메뉴 건너뛰기




Volumn 39, Issue 5, 2017, Pages 517-528

Cytokine storm and sepsis disease pathogenesis

Author keywords

Cytokine; Endothelium; Inflammation; Innate immunity; Sepsis

Indexed keywords

BIOLOGICAL FACTOR; CASPASE RECRUITMENT DOMAIN PROTEIN 15; CASPASE RECRUITMENT DOMAIN PROTEIN 4; CD209 ANTIGEN; CHEMOKINE RECEPTOR CXCR3; COLONY STIMULATING FACTOR 1; CXCL1 CHEMOKINE; CXCL2 CHEMOKINE; DISEASE ASSOCIATED MOLECULAR PATTERN; GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 3; INTERLEUKIN 4; INTERLEUKIN 6; MESSENGER RNA; MYELOID DIFFERENTIATION FACTOR 88; PATHOGEN ASSOCIATED MOLECULAR PATTERN; PATTERN RECOGNITION RECEPTOR; SPHINGOSINE 1 PHOSPHATE; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; AUTACOID; BIOLOGICAL MARKER; CYTOKINE;

EID: 85019757791     PISSN: 18632297     EISSN: 18632300     Source Type: Journal    
DOI: 10.1007/s00281-017-0639-8     Document Type: Review
Times cited : (975)

References (125)
  • 1
    • 0027410737 scopus 로고
    • Cytokine storm of graft-versus-host disease: a critical effector role for interleukin-1
    • COI: 1:STN:280:DyaK3s7ot1Sisw%3D%3D, PID: 8442093
    • Ferrara JL, Abhyankar S, Gilliland DG (1993) Cytokine storm of graft-versus-host disease: a critical effector role for interleukin-1. Transplant Proc 25(1 Pt 2):1216–1217
    • (1993) Transplant Proc , vol.25 , Issue.1 , pp. 1216-1217
    • Ferrara, J.L.1    Abhyankar, S.2    Gilliland, D.G.3
  • 2
    • 1542495260 scopus 로고    scopus 로고
    • Influenza-associated encephalopathy—pathophysiology and disease mechanisms
    • PID: 14619437
    • Yokota S (2003) Influenza-associated encephalopathy—pathophysiology and disease mechanisms. Nihon Rinsho 61(11):1953–1958
    • (2003) Nihon Rinsho , vol.61 , Issue.11 , pp. 1953-1958
    • Yokota, S.1
  • 4
    • 0026724481 scopus 로고
    • The ACCP-SCCM consensus conference on sepsis and organ failure
    • COI: 1:STN:280:DyaK383ovFartA%3D%3D, PID: 1600757
    • Bone RC, Sibbald WJ, Sprung CL (1992) The ACCP-SCCM consensus conference on sepsis and organ failure. Chest 101(6):1481–1483
    • (1992) Chest , vol.101 , Issue.6 , pp. 1481-1483
    • Bone, R.C.1    Sibbald, W.J.2    Sprung, C.L.3
  • 6
    • 84973902514 scopus 로고    scopus 로고
    • Assessment of global incidence and mortality of hospital-treated sepsis. Current estimates and limitations
    • COI: 1:CAS:528:DC%2BC28XhtFaksrjJ, PID: 26414292
    • Fleischmann C, Scherag A, Adhikari NK, Hartog CS, Tsaganos T, Schlattmann P, Angus DC, Reinhart K, International Forum of Acute Care T (2016) Assessment of global incidence and mortality of hospital-treated sepsis. Current estimates and limitations. Am J Respir Crit Care Med 193(3):259–272. doi:10.1164/rccm.201504-0781OC
    • (2016) Am J Respir Crit Care Med , vol.193 , Issue.3 , pp. 259-272
    • Fleischmann, C.1    Scherag, A.2    Adhikari, N.K.3    Hartog, C.S.4    Tsaganos, T.5    Schlattmann, P.6    Angus, D.C.7    Reinhart, K.8
  • 7
    • 77953577951 scopus 로고    scopus 로고
    • Population trends in the incidence and outcomes of acute myocardial infarction
    • COI: 1:CAS:528:DC%2BC3cXnsV2hsbY%3D, PID: 20558366
    • Yeh RW, Sidney S, Chandra M, Sorel M, Selby JV, Go AS (2010) Population trends in the incidence and outcomes of acute myocardial infarction. N Engl J Med 362(23):2155–2165. doi:10.1056/NEJMoa0908610
