Heat shock proteins: The fountainhead of innate and adaptive immune responses

Cell Stress and Chaperones

Volumn 5, Issue 5, 2000, Pages 443-451

  Basu, S ^a   Srivastava, P K ^a  

^a UNIVERSITY OF CONNECTICUT SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEAT SHOCK PROTEIN;

ANTIGEN PRESENTING CELL; ARTICLE; CELL MATURATION; CYTOKINE RELEASE; DENDRITIC CELL; IMMUNE RESPONSE; IMMUNOSTIMULATION; PRIORITY JOURNAL; PROTEIN INTERACTION;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; ANTIGEN PRESENTATION; HEAT-SHOCK PROTEINS; HUMANS; IMMUNE SYSTEM;

EID: 0034520353     PISSN: 13558145     EISSN: None     Source Type: Journal    
DOI: 10.1379/1466-1268(2000)005<0443:HSPTFO>2.0.CO;2     Document Type: Article

References (70)

1. Active specific immunotherapy in patients with renal cell carcinoma (RCC) using autologous tumor derived heat shock protein-peptide complex-96 (HSPP-96) vaccine
2. Active specific immunotherapy in patients with renal cell carcinoma (RCC) using autologous tumor derived heat shock protein-peptide complex-96 (HSPPC-96) vaccine
3. Cross-priming of minor histocompatibility antigen-specific cytotoxic T cells upon immunization with the heat shock protein gp96
4. Influences of transporter associated with antigen processing (TAP) on the repertoire of peptides associated with the endoplasmic reticulum-resident stress protein gp96
5. Cutting edge: Receptor-mediated endocytosis of heat shock proteins by professional antigen-presenting cells
6. Hsp70 stimulates cytokine production through a CD14-dependent pathway, demonstrating its dual role as a chaperone and cytokine
7. Mycobacterial heat shock proteins as carrier molecules II: The use of the 70 kda mycobacterial heat shock protein as carrier for conjugated vaccines can circumvent the need for adjuvants and BCG priming
8. Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NKκB pathway
9. Calreticulin, a peptide-binding chaperone of the endoplasmic reticulum, elicits tumor- and peptide-specific immunity
10. Heat shock proteins as novel mediators of cytokine secretion by macrophages
11. Immunity and invertebrates
12. Minor H antigens introduced on H-2 different stimulating cells cross react at the cytotoxic T cell level during in vivo priming
13. + cells
14. CD91: A receptor for heat shock protein gp96
15. Events involved in representation of heat shock protein-chaperoned peptides
16. Heat shock protein-peptide complexes, reconstituted in vitro, elicit peptide-specific cytotoxic T lymphocyte response and tumor immunity
17. Heat shock protein vaccines against cancer
18. Human tumor antigens recognized by T lymphocytes
19. Mutations of mitotic checkpoint genes in human cancers
20. Receptor-mediated uptake of antigen/heat shock protein complexes results in major histocompatibility complex class I antigen presentation via two distinct processing pathways
21. Immunization with a lymphocytic choriomeningitis virus peptide mixed with heat shock protein 70 results in protective antiviral immunity and specific cytotoxic T lymphocytes
22. Cancer, differentiation and embryonic antigens: Some central problems
23. A mutated intron sequence codes for an antigenic peptide recognized by cytolytic T lymphocytes on a human melanoma
24. Immunogenicity and cross-reactivity of syngeneic murine melanomas
25. Autologous tumor-derived heat-shock protein peptide complex-96 (HSPPC-96) in patients (PTS) with metastatic melanoma
26. Expression of activated H-rasval 12 in nontumorigenic and non-cross-reactive syngeneic cells induces tumor antigens cross-reactive with rat mammary adenocarcinoma 13762
27. Generation of heat shock protein-based vaccines by intracellular loading of gp96 with antigenic peptides
28. The immunodominant major histocompatibility complex class I-restricted antigen of a murine colon tumor derives from an endogenous retroviral gene product
29. Mutated mitogen-activated protein kinase: A tumor rejection antigen of mouse sarcoma
30. Immunization of cancer patients with autologous cancer-derived heat shock protein gp96: A pilot study
