Studies on the possible mechanism of the gastric mucosal protection by Calotropis procera - involvement of 5-lipoxygenase pathway

Fundamental and Clinical Pharmacology

Volumn 12, Issue 1, 1998, Pages 82-87

  Sen, T ^a   Basu, A ^a   Nag Chaudhuri, A K ^a  

^a JADAVPUR UNIVERSITY   (India)

Author keywords

5 lipoxygenase; Calotropis; Leukotrienes; Procera; Ulcer

Indexed keywords

ACETYLSALICYLIC ACID; ALCOHOL; ANTIULCER AGENT; ARACHIDONATE 5 LIPOXYGENASE; CALOTROPIS PROCERA EXTRACT; INDOMETACIN; PLANT EXTRACT; UNCLASSIFIED DRUG;

ANIMAL MODEL; ARACHIDONIC ACID METABOLISM; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; ENZYME INHIBITION; FEMALE; IN VITRO STUDY; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STOMACH MUCOSA LESION; STOMACH PH; STOMACH PROTECTION; STRESS ULCER; ULCER;

CALOTROPIS PROCERA;

EID: 0031930665     PISSN: 07673981     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1472-8206.1998.tb00928.x     Document Type: Article

References (43)

1. Aguwa CN, Ramanujam TR. Antiulcer effects of Trimipramine using various laboratory models. Jap J Pharmacol 1984 ; 36 : 125-9
2. Anonymous. In: Council of Scientific and Industrial Research, eds. The Wealth of India. Vol 2. New Delhi ; 1950. p 20-3
3. Anson ML., Estimation of pepsin, trypsin, papain and cathepsin with haemoglobin. J Gen Physiol 1938 ; 22 : 79-89
4. Atal CK, Sethi PD. Proleolylic activity of some Indian Plants. III : Pharmacological evaluation of calatropain from Calotropis procera. Ind J Pharmacy 1961 ; 24 : 131-4
5. Ayouh SMH, Kingston DGI. Screening of plants used in Sudan folk medicine for an antiulcer activity. Fitoterapia 1981 ; 52 : 281-4
6. Basu A, Nag Chaudhuri AK. Preliminary studies on the anti-inflammatory and analgesic activities of Calotropis procera root extract. J Ethbnopharmacol 1991 ; 31 : 319-24
7. Basu A, Sen T, Ray RN, Nag Chaudhuri AK. Hepatoprotective effects of Calotropis procera root extract on experimental liver damage in animals. Fitoterapia 1992 ; 63 : 507-14
8. Bhargava KP, Gupta MB, Tangri KK, Mechanism of ulcerogenic activity in indomethacin and oxyphenbutazone. Eur J Pharmacol 1973 ; 22 : 191-5
9. Calhoun W, Chang J, Carlson RP. Effect of selected anti-intlammatory agents and other drugs on zymosan, arachidonic acid. PAF and carrageenan induced paw edema in the mouse. Agents Actions 1987 ; 21 : 306-9
10. Carlo GD, Mascolo N, Izzo AA, Autore G, Capasso F. Effects of quercetin on the gastrointestinal tract in rats and mice. Phytother Res 1994 ; 8 : 42-5
11. Chopra RN, Nayar C, Chopra IC. In: Council of Scientific & Industrial Research, eds. Glossary of India Medicinal Plants. New Delhi ; 1956. p 46
12. Cohen MM. Mechanism of injury to gastric mucosa by nonsleroidal anti-inflammatory drugs and the protective role of prostaglandin. In: Prostaglandin and Leukotrienes in Gastrointestinal diseuse. Berlin: Springer-Verlag ; 1988. p 148-51
13. Debnath PK, Gode KD, Govind Das D, Sanyal AK. Effects of propanolol on gastric secretion in albino rats. Br J Pharmacol 1974 ; 51 : 213-16
14. Dhar ML, Dhar MM, Dhawan BH, Mehrotra MN, Roy C. Screening of Indian plants for biological activity part I. Ind J Expt Biol 1968 ; 6 : 231-47
15. DiMartino MJ, Campbell GK Jr, Wolff CE, Hanna N. The pharmacology of arachidonic acid-induced rat paw edema. Agents Actions 1987 ; 21 : 303-5
16. Djahanguiri B, Hemmati M, Ahathi F, Fatrokhsiar M. Preventive effects of indomethacin-induced gastric ulceration in the rat of disulfiram, phenoxybenzamine and bile duct ligation. In: Gheorghin T, ed. Experimental ulcer. Cologne: Gerhard Wiztok, 1975 ; 31-7
17. Egan RW, Tischler AN, Baptista EM, Ham EA. Soderman DD, Gale PH. Specific inhibition and oxidative regulation of 5-lipoxygenase. In: Samuelsson B, Paoletti R, Ramwell P, eds. Advances in prostaglandin, thromboxane and leukotriene research. New York: Raven Press, 1983 ; 151-7
