Effects of grape seed extract beverage on blood pressure and metabolic indices in individuals with pre-hypertension: A randomised, double-blinded, two-arm, parallel, placebo-controlled trial

British Journal of Nutrition

Volumn 115, Issue 2, 2016, Pages 226-238

  Park, Eunyoung ^a   Edirisinghe, Indika ^a   Choy, Ying Yng ^b   Waterhouse, Andrew ^b   Burton Freeman, Britt ^a  

^a ILLINOIS INSTITUTE OF TECHNOLOGY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Blood pressure; Endothelial function; Grape seed extract; Insulin sensitivity; Polyphenols; Pre hypertension

Indexed keywords

GLUCOSE; GRAPE SEED EXTRACT; INSULIN; LIPID; LOW DENSITY LIPOPROTEIN; PHENOLIC ACID; PLACEBO; UNCLASSIFIED DRUG; HYDROXYBENZOIC ACID DERIVATIVE;

ADULT; AGED; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; BLOOD FLOW; BLOOD PRESSURE MEASUREMENT; BLOOD SAMPLING; CLINICAL ARTICLE; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DOUBLE BLIND PROCEDURE; DRUG SAFETY; FEMALE; FOLLOW UP; FRUIT JUICE; GLUCOSE BLOOD LEVEL; HUMAN; INSULIN BLOOD LEVEL; INSULIN SENSITIVITY; LIPID BLOOD LEVEL; LIPOPROTEIN BLOOD LEVEL; MALE; MEDICATION COMPLIANCE; PARALLEL DESIGN; PREHYPERTENSION; RANDOMIZED CONTROLLED TRIAL; SCREENING; SYSTOLIC BLOOD PRESSURE; TREATMENT DURATION; VASODILATATION; BEVERAGE; BLOOD; BLOOD PRESSURE; DIET RESTRICTION; DRUG EFFECTS; HYPERTENSION; INSULIN RESISTANCE; MIDDLE AGED; SYSTOLE;

ADULT; AGED; BEVERAGES; BLOOD PRESSURE; DOUBLE-BLIND METHOD; FASTING; FEMALE; GRAPE SEED EXTRACT; HUMANS; HYDROXYBENZOATES; HYPERTENSION; INSULIN; INSULIN RESISTANCE; MALE; MIDDLE AGED; PLACEBOS; PREHYPERTENSION; SYSTOLE;

EID: 84951561612     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114515004328     Document Type: Article

References (52)

