Chemical characterization and biological effects of sicilian Opuntia ficus indica (L.) Mill. fruit juice: Antioxidant and antiulcerogenic activity

Journal of Agricultural and Food Chemistry

Volumn 51, Issue 17, 2003, Pages 4903-4908

  Galati, Enza Maria ^a   Mondello, Maria Rita ^a   Giuffrida, Daniele ^a   Dugo, Giacomo ^a   Miceli, Natalizia ^a   Pergolizzi, Simona ^a   Taviano, Maria Fernanda ^a  

^a UNIVERSITY OF MESSINA   (Italy)

Author keywords

Antioxidant; Antiulcer activity; Flavonols; Fruit juice; Mucosa structural changes; Opuntia ficus indica

Indexed keywords

ALCOHOL; ANTIOXIDANT; ANTIULCER AGENT; ASCORBIC ACID; COUMARIC ACID; FERULIC ACID; FLAVONOID; ISORHAMNETIN; POLYPHENOL DERIVATIVE; RUTOSIDE DERIVATIVE; SUCRAL; SUCRALFATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG ISOLATION; FRUIT JUICE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HISTOPATHOLOGY; MALE; NONHUMAN; OPUNTIA; OPUNTIA FICUS INDICA; RAT; STOMACH MUCOSA; STOMACH ULCER; ULCEROGENESIS;

ANIMALS; ANTI-ULCER AGENTS; ANTIOXIDANTS; BEVERAGES; ETHANOL; FLAVONOIDS; FREE RADICAL SCAVENGERS; FRUIT; GASTRIC MUCOSA; MALE; OPUNTIA; PHENOLS; RATS; RATS, WISTAR; SICILY; STOMACH ULCER; ULCER;

ANIMALIA; LETHRINIDAE; OPUNTIA; OPUNTIA FICUS-INDICA; PYRUS COMMUNIS;

EID: 0041559951     PISSN: 00218561     EISSN: None     Source Type: Journal    
DOI: 10.1021/jf030123d     Document Type: Article

References (41)

