Gastroprotective properties of Myristica malabarica against indometacin-induced stomach ulceration: A mechanistic exploration

Journal of Pharmacy and Pharmacology

Volumn 59, Issue 11, 2007, Pages 1555-1565

  Banerjee, Debashish ^a   Maity, Biswanath ^a   Bauri, Ajay K ^b   Bandyopadhyay, Sandip K ^a   Chattopadhyay, Subrata ^b  

^a Dr BC Roy Post Graduate Institute of Basic Medical Sciences   (India)

^b BHABHA ATOMIC RESEARCH CENTRE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

INDOMETACIN; LIPID; MUCIN; MYRISTICA MALABARICA EXTRACT; OMEPRAZOLE; PLANT EXTRACT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; CONVALESCENCE; DRUG MECHANISM; HISTOPATHOLOGY; LIPID PEROXIDATION; MALE; MOUSE; MYRISTICA MALABARICA; NONHUMAN; PROTEIN CONTENT; SINGLE DRUG DOSE; SPICE; STOMACH PROTECTION; STOMACH ULCER; ULCER HEALING;

ACUTE TOXICITY TESTS; ANIMALS; ANTI-ULCER AGENTS; ANTIOXIDANTS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FRUIT; INDOMETHACIN; LIPID PEROXIDATION; MALE; MICE; MUCINS; MYRISTICACEAE; OMEPRAZOLE; PHYTOTHERAPY; PLANT EXTRACTS; PROTEIN CARBONYLATION; STOMACH ULCER; SULFHYDRYL COMPOUNDS; TIME FACTORS;

EID: 35948936079     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/jpp.59.11.0014     Document Type: Article

References (31)