1. Roger VL, Go AS, Lloyd-Jones DM, et al. (2012) Heart disease and stroke statistics-2012 update: a report from the American Heart Association. Circulation 125, e2-E220.
2. Fields LE (2004) Mortality from stroke and ischemic heart disease increases exponentially with blood pressure. Hypertension 43, e28; author reply e28.
3. Lewington S, Clarke R, Qizilbash N, et al. (2002) Age-specific relevance of usual blood pressure to vascular mortality: a meta-Analysis of individual data for one million adults in 61 prospective studies. Lancet 360, 1903-1913.
4. Vasan RS, Beiser A, Seshadri S, et al. (2002) Residual lifetime risk for developing hypertension in middle-Aged women and men: ihe Framingham Heart Study. JAMA 287, 1003-1010.
5. Heidenreich PA, Trogdon JG, Khavjou OA, et al. (2011) Forecasting the future of cardiovascular disease in the United States: a policy statement from the American Heart Association. Circulation 123, 933-944.
6. Hansson L, Lindholm LH, Niskanen L, et al. (1999) Effect of angiotensin-converting-Enzyme inhibition compared with conventional therapy on cardiovascular morbidity and mortality in hypertension: the Captopril Prevention Project (CAPPP) randomised trial. Lancet 353, 611-616.
7. Gaciong Z, Sinski M, & Lewandowski J (2013) Blood pressure control and primary prevention of stroke: summary of the recent clinical trial data and meta-Analyses. Curr Hypertens Rep 15, 559-574.
8. Chobanian AV, Bakris GL, Black HR, et al. (2003) The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. JAMA 289, 2560-2572.
9. Vasan RS, Larson MG, Leip EP, et al. (2001) Assessment of frequency of progression to hypertension in non-hypertensive participants in the Framingham Heart Study: a cohort study. Lancet 358, 1682-1686.
10. Eckel RH, Jakicic JM, Ard JD, et al. (2014) 2013 AHA/ACC guideline on lifestyle management to reduce cardiovascular risk: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol 63, 2960-2984.
11. James PA, Oparil S, Carter BL, et al. (2014) 2014 Evidencebased guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8). JAMA 311, 507-520.
12. Chong MF, Macdonald R, & Lovegrove JA (2010) Fruit polyphenols and CVD risk: a review of human intervention studies. Br J Nutr 104, Suppl. 3, S28-S39.
13. Shi J, Yu J, Pohorly JE, et al. (2003) Polyphenolics in grape seeds-biochemistry and functionality. J Med Food 6, 291-299.
14. Sivaprakasapillai B, Edirisinghe I, Randolph J, et al. (2009) Effect of grape seed extract on blood pressure in subjects with the metabolic syndrome. Metabolism 58, 1743-1746.
15. Ras RT, Zock PL, Zebregs YE, et al. (2013) Effect of polyphenol-rich grape seed extract on ambulatory blood pressure in subjects with pre-and stage I hypertension. Br J Nutr 110, 2234-2241.
16. Barona J, Aristizabal JC, Blesso CN, et al. (2012) Grape polyphenols reduce blood pressure and increase flow-mediated vasodilation in men with metabolic syndrome. J Nutr 142, 1626-1632.
17. Robinson M, Lu B, Edirisinghe I, et al. (2012) Effect of grape seed extract on blood pressure in subjects with pre-hypertension. J Pharmacy Nutr Sci 2, 155-159.
18. Edirisinghe I, Burton-Freeman B, & Tissa Kappagoda C (2008) Mechanism of the endothelium-Dependent relaxation evoked by a grape seed extract. Clin Sci (Lond) 114, 331-337.
19. Shen D, Wu Q, Wang M, et al. (2006) Determination of the predominant catechins in Acacia catechu by liquid chromatography/electrospray ionization-mass spectrometry. J Agric Food Chem 54, 3219-3224.
20. Singleton V, & Rossi J (1965) Colorimetry of total phenolics with phosphomolybdic-phosphotungstic acid reagents. Am J Enol Vitic 16, 144-158.
21. Alpert BS (2010) Validation of the Tiba Medical Ambulo 2400 ambulatory blood pressure monitor to the ISO Standard and BHS protocol. Blood Press Monit 15, 275-277.
22. Matthews DR, Hosker JP, Rudenski AS, et al. (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28, 412-419.
23. Corretti MC, Anderson TJ, Benjamin EJ, et al. (2002) Guidelines for the ultrasound assessment of endothelialdependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force. J Am Coll Cardiol 39, 257-265.
24. Belcaro G, Ledda A, Hu S, et al. (2013) Grape seed procyanidins in pre-and mild hypertension: a registry study. Evid Based Complement Alternat Med 2013, 313142.
25. Clifton PM (2004) Effect of grape seed extract and quercetin on cardiovascular and endothelial parameters in high-risk subjects. J Biomed Biotechnol 2004, 272-278.
26. Ward NC, Hodgson JM, Croft KD, et al. (2005) The combination of vitamin C and grape-seed polyphenols increases blood pressure: a randomized, double-blind, placebo-controlled trial. J Hypertens 23, 427-434.
27. Sano A, Uchida R, Saito M, et al. (2007) Beneficial effects of grape seed extract on malondialdehyde-modified LDL. J Nutr Sci Vitaminol (Tokyo) 53, 174-182.
