Mulberry leaf extract inhibits the development of atherosclerosis in cholesterol-fed rabbits and in cultured aortic vascular smooth muscle cells

Journal of Agricultural and Food Chemistry

Volumn 61, Issue 11, 2013, Pages 2780-2788

  Chan, Kuei Chuan ^a,b   Yang, Mon Yuan ^b   Lin, Ming Cheng ^a,b   Lee, Yi Ju ^a,b   Chang, Wen Chun ^b   Wang, Chau Jong ^a,b  

^a CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^b CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

Author keywords

atherosclerosis; migration; mulberry leaf extract; proliferation

Indexed keywords

ATHEROSCLEROSIS; ENDOTHELIAL FUNCTION; LEAF EXTRACTS; LOW DENSITY LIPOPROTEINS; MIGRATION; NEW ZEALAND WHITE RABBIT; PROLIFERATION; VASCULAR SMOOTH MUSCLE CELLS;

BLOOD VESSELS; CHOLESTEROL; DISEASES; FLAVONOIDS;

PLANTS (BOTANY);

CHOLESTEROL; PLANT EXTRACT;

ANIMAL; AORTA; ARTICLE; ATHEROSCLEROSIS; CELL MOTION; CELL PROLIFERATION; CHEMISTRY; CYTOLOGY; DRUG EFFECT; HUMAN; MALE; METABOLISM; MORUS; PATHOPHYSIOLOGY; PLANT LEAF; RABBIT; SMOOTH MUSCLE FIBER;

ANIMALS; AORTA; ATHEROSCLEROSIS; CELL MOVEMENT; CELL PROLIFERATION; CHOLESTEROL; HUMANS; MALE; MORUS; MYOCYTES, SMOOTH MUSCLE; PLANT EXTRACTS; PLANT LEAVES; RABBITS;

MORUS (ANGIOSPERM); ORYCTOLAGUS CUNICULUS;

EID: 84875472163     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf305328d     Document Type: Article

References (47)