    • (2010) N Engl J Med , vol.362 , Issue.23 , pp. 2155-2165
    • Yeh, R.W.1    Sidney, S.2    Chandra, M.3    Sorel, M.4    Selby, J.V.5    Go, A.S.6
  • 8
    • 84892805731 scopus 로고    scopus 로고
    • Cancer statistics, 2014
    • PID: 24399786
    • Siegel R, Ma J, Zou Z, Jemal A (2014) Cancer statistics, 2014. CA Cancer J Clin 64(1):9–29. doi:10.3322/caac.21208
    • (2014) CA Cancer J Clin , vol.64 , Issue.1 , pp. 9-29
    • Siegel, R.1    Ma, J.2    Zou, Z.3    Jemal, A.4
  • 9
    • 77958108729 scopus 로고    scopus 로고
    • Critical care and the global burden of critical illness in adults
    • PID: 20934212
    • Adhikari NK, Fowler RA, Bhagwanjee S, Rubenfeld GD (2010) Critical care and the global burden of critical illness in adults. Lancet 376(9749):1339–1346. doi:10.1016/S0140-6736(10)60446-1
    • (2010) Lancet , vol.376 , Issue.9749 , pp. 1339-1346
    • Adhikari, N.K.1    Fowler, R.A.2    Bhagwanjee, S.3    Rubenfeld, G.D.4
  • 10
    • 0036212849 scopus 로고    scopus 로고
    • Innate immune recognition
    • COI: 1:CAS:528:DC%2BD38XjtlWgt7Y%3D, PID: 11861602
    • Janeway CA Jr, Medzhitov R (2002) Innate immune recognition. Annu Rev Immunol 20:197–216. doi:10.1146/annurev.immunol.20.083001.084359
    • (2002) Annu Rev Immunol , vol.20 , pp. 197-216
    • Janeway, C.A.1    Medzhitov, R.2
  • 11
    • 32944464648 scopus 로고    scopus 로고
    • Pathogen recognition and innate immunity
    • COI: 1:CAS:528:DC%2BD28Xit1Kltb8%3D, PID: 16497588
    • Akira S, Uematsu S, Takeuchi O (2006) Pathogen recognition and innate immunity. Cell 124(4):783–801. doi:10.1016/j.cell.2006.02.015
    • (2006) Cell , vol.124 , Issue.4 , pp. 783-801
    • Akira, S.1    Uematsu, S.2    Takeuchi, O.3
  • 12
    • 84880711233 scopus 로고    scopus 로고
    • Training innate immunity: the changing concept of immunological memory in innate host defence
    • COI: 1:CAS:528:DC%2BC3sXhtFOjurjJ
    • Netea MG (2013) Training innate immunity: the changing concept of immunological memory in innate host defence. Eur J Clin Investig 43(8):881–884. doi:10.1111/eci.12132
    • (2013) Eur J Clin Investig , vol.43 , Issue.8 , pp. 881-884
    • Netea, M.G.1
  • 13
    • 79956080152 scopus 로고    scopus 로고
    • Trained immunity: a memory for innate host defense
    • COI: 1:CAS:528:DC%2BC3MXmtFaju7c%3D, PID: 21575907
    • Netea MG, Quintin J, van der Meer JW (2011) Trained immunity: a memory for innate host defense. Cell Host Microbe 9(5):355–361. doi:10.1016/j.chom.2011.04.006
    • (2011) Cell Host Microbe , vol.9 , Issue.5 , pp. 355-361
    • Netea, M.G.1    Quintin, J.2    van der Meer, J.W.3
  • 14
    • 0030595339 scopus 로고    scopus 로고
    • The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults
    • COI: 1:CAS:528:DyaK28XlvV2nsLY%3D, PID: 8808632
    • Lemaitre B, Nicolas E, Michaut L, Reichhart JM, Hoffmann JA (1996) The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell 86(6):973–983
    • (1996) Cell , vol.86 , Issue.6 , pp. 973-983
    • Lemaitre, B.1    Nicolas, E.2    Michaut, L.3    Reichhart, J.M.4    Hoffmann, J.A.5
  • 15
    • 0030831210 scopus 로고    scopus 로고
    • A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
    • COI: 1:CAS:528:DyaK2sXkvVChurc%3D, PID: 9237759
    • Medzhitov R, Preston-Hurlburt P, Janeway CA Jr (1997) A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 388(6640):394–397. doi:10.1038/41131
