Mechanism(s) of action underlying the gastroprotective effect of ethyl acetate fraction obtained from the crude methanolic leaves extract of Muntingia calabura

BMC Complementary and Alternative Medicine

Volumn 16, Issue 1, 2016, Pages

  Zakaria, Zainul Amiruddin ^a,b   Balan, Tavamani ^a   Azemi, Ahmad Khusairi ^a   Omar, Maizatul Hasyima ^c   Mohtarrudin, Norhafizah ^a   Ahmad, Zuraini ^a   Abdullah, Muhammad Nazrul Hakim ^a   Desa, Mohd Nasir Mohd ^a   Teh, Lay Kek ^b   Salleh, Mohd Zaki ^b  

^a UNIVERSITY PUTRA MALAYSIA   (Malaysia)

^b UNIVERSITI TEKNOLOGI MARA   (Malaysia)

^c INSTITUTE FOR MEDICAL RESEARCH   (Malaysia)

Author keywords

Antioxidant; Antisecretory; Fraction; Gallic acid; Gastric ulcer; Muntingia calabura; Nitric oxide; Prostaglandin; Quercetin; Sulfhydryl compound

Indexed keywords

ACETIC ACID ETHYL ESTER; ALCOHOL; CATALASE; GALLIC ACID; GASTROINTESTINAL MUCOSA PROTECTIVE AGENT; GLUTATHIONE; MALONALDEHYDE; MUNTINGIA CALABURA EXTRACT; N ETHYLMALEIMIDE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; PLANT EXTRACT; PROSTAGLANDIN E2; QUERCETIN; RANITIDINE; SUPEROXIDE DISMUTASE; THIOL DERIVATIVE; UNCLASSIFIED DRUG; ANTIOXIDANT; ANTIULCER AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FRACTIONATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIMIT OF QUANTITATION; MALE; NONHUMAN; PH; PLANT LEAF; PROTEIN CONTENT; PYLORUS LIGATION INDUCED GASTRIC ULCER; RAT; STOMACH CONTENT; STOMACH PROTECTION; TISSUE HOMOGENATE; ANGIOSPERM; ANIMAL; BLOOD; CHEMISTRY; DISEASE MODEL; DRUG EFFECTS; METABOLISM; MUCUS; OXIDATIVE STRESS; PATHOLOGY; PHYTOTHERAPY; SPRAGUE DAWLEY RAT; STOMACH; STOMACH MUCOSA; STOMACH ULCER;

ANGIOSPERMS; ANIMALS; ANTI-ULCER AGENTS; ANTIOXIDANTS; DINOPROSTONE; DISEASE MODELS, ANIMAL; GALLIC ACID; GASTRIC MUCOSA; MALE; MALONDIALDEHYDE; MUCUS; NITRIC OXIDE; OXIDATIVE STRESS; PHYTOTHERAPY; PLANT EXTRACTS; PLANT LEAVES; QUERCETIN; RATS, SPRAGUE-DAWLEY; STOMACH; STOMACH ULCER;

EID: 84959168082     PISSN: None     EISSN: 14726882     Source Type: Journal    
DOI: 10.1186/s12906-016-1041-0     Document Type: Article

References (85)