1. Tsutsui, M.; Shimokawa, H.; Otsuji, Y.; Ueta, Y.; Sasaguri, Y.; Yanagihara, N. Nitric oxide synthases and cardiovascular diseases: insights from genetically modified mice Circ. J. 2009, 73, 986-993
2. Xu, J.; Zou, M. H. Molecular insights and therapeutic targets for diabetic endothelial dysfunction Circulation 2009, 120, 1266-1286
3. Ross, R. Atherosclerosis-an inflammatory disease N. Engl. J. Med. 1999, 340, 1928-1929
4. Hansson, G. K. Inflammation, atherosclerosis, and coronary artery disease N. Engl. J. Med. 2005, 352, 1685-1695
5. Asano, N.; Yamashita, T.; Yasuda, K.; Ikeda, K.; Kizu, H.; Kameda, Y.; Kato, A.; Nash, R. J.; Lee, H. S.; Ryu, K. S. Polyhydroxylated alkaloids isolated from mulberry trees (Morus alba L.) and silkworms (Bombyx mori L.) J. Agric. Food Chem. 2001, 49, 4208-4213
6. Kimura, T.; Nakagawa, K.; Kubota, H.; Kojima, Y.; Goto, Y.; Yamagishi, K.; Oita, S.; Oikawa, S.; Miyazawa, T. Food-grade mulberry powder enriched with 1-deoxynojirimycin suppresses the elevation of postprandial blood glucose in humans J. Agric. Food Chem. 2007, 55, 5869-5874
7. El-Beshbishy, H. A.; Singab, A. N.; Sinkkonen, J.; Pihlaja, K. Hypolipidemic and antioxidant effects of Morus alba L. (Egyptian mulberry) root bark fractions supplementation in cholesterol-fed rats Life Sci. 2006, 78, 2724-2733
8. Isabelle, M.; Lee, B. L.; Ong, C. N.; Liu, X.; Huang, D. Peroxyl radical scavenging capacity, polyphenolics, and lipophilic antioxidant profiles of mulberry fruits cultivated in southern China J. Agric. Food Chem. 2008, 56, 9410-9416
9. Doi, K.; Kojima, T.; Fujimoto, Y. Mulberry leaf extract inhibits the oxidative modification of rabbit and human low density lipoprotein Biol. Pharm. Bull. 2000, 23, 1066-1071
10. Andallu, B.; Suryakantham, V.; Lakshmi Srikanthi, B.; Reddy, G. K. Effect of mulberry (Morus indica L.) therapy on plasma and erythrocyte membrane lipids in patients with type 2 diabetes Clin. Chim. Acta 2001, 314, 47-53
11. Andallu, B.; Varadacharyulu, N. Ch. Antioxidant role of mulberry (Morus indica L. cv. Anantha) leaves in streptozotocin-diabetic rats Clin. Chim. Acta 2003, 338, 3-10
12. Chan, K. C.; Ho, H. H.; Huang, C. N.; Lin, M. C.; Chen, H. M.; Wang, C. J. Mulberry leaf extract inhibits vascular smooth muscle cell migration involving block of small GTPase and Akt/NF-κB signals J. Agric. Food Chem. 2009, 57, 9147-9153
13. Chan, K. C.; Ho, H. H.; Peng, C. H.; Lan, K. P.; Lin, M. C.; Chen, H. M.; Wang, C. J. Polyphenol-rich extract from mulberry leaf inhibits vascular smooth muscle cell proliferation involving upregulation of p53 and inhibition of cyclin-dependent kinase J. Agric. Food Chem. 2010, 58, 2536-2542
14. Yang, M. Y.; Huang, C. N.; Chan, K. C.; Yang, Y. S.; Peng, C. H.; Wang, C. J. Mulberry leaf polyphenols possess antiatherogenesis effect via inhibiting LDL oxidation and foam cell formation J. Agric. Food Chem. 2011, 59, 1985-1995
15. Zhishen, J.; Mengcheng, T.; Jianming, W. The determination of flavonoid contents in mulberry and their scavenging effects on superoxide radicals Food Chem. 1999, 64, 555-559
16. Nagy, M.; Grancai, D. Colorimetric determina-tion of flavanones in propolis Pharmazie 1996, 51, 100-101
17. Lee, Y. C.; McKelvy, J. F.; Lang, D. Rapid automatic analysis of sugar components of glycoproteins. II. Neutral sugars Anal. Biochem. 1969, 27, 567-574
18. Bradford, M. M. A rapid and sensitive method for the quantitation of microgram quantitives of protein utilizing the principle of protein-dye binding Anal. Biochem. 1976, 72, 248-254
19. Bligh, E. G.; Dyer, W. J. A rapid method of total lipid extraction and purification Can. J. Biochem. Physiol. 1959, 37, 911-917
20. Lee, H. J.; Chen, C. C.; Chou, F. P.; Wu, C. H.; Lai, F. S.; Yang, M. Y.; Wang, C. J. Water extracts from Nelumbo nucifera leaf reduced plasma lipids and atherosclerosis in cholesterol-fed rabbits J. Food Biochem. 2010, 34, 779-795
21. Chen, C. C.; Hsu, J. D.; Wang, S. F.; Chiang, H. C.; Yang, M. Y.; Kao, E. S.; Ho, Y. C.; Wang, C. J. Hibiscus sabdariffa extract inhibits the development of atherosclerosis in cholesterol-fed rabbits J. Agric. Food Chem. 2003, 51, 5472-5477
22. Chen, B.; McClements, D. J.; Decker, E. A. Design of foods with bioactive lipids for improved health. Annu. Rev. Food Sci. Technol. 2012, DOI: 10.1146/annurev-food-032112-135808.
23. Lichtenstein, A. H. Dietary fat and cardiovascular disease risk: quantity or quality? J. Womens Health (Larchmt.) 2003, 12, 109-114
24. Monteiro, I.; Vaz Almeid, M. D. Dietary fat and ischemic stroke risk in northern Portugal Acta Med. Port. 2007, 20, 307-318
25. Nijveldt, R. J.; van Nood, E.; van Hoorn, D. E.; Boelens, P. G.; van Norren, K.; van Leeuwen, P. A. Flavonoids: a review of probable mechanisms of action and potential applications Am. J. Clin. Nutr. 2001, 74, 418-425
26. Lakenbrink, C.; Lapczynski, S.; Maiwald, B.; Engelhardt, U. H. Flavonoids and other polyphenols in consumer brews of tea and other caffeinated beverages J. Agric. Food Chem. 2000, 48, 2848-2852
