
5. Miyazawa M, Hisama M. (2003) Antimutagenic activity of phenylpropanoids from clove (Syzygium aromaticum). Journal of Agricultural and Food Chemistry, 51, 6413-6422.
6. Machado KE, Cechinel-Filho V, Tessarolo ML, Mallmann R, Meyre-Silva C, Bella Cruz A. (2005) Potent antibacterial activity of Eugenia umbelliflora. Pharmaceutical Biology, 43, 636-639.
7. Park MJ, Gwak KS, Yang I, Choi WS, Jo HJ, Chang JW, Jeung EB, Choi IG. (2007) Antifungal activities of the essential oils in Syzygium aromaticum (L.) Merr. Et Perry and Leptospermum petersonii Bailey and their constituents against various dermatophytes. Journal of Microbiological Method, 45, 460-465.
8. Tragoolpua Y, Jatisatienr A. (2007) Anti-herpes simplex virus activities of Eugenia caryophyllus (Spreng.) Bullock & S. G. Harrison and essential oil, eugenol. Phytotherapy Research, 21, 1153-1158.
9. Ramirez RO, Roa Jr. CC. (2003) The gastroprotective effect of tannins extracted from duhat (Syzygium cumini Skeels) bark on HCl/ethanol induced gastric mucosal injury in Sprague-Dawley rats. Clinical Hemorheology and Microcirculation, 29, 253-261.
10. Sharma SB, Nasir A, Prabhu KM, Murthy PS. (2006) Antihyperglycemic effect of the fruit-pulp of Eugenia jambolana in experimental diabetes mellitus. Journal of Ethnopharmacology, 104, 367-373.
11. Sultana B, Anwar F, Przybylski R. (2007) Antioxidant activity of phenolic components present in barks of Azadirachta indica, Terminalia arjuna, Acacia nilotica, and Eugenia jambolana Lam. trees. Food Chemistry, 104, 1106-1114. (Pubitemid 46764464)
12. Kukongviriyapan U, Luangaram S, Leekhaosoong K, Kukongviriyapan V, Preeprame S. (2007) Antioxidant and vascular protective activities of Cratoxylum formosum, Syzygium gratum and Limnophila aromatica. Biological and Pharmaceutical Bulletin, 30, 661-666.
13. Hussein SAM, Hashem ANM, Seliem MA, Lindequist U, Nawwar MAM. (2003) Polyoxygenated flavonoids from Eugenia edulis. Phytochemistry, 64, 883-889.
14. Rajasekaran M, Bapna JS, Lakshmanan S, Ramachandran NAG, Veliath AJ, Panchanadam M. (1988) Antifertility effect in male rats of oleanolic acid, a triterpene from Eugenia jambolana flowers. Journal of Ethnopharmacology, 24, 115-121.
15. Jayasinghe UL, Ratnayake RM, Medawala MM, Fujimoto Y (2007) Dihydrochalcones with radical scavenging properties from the leaves of Syzygium jambos. Natural Products Research, 20, 551-554.
16. Oliveira AL, Lopes RB, Cabral FA, Eberlin MN. (2006) Volatile compounds from pitanga fruit (Eugenia uniflora L.). Food Chemistry, 99, 1-5.
17. Cole RA, Haber WA, Setzer WN. (2007) Chemical composition of essential oils of seven species of Eugenia from Monteverde, Costa Rica. Biochemical Systematics and Ecology, 35, 877-886.
18. Kuskoski LM, Vega JM, Rios J, Fett R, Troncoso AM, Asuero AG. (2003) Characterization of anthocyanins from the fruits of baguaçú (Eugenia umbelliflora). Journal of Agricultural and Food Chemistry, 51, 5450-5454.
19. a ed. Guanabara Koogan, Rio de Janeiro.