    • (1997) Nature , vol.388 , Issue.6640 , pp. 394-397
    • Medzhitov, R.1    Preston-Hurlburt, P.2    Janeway, C.A.3
  • 18
    • 79956300649 scopus 로고    scopus 로고
    • Toll-like receptors and their crosstalk with other innate receptors in infection and immunity
    • COI: 1:CAS:528:DC%2BC3MXms12rs7w%3D, PID: 21616434
    • Kawai T, Akira S (2011) Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. Immunity 34(5):637–650. doi:10.1016/j.immuni.2011.05.006
    • (2011) Immunity , vol.34 , Issue.5 , pp. 637-650
    • Kawai, T.1    Akira, S.2
  • 19
    • 38749102775 scopus 로고    scopus 로고
    • Severe sepsis and Toll-like receptors
    • COI: 1:CAS:528:DC%2BD1cXht1Sit7Y%3D, PID: 18071706
    • Gao H, Leaver SK, Burke-Gaffney A, Finney SJ (2008) Severe sepsis and Toll-like receptors. Semin Immunopathol 30(1):29–40. doi:10.1007/s00281-007-0101-4
    • (2008) Semin Immunopathol , vol.30 , Issue.1 , pp. 29-40
    • Gao, H.1    Leaver, S.K.2    Burke-Gaffney, A.3    Finney, S.J.4
  • 20
    • 11444249412 scopus 로고    scopus 로고
    • Septic shock
    • COI: 1:CAS:528:DC%2BD2MXhvF2gsA%3D%3D, PID: 15639681
    • Annane D, Bellissant E, Cavaillon JM (2005) Septic shock. Lancet 365(9453):63–78. doi:10.1016/S0140-6736(04)17667-8
    • (2005) Lancet , vol.365 , Issue.9453 , pp. 63-78
    • Annane, D.1    Bellissant, E.2    Cavaillon, J.M.3
  • 21
    • 3142724031 scopus 로고    scopus 로고
    • Toll-like receptor signalling
    • COI: 1:CAS:528:DC%2BD2cXlt1Cqur0%3D, PID: 15229469
    • Akira S, Takeda K (2004) Toll-like receptor signalling. Nat Rev Immunol 4(7):499–511. doi:10.1038/nri1391
    • (2004) Nat Rev Immunol , vol.4 , Issue.7 , pp. 499-511
    • Akira, S.1    Takeda, K.2
  • 22
    • 2142703865 scopus 로고    scopus 로고
    • Differential expression of Toll-like receptor (TLR)-2 and TLR-4 on monocytes in human sepsis
    • COI: 1:CAS:528:DC%2BD2cXksVSjsL8%3D, PID: 15086396
    • Armstrong L, Medford AR, Hunter KJ, Uppington KM, Millar AB (2004) Differential expression of Toll-like receptor (TLR)-2 and TLR-4 on monocytes in human sepsis. Clin Exp Immunol 136(2):312–319. doi:10.1111/j.1365-2249.2004.02433.x
    • (2004) Clin Exp Immunol , vol.136 , Issue.2 , pp. 312-319
    • Armstrong, L.1    Medford, A.R.2    Hunter, K.J.3    Uppington, K.M.4    Millar, A.B.5
  • 23
    • 8144222235 scopus 로고    scopus 로고
    • Increased expression of toll-like receptor-2 and -4 on leukocytes from patients with sepsis
    • PID: 15489631
    • Harter L, Mica L, Stocker R, Trentz O, Keel M (2004) Increased expression of toll-like receptor-2 and -4 on leukocytes from patients with sepsis. Shock 22(5):403–409
    • (2004) Shock , vol.22 , Issue.5 , pp. 403-409
    • Harter, L.1    Mica, L.2    Stocker, R.3    Trentz, O.4    Keel, M.5
  • 24
    • 33845890803 scopus 로고    scopus 로고
    • Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation
    • COI: 1:CAS:528:DC%2BD28XhtlChtL7M, PID: 17186029
    • Mariathasan S, Monack DM (2007) Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation. Nat Rev Immunol 7(1):31–40. doi:10.1038/nri1997
    • (2007) Nat Rev Immunol , vol.7 , Issue.1 , pp. 31-40
    • Mariathasan, S.1    Monack, D.M.2
  • 26
    • 0038558248 scopus 로고    scopus 로고
