The relevance of dietary polyphenols in cardiovascular protection

Current Pharmaceutical Design

Volumn 23, Issue 17, 2017, Pages 2444-2452

  Murillo, Ana G ^a   Fernandez, Maria L ^a  

^a UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

Atherosclerosis; Cardioprotective effects; Dietary polyphenols; Dyslipidemia; Hypertension; Inflammation

Indexed keywords

ADIPONECTIN; ANTHOCYANIN; ASCORBIC ACID; C REACTIVE PROTEIN; CAFFEIC ACID; CAFFEINE; CATECHIN; CHLOROGENIC ACID; COUMARIC ACID; CYTOKINE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; EPICATECHIN; FLAVANOL DERIVATIVE; FLAVANONE DERIVATIVE; FLAVONOID; FLAVONOL DERIVATIVE; HYDROXYBENZOIC ACID DERIVATIVE; HYDROXYTYROSOL; MORIN; OLIVE OIL; PHENOL DERIVATIVE; PLACEBO; POLYPHENOL DERIVATIVE; PROCYANIDIN DERIVATIVE; QUERCETIN; RENIN INHIBITOR; RESVERATROL; SINECATECHINS; TUMOR NECROSIS FACTOR; UNINDEXED DRUG; POLYPHENOL;

ANTIHYPERTENSIVE ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ATHEROSCLEROSIS; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CAROTID ATHEROSCLEROSIS; CORONARY ARTERY DISEASE; DIETARY INTAKE; DYSLIPIDEMIA; ENDOTHELIAL DYSFUNCTION; HEART PROTECTION; HUMAN; HYPERLIPIDEMIA; HYPERTENSION; ISCHEMIC HEART DISEASE; MEDITERRANEAN DIET; META ANALYSIS (TOPIC); METABOLIC SYNDROME X; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; ANIMAL; CHEMISTRY; DIET; FOOD ANALYSIS;

ANIMALS; CARDIOVASCULAR DISEASES; DIET; FOOD ANALYSIS; HUMANS; POLYPHENOLS;

EID: 85025157304     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/1381612823666170329144307     Document Type: Review

References (110)

