Anti-ulcerogenic effect of Momordica charantia L. fruits on various ulcer models in rats

Journal of Ethnopharmacology

Volumn 71, Issue 1-2, 2000, Pages 77-82

  Gürbüz, Ilhan ^a   Akyüz, Çigdem ^a   Yeşilada, Erdem ^a   Şener, Bilge ^a  

^a GAZI UNIVERSITY   (Turkey)

Author keywords

Antiulcerogenic activity; Cucurbitaceae; Cytoprotective effect; Momordica charantia L. fruit

Indexed keywords

ALCOHOL; DIETHYLDITHIOCARBAMIC ACID; INDOMETACIN; MOMORDICA CHARANTIA EXTRACT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; DRUG ACTIVITY; FEMALE; FRACTIONATION; FRUIT; MALE; NONHUMAN; PEPTIC ULCER; RAT; TRADITIONAL MEDICINE; ULCEROGENESIS;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTI-ULCER AGENTS; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CHELATING AGENTS; DITIOCARB; ETHANOL; FEMALE; FRUIT; INDOMETHACIN; MALE; PLANT EXTRACTS; RATS; RATS, WISTAR; STOMACH ULCER;

EID: 0343168082     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-8741(99)00178-6     Document Type: Article

References (16)

1. Baytop T. Türkiye' de Bitkilerle Tedavi (Phytotherapy in Turkey, Past and Present). 1984;İstanbul Üniversitesi Yayinlari (Publication), Istanbul.
2. Brodie D.A., Marshall R.W., Moreno O.M. Effects of restraint on gastric acidity in the rat. Am. J. Physiol. 202:1962;812.
3. 2α and cimetidine on the β-carotene induced cytoprotection in ethanol-treated rats. Acta Physiol. Hung. 73:1989;221-224. CA. 112:69747x (1990).
4. Kiraly A., Suto G., Vincze A., Toth Gy., Matus Z., Mozsik Gy. Correlation between the cytoprotective effect of β-carotene and its gastric mucosal level in indomethacin-treated rats with or without acute surgical vagotomy. Acta Physiol. Hung. 80:1992;213-218. CA. 121:552y (1994).
5. Oka S., Ogino K., Hobara T., Yoshimura H., Okazaki Y., Takemoto T., Ishiyaöa H., Imaizumi T., Yamasaki K., Kanbe T. Role of active oxygen species in diethyldithiocarbamate-induced gastric ulcer in the rat. Experientia. 46:1990;281-283.
6. Oka S., Ogino K., Hobara T., Yoshimura S., Okazaki Y., Takemoto T., Iida Y. Effects of various mucosal protective drugs on diethyldithiocarbamate-induced antral ulcer in rats. Eur. J. Pharmacol. 197:1991;99-102.
7. 2-receptor antagonist, on various experimental gastric and duodenal ulcers. Am. J. Dig. Dis. 22:1977;677-684.
8. Oliver-Bever B. 'Medicinal Plants in Tropical West Africa'. 1986;Cambridge University Press, Cambridge.
9. Raman A., Lau C. Anti-diabetic properties and phytochemistry of Momordica charantia L. Phytomedicine. 2:1996;349-362.
10. Robert A., Nezamis J.E., Lancester C., Hanchar A.J. Cytoprotection by prostaglandins in rats. Gastroenterology. 77:1979;433.
11. Szelenyi I., Brune K. Possible role of oxygen free radicals in ethanol-induced gastric mucosal damage in rats. Dig. Dis. Sci. 33:1988;865.
12. Vincze A., Garamszegi M., Javor T., Suto G., Tigyi A., Toth Gy., Zsoldos T., Mozsik Gy. The free-radical mechanism in β-carotene induced gastric cytoprotection in hydrochloric acid model. Acta Physiol. Hung. 73:1989;351-355. CA. 112:69749z (1990).
13. Yamomoto K., Kakegawa H., Ueda H., Matsumoto H., Miki T., Satoh T. Gastric cytoprotective anti-ulcerogenic actions of hydroxychalcons in rats. Planta Med. 58:1992;389-393.
14. Yeşilada E., Sezik E., Honda G., Takaishi Y., Takeda Y., Tanaka T. Traditional medicine in Turkey IX: folk medicine in north-west Anatolia. J. Ethnopharmacol. 64:1999;199-206.
15. Yeşilada E., Gürbüz İ, Shibata H. Screening of Turkish anti-ulcerogenic folk remedies for anti-Helicobacter pylori activity. J. Ethnopharmacol. 66:1999;289-293.
16. Yildirim Ö.F. Momordica charantia L. (Kudret Nari) Bitkisinin Çeşitli Ekstrelerinin Siçanlarda Deneysel Olarak Oluşturulan Peptik Ülserde Etkisinin Incelenmesi (Studies on the Effect of Momordica charantia L. on the Experimentally-Induced Peptic Ulcer in Rats). 1994;Yüksek Lisans tezi (Master thesis), Gazi Üniv. Saglik Bilimleri Enstitüsü (Gazi University, Institute of Medical Sciences).