20. Chan FK, Leung WK. (2002) Peptic ulcer disease. Lancet, 360, 933-941.
21. Lee JH, Lee KT, Yang JH, Baek N I, Kim DK. (2004) Acetylcholinesterase inhibitors from the twigs of Vaccinium oldhami Miquel. Archives of Pharmacal Research, 27, 53-56.
22. El Deeb KS, Al-Haidari RA, Mossa JS, Ateya A. (2003) Phytochemical and pharmacological studies of Maytenus forsskaoliana. Saudi Pharmaceutical Journal, 11, 184-191.
23. Laphookhieo S, Karalai C, Ponglimanont C. (2004) New sesquiterpenoid and triterpenoids from fruits of Rhizophora mucronata. Chemical & Pharmaceutical Bulletin, 52, 883-885.
24. 13C NMR spectra of pentacyclic triterpenoids-a compilation and some salient features. Phytochemistry, 37, 1517-1575.
25. Serafin C, Nart V, Malheiros A, De Souza MM, Fischer LG, Delle-Monache F, Cechinel-Filho V. (2007) Bioactive phenolic compounds from aerial parts of Plinia glomerata. Zeitschrift fuer Naturforschung, C: Journal of Biosciences, 62, 196-200.
26. Lewis DA, Hanson PJ. (1991) Anti-ulcer drugs of plant origin. Progress in Medicinal Chemistry, 28, 201-231.
27. Andrade SF, Antoniolli D, Comunello E, Cardoso LGV, Carvalho, JCT, Bastos JK. (2006) Antiulcerogenic activity of crude extract, fractions and populnoic acid isolated from Austroplenckia populnea (Celastraceae). Zeistschrift fuer Naturforschung C. 61, 5-6, 329-33. (Pubitemid 44073422)
28. Andrade SF, Comunello E, Noldin VF, Monache FD, Cechinel Filho V, Niero R. (2008) Antiulcerogenic activity of fractions and 3,15-dioxo-21-alpha-hydroxy friedelane isolated from Maytenus robusta (Celastraceae). Archives of Pharmacal Research, 31, 41-46.
29. Wallace JL. (2001) Mechanisms of protection and healing: current knowledge and future research. American Journal of Medicine. 110, 19S-22S.
30. Kinoshita M, Tsunehisa N, Tamaki H. (1995) Effect of a combination of ecabet sodium and cimetidine on experimentally induced gastric-lesions and gastric-mucosal resistance to ulcerogenic agents in rats. Biological and Pharmaceutical Bulletin, 18, 2, 223-226.
31. Oates PJ, Hakkinen JP. (1988) Studies on the mechanism of ethanol-induced gastric damage in rats. Gastroenterology, 94, 10-21. (Pubitemid 18029754)
32. Szabo S, Vattay P. (1990) Experimental gastric and duodenal ulcers. Advances in pathogenesis. Gastroenterology Clinical North American, 19, 67-85.
33. Hayllar J, Bjarnason I. (1995) NSAIDs, Cox-2 inhibitors, and the gut. Lancet, 346, 521-522.
34. Peskar BM, Maricic N. (1998) Role of prostaglandins in gastroprotection. Digestion Disease Science, 43, 23S-29S.
35. Schubert ML. (2000) Gastric secretion. Current Opinion in Gastroenterology, 16, 463-8.
36. Morimoto Y, Shimohara K, Oshima S, Sukamoto T. (1991) Effects of the new anti-ulcer agent KB-5492 on experimental gastric mucosal lesions and gastric mucosal defensive factors, as compared to those of terprenone and cimetidine. Japanese Journal of Pharmacology, 57, 595-605.
37. Rainsford KD. (1978) Gastric ulcerogenicity of non-steroidal anti-inflammatory drugs in mice with mucosa sensitized by cholinomimetic treatment. Journal of Pharmaceutics and Pharmacology, 39, 669-672.
38. Levine RA, Wilson DE. (1971) The role of cyclic AMP in gastric secretion. Annals of the New York Academy of Sciences, 30, 363-375.