Evaluation of the gastroprotective activity of the extracts, fractions, and pure compounds obtained from aerial parts of Rubus imperialis in different experimental models

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 387, Issue 4, 2014, Pages 313-319

  Berté, Priscila Elisabeth ^a   Da Silva Lopes, Jhonny ^a   Comandulli, Nicole Garbin ^a   Rangel, Daniele Wolff ^a   Monache, Franco Delle ^a   Filho, Valdir Cechinel ^a   Niero, Rivaldo ^a   De Andrade, Sergio Faloni ^a  

^a UNIVERSIDADE DO VALE DO ITAJAÍ   (Brazil)

Author keywords

Antiulcer; Gastroprotective activity; Rubus imperialis

Indexed keywords

ACETIC ACID; ALCOHOL; ANTIULCER AGENT; INDOMETACIN; NIGA-ICHIGOSIDE F1; NONSTEROID ANTIINFLAMMATORY AGENT; PLANT EXTRACT; SAPONIN; TRITERPENE;

ANIMAL; CHEMICALLY INDUCED; ISOLATION AND PURIFICATION; MALE; METABOLISM; MOUSE; MUCUS; PHYTOTHERAPY; PLANT; RAT; ROSACEAE; STOMACH ULCER; WISTAR RAT;

ACETIC ACID; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTI-ULCER AGENTS; ETHANOL; INDOMETHACIN; MALE; MICE; MUCUS; PHYTOTHERAPY; PLANT COMPONENTS, AERIAL; PLANT EXTRACTS; RATS; RATS, WISTAR; ROSACEAE; SAPONINS; STOMACH ULCER; TRITERPENES;

EID: 84898875280     PISSN: 00281298     EISSN: 14321912     Source Type: Journal    
DOI: 10.1007/s00210-013-0954-0     Document Type: Article

References (22)

1. Andrade SF, Antoniolli D, Comunello E, Cardoso LGV, Carvalho JCT, Bastos JK (2006) Antiulcerogenic activity of crude extract, fractions and populnoic acid isolated from Austroplenckia populnea (Celastraceae). Z Naturforsc 61:329-333
2. Andrade SF, Comunello E, Noldin VF, Monache FD, Cechinel Filho V, Niero R (2008) Antiulcerogenic activity of fractions and 3,15-dioxo-21α-hydroxy- friedelane isolated from Maytenus robusta (Celastraceae). Arch Pharm Res 31:41-46
3. 1 obtained from Rubus imperialis (Rosaceae). Pharm Pharmacol 58:1669-1675
4. Calvo TR, Lima ZP, Silva JS, Ballesteros KV, Pellizzon CH, Hiruma-Lima CA (2007) Constituents and antiulcer effect of Alchornea glandulosa: activation of cell proliferation in gastric mucosa during the healing process. Biol Pharm Bull 30:451-459
5. Emendörfer F, Emendörfer F, Bellato F, Noldin VF, Niero R, Cechinel-Filho V, Cardozo AMJ (2005) Evaluation of the relaxant action of some Brazilian medicinal plants in isolated guinea-pig ileum and rat duodenum. J Pharma Pharma Sci 18:63-68
6. Kanegusuku M, Sbors D, Bastos E, De Souza MM, Cechinel-Filho V, YUNES RA, Delle Monache F, Niero R (2007) Phytochemical and analgesic activity of extract, fractions and a 19-hydroxyursane-type triterpenoid obtained from Rubus rosaefolius (Rosaceae). Biol Pharm Bull 30:999-1002
7. Kim EJ, Lee YJ, Shin HK, Park JH (2005) Induction of apoptosis by the aqueous extract of Rubus coreanum in HT-29 human colon cancer cells. Nutrition 21:1141-1148
8. Klein LC Jr, Gandolfi RB, Santin JR, Lemos M, Cechinel Filho V, Andrade SF (2010) Antiulcerogenic activity of extract, fractions, and some compounds obtained from Polygala cyparissias St. Hillaire & Moquin (Poligalaceae). Naunyn-Schmiedeberg's Arch Pharmacol 381:121-126
9. Klein-Júnior LC, Santin JR, Niero R, Andrade SF, Cechinel-Filho V (2012) The therapeutic lead potential of metabolites obtained from natural sources for the treatment of peptic ulcer. Phytochem Rev 11(4):567-616
10. Lakshimi V, Singh N, Shrivastva S, Mishra SK, Dharmani P, Mishra V, Palit G (2009) Gedunin and photogedunin of Xylocarpus granatum show significant anti-secretory effects and protect the gastric mucosa of peptic ulcer in rats. Phytomedicine 17:569-574
11. Lewis DA, Hanson PJ (1991) Anti-ulcer drugs of plant origin. Prog Med Chem 28:201-231
12. Marrotta F, Tajiri H, Safran P, Fesce E, Ideo G (1999) Ethanol related gastric mucosal damage: evidence of a free radical mediated mechanism and beneficial effect of oral supplementation with bionormalizer, a novel natural antioxidant. Digestion 60:538-543
13. Niero R, Cechinel-Filho V (2008) Therapeutic potential and chemical composition of plants from the genus Rubus: a mini review of the last 10 years. Nat Prod Commun 3:437-444
14. Niero R, Kanegusuku M, Souza MM, Yunes RA, Cechinel-Filho V (2002) Antinociceptive action of extracts and fractions from Rubus imperialis (Rosaceae). Therapie 57:242-245
15. Novaes AP, Rossi C, Poffo C, Pretti-Júnior E, Oliveira AE, Schlemper V, Niero R, Cechinel Filho V, Bürger C (2001) Preliminary evaluation of the hypoglycemic effect of some Brazilian medicinal plants. Therapie 56:427-430
16. Nwafor PA, Okwuasaba FK, Binda LG (2000) Antidiarrhoeal and antiulcerogenic effects of methanolic extract of Asparagus pubescens root in rats. J Ethnopharmacol 72:421-427
17. Okabe S, Pfeiffer CJ (1971) The acetic acid ulcer model - a procedure for chronic duodenal or gastric ulcer. In: Pfeiffer CJ (ed) Peptic ulcer. Munksgaard, Copenhagen, pp 13-20
18. Santin JR, Lemos M, Klein-Júnior LC, Machado ID, Costa P, Oliveira AP, Tilia C, Souza JP, Sousa JPB, Bastos JK, Andrade SF (2011) Gastroprotective activity of essential oil of the Syzygium aromaticum and its major component eugenol in different animal models. Naunyn-Schmiedeberg's Arch Pharmacol 383:149-158
19. Schmeda-Hirschmann G, Astudillo L, Rodríguez JA, Theoduloz C, Yáñez T (2005) Gastroprotective effect of the Mapuche crude drug Araucaria araucana resin and its main constituents. J Ethnopharmacol 101:271-276
20. Shay H, Komarov SA, Fels SS, Meranze D, Gruenstein M, Siplet H (1945) A simple method for the uniform production of gastric ulceration in the rat. Gastroenterol 5:43-61
21. Sun SB, Matsumoto T, Yamada H (1991) Effects of a polysaccharide fraction from the roots of Bupleurum folcatum L. on experimental gastric ulcer models in rats and mice. J Pharm Pharmacol 43:699-704
22. Takagi K, Okabe S, Saziki R (1969) A new method for the production of chronic gastric ulcer in rats and the effect of several drugs on its healing. J Pharmacol 19:418-426