1. Chen H, Liao H, Liu Y, Zheng Y, Wu X, Su Z, et al. Protective effects of pogostone from Pogostemonis Herba against ethanol-induced gastric ulcer in rats. Fitoterapia. 2015;100:110-7.
2. O'Malley P. Gastric ulcers and GERD: the new "plagues" of the 21st century update for the clinical nurse specialist. Clinical Nurse Specialist CNS. 2003;17(6):286-9.
3. Laloo D, Prasad SK, Krishnamurthy S, Hemalatha S. Gastroprotective activity of ethanolic root extract of Potentilla fulgens Wall. ex Hook. J Ethnopharmacol. 2013;146(2):505-14.
4. Laine L, Takeuchi K, Tarnawski A. Gastric mucosal defense and cytoprotection: bench to bedside. Gastroenterology. 2008;135(1):41-60.
5. Rang HP, Dale MM, Ritter JM, Flower RJ GH. Rang and Dale's Pharmacology. 7th ed. Edinburgh: Elsevier Churchill Livingstone 2012.
6. Zheng YF, Xie JH, Xu YF, Liang YZ, Mo ZZ, Jiang WW, et al. Gastroprotective effect and mechanism of patchouli alcohol against ethanol, indomethacin and stress-induced ulcer in rats. Chem Biol Interact. 2014;222C:27-36.
7. Mota KS, Dias GE, Pinto ME, Luiz-Ferreira A, Souza-Brito AR, Hiruma-Lima CA, et al. Flavonoids with gastroprotective activity. Molecules. 2009;14(3):979-1012.
8. Amaral GP, de Carvalho NR, Barcelos RP, Dobrachinski F, Portella Rde L, da Silva MH, et al. Protective action of ethanolic extract of Rosmarinus officinalis L. in gastric ulcer prevention induced by ethanol in rats. Food and Chemical Toxicology. 2013;55:48-55.
9. Panda VS, Khambat PD. Antiulcer activity of Garcinia indica fruit rind (kokum berry) in rats. Biomedicine Aging Pathology. 2014;4(4):309-16.
10. Jain KS, Shah AK, Bariwal J, Shelke SM, Kale AP, Jagtap JR, et al. Recent advances in proton pump inhibitors and management of acid-peptic disorders. Bioorg Med Chem. 2007;15(3):1181-205.
11. Kahraman A, Erkasap N, Koken T, Serteser M, Aktepe F, Erkasap S. The antioxidative and antihistaminic properties of quercetin in ethanol-induced gastric lesions. Toxicology. 2003;183(1-3):133-42.
12. Boligon AA, de Freitas RB, de Brum TF, Waczuk EP, Klimaczewski CV, de Ávila DS, et al. Antiulcerogenic activity of Scutia buxifolia on gastric ulcers induced by ethanol in rats. Acta Pharmaceutica Sinica B. 2014;4(5):358-67.
13. Bighetti AE, Antonio MA, Kohn LK, Rehder VL, Foglio MA, Possenti A, et al. Antiulcerogenic activity of a crude hydroalcoholic extract and coumarin isolated from Mikania laevigata Schultz Bip. Phytomedicine. 2005;12(1-2):72-7.
14. Wallace JL. Recent advances in gastric ulcer therapeutics. Curr Opin Pharmacol. 2005;5(6):573-7.
15. Malfertheiner P, Chan FKL, McColl KEL. Peptic ulcer disease. The Lancet. 2009;374(9699):1449-61.
16. Sheen E, Triadafilopoulos G. Adverse effects of long-term proton pump inhibitor therapy. Dig Dis Sci. 2011;56(4):931-50.
17. Al Mofleh IA. Spices, herbal xenobiotics and the stomach: friends or foes? World J Gastroenterology. 2010;16(22):2710-9.
18. Chin WY. A Guide to the Wayside Trees of Singapore. 2nd ed. Singapore: BP Singapore Science Centre; 1989.
19. Zakaria ZA, Sulaiman MR, Jais AM, Somchit MN, Jayaraman KV, Balakhrisnan G, et al. The antinociceptive activity of Muntingia calabura aqueous extract and the involvement of L-arginine/nitric oxide/cyclic guanosine monophosphate pathway in its observed activity in mice. Fundam Clin Pharmacol. 2006;20(4):365-72.