28. Urpi-Sarda M, Monagas M, Khan N, et al. (2009) Targeted metabolic profiling of phenolics in urine and plasma after regular consumption of cocoa by liquid chromatographytandem mass spectrometry. J Chromatogr A 1216, 7258-7267.
29. Koli R, Erlund I, Jula A, et al. (2010) Bioavailability of various polyphenols from a diet containing moderate amounts of berries. J Agric Food Chem 58, 3927-3932.
30. Mountzouris KC, McCartney AL, & Gibson GR (2002) Intestinal microflora of human infants and current trends for its nutritional modulation. Br J Nutr 87, 405-420.
31. Benson AK, Kelly SA, Legge R, et al. (2010) Individuality in gut microbiota composition is a complex polygenic trait shaped by multiple environmental and host genetic factors. Proc Natl Acad Sci U S A 107, 18933-18938.
32. Rechner AR, Spencer JP, Kuhnle G, et al. (2001) Novel biomarkers of the metabolism of caffeic acid derivatives in vivo. Free Radic Biol Med 30, 1213-1222.
33. Natsume M, Osakabe N, Yamagishi M, et al. (2000) Analyses of polyphenols in cacao liquor, cocoa, and chocolate by normal-phase and reversed-phase HPLC. Biosci Biotechnol Biochem 64, 2581-2587.
34. Schroeter H, Heiss C, Balzer J, et al. (2006) (-)-Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humans. Proc Natl Acad Sci U S A 103, 1024-1029.
35. Baba S, Osakabe N, Natsume M, et al. (2001) Absorption and urinary excretion of (-)-Epicatechin after administration of different levels of cocoa powder or (-)-Epicatechin in rats. J Agric Food Chem 49, 6050-6056.
36. Kar P, Laight D, Rooprai HK, et al. (2009) Effects of grape seed extract in type 2 diabetic subjects at high cardiovascular risk: a double blind randomized placebo controlled trial examining metabolic markers, vascular tone, inflammation, oxidative stress and insulin sensitivity. Diabet Med 26, 526-531.
37. Engler MB, Engler MM, Chen CY, et al. (2004) Flavonoid-rich dark chocolate improves endothelial function and increases plasma epicatechin concentrations in healthy adults. J Am Coll Nutr 23, 197-204.
38. Heiss C, Kleinbongard P, Dejam A, et al. (2005) Acute consumption of flavanol-rich cocoa and the reversal of endothelial dysfunction in smokers. J Am Coll Cardiol 46, 1276-1283.
39. Ottaviani JI, Actis-Goretta L, Villordo JJ, et al. (2006) Procyanidin structure defines the extent and specificity of angiotensin I converting enzyme inhibition. Biochimie 88, 359-365.
40. Alvarez E, Rodino-Janeiro BK, Jerez M, et al. (2012) Procyanidins from grape pomace are suitable inhibitors of human endothelial NADPH oxidase. J Cell Biochem 113, 1386-1396.
41. Addison S, Stas S, Hayden MR, et al. (2008) Insulin resistance and blood pressure. Curr Hypertens Rep 10, 319-325.
42. Hu FB, & Stampfer MJ (2005) Insulin resistance and hypertension: the chicken-Egg question revisited. Circulation 112, 1678-1680.
43. Kim JA, Montagnani M, Koh KK, et al. (2006) Reciprocal relationships between insulin resistance and endothelial dysfunction: molecular and pathophysiological mechanisms. Circulation 113, 1888-1904.
44. Rodriguez-Mateos A, Rendeiro C, Bergillos-Meca T, et al. (2013) Intake and time dependence of blueberry flavonoidinduced improvements in vascular function: a randomized, controlled, double-blind, crossover intervention study with mechanistic insights into biological activity. Am J Clin Nutr 98, 1179-1191.
45. Sowers JR (2004) Insulin resistance and hypertension. Am J Physiol Heart Circ Physiol 286, H1597-H1602.
46. El-Atat F, Aneja A, McFarlane S, et al. (2003) Obesity and hypertension. Endocrinol Metab Clin North Am 32, 823-854.
47. Goff DC Jr, Zaccaro DJ, Haffner SM, et al.2003) Insulin sensitivity and the risk of incident hypertension: insights from the Insulin Resistance Atherosclerosis Study. Diabetes Care 26, 805-809.
48. Forman JP, Choi H, & Curhan GC (2009) Uric acid and insulin sensitivity and risk of incident hypertension. Arch Intern Med 169, 155-162.
49. Edirisinghe I, Randolph J, Cheema M, et al. (2012) Effect of grape seed extract on postprandial oxidative status and metabolic responses in men and women with the metabolic syndrome. Funct Food Health Dis 2, 508-521.
50. Meeprom A, Sompong W, Suwannaphet W, et al. (2011) Grape seed extract supplementation prevents high-fructose diet-induced insulin resistance in rats by improving insulin and adiponectin signalling pathways. Br J Nutr 106, 1173-1181.
51. Grassi D, Desideri G, Necozione S, et al. (2008) Blood pressure is reduced and insulin sensitivity increased in glucose-intolerant, hypertensive subjects after 15 days of consuming high-polyphenol dark chocolate. J Nutr 138, 1671-1676.
52. Kishi S, Teixido-Tura G, Ning H, et al. (2015) Cumulative blood pressure in early adulthood and cardiac dysfunction in middle age: the CARDIA study. J Am Coll Cardiol 65, 2679-2687.