1. Sàenz, C. H. Usi potenziali del frutto e dei cladodi di ficodindia nell'industria alimentare. Riv. Fruttic. 1997, 12, 47-51.
2. Meyer, B. N.; McLaughlin, J. L. Economic use of Opuntia. Cact. Succulent J. (U.S.) 1981, 53, 107-112.
3. Kasumov, M. A. Novel plant sources for food colorings. Pishch. Prom-st. 1991, 12, 75-77.
4. Barbera, G.; Inglese, P. La Coltura del Ficodindia; Edagricole: Bologna, 1993.
5. Duro, F. Sul contenuto di sostanze minerali nel succo dei frutti della "Cactus Opuntia". Quad. Merceol. 1971, 10, 49-54.
6. Askar, A.; El Samahy, S. K. Chemical composition of prickly pear fruits. Dtsch. Lebensm.-Rundsh. 1981, 77, 279-281.
7. Diaz-Alarcón, J. P.; Navarro-Alarcón, M.; Lopéz-García de la Serrana, H.; Lopéz-Martínez, M. G. Determination of selenium levels in vegetables and fruits by hydride generation atomic absorption spectrometry. J. Agric. Food Chem. 1994, 42, 2848-2851.
8. Gurrieri, S.; Miceli, L.; Lanza, C. M.; Tomaselli, F.; Bonomo, R. P.; Rizzarelli, E. Chemical characterization of Sicilian prickly pear (Opuntia ficus indica) and perspectives for the storage of its juice. J. Agric. Food Chem. 2000, 48, 5424-5431.
9. Sàenz, C. H. Cactus-Pear Juice. J. PACD 2001, 3-10.
10. Fernández de Simón, B.; Pérez-Ilzarbe, J.; Hernández, T.; Gómez-Cordovés, C.; Estrella, I. Importance of phenolic compounds for the characterization of fruit juices. J. Agric. Food Chem. 1992, 40, 1531-1535.
11. Singleton, V. L.; Rossi, J. A. Colorimetry of total phenolics with phosphomolybdic-phosphotungstic acid reagents. Am. J. Enol. Vitic. 1965, 16, 144-158.
12. Cunniff, P. AOAC Official Method 967.21. Ascorbic Acid in Vitamin Preparation and Juice. AOAC Official Methods of Analysis; AOAC International Suite 400 Ed.: Arlington, VA, 1997; pp 16-17.
13. Ohinishi, M.; Morishita, H.; Iwahashi, H.; Shitzuo, T.; Yoshiaki, S.; Kimura, M.; Kido, R. Inhibitory effects of Chlorogenic acid on linoleic acid, perossidation and haemolysis. Phytochemistry 1994, 36, 579-583.
14. Litchfield, J. T.; Wilcoxon, F. A simplified method of evaluating dose-effect experiments. J. Pharmacol. Exp. Ther. 1949, 96, 99-113.
15. Del Soldato, P.; Foschi, D.; Varin, L.; Daniotti, S. Comparison of the gastric cytoprotective properties of atropin, ranitidine and PGE2 in rats. Eur. J. Pharmacol. 1984, 106, 53-58.
16. Magistretti, M. J.; Conti, M.; Cristoni, A. Antiulcer activity of an anthocyanidin from Vaccinum myrtillus. Arzneim. Forsch. 1988, 38, 686-690.
17. McManus, J. F. A. Histological demonstration of mucin after periodic acid. Nature 1946, 158, 202.
18. Kuti, J. O.; Galloway, C. M. Sugar composition and invertase activity in prickly pear fruit. J. Food Sci. 1994, 59, 387-388.
19. El Kossori, R. L.; Villanume, C.; El Boustani, E.; Sauvaire, Y.; Mejean, L. Composition of pulp, skin and seeds of prickly pears fruit (Opuntia ficus indica sp.). Plant Foods Hum. Nutr. 1998, 52, 263-270.
20. Safina, G.; Micale, A. Studio bromatologico del ficodindia di Sicilia. Conserve Deriv. Agrum. 1956, 18, 78-79.
21. Chessa, I.; Barbera G. Indagine sulla frigoconservazione dei frutti della cv Gialla di Ficodindia. Riv. Fruttic. 1984, 8, 57-61.
22. Barbera, G.; Inglese, P. The Quality of Cactus Pear Fruit. Actas del II Congreso Internacional de Tuna Y Cochinilla; 22-25 September 1992, Santiago, Chile; pp 143-148.
23. Barbera, G.; Carimi, F.; Inglese P.; Panno, M. Physical, morphological and chemical changes during fruit development and ripening in three cultivars of prickly pear, Opuntia ficus indica (L.) Miller. J. Hortic. Sci. 1992, 67, 307-312.
24. Kuti, J. O. Growth and compositional changes during the development of prickly pear fruit. J. Hortic. Sci. 1992, 67, 861-868.
25. Fenech, L.; Di Pisa, A. Alcune caratteristiche organolettiche dei fichidindia siciliani. Sviluppo Agricolo 1995, XXIX, 60-64.
26. Schirra, M.; Agabbio, M.; D'Aquino, S.; McCollum, T. G. Postharvest heat conditioning effects on early ripening "Gialla" cactus pear fruit. Hortic. Sci. 1997, 32, 702-704.
27. Butera, D.; Tesoriere, L.; Di Gaudio, F.; Allegra, M.; Pintaudi, A. M.; Kohen, R.; Livrea, M. A. Antioxidant activities of sicilian prickly pear (Opuntia ficus indica) fruit extracts and reducing properties of its betalains: betanin and indicaxanthin. J. Agric. Food Chem. 2002, 50, 6895-6901.
28. Pavlov, A.; Kovatcheva, P.; Georgiev, V.; Koleva, I.; Ilieva, M. Biosynthesis and radical scavenging activity of betalains during the cultivation of red beet (Beta vulgaris) hairy root cultures. Z. Naturforsch. 2002, 57, 640-644.
29. Rapisarda, P.; Tomaino, A.; Lo Cascio, R.; Bonina, F.; De Pasquale, A.; Saija, A. Antioxidant effectiveness as influenced by phenolic content of fresh orange juices. J. Agric. Food Chem. 1999, 47, 4718-4723.
30. Morimoto, Y.; Shimohara, K.; Oshima, S.; Sukamoto, T. Effects of the new anti-ulcer agent KB-5492 on experimental gastric mucosal lesions and gastric mucosal defensive factors, as compared to those of terpenone and cimetidine. Jpn. J. Pharmacol. 1991, 57, 495-505.
31. Gugler, R.; Leschik, M.; Dengler, H. J. Disposition of quercetin in man after single oral and intravenous doses. Eur. J. Clin. Pharmacol. 1975, 9, 229-234.
32. Breinholt, V. M.; Offord, E. A.; Brouwer, C.; Nielsen, S. E.; Brosen, K.; Friedberg, T. In vitro investigation of cytochrome P450-mediated metabolism of dietary flavonoids. Food Chem. Toxicol. 2002, 40, 609-616.
33. Struckmann, J. R. Clinical efficacy of micronized purified flavonoid fraction: An overview. J. Vasc. Res. 1999, 36, 37-41.
34. Redman, D. A. Ruscus aculeatus (butcher's broom) as a potential treatment for orthostatic hypotension, with a case report. J. Altern. Complement. Med. 2000, 6, 539-549.
35. Beil, W.; Birkholz, C.; Sewing, K. F. Effects of flavonoids on parietal cell acid secretion, gastric, mucosal prostaglandin production and Helicobacter pylori growth. Arzneim.-Forsch. 1995, 45, 697-700.
36. Ito, S.; Lacy, E. R.; Rutten, M. J.; Critchlow, J.; Silen, W. Rapid repair of injured gastric mucosa. Scand. J. Gastroenterol. 1984, 19 (Suppl. 101), 87-91.
37. Mata, R.; Rojas, A.; Acevedo, L.; Estrada, S.; Calzada, F.; Rojas, I.; Bye, R.; Linares, E. Smooth muscle relaxing flavonoids and terpenoids from Conyza filaginoides. Planta Med. 1997, 63, 31-35.
38. Zheng, X. L.; Mokashi, S.; Hollenberg, M. D. Contractile action of ethanol in guinea pig gastric smooth muscle. J. Pharmacol. Exp. Ther. 1997, 282, 485-495.
39. Mersereau, W. A.; Hinchey, E. J. Role of gastric mucosal fold information of focal ulcers in rats. Surgery 1982, 91, 150-155.
40. Lonchampt, M.; Guardiola, B.; Sicot, N.; Bertrand, M.; Perdrix, L.; Duhault, J. G. Protective effect of a purified flavonoid fraction against oxygen radicals. Arzneim.-Forsch. 1989, 39, 882-885.
41. Antonio, M. A.; Souza Brito, A. R. Oral antiinflammatory and anti-ulcerogenic activities of a hydro alcoholic extract and partitioned fractions of Turnera ulmifolia (Tumeraceae). J. Ethnopharmacol. 1998, 61, 215-228.