Acute administration of single oral dose of grape seed polyphenols restores blood pressure in a rat model of metabolic syndrome: role of nitric oxide and prostacyclin

European Journal of Nutrition

Volumn 55, Issue 2, 2016, Pages 749-758

  Pons, Zara ^a   Margalef, Maria ^a   Bravo, Francisca I ^a   Arola Arnal, Anna ^a   Muguerza, Begoña ^a,b  

^a UNIVERSITAT ROVIRA I VIRGILI   (Spain)

^b Centre Tecnològic de Nutrició i Salut CTNS   (Spain)

Author keywords

Antihypertensive agent; Cafeteria diet; Endothelial relaxing factors; Hypertension

Indexed keywords

CAPTOPRIL; CATECHIN; CHOLESTEROL; DIMER; EPICATECHIN; EPICATECHIN GALLATE; EPIGALLOCATECHIN GALLATE; GALLIC ACID; GLUCOSE; GRAPE SEED EXTRACT; INDOMETACIN; INSULIN; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; POLYPHENOL; PROCYANIDIN; PROSTACYCLIN; PROTOCATECHUIC ACID; TETRAMER; TRIACYLGLYCEROL; ANTIHYPERTENSIVE AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; BLOOD PRESSURE REGULATION; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DRUG ANTAGONISM; DRUG DOSE REGIMEN; DRUG EFFICACY; MALE; METABOLIC SYNDROME X; NONHUMAN; RAT; RAT MODEL; SYSTOLIC BLOOD PRESSURE; ADVERSE EFFECTS; ANIMAL; ANTAGONISTS AND INHIBITORS; BLOOD PRESSURE; CHEMICALLY INDUCED; CHEMISTRY; DIET; DOSE RESPONSE; DRUG EFFECTS; HYPERTENSION; METABOLISM; ORAL DRUG ADMINISTRATION; PLANT SEED; VITIS; WISTAR RAT;

ADMINISTRATION, ORAL; ANIMALS; ANTIHYPERTENSIVE AGENTS; BLOOD PRESSURE; DIET; DOSE-RESPONSE RELATIONSHIP, DRUG; EPOPROSTENOL; GRAPE SEED EXTRACT; HYPERTENSION; INDOMETHACIN; MALE; METABOLIC SYNDROME X; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; POLYPHENOLS; RATS; RATS, WISTAR; SEEDS; VITIS;

EID: 84959085988     PISSN: 14366207     EISSN: 14366215     Source Type: Journal    
DOI: 10.1007/s00394-015-0895-0     Document Type: Article

References (35)