20. Kaneda N, Pezzuto JM, Soejarto DD, Kinghorn AD, Farnsworth NR, Santisuk T, et al. Plant Anticancer Agents, XLVIII. New Cytotoxic Flavonoids from Muntingia calabura Roots. J Nat Prod. 1991;54(1):196-206.
21. Nshimo CM, Pezzuto JM, Kinghorn AD, Farnsworth NR. Cytotoxic Constituents of Muntingia calabura Leaves and Stems Collected in Thailand. Pharm Biol. 1993;31(1):77-81.
22. Su B-N, Jung Park E, Vigo JS, Graham JG, Cabieses F, Fong HHS, et al. Activity-guided isolation of the chemical constituents of Muntingia calabura using a quinone reductase induction assay. Phytochemistry. 2003;63(3):335-41.
23. Zakaria ZA, Fatimah CA, Jais AMM, Zaiton H, Henie EFP, Sulaiman MR, et al. The in vitro Antibacterial Activity of Muntingia calabura Extracts. Int J Pharmacology. 2006;2(4):439-42.
24. Zakaria ZA, Mustapha S, Sulaiman MR, Mat Jais AM, Somchit MN, Abdullah FC. The antinociceptive action of aqueous extract from Muntingia calabura leaves: the role of opioid receptors. Medical Principles Practice. 2007;16(2):130-6.
25. Zakaria ZA, Nor Hazalin NAM, Zaid SNHM, Ghani MA, Hassan MH, Gopalan HK, et al. Antinociceptive, anti-inflammatory and antipyretic effects of Muntingia calabura aqueous extract in animal models. J Nat Med. 2007;61(4):443-8.
26. Zakaria ZA, Mohamed AM, Jamil NSM, Rofiee MS, Hussain MK, Sulaiman MR, et al. In VitroAntiproliferative and Antioxidant Activities of the Extracts ofMuntingia calaburaLeaves. Am J Chin Med. 2011;39(01):183-200.
27. Chen JJ, Lee HH, Duh CY, Chen IS. Cytotoxic chalcones and flavonoids from the leaves of Muntingia calabura. Planta Med. 2005;71(10):970-3.
28. Sufian AS, Ramasamy K, Ahmat N, Zakaria ZA, Yusof MI. Isolation and identification of antibacterial and cytotoxic compounds from the leaves of Muntingia calabura L. J Ethnopharmacol. 2013;146(1):198-204.
29. Zakaria ZA, Balan T, Suppaiah V, Ahmad S, Jamaludin F. Mechanism(s) of action involved in the gastroprotective activity of Muntingia calabura. J Ethnopharmacol. 2014;151(3):1184-93.
30. Balan T, Sani MHM, Mumtaz Ahmad SH, Suppaiah V, Mohtarrudin N, Zakaria ZA. Antioxidant and anti-inflammatory activities contribute to the prophylactic effect of semi-purified fractions obtained from the crude methanol extract of Muntingia calabura leaves against gastric ulceration in rats. J Ethnopharmacol. 2015;164:1-15.
31. Kumar A, Singh V, Chaudhary AK. Gastric antisecretory and antiulcer activities of Cedrus deodara (Roxb.) Loud. in Wistar rats. J Ethnopharmacol. 2011;134(2):294-7.
32. Zakaria ZA, Balan T, Mamat SS, Mohtarrudin N, Kek TL, Salleh MZ. Mechanisms of gastroprotection of methanol extract of Melastoma malabathricum leaves. BMC Complement Altern Med. 2015;15:135.
33. Strasser M, Noriega P, Lobenberg R, Bou-Chacra N, Bacchi EM. Antiulcerogenic potential activity of free and nanoencapsulated Passiflora serratodigitata L. extracts. BioMed Res International. 2014;2014:434067.
34. Zakaria ZA, Abdul Hisam EE, Norhafizah M, Rofiee MS, Othman F, Hasiah AH, et al. Methanol extract of Bauhinia purpurea leaf possesses anti-ulcer activity. Medical Principles Practice. 2012;21(5):476-82.
35. Shay H, Komarov SA, Fels SS, Meranze D, Gruenstein MHS. A simple method for the uniform production of gastric ulceration in the rat. Gastroenterology. 1945;5:43-61.