    • Dectin-1 mediates the biological effects of beta-glucans
    • COI: 1:CAS:528:DC%2BD3sXjs1ygs7k%3D, PID: 12719478
    • Brown GD, Herre J, Williams DL, Willment JA, Marshall AS, Gordon S (2003) Dectin-1 mediates the biological effects of beta-glucans. J Exp Med 197(9):1119–1124. doi:10.1084/jem.20021890
    • (2003) J Exp Med , vol.197 , Issue.9 , pp. 1119-1124
    • Brown, G.D.1    Herre, J.2    Williams, D.L.3    Willment, J.A.4    Marshall, A.S.5    Gordon, S.6
  • 28
    • 33747036397 scopus 로고    scopus 로고
    • Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity
    • COI: 1:CAS:528:DC%2BD28XnvVynsrg%3D, PID: 16862125
    • Gross O, Gewies A, Finger K, Schafer M, Sparwasser T, Peschel C, Forster I, Ruland J (2006) Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity. Nature 442(7103):651–656. doi:10.1038/nature04926
    • (2006) Nature , vol.442 , Issue.7103 , pp. 651-656
    • Gross, O.1    Gewies, A.2    Finger, K.3    Schafer, M.4    Sparwasser, T.5    Peschel, C.6    Forster, I.7    Ruland, J.8
  • 29
    • 0035817818 scopus 로고    scopus 로고
    • Immune recognition. A new receptor for beta-glucans
    • COI: 1:CAS:528:DC%2BD3MXmvFSmurs%3D, PID: 11544516
    • Brown GD, Gordon S (2001) Immune recognition. A new receptor for beta-glucans. Nature 413(6851):36–37. doi:10.1038/35092620
    • (2001) Nature , vol.413 , Issue.6851 , pp. 36-37
    • Brown, G.D.1    Gordon, S.2
  • 30
    • 34547797521 scopus 로고    scopus 로고
    • The role of the beta-glucan receptor Dectin-1 in control of fungal infection
    • COI: 1:CAS:528:DC%2BD2sXos12rtbk%3D, PID: 17475782
    • Dennehy KM, Brown GD (2007) The role of the beta-glucan receptor Dectin-1 in control of fungal infection. J Leukoc Biol 82(2):253–258. doi:10.1189/jlb.1206753
    • (2007) J Leukoc Biol , vol.82 , Issue.2 , pp. 253-258
    • Dennehy, K.M.1    Brown, G.D.2
  • 31
    • 67349265964 scopus 로고    scopus 로고
    • Innate signaling by the C-type lectin DC-SIGN dictates immune responses
    • den Dunnen J, Gringhuis SI, Geijtenbeek TB (2009) Innate signaling by the C-type lectin DC-SIGN dictates immune responses. Cancer Immunol, Immunother 58(7):1149–1157. doi:10.1007/s00262-008-0615-1
    • (2009) Cancer Immunol, Immunother , vol.58 , Issue.7 , pp. 1149-1157
    • den Dunnen, J.1    Gringhuis, S.I.2    Geijtenbeek, T.B.3
  • 32
    • 84901981964 scopus 로고    scopus 로고
    • An evolving arsenal: viral RNA detection by RIG-I-like receptors
    • COI: 1:CAS:528:DC%2BC2cXhtlakurvF, PID: 24912143
    • Fitzgerald ME, Rawling DC, Vela A, Pyle AM (2014) An evolving arsenal: viral RNA detection by RIG-I-like receptors. Curr Opin Microbiol 20:76–81. doi:10.1016/j.mib.2014.05.004
    • (2014) Curr Opin Microbiol , vol.20 , pp. 76-81
    • Fitzgerald, M.E.1    Rawling, D.C.2    Vela, A.3    Pyle, A.M.4
  • 33
    • 0037588986 scopus 로고    scopus 로고
    • The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome
    • COI: 1:CAS:528:DC%2BD3sXktVGnt78%3D, PID: 12543869
    • Aird WC (2003) The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome. Blood 101(10):3765–3777. doi:10.1182/blood-2002-06-1887
    • (2003) Blood , vol.101 , Issue.10 , pp. 3765-3777
    • Aird, W.C.1
  • 35
    • 0037389936 scopus 로고    scopus 로고
    • Bench-to-bedside review: endothelial cell dysfunction in severe sepsis: a role in organ dysfunction?