1. Papadogiannis DE, Protogerou AD (2010) Blood pressure variability: a confounder and a cardiovascular risk factor. Hypertens Res 34:162–163. doi:10.1038/hr.2010.223
2. Collins R, Peto R, MacMahon S, Godwin J, Qizilbash N, Hebert P, Eberlein KA, Taylor JO, Hennekens CH, Fiebach NH (1990) Blood pressure, stroke, and coronary heart disease: part 2, short-term reductions in blood pressure: overview of randomised drug trials in their epidemiological context. Lancet 335:827–838
3. Isezuo SA, Badung SLH, Omotoso ABO (2003) Comparative analysis of lipid profiles among patients with type 2 diabetes mellitus, hypertension and concurrent type 2 diabetes, and hypertension: a view of metabolic syndrome. J Natl Med Assoc 95:328–334
4. Sampey BP, Vanhoose AM, Winfield HM, Freemerman AJ, Muehlbauer MJ, Fueger PT, Newgard CB, Makowski L (2011) Cafeteria diet is a robust model of human metabolic syndrome with liver and adipose inflammation: comparison to high-fat diet. Obesity 19:1109–1117. doi:10.1038/oby.2011.18
5. Redon J, Cifkova R, Laurent S, Nilsson P, Narkiewicz K, Erdine S, Mancia G (2008) The metabolic syndrome in hypertension: European society of hypertension position statement. J Hypertens 26:1891–1900. doi:10.1097/HJH.0b013e328302ca38
6. Panchal SK, Brown L (2010) Rodent models for metabolic syndrome research. J Biomed Biotechnol 2011:351982. doi:10.1155/2011/351982
7. Coatmellec-Taglioni G, Dausse JP, Giudicelli Y, Ribière C (2003) Sexual dimorphism in cafeteria diet-induced hypertension is associated with gender-related difference in renal leptin receptor down-regulation. J Pharmacol Exp Ther 305:362–367
8. Pons Z, Guerrero L, Margalef M, Arola L, Arola-Arnal A, Muguerza B (2014) Effect of low molecular grape seed proanthocyanidins on blood pressure and lipid homeostasis in cafeteria diet-fed rats. J Physiol Biochem 70:629–637. doi:10.1007/s13105-014-0329-0
9. Mancia G, De Backer G, Dominiczak A, Cifkova R, Fagard R, Germano G, Grassi G, Heagerty AM, Kjeldsen SE, Laurent S (2007) 2007 Guidelines for the management of arterial hypertension: the task force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Eur Heart J 28:1462–1536. doi:10.1093/eurheartj/ehm236
10. Cienfuegos-Jovellanos E, Quiñones M, Muguerza B, Moulay L, Miguel M, Aleixandre A (2009) Antihypertensive effect of a polyphenol-rich cocoa powder industrially processed to preserve the original flavonoids of the cocoa beans. J Agric Food Chem 57:6156–6162. doi:10.1021/jf804045b
11. Quiñones M, Miguel M, Muguerza B, Aleixandre A (2011) Effect of a cocoa polyphenol extract in spontaneously hypertensive rats. Food Funct 2:649–653. doi:10.1039/c1fo10119f
12. Quiñones M, Guerrero L, Suarez M, Pons Z, Aleixandre A, Arola L, Muguerza B (2013) Low-molecular procyanidin rich grape seed extract exerts antihypertensive effect in males spontaneously hypertensive rats. Food Res Int 51:587–595. doi:10.1016/j.foores.2013.01.023
13. Quiñones M, Muguerza B, Miguel M, Aleixandre A (2011) Evidence that nitric oxide mediates the blood pressure lowering effect of a polyphenol-rich cocoa powder in spontaneously hypertensive rats. Pharmacol Res 64:478–481. doi:10.1016/j.phrs.2011.06.005
14. Quiñones M, Guerrero L, Fernandez-Vallinas S, Pons Z, Arola L, Aleixandre A, Muguerza B (2014) Involvement of nitric oxide and prostacyclin in the antihypertensive effect of low-molecular-weight procyanidin rich grape seed extract in male spontaneously hypertensive rats. J Funct Foods 6:419–427. doi:10.1016/j.jff.2013.11.008
15. Singleton VL, Rossi JA (1965) Colorimetry of total phenolics with phosphomolybdic-phosphotungstic acid reagents. Am J Enol Vitic 16:144–158 citeulike-article-id:7170825
16. Suárez M, Romero MP, Macià A, Valls RM, Fernández S, Solà R, Motilva MJ (2009) Improved method for identifying and quantifying olive oil phenolic compounds and their metabolites in human plasma by microelution solid-phase extraction plate and liquid chromatography–tandem mass spectrometry. J Chromatogr B 877:4097–4106. doi:10.1016/j.jchromb.2009.10.025