36. Balan T, Mohd Sani MH, Suppaiah V, Mohtarrudin N, Suhaili Z, Ahmad Z, et al. Antiulcer activity ofMuntingia calaburaleaves involves the modulation of endogenous nitric oxide and nonprotein sulfhydryl compounds. Pharm Biol. 2014;52(4):410-8.
37. Srivastava V, Viswanathaswamy AH, Mohan G. Determination of the antiulcer properties of sodium cromoglycate in pylorus-ligated albino rats. Indian J Pharmacology. 2010;42(3):185-8.
38. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951;193(1):265-75.
39. Corne SJ, Morrissey SM, Woods RJ. Proceedings: A method for the quantitative estimation of gastric barrier mucus. J Physiol. 1974;242(2):116P-7P.
40. Takayama C, De-Faria FM, de Almeida AC, Valim-Araujo Dde A, Rehen CS, Dunder RJ, et al. Gastroprotective and ulcer healing effects of essential oil from Hyptis spicigera Lam. (Lamiaceae). J Ethnopharmacol. 2011;135(1):147-55.
41. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976;72:248-54.
42. Li WF, Hao DJ, Fan T, Huang HM, Yao H, Niu XF. Protective effect of chelerythrine against ethanol-induced gastric ulcer in mice. Chem Biol Interact. 2014;208:18-27.
43. Ahmad A, Gupta G, Afzal M, Kazmi I, Anwar F. Antiulcer and antioxidant activities of a new steroid from Morus alba. Life Sci. 2013;92(3):202-10.
44. Shine VJ, Latha PG, Shyamal S, Suja SR, Anuja GI, Sini S, et al. Gastric antisecretory and antiulcer activities of Cyclea peltata (Lam.) Hook. f. & Thoms. in rats. J Ethnopharmacol. 2009;125(2):350-5.
45. Choudhary MK, Bodakhe SH, Gupta SK. Assessment of the antiulcer potential of Moringa oleifera root-bark extract in rats. J Acupunct Meridian Stud. 2013;6(4):214-20.
46. Mahendran P, Sabitha KE, Devi CS. Prevention of HCl-ethanol induced gastric mucosal injury in rats by Garcinia cambogia extract and its possible mechanism of action. Indian J Exp Biol. 2002;40(1):58-62.
47. Allen A, Flemstrom G. Gastroduodenal mucus bicarbonate barrier: protection against acid and pepsin. Am J Physiol Cell Physiol. 2005;288(1):C1-19.
48. Venables CW. Mucus, pepsin, and peptic ulcer. Gut. 1986;27(3):233-8.
49. De-Faria FM, Almeida AC, Luiz-Ferreira A, Takayama C, Dunder RJ, da Silva MA, et al. Antioxidant action of mangrove polyphenols against gastric damage induced by absolute ethanol and ischemia-reperfusion in the rat. The Scientific World Journal. 2012;2012:327071.
50. Hajrezaie M, Golbabapour S, Hassandarvish P, Gwaram NS, AH AH, Mohd Ali H, et al. Acute toxicity and gastroprotection studies of a new schiff base derived copper (II) complex against ethanol-induced acute gastric lesions in rats. PLoS One. 2012;7(12):e51537.
51. Nordin N, Salama SM, Golbabapour S, Hajrezaie M, Hassandarvish P, Kamalidehghan B, et al. Anti-ulcerogenic effect of methanolic extracts from Enicosanthellum pulchrum (King) Heusden against ethanol-induced acute gastric lesion in animal models. PLoS One. 2014;9(11):e111925.
52. Rouhollahi E, Moghadamtousi SZ, Hamdi OA, Fadaeinasab M, Hajrezaie M, Awang K, et al. Evaluation of acute toxicity and gastroprotective activity of curcuma purpurascens BI. rhizome against ethanol-induced gastric mucosal injury in rats. BMC Complementary Alternative Med. 2014;14:378.