    • PID: 12720559
    • Vallet B (2003) Bench-to-bedside review: endothelial cell dysfunction in severe sepsis: a role in organ dysfunction? Crit Care 7(2):130–138
    • (2003) Crit Care , vol.7 , Issue.2 , pp. 130-138
    • Vallet, B.1
  • 36
    • 69849099496 scopus 로고    scopus 로고
    • Bench-to-bedside review: association of genetic variation with sepsis
    • PID: 19439056
    • Sutherland AM, Walley KR (2009) Bench-to-bedside review: association of genetic variation with sepsis. Crit Care 13(2):210. doi:10.1186/cc7702
    • (2009) Crit Care , vol.13 , Issue.2 , pp. 210
    • Sutherland, A.M.1    Walley, K.R.2
  • 37
    • 26244452958 scopus 로고    scopus 로고
    • Genetic polymorphisms and sepsis
    • COI: 1:CAS:528:DC%2BD2MXhtFGlt7zP, PID: 16205313
    • Arcaroli J, Fessler MB, Abraham E (2005) Genetic polymorphisms and sepsis. Shock 24(4):300–312
    • (2005) Shock , vol.24 , Issue.4 , pp. 300-312
    • Arcaroli, J.1    Fessler, M.B.2    Abraham, E.3
  • 38
    • 2942726193 scopus 로고    scopus 로고
    • Importance of hemostatic gene polymorphisms for susceptibility to and outcome of severe sepsis
    • PID: 15118537
    • Texereau J, Pene F, Chiche JD, Rousseau C, Mira JP (2004) Importance of hemostatic gene polymorphisms for susceptibility to and outcome of severe sepsis. Crit Care Med 32(5 Suppl):S313–S319
    • (2004) Crit Care Med , vol.32 , pp. S313-S319
    • Texereau, J.1    Pene, F.2    Chiche, J.D.3    Rousseau, C.4    Mira, J.P.5
  • 39
    • 84055182880 scopus 로고    scopus 로고
    • Genetic predisposition to respiratory infection and sepsis
    • COI: 1:CAS:528:DC%2BC3MXhs1KrsbbJ, PID: 22185617
    • Chung LP, Waterer GW (2011) Genetic predisposition to respiratory infection and sepsis. Crit Rev Clin Lab Sci 48(5–6):250–268. doi:10.3109/10408363.2011.641517
    • (2011) Crit Rev Clin Lab Sci , vol.48 , Issue.5-6 , pp. 250-268
    • Chung, L.P.1    Waterer, G.W.2
  • 40
    • 77953075386 scopus 로고    scopus 로고
    • Mechanisms and regulation of the gene-expression response to sepsis
    • PID: 20478944
    • Cornell TT, Wynn J, Shanley TP, Wheeler DS, Wong HR (2010) Mechanisms and regulation of the gene-expression response to sepsis. Pediatrics 125(6):1248–1258. doi:10.1542/peds.2009-3274
    • (2010) Pediatrics , vol.125 , Issue.6 , pp. 1248-1258
    • Cornell, T.T.1    Wynn, J.2    Shanley, T.P.3    Wheeler, D.S.4    Wong, H.R.5
  • 42
    • 0042921428 scopus 로고    scopus 로고
    • Influence of the TNF-alpha and TNF-beta polymorphisms upon infectious risk and outcome in surgical intensive care patients
    • Calvano JE, Um JY, Agnese DM, Hahm SJ, Kumar A, Coyle SM, Calvano SE, Lowry SF (2003) Influence of the TNF-alpha and TNF-beta polymorphisms upon infectious risk and outcome in surgical intensive care patients. Surg Infect 4(2):163–169. doi:10.1089/109629603766956951
    • (2003) Surg Infect , vol.4 , Issue.2 , pp. 163-169
    • Calvano, J.E.1    Um, J.Y.2    Agnese, D.M.3    Hahm, S.J.4    Kumar, A.5    Coyle, S.M.6    Calvano, S.E.7    Lowry, S.F.8
  • 43
    • 0037079943 scopus 로고    scopus 로고
    • Influence of interleukin-1 receptor antagonist gene polymorphism on disease
    • COI: 1:CAS:528:DC%2BD38XntFOjtA%3D%3D, PID: 11740709
    • Witkin SS, Gerber S, Ledger WJ (2002) Influence of interleukin-1 receptor antagonist gene polymorphism on disease. Clin Infect Dis 34(2):204–209. doi:10.1086/338261