1. Akhtar, M. S., Akhtar, A. H., Khan, M. A. (1992) Antiulcerogenic effects of Ocimum basilicum extracts, volatile oils and flavonoid glycosides in albino rats. Int. J. Pharmacog. 30: 97-104
2. Alanko, J., Riutta, A., Holm, P., Mucha, I., Vapatalo, H., MetsaKetela, T. (1999) Modulation of arachidonic acid metabolism by phenols: relation to their structure and antioxidant/pro-oxidant properties. Free Radic. Biol. Med. 26 (Suppl 1-2): 193-201
3. Avila, J. R, de la Lastra, C. A., Martin, M. J., Motilva, V., Luque, I., Delgado, D., Esteban, J., Herrerias, J. (1996) Role of endogenous sulphydryls and neutrophil infiltration in the pathogenesis of gastric mucosal injury induced by piroxicam in rats. Inflamm. Res. 45: 83-88
4. Baolin, K., Alderman, B. M., Nicoll, A. J., Cook, G. A., Giraud, A. S. (2001) Effect of omeprazole-induced achlorhydria on trefoil peptide expression in the rat stomach. J. Gastroenterol. Hepatol. 16: 1222-1227
5. Beck, W. L., Xavier, R. (2000) Mechanism of NSAID induced gastrointestinal injury defined using mutant mice. Gastroenterology 9: 699-705
6. Bernier, J. J., Florent, C. (1986) Les défences de l'estomac. Recherche 117: 614-621
7. Bilici, D., Suleyman, H., Banoglu, Z. N., Kiziltunc, A., Avci, B., Ciftcioglu, A., Bilici, S. (2002) Melatonin prevents ethanol-induced gastric mucosal damage possibly due to its antioxidant effect. Dig. Dis. Sci. 47: 856-861
8. Biswas, K., Bandyopadhyay, U., Chattopadhyay, I., Varadaraj, A., Ali, E., Banerjee; R. K. (2003) A novel antioxidant and antiapoptotic role of omeprazole to block gastric ulcer through scavenging of hydroxyl radical. J. Biol. Chem. 278: 10993-11001
9. Chiverton, S. G., Burget, D. W., Salena, B. J., Hunt, R. H. (1989) Does misoprostol given as a single large dose improve its antisecretory effect? Aliment Pharmacol. Ther. 3: 403-407
10. Dhikav, V., Singh, S., Pande, S., Chawla, A., Anand, K. S. (2003) Non-steroidal drug-induced gastrointestinal toxicity: Mechanisms and management. J. Indian Clin. Med. 4: 315-322
11. Dokmeci, D., Akpolat, M., Aydogu, N., Doganay, L., Turan, F. N. (2005) L-Carnitine inhibits ethanol-induced gastric mucosal injury in rats. Pharmacol. Rep. 57: 481-488
12. Duggal, S. P., Kartha, A. R. S. (1956) Antioxidants for edible oils and fats from seeds of Myristica species. Indian J. Agric. Sci. 26: 391-399
13. El-Missiry, M. A., El-Sayed, L. H., Othman, A. I. (2001) Protection by metal complexes with SOD-mimetic activity against oxidative gastric injury induced by indomethacin and ethanol in rats. Ann. Clin. Biochem. 38: 694-700
14. James, A. H. (1964) Gastric epithelium in the duodenum. Gut 105: 285-294
15. Jones, D. B., Howden, C. W., Burget, D. W. (1987) Acid suppression in duodenal ulcer: A meta-analysis to define optimal dosing with antisecretory drugs. Gut 28: 1120-1127
16. Khanom, F., Kayahara, H., Tadasa, K. (2000) Superoxide-scavenging and prolyl endopeptidase inhibitory activities of Bangladeshi indigenous medicinal plants. Biosci. Biotechnol. Biochem. 64: 837-840
17. Lad, R., Armstrong, D. (1999) Management of nonsteroidal anti-inflammatory drug-induced gastroduodenal disease by acid suppression. Can. J. Gastroenterol. 13: 135-142
18. McManus, J. F. A. (1946) Histological demonstration of mucin after periodic acid. Nature 158: 202
19. Naito, Y., Yoshikawa, T., Matsuyama, K., Yagi, N., Arai, M., Nakamura, Y., Nishimura, S., Yoshida, N., Kondo, M. (1995) Effects of oxygen radical scavengers on the quality of gastric ulcer healing in rats. J. Clin. Gastroenterol. 21: S82-S86
20. Patro, B. S., Bauri, A. K., Mishra, S., Chattopadhyay, S. (2005) Antioxidant activity of Myristica malabarica extracts and their constituents. J. Agric. Food Chem. 53: 6912-6918
21. Rainsford, K. D. (1978) The effects of aspirin and other nonsteroid antiinflammatory analgesic drugs on gastrointestinal mucus glycoprotein biosynthesis in vivo: relationship to ulcerogenic actions. Biochem. Pharmacol. 27: 877-885
22. Rastogi, R. P., Mehrotra, B. N. Compendium of Indian medicinal Plants. CSIR, New Delhi, India, 1991
23. Sedlak, J., Lindsay, R. H. (1968) Estimation of total protein-bound, and nonprotein sulphydryl groups in tissue with Ellman's reagent. Anal. Biochem. 25: 192-205
24. Swarnakar, S., Ganguly, K., Kundu, P., Banerjee, A., Maity, P., Sharma, A. V. (2005) Curcumin regulates expression and activity of matrix metalloproteinases 9 and 2 during prevention and healing of indomethacin-induced gastric ulcer. J. Biol. Chem. 280: 9409-9415
25. Szabo, S., Trier, J. S., Brown, A. (1985) A quantitative method for assessing the extent of experimental gastric erosions and ulcer. J. Pharmacol. Methods 13: 59-66
26. Tabor, C. W., Tabor, H. (1984) Polyamines. Annu. Rev. Biochem. 53: 749-790
27. Tariq, M., Moutaery, A. L. (2005) Menadione protects gastric mucosa against ethanol-induced ulcers. Exp. Toxicol. Pathol. 56: 393-399
28. Wang, J. Y., Hsich, J. S., Huang, T. J. (1997) Changes in rat gastric mucosal glycoprotein in portal hypertension. Eur. Surg. Res. 29: 280-286
29. Wolfe, M. M., Lichtenstein, D. R., Singh, G. (1999) Gastrointestinal toxicity of nonsteroidal antiinflammatory drugs. N. Engl. J. Med. 340: 1888-1899; Erratum N. Engl. J. Med. 341: 548
30. Yesilada, E., Gurbuz, I. (2003) A compilation of the studies on the antiulcerogenic effects of medicinal plants. In: Singh S, Singh VK, Govil JN (eds) Recent progress in medicinal plants vol. II: phytochemistry and pharmacology. SCI Tech Publishing LLC, Houston, pp 111-174
31. Yoshimura, K, Delbarre, S. G., Kraus, E., Boland, C. R. (1996) The effects of omeprazole and famotidine on mucin and PGE2 release in the rat stomach. Aliment. Pharmacol. Ther. 10: 111-117