1. World Health Organization Chapter 1: Burden : mortality, morbidity and risk factors. In Global Status Report on noncommunicable diseases 2010; 2011; pp. 9-31.
2. Grundy SM. Metabolic syndrome update. Trends Cardiovasc Med 2015; 1-10.
3. Rafieian-Kopaei M, Setorki M, Doudi M, Baradaran A, Nasri H. Atherosclerosis: Process, indicators, risk factors and new hopes. Int J Prev Med 2014; 5: 927-946.
4. Aggarwal S, Loomba RS, Arora R. Preventive aspects in peripheral artery disease. Ther Adv Cardiovasc Dis 2012; 6: 53-70.
5. Howes MJR, Simmonds MSJ. The role of phytochemicals as micronutrients in health and disease. Curr Opin Clin Nutr Metab Care 2014; 17: 558-66.
6. Shi J, Yu J, Pohorly JE, Kakuda Y. Polyphenolics in grape seedsbiochemistry and functionality. J Med Food 2003; 6: 291-9.
7. Teixeira A, Baenas N, Dominguez-Perles R, et al. Natural bioactive compounds from winery by-products as health promoters: A review. Int J Mol Sci 2014; 15: 15638-78.
8. Yang J, Xiao YY. Grape phytochemicals and associated health benefits. Crit Rev Food Sci Nutr 2013; 53: 1202-25.
9. Velayutham P, Babu A, Liu D. Green tea catechins and cardiovascular health: an update. Curr Med Chem 2008; 15: 1840-50.
10. Zern TL, Fernandez ML. Cardioprotective effects of dietary polyphenols. J Nutr 2005; 2291-4.
11. Vinson JA, Proch J, Bose P, et al. Chocolate is a powerful ex vivo and in vivo antioxidant, an antiatherosclerotic agent in an animal model, and a significant contributor to antioxidants in the European and American diets. J Agric Food Chem 2006; 54: 8071-6.
12. Basu A, Nguyen A, Betts NM, Lyons TJ. Strawberry as a functional food: an evidence-based review. Crit Rev Food Sci Nutr 2014; 54: 790-806.
13. Lai HTM, Threapleton DE, Day AJ, Williamson G, Cade JE, Burley VJ. Fruit intake and cardiovascular disease mortality in the UK women’s cohort study. Eur J Epidemiol 2015; 30: 1035-48.
14. Tresserra-Rimbau A, Rimm EB, Medina-Remón A, et al. Inverse association between habitual polyphenol intake and incidence of cardiovascular events in the PREDIMED study. Nutr Metab Cardiovasc Dis 2014; 24: 639-47.
15. Rader DJ. New therapeutic approaches to the treatment of dyslipidemia. Cell Metab 2016; 1-8.
16. Upadhyay S, Dixit M. Role of polyphenols and other phytochemicals on molecular signaling. Oxid Med Cell Longev 2015; 2015; 504253.
17. Chen G, Wang H, Zhang X, Yang ST. Nutraceuticals and functional foods in the management of hyperlipidemia. Crit Rev Food Sci Nutr 2014; 54: 1180-201.
18. Annuzzi G, Bozzetto L, Costabile G, et al. Diets naturally rich in polyphenols improve fasting and postprandial dyslipidemia and reduce oxidative stress: A randomized controlled trial. Am J Clin Nutr 2014; 99: 463-71.
19. Yao Z, Zhang L, Ji G. Efficacy of polyphenolic ingredients of Chinese herbs in treating dyslipidemia of metabolic syndromes. J Chinese Integr Med 2014; 12: 135-46.
20. Koo S, Noh S. Green tea as inhibitor of the intestinal absorption of lipids: potential mechanism for its lipid-lowering effect. J Nutr Biochem 2007; 18: 179-83.
21. Chong MFF, Macdonald R, Lovegrove JA. Fruit polyphenols and CVD risk: a review of human intervention studies. Br J Nutr 2010; (104 Suppl): S28-39.
22. Zern TL, Wood RJ, Greene C, et al. Grape polyphenols exert a cardioprotective effect in pre-and postmenopausal women by lowering plasma lipids and reducing oxidative stress. J Nutr 2005; 135: 1911-7.
23. Barona J, Aristizabal JC, Blesso CN, Volek JS, Fernandez ML. Grape polyphenols reduce blood pressure and increase flowmediated vasodilation in men with metabolic syndrome. J Nutr 2012; 142: 1626-32.
24. Koutelidakis AE, Rallidis L, Koniari K, et al. Effect of green tea on postprandial antioxidant capacity, serum lipids, C-reactive protein and glucose levels in patients with coronary artery disease. Eur J Nutr 2014; 53: 479-86.