53. Zima T, Fialova L, Mestek O, Janebova M, Crkovska J, Malbohan I, et al. Oxidative stress, metabolism of ethanol and alcohol-related diseases. J Biomed Sci. 2001;8(1):59-70.
54. Gupta M, Eisen GM. NSAIDs and the gastrointestinal tract. Curr Gastroenterol Rep. 2009;11(5):345-53.
55. Cristians S, Bye R, Navarrete A, Mata R. Gastroprotective effect of Hintonia latiflora and Hintonia standleyana aqueous extracts and compounds. J Ethnopharmacol. 2013;145(2):530-5.
56. Okado-Matsumoto A, Fridovich I. Subcellular distribution of superoxide dismutases (SOD) in rat liver: Cu, Zn-SOD in mitochondria. J Biol Chem. 2001;276(42):38388-93.
57. Hussein SA, El-Senosy YA, Hassan Marwa F. Gastro Protective, Antiapoptotic and Anti-inflammatory Effect of Alpha-lipoic Acid on Ethanol Induced Gastric Mucosal Lesions in Rats. Ame J Biochemistry Mol Biol. 2014;4(2):48-63.
58. Rahim NA, Hassandarvish P, Golbabapour S, Ismail S, Tayyab S, Abdulla MA. Gastroprotective effect of ethanolic extract of Curcuma xanthorrhiza leaf against ethanol-induced gastric mucosal lesions in Sprague-Dawley rats. BioMed Res Int. 2014;2014:416409.
59. Wong J-Y, Abdulla MA, Raman J, Phan C-W, Kuppusamy UR, Golbabapour S, et al. Gastroprotective Effects of Lion's Mane Mushroom Hericium erinaceus (Bull.:Fr.) Pers. (Aphyllophoromycetideae) Extract against Ethanol-Induced Ulcer in Rats. Evidence-Based Complementary Alternative Med. 2013;2013:1-9.
60. Sowndhararajan K, Chin NL. Antioxidant and Anti-ulcer Effects of Ethyl Acetate Fraction of Merremia Tridentata (L.) Hallier F. Root. Agriculture and Agricultural Science Procedia. 2014;2:406-14.
61. Martins JL, Rodrigues OR, da Silva DM, Galdino PM, de Paula JR, Romao W, et al. Mechanisms involved in the gastroprotective activity of Celtis iguanaea (Jacq.) Sargent on gastric lesions in mice. J Ethnopharmacol. 2014;155(3):1616-24.
62. Brzozowski T, Konturek PC, Konturek SJ, Brzozowska I, Pawlik T. Role of prostaglandins in gastroprotection and gastric adaptation. J Physiol Pharmacol. 2005;56 Suppl 5:33-55.
63. Heeba GH, Hassan MK, Amin RS. Gastroprotective effect of simvastatin against indomethacin-induced gastric ulcer in rats: role of nitric oxide and prostaglandins. Eur J Pharmacol. 2009;607(1-3):188-93.
64. Takeuchi K. Prostaglandin EP receptors and their roles in mucosal protection and ulcer healing in the gastrointestinal tract. Adv Clin Chem. 2010;51:121-44.
65. Lakhanpal P, DK R. Quercetin: A Versatile Flavonoid. Internet J Medical Update. 2007;2:22-37.
66. Mojzis J, Hviscova K, Germanova D, Bukovicova D, Mirossay L. Protective effect of quercetin on ischemia/reperfusion-induced gastric mucosal injury in rats. Physiol Res. 2001;50(5):501-6.
67. Kahraman A, Cakar H, Koken T. The protective effect of quercetin on long-term alcohol consumption-induced oxidative stress. Mol Biol Rep. 2012;39(3):2789-94.
68. Coskun O, Kanter M, Armutcu F, Cetin K, Kaybolmaz B, Kaybolmaz BOY. Protective effects of quercetin, a flavonoid antioxidant, in absolute ethanol-induced acute gastric ulcer. European J Gen Meds. 2004;1:37-42.
69. Gonzalez-Segovia R, Quintanar JL, Salinas E, Ceballos-Salazar R, Aviles-Jimenez F, Torres-Lopez J. Effect of the flavonoid quercetin on inflammation and lipid peroxidation induced by Helicobacter pylori in gastric mucosa of guinea pig. J Gastroenterol. 2008;43(6):441-7.