31. Tumor rejection antigen gp96/grp94 is an ATPase: Implications for protein folding and antigen presentation
32. Identification of the peptide-binding site in the heat shock chaperone/tumor rejection antigen gp96 (Grp94)
33. Mycobacterial heat shock proteins as carrier molecules
34. Tolerance, danger, and the extended family
35. A unique tumor antigen produced by a single amino acid substitution
36. Induction of cellular immunity by immunization with novel hybrid peptides complexed to heat shock protein 70
37. Biochemical, cell biological and immunological issues surrounding the endoplasmic reticulum chaperone GRP94/gp96
38. Isolation of an immunodominant viral peptide that is endogenously bound to the stress protein GP96/GRP94
39. Cancer immunology: The search for specificity-G. H. A. Clowes memorial lecture
40. The invertebrate phagocytic immunocyte: Clues to a common evolution of immune and neuroendocrine systems
41. Identification and structural characterization of the AYP/ADP-binding site in the hsp90 molecular chaperone
42. A molecular clamp in the crystal structure of the N-terminal domain of the yeast hsp90-chaperone
43. T cell costimulation by B7/BB1 induces CD8 T cell-dependent tumor rejection: An important role of B7/BB1 in the induction, recruitment, and effector function of antitumor T cells
44. gp96 is the Swiss Army Knife of the immune system
45. A mutated beta-catenin gene encodes a melanoma-specific antigen recognized by tumor infiltrating lymphocytes
46. Differential recognition of murine tumor-associated oncofetal transplantation antigen and individually specific tumor transplantation antigens by syngeneic cloned BALB/c and RFM mouse T cells
47. Synthetic peptides non-covalently bound to bacterial hsp 70 elicit peptide-specific T-cell responses in vivo
48. Molecular mechanisms of peptide loading by the tumor rejection antigen/heat shock chaperone gp96 (GRP94)
49. Two chaperone sites in Hsp90 differing in substrate specificity and ATP dependence
50. Cross-presentation of glycoprotein 96-associated antigens on major histocompatibility complex class I molecules requires receptor-mediated endocytosis
51. Peptide-binding heat shock proteins in the endoplasmic reticulum: Role in immune response to cancer and in antigen presentation
52. Do human cancers express shared protective antigens? Or the necessity of remembrance of things past
53. Immunotherapy of human cancer: Lessons from mice
54. Tumor-specific immunogenicity of stress-induced proteins: Convergence of two evolutionary pathways of antigen presentation?
55. Stress-induced proteins in immune response to cancer
56. Heat shock proteins come of age: Primitive functions acquire new roles in an adaptive world
57. Individually distinct transplantation antigens of chemically induced mouse tumors
58. Heat shock proteins transfer peptides during antigen processing and CTL priming
59. Crystal structure of an Hsp90-geldanamycin complex: Targeting of a protein chaperone by an anti-tumor agent
60. A mechanism for the specific immunogenicity of heat shock protein-chaperoned peptides
61. Heat shock fusion proteins as vehicles for antigen delivery into the major histocompatibility complex class I presentation pathway
62. Immunotherapy of tumors with autologous tumor-derived heat shock protein preparations
63. Cellular requirements for tumor-specific immunity elicited by heat shock proteins: Tumor rejection antigen gp96 primes CD8+ T cells in vivo
64. Heat shock protein 70-associated peptides elicit specific cancer immunity
65. Comparison of tumor-specific immunogenicities of stress-induced proteins gp96, hsp90, and hsp70
66. Receptor mediated and fluid phase pathways for internalization of the ER Hsp90 chaperone GRP94 in murine macrophages
67. Interaction of endoplasmic reticulum chaperone GRP94 with peptide substrates is adenine nucleotide-independent
68. Structural transitions accompanying the activation of peptide binding to the endoplasmic reticulum hsp90 chaperone GRP94
69. A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma
70. Structural analysis of substrate binding by the molecular chaperone DnaK