    • (2002) Clin Infect Dis , vol.34 , Issue.2 , pp. 204-209
    • Witkin, S.S.1    Gerber, S.2    Ledger, W.J.3
  • 46
    • 84055218634 scopus 로고    scopus 로고
    • Polymorphisms of genes encoding tumor necrosis factor-alpha, interleukin-10, cluster of differentiation-14 and interleukin-1ra in critically ill patients
    • PID: 20163933, e541-548
    • Surbatovic M, Grujic K, Cikota B, Jevtic M, Filipovic N, Romic P, Strelic N, Magic Z (2010) Polymorphisms of genes encoding tumor necrosis factor-alpha, interleukin-10, cluster of differentiation-14 and interleukin-1ra in critically ill patients. J Crit Care 25(3):542 e541-548. doi:10.1016/j.jcrc.2009.12.003
    • (2010) J Crit Care , vol.25 , Issue.3 , pp. 542
    • Surbatovic, M.1    Grujic, K.2    Cikota, B.3    Jevtic, M.4    Filipovic, N.5    Romic, P.6    Strelic, N.7    Magic, Z.8
  • 47
    • 0037071251 scopus 로고    scopus 로고
    • Relevance of mutations in the TLR4 receptor in patients with gram-negative septic shock
    • COI: 1:CAS:528:DC%2BD38Xkt12rsbs%3D, PID: 11996613
    • Lorenz E, Mira JP, Frees KL, Schwartz DA (2002) Relevance of mutations in the TLR4 receptor in patients with gram-negative septic shock. Arch Intern Med 162(9):1028–1032
    • (2002) Arch Intern Med , vol.162 , Issue.9 , pp. 1028-1032
    • Lorenz, E.1    Mira, J.P.2    Frees, K.L.3    Schwartz, D.A.4
  • 49
    • 0037312723 scopus 로고    scopus 로고
    • Association of IL-10 polymorphism with severity of illness in community acquired pneumonia
    • COI: 1:STN:280:DC%2BD3s%2FksFKmtQ%3D%3D, PID: 12554901
    • Gallagher PM, Lowe G, Fitzgerald T, Bella A, Greene CM, McElvaney NG, O’Neill SJ (2003) Association of IL-10 polymorphism with severity of illness in community acquired pneumonia. Thorax 58(2):154–156
    • (2003) Thorax , vol.58 , Issue.2 , pp. 154-156
    • Gallagher, P.M.1    Lowe, G.2    Fitzgerald, T.3    Bella, A.4    Greene, C.M.5    McElvaney, N.G.6    O’Neill, S.J.7
  • 51
    • 0014376435 scopus 로고
    • Lymphocyte in vitro cytotoxicity: characterization of human lymphotoxin
    • COI: 1:CAS:528:DyaF1MXnsVertg%3D%3D, PID: 5249808
    • Kolb WP, Granger GA (1968) Lymphocyte in vitro cytotoxicity: characterization of human lymphotoxin. Proc Natl Acad Sci U S A 61(4):1250–1255
    • (1968) Proc Natl Acad Sci U S A , vol.61 , Issue.4 , pp. 1250-1255
    • Kolb, W.P.1    Granger, G.A.2
  • 52
    • 37049236423 scopus 로고
    • Cytotoxic effect of lymphocyte-antigen interaction in delayed hypersensitivity
    • COI: 1:CAS:528:DyaF2sXkvV2hsrY%3D, PID: 6036235
    • Ruddle NH, Waksman BH (1967) Cytotoxic effect of lymphocyte-antigen interaction in delayed hypersensitivity. Science 157(3792):1060–1062
    • (1967) Science , vol.157 , Issue.3792 , pp. 1060-1062
    • Ruddle, N.H.1    Waksman, B.H.2
  • 54
    • 0022371461 scopus 로고
    • Identity of tumour necrosis factor and the macrophage-secreted factor cachectin
    • COI: 1:CAS:528:DyaL2MXlt1Wntr0%3D, PID: 2993897
    • Beutler B, Greenwald D, Hulmes JD, Chang M, Pan YC, Mathison J, Ulevitch R, Cerami A (1985) Identity of tumour necrosis factor and the macrophage-secreted factor cachectin. Nature 316(6028):552–554
    • (1985) Nature , vol.316 , Issue.6028 , pp. 552-554
    • Beutler, B.1    Greenwald, D.2    Hulmes, J.D.3    Chang, M.4    Pan, Y.C.5    Mathison, J.6    Ulevitch, R.7    Cerami, A.8
  • 55
    • 0024942129 scopus 로고
    • Is TNF a key to acute infectious illness?