25. Bogdanski P, Suliburska J, Szulinska M, Stepien M, Pupek-Musialik D, Jablecka A. Green tea extract reduces blood pressure, inflammatory biomarkers, and oxidative stress and improves parameters associated with insulin resistance in obese, hypertensive patients. Nutr Res 2012; 32: 421-7.
26. Hernáez Á, Remaley AT, Farràs M, et al. Olive oil polyphenols decrease LDL concentrations and LDL atherogenicity in men in a randomized controlled trial. J Nutr 2015; 115: 211557-.
27. Hernaez A, Fernandez-Castillejo S, Farras M, et al. Olive oil polyphenols enhance high-density lipoprotein function in humans: A randomized controlled trial. Arterioscler Thromb Vasc Biol 2014; 34: 2115-9.
28. Farras M, Valls RM, Fernandez-Castillejo S, et al. Olive oil polyphenols enhance the expression of cholesterol efflux related genes in vivo in humans. A randomized controlled trial. J Nutr Biochem 2013; 24: 1334-9.
29. Khan, N, Monagas, M, Andres-Lacueva, C, et al. R. Regular consumption of cocoa powder with milk increases HDL cholesterol and reduces oxidized LDL levels in subjects at high-risk of cardiovascular disease. Nutr Metab Cardiovasc Dis 2012; 22: 1046-53.
30. Suzuki T, Kumazoe M, Kim Y, et al. Green tea extract containing a highly absorbent catechin prevents diet-induced lipid metabolism disorder. Sci Rep 2013; 3: 2749.
31. Suh JH, Virsolvy A, Goux A, et al. Polyphenols prevent lipid abnormalities and arterial dysfunction in hamsters on a high-fat diet: a comparative study of red grape and white persimmon wines. Food Funct 2011; 555-61.
32. Shrestha S, Ehlers SJ, Lee J, Fernandez M, Koo SI. Dietary green tea extract lowers plasma and hepatic triglycerides and decreases the expression of sterol regulatory element-binding protein-1c mRNA and its responsive genes in fructose-fed, ovariectomized rats. J Nutr 2009; 139: 640-5.
33. Zern TL, West KL, Fernandez ML. Grape polyphenols decrease plasma triglycerides and cholesterol accumulation in the aorta of ovariectomized guinea pigs. J Nutr 2003; 133: 2268-72.
34. Chamorro S, Viveros A, Centeno C, Romero C, Arija I, Brenes A. Effects of dietary grape seed extract on growth performance, amino acid digestibility and plasma lipids and mineral content in broiler chicks. Animal 2013; 7: 555-61.
35. Brader L, Overgaard A, Christensen LP, Jeppesen PB, Hermansen K. Polyphenol-rich bilberry ameliorates total cholesterol and LDLcholesterol when implemented in the diet of Zucker diabetic fatty rats. Rev Diabet Stud 2013; 10: 270-82.
36. Meguro S, Hasumura T, Hase T. Coffee polyphenols exert hypocholesterolemic effects in zebrafish fed a high-cholesterol diet. Nutr Metab (Lond) 2013; 10: 61.
37. Kim B, Ku CS, Pham TX, et al. Aronia melanocarpa (chokeberry) polyphenol-rich extract improves antioxidant function and reduces total plasma cholesterol in apolipoprotein E knockout mice. Nutr Res 2013; 33: 406-13.
38. Jaroslawska J, Juskiewicz J, Wroblewska M, Jurgonski A, Krol B, Zdunczyk Z. Polyphenol-rich strawberry pomace reduces serum and liver lipids and alters gastrointestinal metabolite formation in fructose-fed rats. J Nutr 2011; 141: 1777-83.
39. Roger V, Lloyd-jones DM, Benjamin EJ, et al. Heart disease and stroke statistics. Circulation 2015; 125.
40. Ma TKW, Kam KKH, Yan BP, Lam YY. Renin-angiotensinaldosterone system blockade for cardiovascular diseases: Current status. Br J Pharmacol 2010; 160: 1273-92.
41. Calhoun DA. Use of aldosterone antagonists in resistant hypertension. Prog Cardiovasc Dis 2006; 48: 387-96.
42. Li F, Takahashi Y, Yamaki K. Inhibitory effect of catechin-related compounds on renin activity. BioMed Res 2013; 34: 167-71.
43. Sohrab G, Hosseinpour-Niazi S, Hejazi J, Yuzbashian E, Mirmiran P, Azizi F. Dietary polyphenols and metabolic syndrome among Iranian adults. Int J Food Sci Nutr 2013; 64: 661-7.
44. Peng X, Zhou R, Wang B, et al. Effect of green tea consumption on blood pressure: a meta-analysis of 13 randomized controlled trials. Sci Rep 2014; 4: 6251.
