A new therapeutic candidate for oral aphthous ulcer: Allicin

Medical Hypotheses

Volumn 71, Issue 6, 2008, Pages 897-899

  Jiang, Xiao Wen ^a   Hu, Jing ^a   Mian, Farrukh Imran ^b  

^a SICHUAN UNIVERSITY   (China)

^b Department of Dentistry Rural Health Complex   (Pakistan)

Author keywords

[No Author keywords available]

Indexed keywords

ALLICIN;

ANTIINFLAMMATORY ACTIVITY; ANTIMICROBIAL ACTIVITY; ANTIOXIDANT ACTIVITY; APHTHOUS ULCER; ARTICLE; CELL MIGRATION; DRUG RELEASE; DRUG SYNTHESIS; FOOD COMPOSITION; GARLIC; HUMAN; IMMUNOMODULATION; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; STOMACH ULCER; ULCER HEALING; UNSPECIFIED SIDE EFFECT;

ANTI-INFLAMMATORY AGENTS; GARLIC; HUMANS; ORAL ULCER; RNA, MESSENGER; STOMATITIS, APHTHOUS; SULFINIC ACIDS; TUMOR NECROSIS FACTOR-ALPHA;

ALLIUM SATIVUM; BACTERIA (MICROORGANISMS);

EID: 53949111151     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2008.07.028     Document Type: Article

References (27)

1. Miller M.F., and Ship I.I. A retrospective study of the prevalence and incidence of recurrent aphthous ulcers in a professional population 1958-1971. Oral Surg Oral Med Oral Pathol 43 (1977) 532-537
2. Barrons R.W. Treatment strategies for recurrent oral aphthous ulcers. Am J Health Syst Pharm 58 (2001) 41-53
3. Porter S.R., Scully C., and Pedersen A. Recurrent aphthous stomatitis. Crit Rev Oral Biol Med 9 (1998) 306-321
4. Augusti K.T. Therapeutic values of onion (Allium cela L.) and garlic (Allium sativum L.). Indian J Exp Biol 34 (1996) 634-640
5. Bolton S., Null G., and Troetel W.M. The medical uses of garlic-fact and fiction. J Am Pharm Assoc 22 (1982) 40-43
6. Block E. Chemistry of garlic and onions. Sci Am 252 (1985) 94-99
7. Rabinikov A., Miron T., Konstantinovski L., Wilchek M., Mirelman D., and Weiner L. The mode of action of allicin: trapping of radicals and interaction with thiol containing proteins. Biochim Biophys Acta 1379 (1998) 233-244
8. Miron T., Rabinikov A., Mirelman D., Wilchek M., and Weiner L. The mode of action of allicin: its ready permeability through phospholipids membranes may contribute to its biological activity. Biochim Biophys Acta 1463 (2000) 20-30
9. Hodge G., Hodge S., and Hanl P. Allium sativum (Garlic) suppresses leukocyte inflammatory cytokine production in vitro: potential therapeutic use in the treatment of inflammatory bowel disease. Cytometry 48 (2002) 209-215
10. Salman H., Bergman M., Bessler H., Punsky I., and Djaldetti M. Effect of a garlic derivative (allicin) on peripheral blood cell immune responses. Int J Immunopharmacol 21 (1999) 589-597
11. Lang A., Lahav M., Sakhnini E., Barshack I., Fidder H.H., Avidan B., et al. Allicin inhibits spontaneous and TNF-α induced secretion of proinflammatory cytokines and chemokines from intestinal epithelial cells. Clin Nutr 23 (2004) 1199-1208
12. Batirel H.F., Aktan S., Aykut C., Yeǧen B.C., and Coşkun T. The effect of aqueous garlic extract on the levels of arachidonic acid metabolites (leukotriene C4 and prostaglandin E2) in rat forebrain after ischemia reperfusion injury. Prostaglandins Leukot Essent Fatty Acids 54 4 (1996) 289-292
13. Makrisa A., Thorntona C.E., Xua B., and Hennessya A. Garlic increases IL-10 and inhibits TNF-α and IL-6 production in endotoxin-stimulated human placental explants. Placenta 26 (2005) 828-834
14. Willems F., Marchant A., Delville J.P., Gerard C., Delvaux A., Velu T., et al. Interleukin-10 inhibits B7 and intercellular adhesion molecule-1 expression on human monocytes. Eur J Immunol 24 (1994) 1007-1009
15. Hasan N., Siddiqui M.U., Toossi Z., Khan S., Iqbal J., and Islam N. Allicin-induced suppression of Mycobacterium tuberculosis 85B mRNA in human monocytes. Biochem Biophys Res Commun 355 (2007) 471-476
16. Ankri S., and Mirelman D. Antimicrobial properties of allicin from garlic. Microb Infect 1 (1999) 125-129
17. Bakri I.M., and Douglas C.W.I. Inhibitory effect of garlic extract on oral bacteria. Arch Oral Biol 50 7 (2005) 645-651
18. Hasan A., Shinnick T., Mizushima Y., vander Zee R., and Lehner T. Defining a T-cell epitope within HSP 65 in recurrent aphthous stomatitis. Clin Exp Immunol 128 (2002) 318-325
19. O'Gara E.A., Maslin D.J., Nevill A.M., and Hill D.J. The effect of simulated gastric environments on the anti-Helicobacter activity of garlic oil. J Appl Microbiol 104 (2008) 1324-1331
20. Iamaroon A., Chaimano S., Linpisarn S., et al. Detection of Helicobacter pylori in recurrent aphthous ulceration by nested PCR. J Oral Sci 45 (2003) 107-110
21. Weber N.D., Andersen D.O., North J.A., et al. In-vitro virucidal effects of Allium sativum (garlic) extract and compounds. Planta Med 58 (1992) 417-423
22. Lin S.S., Chou M.Y., Ho C.C., Kao C.T., Tsai C.H., Wang L., et al. Study of the viral infections and cytokines associated with recurrent aphthous ulceration. Microb Infect 7 (2005) 635-644
23. Prasad K., Laxdal V.A., Yu M., and Raney B.L. Antioxidant activity of allicin, an active principle in garlic. Mol Cell Biochem 148 2 (1995) 183-189
24. Avci A., Atli T., Ergüder I.B., Varli M., Devrim E., Aras S., et al. Effects of garlic consumption on plasma and erythrocyte antioxidant parameters in elderly subjects. Gerontology 54 (2008) 173-176
25. Çimen M.Y.B., Kaya T.I., Eskandari G., Tursen U., Ikizoglu G., and Atik U. Oxidant/antioxidant status in patients with recurrent aphthous stomatitis. Clin Exp Dermatol 28 (2003) 647-650
26. Kyo E., Uda N., Kasuga S., and Itakura Y. Immunomodulatory effects of aged garlic extract. J Nutr 131 (2001) 1075S-1079S
27. Burgess J.A., Johnson B.D., and Sommers E. Pharmacological management of recurrent oral mucosal ulceration. Drugs 39 (1990) 54-65