    • Clark IA, Cowden WB (1989) Is TNF a key to acute infectious illness? Today’s Life Sci 1:26–29
    • (1989) Today’s Life Sci , vol.1 , pp. 26-29
    • Clark, I.A.1    Cowden, W.B.2
  • 56
    • 0019405404 scopus 로고
    • Possible importance of macrophage-derived mediators in acute malaria
    • COI: 1:CAS:528:DyaL3MXkt1arsrc%3D, PID: 6166564
    • Clark IA, Virelizier JL, Carswell EA, Wood PR (1981) Possible importance of macrophage-derived mediators in acute malaria. Infect Immun 32(3):1058–1066
    • (1981) Infect Immun , vol.32 , Issue.3 , pp. 1058-1066
    • Clark, I.A.1    Virelizier, J.L.2    Carswell, E.A.3    Wood, P.R.4
  • 57
    • 0019957124 scopus 로고
    • Suggested importance of monokines in pathophysiology of endotoxin shock and malaria
    • COI: 1:CAS:528:DyaL3sXhslOjsL8%3D, PID: 6181289
    • Clark IA (1982) Suggested importance of monokines in pathophysiology of endotoxin shock and malaria. Klin Wochenschr 60(14):756–758
    • (1982) Klin Wochenschr , vol.60 , Issue.14 , pp. 756-758
    • Clark, I.A.1
  • 59
    • 0023491364 scopus 로고
    • Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia
    • COI: 1:CAS:528:DyaL1cXlsVSktg%3D%3D, PID: 3317066
    • Tracey KJ, Fong Y, Hesse DG, Manogue KR, Lee AT, Kuo GC, Lowry SF, Cerami A (1987) Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia. Nature 330(6149):662–664. doi:10.1038/330662a0
    • (1987) Nature , vol.330 , Issue.6149 , pp. 662-664
    • Tracey, K.J.1    Fong, Y.2    Hesse, D.G.3    Manogue, K.R.4    Lee, A.T.5    Kuo, G.C.6    Lowry, S.F.7    Cerami, A.8
  • 60
    • 0024217781 scopus 로고
    • Cachectin/tumor necrosis factor and other cytokines in infectious disease
    • COI: 1:STN:280:DyaK3c%2Fislagsg%3D%3D, PID: 2679705
    • Tracey KJ, Cerami A (1989) Cachectin/tumor necrosis factor and other cytokines in infectious disease. Curr Opin Immunol 1(3):454–461
    • (1989) Curr Opin Immunol , vol.1 , Issue.3 , pp. 454-461
    • Tracey, K.J.1    Cerami, A.2
  • 61
    • 36248974200 scopus 로고    scopus 로고
    • Historical insights into cytokines
    • COI: 1:CAS:528:DC%2BD2sXhsVSgtbbF, PID: 17972343
    • Dinarello CA (2007) Historical insights into cytokines. Eur J Immunol 37(Suppl 1):S34–S45. doi:10.1002/eji.200737772
    • (2007) Eur J Immunol , vol.37 , pp. S34-S45
    • Dinarello, C.A.1
  • 62
    • 77952295021 scopus 로고    scopus 로고
    • Interleukin-1 (IL-1) pathway
    • PID: 20086235
    • Weber A, Wasiliew P, Kracht M (2010) Interleukin-1 (IL-1) pathway. Sci Signal 3(105):cm1. doi:10.1126/scisignal.3105cm1
    • (2010) Sci Signal , vol.3 , Issue.105 , pp. cm1
    • Weber, A.1    Wasiliew, P.2    Kracht, M.3
  • 63
    • 78650835112 scopus 로고    scopus 로고
    • Multiplex cytokine profiling in patients with sepsis
    • COI: 1:CAS:528:DC%2BC3MXhvVGmur4%3D, PID: 21208283
    • Mera S, Tatulescu D, Cismaru C, Bondor C, Slavcovici A, Zanc V, Carstina D, Oltean M (2011) Multiplex cytokine profiling in patients with sepsis. APMIS 119(2):155–163. doi:10.1111/j.1600-0463.2010.02705.x
    • (2011) APMIS , vol.119 , Issue.2 , pp. 155-163
    • Mera, S.1    Tatulescu, D.2    Cismaru, C.3    Bondor, C.4    Slavcovici, A.5    Zanc, V.6    Carstina, D.7    Oltean, M.8
  • 64
    • 80052358980 scopus 로고    scopus 로고
    • Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling
    • COI: 1:CAS:528:DC%2BC3MXhtFOhsbjF, PID: 21881215
    • Jones SA, Scheller J, Rose-John S (2011) Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling. J Clin Invest 121(9):3375–3383. doi:10.1172/JCI57158
    • (2011) J Clin Invest , vol.121 , Issue.9 , pp. 3375-3383
    • Jones, S.A.1    Scheller, J.2    Rose-John, S.3
  • 65
    • 84858234363 scopus 로고    scopus 로고
    • Early interleukin-6 and slope of monocyte human leukocyte antigen-DR: a powerful association to predict the development of sepsis after major trauma
    • COI: 1:CAS:528:DC%2BC38Xks1KitLg%3D, PID: 22431998