18. Giridhar G, Devel K, Mittel PK, Vasudevan P. Mosquito control by Calotropis latex. Pesticides 1984 ; 18 : 82-7
19. Kirtikar KR, Basu BD. Indian Medical Plants (Lolit Mohan Basu). Allahabad ; 1935 : 1606
20. Kulkarni AP, Mitra A, Chaudhuri J, Byczkowski JZ, Richards I. Hydrogen peroxide: A potent activator of dioxygenase activity of soyabean lopoxygenase. Biochem Biophys Res Comm 1990 ; 166 : 417-23
21. Lange K, Peskar BA, Peskar BM. Stimulation of rat gastric mucosal leukotriene formation by ethanol. Naunyn Schmiedherg's Arch Pharmacol Suppl 1985 ; 330 : R27
22. Leyek S, Parnham MJ. Acute anti-inflammatory and gastric effects of the seleno-organic compound ebselen. Agents Actions 1990 ; 30 : 427-31
23. Lowry OH, Rosebrough NL, Farr AL, Randall RJ. Protein measurement with Folin phenol reagent. J Biol Chem 1951 ; 193 : 265-75
24. Malik NN, Chughati MID. Antimicronial activity of Calotropis procera - A preliminary study. Pak J Science 1979 ; 31 : 127-39
25. Nielsen AST, Beninati L and Chang J. REV 5901 and LY 171, 883 protect rat gastric mucosa against ethanol-induced damage. Agents Actions 1987 ; 21 : 320-2
26. Ogle CW and Cho CH. Effects of Sulphasalazine on stress ulceration and mast cell degranulation in rat stomach. Eur J Pharmacol 1985 ; 112 : 285-6
27. Ogle CW and Cho CH. The protective mechanism of FPL 55712 against stress-induced gastric ulceration in rats. Agents Actions 1989 ; 26 : 350-4
28. Okabe S, Takata Y, Takeuchi K, Naganuma T, Takagi K. Effects of carbenoxolone Na on acute and chronic gastric lesions induced by non steroidal anti-inflammatory drugs in mice. Agents Actions 1976 ; 21 : 316-19
29. Pal S, Bhattacharya S, Nag Chaudhuri AK. The effects of Mikania Cordata (Burm) BL Robins root extract on gastro-duodenal ulcer models in rats and guinea pigs. Phvtotherapv Research 1988 ; 2 : 180-2
30. Pal S, Nag Chaudhuri AK. The antiulcer activity of a Bryophyllum pinnatum leaf extract in experimental animal. J Ethnopharmacol 1991 ; 33 : 97-102
31. Parmar NS, Tariq M, Ageel AM. Gastric cytoprotection: a critical appraisal of the concept, methodology, implication, mechanism and future research prospects. Agents Actions 1987 ; 22 : 114-20
32. Pendelton RG, Stavorski JR. Evidence for different leukotriene receptor in gastric mucosa. Eur J Pharmacol 1986 ; 125 : 297-9
33. 4 in rat gastric mucosa. Prostaglandins 1986 ; 31 : 283-93
34. Pillai NR, Santhakumari G. Effects of Nimbidin on acute and chronic gastro-duodenal ulcer models in experimental animals. Planta Med 1984 ; 50 : 143-6
35. Rainsford KD. The effects of 5-lipoxygenase inhibitors and leukotriene antagonists on the development of gastric ulcer models in experimental animals. Dig Diseases 198 ; 21 : 618-25
36. Robert A. Cytoprotection by prostaglandins. Gastroenterol 1979 ; 77 : 761-7
37. Sen T, Ghosh TK and Nag Chaudhuri AK. Studies on the mechanism of anti-inflammatory and antiulcer activity of Pluchea indica - probable involvement of 5-lipoxygenase pathway. Life Sci 1993 ; 52 : 737-43
38. Sen T, Ghosh TK, Bhattacharjee S, Nag Chaudhuri AK. Action of Pluchea indica methanolic extract as a dual inhibitor on PAF-induced paw oedema and gastric damage. Phytotherapy Research 1996 ; 10 : 74-6
39. Shay H, Sun DCH. Etiology and pathology of gastric and duodenal ulcer. In: Buchus HL, ed. Gastroenterology. Philadelphia. London: WB Saunders Co ; 1963. p 420-65
40. Vane JR. Inhibition of prostaglandin synthesis as a mechanism of action of aspirin-like drugs. Nature 1971 ; 231 : 232-5
41. Wallace JL. Lipid mediators of inflammation in gastric ulcer. Am J Physiol 1990 ; 258 : G1-11
42. Yamamoto H, Nakamura Y, Kunoh Y, Ichihara K, Nagasaka M, Asni H. Antiulcer effect of (-) -cis-2, 3 dihydro-3-(4-methylpiperazinyl-methyl)-2-phenyl-1, 5-6 benzothiazepin-4-(5H)-one hydrochloride (BTM-1086) in experimental animals. Jap J Pharmacol 1986 ; 41 : 283-92
43. Young JM, Tomlonis AJ. Diphendisufide inhibits indomethecin-induced ulcerogenesis in rats. Agents Action 1987 ; 21 : 314-15