45. Medina-Remon A, Tresserra-Rimbau A, Pons A, et al. Effects of total dietary polyphenols on plasma nitric oxide and blood pressure in a high cardiovascular risk cohort. The PREDIMED randomized trial. Nutr Metab Cardiovasc Dis 2015; 25: 60-7.
46. Hodgson JM, Croft KD, Woodman RJ, et al. Effects of vitamin E, vitamin C and polyphenols on the rate of blood pressure variation: results of two randomised controlled trials. Br J Nutr 2014; 1-11.
47. Rostami A, Khalili M, Haghighat N, et al. High-cocoa polyphenolrich chocolate improves blood pressure in patients with diabetes and hypertension. ARYA Atheroscler 2015; 11: 21-9.
48. Park E, Edirisinghe I, Choy YY, Waterhouse A, Burton-Freeman B. Effects of grape seed extract beverage on blood pressure and metabolic indices in individuals with pre-hypertension: a randomised, double-blinded, two-arm, parallel, placebo-controlled trial. Br J Nutr 2016; 115: 226-38.
49. Bhullar KS, Lassalle-Claux G, Touaibia M, Vasantha Rupasinghe HP. Antihypertensive effect of caffeic acid and its analogs through dual renin-angiotensin-aldosterone system inhibition. Eur J Pharmacol 2014; 730: 125-32.
50. Pons Z, Margalef M, Bravo FI, Arola-Arnal A, Muguerza B. Acute administration of single oral dose of grape seed polyphenols restores blood pressure in a rat model of metabolic syndrome: role of nitric oxide and prostacy. Clin Eur J Nutr 2016; 55: 749-58.
51. Quiñones M, Miguel M, Muguerza B, Aleixandre A. Effect of a cocoa polyphenol extract in spontaneously hypertensive rats. Food Funct 2011; 2: 649-53.
52. Cassidy A, Rogers G, Peterson JJ, Dwyer JT, Lin H, Jacques PF. Higher dietary anthocyanin and flavonol intakes are associated with anti-inflammatory effects in a population of US adults. Am J Clin Nutr 2015; 102: 172-81.
53. Vislocky LM, Fernandez ML. Biomedical effects of grape products. Nutr Rev 2010; 68: 656-70.
54. Pounis G, Di Castelnuovo A, Bonaccio M, et al. Flavonoid and lignan intake in a Mediterranean population: proposal for a holistic approach in polyphenol dietary analysis, the Moli-sani Study. Eur J Clin Nutr 2015; 1-8.
55. Barona J, Blesso CN, Andersen CJ, Park Y, Lee J, Fernandez ML. Grape consumption increases anti-inflammatory markers and upregulates peripheral nitric oxide synthase in the absence of dyslipidemias in men with metabolic syndrome. Nutrients 2012; 4: 1945-57.
56. Tome-Carneiro J, Gonzalvez M, Larrosa M, et al. Grape resveratrol increases serum adiponectin and downregulates inflammatory genes in peripheral blood mononuclear cells: A triple-blind, placebocontrolled, one-year clinical trial in patients with stable coronary artery disease. Cardiovasc Drugs Ther 2013; 27: 37-48.
57. Puglisi MJ, Vaishnav U, Shrestha S, et al. Raisins and additional walking have distinct effects on plasma lipids and inflammatory cytokines. Lipids Health Dis 2008; 7: 14.
58. Basu A, Du M, Sanchez K, et al. Green tea minimally affects biomarkers of inflammation in obese subjects with metabolic syndrome. Nutrition 2011; 27: 206-13.
59. Uhlar C, Whitehead A. Serum amyloid A, the major vertebrate acute phase reactant. Eur J Biochem 1999; 265: 501-23.
60. Gómez-Zorita S, Fernández-Quintela A, Lasa A, Hijona E, Bujanda L, Portillo MP. Effects of resveratrol on obesity-related inflammation markers in adipose tissue of genetically obese rats. Nutrition 2013; 29: 1374-80.
61. Wahyudi S, Sargowo D. Green tea polyphenols inhibit oxidized LDL-induced NF-K B activation in human umbilical vein endothelial cells. Acta Med Indones 2007; 39: 66-70.
62. Zapolska-Downar D, Bryk D, Małecki M, Hajdukiewicz K, Sitkiewicz D. Aronia melanocarpa fruit extract exhibits antiinflammatory activity in human aortic endothelial cells. Eur J Nutr 2012; 51: 563-72.
63. Vane JR, Angaard EE, Botting RM. Regulatory functions of the vascular endothelium. N Engl J Med 1990; 233: 27-36.
64. Deanfield JE, Halcox JP, Rabelink TJ Endothelial function and dysfunction: Testing and clinical relevance. Circulation 2007; 115: 1285-95.