70. Arsić I, Žugić A, Antić DR, Zdunić G, Dekanski D, Marković G, et al. Hypericum Perforatum L. Hypericaceae/Guttiferae Sunflower, Olive and Palm Oil Extracts Attenuate Cold Restraint Stress - Induced Gastric Lesions. Molecules. 2010;15(10):6688-98.
71. Shakeerabanu M, Sujatha K, Shakeerabanu M, Sujatha K, Praveen Rajneesh CP, Manimaran A. The defensive effect of quercetin on indomethacin induced gastric damage in rats. Advances Biol Res. 2011;5:64-70.
72. Yan XM, Joo MJ, Lim JC, Whang WK, Sim SS, Im C, et al. The effect of quercetin-3-O-beta-D-glucuronopyranoside on indomethacin-induced gastric damage in rats via induction of mucus secretion and down-regulation of ICAM-1 expression. Arch Pharm Res. 2011;34(9):1527-34.
73. Martin MJ, La-Casa C, Alarcon-de-la-Lastra C, Cabeza J, Villegas I, Motilva V. Anti-oxidant mechanisms involved in gastroprotective effects of quercetin. Zeitschrift fur Naturforschung C. 1998;53(1-2):82-8.
74. Hu XT, Ding C, Zhou N, Xu C. Quercetin protects gastric epithelial cell from oxidative damage in vitro and in vivo. Eur J Pharmacol. 2015;754:115-24.
75. Beil W, Birkholz C, Sewing KF. Effects of flavonoids on parietal cell acid secretion, gastric mucosal prostaglandin production and Helicobacter pylori growth. Arzneimittelforschung. 1995;45(6):697-700.
76. Roberts AT, Martin CK, Liu Z, Amen RJ, Woltering EA, Rood JC, et al. The safety and efficacy of a dietary herbal supplement and gallic acid for weight loss. J Med Food. 2007;10(1):184-8.
77. Sen S, Asokkumar K, Umamaheswari M, Sivashanmugam AT, Subhadradevi V. Antiulcerogenic effect of gallic Acid in rats and its effect on oxidant and antioxidant parameters in stomach tissue. Indian J Pharmaceutical sciences. 2013;75(2):149-55.
78. Abdelwahab SI. Protective mechanism of gallic acid and its novel derivative against ethanol-induced gastric ulcerogenesis: Involvement of immunomodulation markers, Hsp70 and Bcl-2-associated X protein. Int Immunopharmacol. 2013;16(2):296-305.
79. Yen G-C, Duh P-D, Tsai H-L. Antioxidant and pro-oxidant properties of ascorbic acid and gallic acid. Food Chem. 2002;79(3):307-13.
80. Mahmood ND, Nasir NL, Rofiee MS, Tohid SF, Ching SM, Teh LK, et al. Muntingia calabura: a review of its traditional uses, chemical properties, and pharmacological observations. Pharm Biol. 2014;52(12):1598-623.
81. Kakkar S, Bais S. A review on protocatechuic Acid and its pharmacological potential. ISRN Pharmacology. 2014;2014:952943.
82. Kumar N, Pruthi V. Potential applications of ferulic acid from natural sources. Biotechnology Reports. 2014;4:86-93.
83. Abreu Miranda M, Lemos M, Alves Cowart K, Rodenburg D, D McChesney J, Radwan MM, et al. Gastroprotective activity of the hydroethanolic extract and isolated compounds from the leaves of Solanum cernuum Vell. J Ethnopharmacol. 2015;172:421-9.
84. Moharram FA, Marzouk MS, Ibrahim MT, Mabry TJ. Antioxidant galloylated flavonol glycosides from Calliandra haematocephala. Nat Prod Res. 2006;20(10):927-34.
85. Goel R, Sairam K. Anti-ulcer drugs from indigenous sources with emphasis on musa sapientum, tamarabhasma, asparagus racemosus and zingiber officinale. Indian J Pharmacology. 2002;34(2):100-10.