17. Buñag RD (1973) Validation in awake rats of a tail-cuff method for measuring systolic pressure. J Appl Physiol 34:279–282
18. Cordero A, Moreno J, Alegría E (2006) Hipertensión arterial y síndrome metabólico. Rev Española Cardiol Supl 5:38D–45D. doi:10.1016/S1131-3587(05)74119-4
19. Quiñones M, Sánchez D, Muguerza B, Moulay L, Laghi S, Miguel M, Aleixandre A (2010) Long-term intake of CocoanOX attenuates the development of hypertension in spontaneously hypertensive rats. Food Chem 122:1013–1019. doi:10.1016/j.foodchem.2010.03.059
20. Mancia G, Fagard R, Narkiewicz K, Redón J, Zanchetti A, Böhm M, Christiaens T, Cifkova R, De Backer G, Dominiczak A, Galderisi M, Grobbee DE, Jaarsma T, Kirchhof P, Kjeldsen SE, Laurent S, Manolis AJ, Nilsson PM, Ruilope LM et al (2013) 2013 ESH/ESC Guidelines for the management of arterial hypertension: the Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens 31:1281–1357. doi:10.1097/01.hjh.0000431740.32696.cc
21. Cedó L, Castell-Auví A, Pallarès V, Blay M, Ardévol A, Pinent M (2013) Grape seed procyanidin extract improves insulin production but enhances Bax protein expression in cafeteria-treated male rats. Int J Food Sci 2013:875314. doi:10.1155/2013/875314
22. Procházková D, Bousova I, Wilhelmová N (2011) Antioxidant and prooxidant properties of flavonoids. Fitoterapia 82:513–523. doi:10.1016/j.fitote.2011.01.018
23. Touyz RM (2004) Reactive oxygen species, vascular oxidative stress, and redox signaling in hypertension what is the clinical significance? Hypertension 44:248–252. doi:10.1161/01.HYP.0000138070.47616.9d
24. Actis-Goretta L, Ottaviani JI, Keen CL, Fraga CG (2003) Inhibition of angiotensin converting enzyme (ACE) activity by flavan-3-ols and procyanidins. FEBS Lett 555:597–600
25. Actis-Goretta L, Ottaviani JI, Fraga CG (2006) Inhibition of angiotensin converting enzyme activity by flavanol-rich foods. J Agric Food Chem 54:229–234
26. Guerrero L, Castillo J, Quiñones M, Garcia-Vallvé S, Arola L, Pujadas G, Muguerza B (2012) Inhibition of angiotensin-converting enzyme activity by flavonoids: structure–activity relationship studies. PLoS One 7:e49493
27. Ottaviani JI, Actis-Goretta L, Villordo JJ, Fraga CG (2006) Procyanidin structure defines the extent and specificity of angiotensin I converting enzyme inhibition. Biochimie 88:359–365
28. Persson IAL, Persson K, Hägg S, Andersson RGG (2011) Effects of cocoa extract and dark chocolate on angiotensin-converting enzyme and nitric oxide in human endothelial cells and healthy volunteers—a nutrigenomics perspective. J Cardiovasc Pharmacol 57:44–50
29. Tesauro M, Cardillo C (2011) Obesity, blood vessels and metabolic syndrome. Acta Physiol 203:279–286. doi:10.1111/j.1748-1716.2011.02290.x
30. Sekiguchi F, Yanamoto A, Sunano S (2004) Superoxide dismutase reduces the impairment of endothelium-dependent relaxation in the spontaneously hypertensive rat aorta. J Smooth Muscle Res 40:65–74. doi:10.1540/jsmr.40.65
31. Dobrian AD, Davies MJ, Schriver SD, Lauterio TJ, Prewitt RL (2001) Oxidative stress in a rat model of obesity-induced hypertension. Hypertension 37:554–560. doi:10.1161/01.HYP.37.2.554
32. Rees DD, Schulz R, Hodson HF, Palmer RMJ, Moncada S (1990) Identification of some novel inhibitors of the vascular nitric oxide synthase in vivo and in vitro. Nitric oxide from l-arginine a bioregulatory Syst. In: Proceedings of a symposium held at the Royal Society of London, Elsevier, Amsterdam, pp 485–487
33. Vane JR, Gryglewski RJ, Botting RM (1987) The endothelial cell as a metabolic and endocrine organ. Trends Pharmacol Sci 8:491–496. doi:10.1016/0165-6147(87)90045-9
34. Schramm DD, Wang JF, Holt RR, Ensunsa JL, Gonsalves JL, Lazarus SA, Schmitz HH, German JB, Keen CL (2001) Chocolate procyanidins decrease the leukotriene-prostacyclin ratio in humans and human aortic endothelial cells. Am J Clin Nutr 73:36–40
35. Maffei R, Carini M, Aldini G, Berti F, Rossoni G, Bombardelli E, Morazzoni P (1999) Diet enriched with procyanidins enhances antioxidant activity and reduces myocardial post-ischaemic damage in rats. Life Sci 64:627–642. doi:10.1016/S0024-3205(98)00605-5