65. Perez-Vizcaino F, Duarte J, Andriantsitohaina R. Endothelial function and cardiovascular disease: effects of quercetin and wine polyphenols. Free Radic Res 2006; 40: 1054-65.
66. Hadi HA R, Carr CS, Al Suwaidi J. Endothelial dysfunction: cardiovascular risk factors, therapy, and outcome. Vasc Health Risk Manag 2005; 1: 183-98.
67. Bonetti PO, Lerman LO, Lerman A. Endothelial dysfunction: A marker of atherosclerotic risk. Arterioscler Thromb Vasc Biol 2003; 23: 168-75.
68. Libby P. Inflammation and atherosclerosis. Circulation 2002; 105: 1135-43.
69. Endemann DH, Schiffrin EL. Endothelial dysfunction. J Am Soc Nephrol 2004; 15, 1983-92.
70. Lerman A, Zeiher AM. Endothelial function: Cardiac events. Circulation 2005; 111: 363-8.
71. Cai H, Harrison DG. Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Blood Press 2000; 840-4.
72. Salzano S, Checconi P, Hanschmann EM, et al. Linkage of inflammation and oxidative stress via release of glutathionylated peroxiredoxin-2, which acts as a danger signal. Proc Natl Acad Sci USA 2014; 111: 12157-62.
73. Higdon JV, Frei B. Obesity and oxidative stress: a direct link to CVD? Arterioscler Thromb Vasc Biol 2003; 23: 365-7.
74. Violi F, Micheletta F, Luliano L. Antioxidants and atherosclerosis: an overview. Eur Hear J Suppl 2002; 4: B17-B21.
75. Vita JA. Polyphenols and cardiovascular disease : effects on endothelial and platalet function. Am J Clin Nutr 2005; 81: 292-7.
76. Tomasian D, Keaney JF, Vita JA. Antioxidants and the bioactivity of endothelium-derived nitric oxide. Cardiovasc Res 2000; 47: 426-35.
77. Raitakari OT, Celermajer DS. Flow-mediated dilatation. Br J Clin Pharmacol 2000; 50: 397-404.
78. Labonté K, Couillard C, Motard-Bélanger A, Paradis ME, Couture P, Lamarche B. Acute effects of polyphenols from cranberries and grape seeds on endothelial function and performance in elite athletes. Sports 2013; 1: 55-68.
79. Lekakis J, Rallidis LS, Andreadou I, et al. Polyphenolic compounds from red grapes acutely improve endothelial function in patients with coronary heart disease. Eur J Cardiovasc Prev Rehabil 2005; 12: 596-600.
80. Grassi D, Desideri G, Ferri C. Protective effects of dark chocolate on endothelial function and diabetes. Curr Opin Clin Nutr Metab Care 2013; 16: 662-8.
81. Engler MB, Engler MM, Chen CY, et al. Flavonoid-rich dark chocolate improves endothelial function and increases plasma epicatechin concentrations in healthy adults. Nutrition 2004; 23: 197-204.
82. Grassi D, Desideri G, Necozione S, et al. Cocoa consumption dosedependently improves flow-mediated dilation and arterial stiffness decreasing blood pressure in healthy individuals. J Hypertens 2015; 33: 294-303.
83. López-Sepúlveda R, Gómez-Guzmán M, Zarzuelo MJ, et al. Red wine polyphenols prevent endothelial dysfunction induced by endothelin-1 in rat aorta: role of NADPH oxidase. Clin Sci (Lond) 2011; 120: 321-33.
84. Taguchi K, Hida M, Matsumoto T, Ikeuchi-Takahashi Y, Onishi H, Kobayashi T. Effect of short-term polyphenol treatment on endothelial dysfunction and thromboxane A2 levels in streptozotocin-induced diabetic mice. Biol Pharm Bull 2014; 37: 1056-61.
85. Taguchi K, Hida M, Hasegawa M, Matsumoto T, Kobayashi T. Dietary polyphenol morin rescues endothelial dysfunction in a diabetic mouse model by activating the Akt/eNOS pathway. Mol Nutr Food Res 2016; 60: 580-8.
86. Li K, Cheong JD, Croft KD, et al. Green coffee polyphenols do not attenuate features of the metabolic syndrome and improve endothelial function in mice fed a high fat diet. Arch Biochem Biophys 2014; 559: 46-52.
87. Leikert JF, Rathel TR, Wohlfart P, Cheynier V, Vollmar AM, Dirsch VM. Red wine polyphenols enhance endothelial nitric oxide synthase expression and subsequent nitric oxide release from endothelial cells. Circulation 2002; 106: 1614-7.
88. Storniolo CE, Roselló-Catafau J, Pintó X, Mitjavila MT, Moreno J. J Polyphenol fraction of extra virgin olive oil protects against endothelial dysfunction induced by high glucose and free fatty acids through modulation of nitric oxide and endothelin-Redox Biol 2014; 2: 971-7.