27. Kris-Etherton, P. M.; Keen, C. L. Evidence that the antioxidant flavonoids in tea and cocoa are beneficial for cardiovascular health Curr. Opin. Lipidol. 2002, 13, 41-49
28. Arai, Y.; Watanabe, S.; Kimira, M.; Shimoi, K.; Mochizuki, R.; Kinae, N. Dietary intakes of flavonols, flavones and isoflavones by Japanese women and the inverse correlation between quercetin intake and plasma LDL cholesterol concentration J. Nutr. 2000, 130, 2243-2250
29. Hertog, M. G.; Kromhout, D.; Aravanis, C.; Blackburn, H.; Buzina, R.; Fidanza, F.; Giampaoli, S.; Jansen, A.; Menotti, A.; Nedeljkovic, S.; Pekkarinen, M.; Simic, B. S.; Toshima, H.; Feskens, E. J. M.; Hollman, P. C. H.; Katan, M. B. Flavonoid intake and long-term risk of coronary heart disease and cancer in the seven countries study Arch. Intern. Med. 1995, 155, 381-386
30. Hertog, M. G.; Feskens, E. J.; Hollman, P. C.; Katan, M. B.; Kromhout, D. Dietary antioxidant flavonoids and risk of coronary heart disease: The Zutphen Elderly Study Lancet 1993, 342, 1007-1011
31. Shoskes, D. A. Effect of bioflavonoids quercetin and curcumin on ischemic renal injury: a new class of renoprotective agents Transplantation 1998, 66, 147-152
32. Kim, H. P.; Mani, I.; Iversen, L.; Ziboh, V. A. Effects of naturally occurring flavonoids and biflavonoids on epidermal cyclooxygenase and lipoxygenase from guinea pigs Prostaglandins, Leukotrienes Essent. Fatty Acids 1998, 58, 17-24
33. Colon, M.; Nerin, C. Role of catechins in the antioxidant capacity of an active film containing green tea, green coffee, and grapefruit extracts J. Agric. Food Chem. 2012, 60, 9842-9849
34. Arimboor, R.; Arumughan, C. Effect of polymerization on antioxidant and xanthine oxidase inhibitory potential of sea buckthorn (H. rhamnoides) proanthocyanidins J. Food Sci. 2012, 77, C1036-C1041
35. Yang, M. Y.; Huang, C. N.; Chan, K. C.; Yang, Y. S.; Peng, C. H.; Wang, C. J. Mulberry leaf polyphenols possess antiatherogenesis effect via inhibiting LDL oxidation and foam cell formation J. Agric. Food Chem. 2011, 59, 1985-1995
36. Chen, W.; Wang, D.; Wang, L. S.; Bei, D.; Wang, J.; See, W. A.; Mallery, S. R.; Stoner, G. D.; Liu, Z. Pharmacokinetics of protocatechuic acid in mouse and its quantification in human plasma using LC-tandem mass spectrometry J. Chromatogr., B: Anal. Technol. Biomed. Life Sci. 2012, 908, 39-44
37. Li, J.; Deng, Y.; Yuan, C.; Pan, L.; Chai, H.; Keller, W. J.; Kinghorn, A. D. Antioxidant and quinone reductase-inducing constituents of black chokeberry (Aronia melanocarpa) fruits J. Agric. Food Chem. 2012, 60, 11551-11559
38. Kim, K.; Bae, O. N.; Lim, K. M.; Noh, J. Y.; Kang, S.; Chung, K. Y.; Chung, J. H. Novel antiplatelet activity of protocatechuic acid through the inhibition of high shear stress-induced platelet aggregation J. Pharmacol. Exp. Ther. 2012, 343, 704-711
39. Hou, L.; Zhou, B.; Yang, L.; Liu, Z. L. Inhibition of human low density lipoprotein oxidation by flavonols and their glycosides Chem. Phys. Lipids 2004, 129, 209-219
40. Vieira, O.; Escargueil-Blanc, I.; Meilhac, O.; Basile, J. P.; Laranjinha, J.; Almeida, L.; Salvayre, R.; Nègre-Salvayre, A. Effect of dietary phenolic compounds on apoptosis of human cultured endothelial cells induced by oxidized LDL Br. J. Pharmacol. 1998, 123, 565-573
41. Katsube, T.; Yamasaki, M.; Shiwaku, K.; Ishijima, T.; Matsumoto, I.; Abe, K.; Yamasaki, Y. Effect of flavonol glycoside in mulberry (Morus alba L.) leaf on glucose metabolism and oxidative stress in liver in diet-induced obese mice J. Sci. Food Agric. 2010, 90, 2386-2392
42. Choi, S. H.; Chae, A.; Miller, E.; Messig, M.; Ntanios, F.; DeMaria, A. N.; Nissen, S. E.; Witztum, J. L.; Tsimikas, S. Relationship between biomarkers of oxidized low-density lipoprotein, statin therapy, quantitative coronary angiography, and atheroma: volume observations from the REVERSAL (reversal of atherosclerosis with aggressive lipid lowering) study J. Am. Coll. Cardiol. 2008, 52, 24-32
43. Nissen, S. E.; Nicholls, S. J.; Sipahi, I.; Libby, P.; Raichlen, J. S.; Ballantyne, C. M.; Davignon, J.; Erbel, R.; Fruchart, J. C.; Tardif, J. C.; Schoenhagen, P.; Crowe, T.; Cain, V.; Wolski, K.; Goormastic, M.; Tuzcu, E. M. ASTEROID investigators. Effect of very high-intensity statin therapy on regression of coronary atherosclerosis: the ASTEROID trial J., J. Am. Med. Assoc. 2006, 295, 1556-1565
44. Aramwit, P.; Petcharat, K.; Supasyndh, O. Efficacy of mulberry leaf tablets in patients with mild dyslipidemia Phytother. Res. 2011, 25, 365-369
45. Ross, R. Cell biology of atherosclerosis Annu. Rev. Physiol. 1995, 57, 791-804
46. Schwartz, S. M.; deBlois, D.; O'Brien, E. R. The intima. Soil for atherosclerosis and restenosis Circ. Res. 1995, 77, 445-465
47. Braun-Dullaeus, R. C.; Mann, M. J.; Dzau, V. J. Cell cycle progression: new therpeutic target for vascular proliferative disease Circulation 1998, 98, 82-89