Protective effect of leaves of Raphinus sativus Linn on experimentally induced gastric ulcers in rats

Saudi Pharmaceutical Journal

Volumn 19, Issue 3, 2011, Pages 171-176

  Devaraj, V C ^a   Gopala Krishna, B ^b   Viswanatha, G L ^c   Satya Prasad, V ^d   Vinay Babu, S N ^a  

^a Bioneeds Pre Clinical services ^*  (India)

^b RR College of Pharmacy   (India)

^c PES COLLEGE OF PHARMACY   (India)

^d MNR College of Pharmacy   (India)

Author keywords

Acetic acid; Collagen content; Gastric ulcer; Raphinus sativus; Regenerated epithelium; Ulcer index

Indexed keywords

ACETIC ACID; GASTROINTESTINAL AGENT; OMEPRAZOLE; PLANT EXTRACT; RANITIDINE; RAPHINUS SATIVUS EXTRACT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ISOLATION; DRUG SAFETY; DRUG SCREENING; HISTOPATHOLOGY; MALE; NONHUMAN; PLANT LEAF; PYLORUS LIGATION; RAT; SOLVENT EXTRACTION; STOMACH PROTECTION; STOMACH ULCER;

EID: 79957942594     PISSN: 13190164     EISSN: 13190164     Source Type: Journal    
DOI: 10.1016/j.jsps.2011.03.003     Document Type: Article

References (28)

1. Aguwa C.N., Okunji C.O. Gastrointestinal studies of Pyrenacantha staudii leaf extracts. J. Ethnopharmacol. 1986, 15:45-55.
2. Alqasoumi S., Yahya M.A., Al-Howiriny T., Rafatullah S. Gastroprotective effect of radish (Raphanus sativus L.) on experimental gastric ulcer models in rats. Farmacia LVI 2008, (2):204-214.
3. Barillari J., Cervellati R., Costa S. Antioxidant and Choleretic Properties of Raphanus sativus L. Sprout (Kaiware Daikon) Extract. J. Agric. Food Chem. 2006, 54:9773-9778.
4. Cara K. A gut full of complaints. The Aus. J. Pharm. 2001, 82:624-630.
5. Gilani A.H., Ghayur M.N. Pharmacological basis for the gut stimulatory activity of Raphanus sativus leaves. J. Ethnopharmacol. 2004, 95:169-172.
6. Goel R.K., Bhattacharya S.K. Gastroduodenal mucosal defense and mucosal protective agents. Ind. J. Exp. Biol. 1991, 29:701-714.
7. Guaraldo L., Sertie J.A.A., Bachi E.M. Anti-ulcer action of the hydroalchoholic extract and fractions of Davilla rugosa Poiret in rat. J. Ethnopharmacol. 2001, 76:191-195.
8. Gutierrez R.M., Perez R.L. Raphanus sativus (radish): their chemistry and biology. Sci. World J. 2004, 4:811-837.
9. Hawk, P.B., Oser, B.L., Summerson, H.W., 1947. Practical Physiological Chemistry. Churchill, London, pp. 347-348.
10. Izzo A.A., Dicarlo G., Mascolo N., Autore G., Capasso F. Antiulcer effect of flavonoids Role of endogenous PAF. Phtyother. Res. 1994, 6:179-181.
11. Jain S.G., Santani D.D. Peptic ulcer disease and status of current drug therapy. Ind. Drugs 1994, 31:395-401.
12. Jayaraj A.P., Tovey F.I., Clark C.G. Possible dietary protective factors in relation to the distribution of duodenal ulcer in India and Bangladesh. Gut 1998, 21:1068-1076.
13. Khandelwal, K.R., 1996. Practical Pharmacognosy techniques and experiments; Nirali Prakashan, Pune, pp. 171-172.
14. Lewis D.A., Hanson D. Anti-ulcer drugs of plant origin. Prog. Med. Chem. 1991, 28:208-210.
15. Nwafor P.A., Okwuasaba F.K., Binda L.G. Antidiarrhoeal and anti-ulcerogenic effects of methanolic extract of Asparagus Pubescens root in rats. J. Ethnopharmacol. 2000, 72:421-427.
16. OECD, 2001. OECD guidelines for testing of chemicals no. 425. Acute oral toxicity-modified up and down procedure. Paris, France: Organization of Economic Co operation and development http://www.epa.gov/oppfead1/harmonization/.
17. Okabe S., Pfeiffer C.J., Roth J.L. Experimental production of duodenal and antral ulcers in rats. Federal Proc. 1970, 29:255-260.
18. Okabe S., Pfeiffer C. Chronicity of acetic acid in the rat stomach. Dig. Dis. 1972, 7:619-629.
19. Okabe S., Roth J.L., Pfeiffer C.J. Differential healing periods of the acetic acid ulcer model in rats and cats. Experientia 1971, 27:146-148.
20. Piper D.W., Stiel D.D. Pathogenesis of chronic peptic ulcer. Current thinking and clinical implications. Med. Prog. 1986, 2:7-10.
21. Reyes M., Martin C., Alarcon de-L.L.C., Trujillo J., Toro M.V., Ayuso M.J. Anti-ulcerogenicity of the flavonoids fraction from Erica andevalensis Cabezudo Rivera. Z. Naturforsch. 1996, 51:563-569.
22. Ross, I.A., 1999. Medicinal Plants of the World. Humana Press Inc., Totowa, New Jersey, pp. 213-229.
23. Sairam K. Effect of Centella asiatica L. on physical and chemical factors induced gastric ulceration and secretion in rats. Ind. J. Exp. Biol. 2001, 39:137-142.
24. Shay H., Komarov S.A., Fele S.S., Meranze D., Gruenstein H., Siplet H. A simple method for uniform production of gastric ulceration in rat. Gastroenterology 1945, 5:43-61.
25. Vargas B.R., Perez G.R.M., Perez G.S., Zavala S.M.A., Perez G.C. Antiurolithiatic activity of Raphinus sativus L. aqueous extract on rats. J. Ethnopharmacol. 1999, 68:335-338.
26. Wang J.Z., Wuy J., Rao C.M., Gao M.T., Li W.G. Effect of recombinant human basic fibroblast growth factor on stomach ulcers in rats and mice. Acta Pharmacol. Sin. 1999, 209:763-768.
27. Zaman R.U., Ahmad M. Evaluation of Hepatoprotective effects of Raphanus sativus L. J. Biol. Sci. 2004, 4:463-469.
28. Zaman R.U. Study of cardioprotective activity of Raphinus sativus L. in the rabbits. Pak. J. Biol. Sci. 2004, 7:843-847.