89. Boden G, Shulman GI. Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and beta-cell dysfunction. Eur J Clin Invest 2002; 32 (Suppl 3): 14-23.
90. Wang JC, Bennett M. Aging and atherosclerosis: mechanisms, functional consequences, and potential therapeutics for cellular senescence. Circ Res 2012; 111: 245-59.
91. Botden IP, Oeseburg H, Durik M, et al. Red wine extract protects against oxidative-stress-induced endothelial senescence. Clin Sci 2012; 123: 499-507.
92. Yamagata K, Tagami M, Yamori Y. Dietary polyphenols regulate endothelial function and prevent cardiovascular disease. Nutrition 2015; 31: 28-37.
93. Llorente V. Bases celulares y moleculares de la acumulación de colesterol en la pared vascular y su contribución a la progresión de la lesión aterosclerótica cholesterol accumulation in the. Rev Española Cardiol Supl 1998; 51: 633-41.
94. Robinson JG, Fox KM, Bullano MF, Grandy S. Atherosclerosis profile and incidence of cardiovascular events: a population-based survey. BMC Cardiovasc Disord 2009; 9: 46.
95. Weber C, Noels H. Atherosclerosis: current pathogenesis and therapeutic options. Nat Med 2011; 17: 1410-22.
96. Barquera S, Pedroza-Tobías A, Medina C, et al. Global overview of the epidemiology of atherosclerotic cardiovascular disease. Arch Med Res 2015; 46: 328-38.
97. Kaliora AC, Dedoussis GVZ, Schmidt H. Dietary antioxidants in preventing atherogenesis. Atherosclerosis 2006; 187: 1-17.
98. Gale CR, Ashurst HE, Powers HJ, Martyn CN. Antioxidant vitamin status and carotid atherosclerosis in the elderly. Am J Clin Nutr 2001; 74: 402-8.
99. Murillo AG, Fernandez ML. Lycopene and lutein and the prevention of atherosclerosis: is supplementation necessary? ECronicon 2015; 465-73.
100. Lou-Bonafonte JM, Arnal C, Navarro MA, Osada J. Efficacy of bioactive compounds from extra virgin olive oil to modulate atherosclerosis development. Mol Nutr Food Res 2012; 56: 1043-57.
101. Widmer RJ, Freund MA, Flammer AJ, et al. Beneficial effects of polyphenol-rich olive oil in patients with early atherosclerosis. Eur J Nutr 2014; 52: 1223-31.
102. Degennaro M, Hurd TR, Siekhaus DE, Biteau B, Jasper H, Lehmann R. Chocolate consumption is inversely associated with calcified atherosclerotic plaque in the coronary arteries: The NHLBI family heart study. Clin Nutr 2013; 20: 233-43.
103. Cao AH, Wang J, Gao HQ, Zhang P, Qiu J. Beneficial clinical effects of grape seed proanthocyanidin extract on the progression of carotid atherosclerotic plaques. J Geriatr Cardiol 2015; 12: 417-23.
104. Polotsky H. N, Polotsky A. J Metabolic implications of menopause. Semin Reprod Med 2010; 28: 426-34.
105. Naissides M, Mamo JCL, James AP, Pal S. The effect of chronic consumption of red wine on cardiovascular disease risk factors in postmenopausal women. Atherosclerosis 2006; 185: 438-45.
106. Getz GS, Reardon CA. Animal models of atherosclerosis. Arterioscler Thromb Vasc Biol 2013; 32: 1104-15.
107. Chan KC, Yang MY, Lin MC, Lee YJ, Chang WC, Wang CJ. Mulberry leaf extract inhibits the development of atherosclerosis in cholesterol-fed rabbits and in cultured aortic vascular smooth muscle cells. J Agric Food Chem 2013; 61: 2780-8.
108. Chyu KY, Babbidge S. M, Zhao X, et al. Differential effects of green tea-derived catechin on developing versus established atherosclerosis in apolipoprotein E-null mice. Circulation 2004; 109: 2448-53.
109. Do GM, Kwon EY, Kim HJ, et al. Long-term effects of resveratrol supplementation on suppression of atherogenic lesion formation and cholesterol synthesis in apo E-deficient mice. Biochem Biophys Res Commun 2008; 374: 55-9.
110. Norata GD, Marchesi P, Passamonti S, Pirillo A, Violi F, Catapano AL. Anti-inflammatory and anti-atherogenic effects of cathechin, caffeic acid and trans-resveratrol in apolipoprotein E deficient mice. Atherosclerosis 2007; 191: 265-71.