    • Gouel-Cheron A, Allaouchiche B, Guignant C, Davin F, Floccard B, Monneret G, AzuRea G (2012) Early interleukin-6 and slope of monocyte human leukocyte antigen-DR: a powerful association to predict the development of sepsis after major trauma. PLoS One 7(3):e33095. doi:10.1371/journal.pone.0033095
    • (2012) PLoS One , vol.7 , Issue.3
    • Gouel-Cheron, A.1    Allaouchiche, B.2    Guignant, C.3    Davin, F.4    Floccard, B.5    Monneret, G.6    AzuRea, G.7
  • 66
    • 84871881145 scopus 로고    scopus 로고
    • Serial cytokine levels in patients with severe sepsis
    • COI: 1:CAS:528:DC%2BD1MXot1Gnur4%3D, PID: 19262987
    • Wu HP, Chen CK, Chung K, Tseng JC, Hua CC, Liu YC, Chuang DY, Yang CH (2009) Serial cytokine levels in patients with severe sepsis. Inflamm Res 58(7):385–393. doi:10.1007/s00011-009-0003-0
    • (2009) Inflamm Res , vol.58 , Issue.7 , pp. 385-393
    • Wu, H.P.1    Chen, C.K.2    Chung, K.3    Tseng, J.C.4    Hua, C.C.5    Liu, Y.C.6    Chuang, D.Y.7    Yang, C.H.8
  • 67
    • 34548022149 scopus 로고    scopus 로고
    • Understanding the inflammatory cytokine response in pneumonia and sepsis: results of the Genetic and Inflammatory Markers of Sepsis (GenIMS) Study
    • COI: 1:CAS:528:DC%2BD2sXhtVSqtrvL, PID: 17698689
    • Kellum JA, Kong L, Fink MP, Weissfeld LA, Yealy DM, Pinsky MR, Fine J, Krichevsky A, Delude RL, Angus DC, Gen IMSI (2007) Understanding the inflammatory cytokine response in pneumonia and sepsis: results of the Genetic and Inflammatory Markers of Sepsis (GenIMS) Study. Arch Intern Med 167(15):1655–1663. doi:10.1001/archinte.167.15.1655
    • (2007) Arch Intern Med , vol.167 , Issue.15 , pp. 1655-1663
    • Kellum, J.A.1    Kong, L.2    Fink, M.P.3    Weissfeld, L.A.4    Yealy, D.M.5    Pinsky, M.R.6    Fine, J.7    Krichevsky, A.8    Delude, R.L.9    Angus, D.C.10    Gen, I.M.S.I.11
  • 69
    • 0037218519 scopus 로고    scopus 로고
    • Protective effects of IL-6 blockade in sepsis are linked to reduced C5a receptor expression
    • COI: 1:CAS:528:DC%2BD3sXhtFKhsg%3D%3D, PID: 12496437
    • Riedemann NC, Neff TA, Guo RF, Bernacki KD, Laudes IJ, Sarma JV, Lambris JD, Ward PA (2003) Protective effects of IL-6 blockade in sepsis are linked to reduced C5a receptor expression. J Immunol 170(1):503–507
    • (2003) J Immunol , vol.170 , Issue.1 , pp. 503-507
    • Riedemann, N.C.1    Neff, T.A.2    Guo, R.F.3    Bernacki, K.D.4    Laudes, I.J.5    Sarma, J.V.6    Lambris, J.D.7    Ward, P.A.8
  • 70
    • 0035164602 scopus 로고    scopus 로고
    • The soluble interleukin 6 receptor: mechanisms of production and implications in disease
    • COI: 1:CAS:528:DC%2BD3MXht1Sns7Y%3D, PID: 11149892
    • Jones SA, Horiuchi S, Topley N, Yamamoto N, Fuller GM (2001) The soluble interleukin 6 receptor: mechanisms of production and implications in disease. FASEB J 15(1):43–58. doi:10.1096/fj.99-1003rev
    • (2001) FASEB J , vol.15 , Issue.1 , pp. 43-58
    • Jones, S.A.1    Horiuchi, S.2    Topley, N.3    Yamamoto, N.4    Fuller, G.M.5
  • 71
    • 0027336689 scopus 로고
    • Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages
    • COI: 1:CAS:528:DyaK3sXitlajsLg%3D, PID: 8097338
    • Hsieh CS, Macatonia SE, Tripp CS, Wolf SF, O’Garra A, Murphy KM (1993) Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages. Science 260(5107):547–549
    • (1993) Science , vol.260 , Issue.5107 , pp. 547-549
    • Hsieh, C.S.1    Macatonia, S.E.2    Tripp, C.S.3    Wolf, S.F.4    O’Garra, A.5    Murphy, K.M.6
  • 72
    • 78349278907 scopus 로고    scopus 로고
    • Unregulated IL-23/IL-17 immune response in autoimmune diseases
    • COI: 1:CAS:528:DC%2BC3cXntVeltL4%3D, PID: 20392505
    • Costa VS, Mattana TC, da Silva ME (2010) Unregulated IL-23/IL-17 immune response in autoimmune diseases. Diabetes Res Clin Pract 88(3):222–226. doi:10.1016/j.diabres.2010.03.014
    • (2010) Diabetes Res Clin Pract , vol.88 , Issue.3 , pp. 222-226
    • Costa, V.S.1    Mattana, T.C.2    da Silva, M.E.3
  • 73
    • 78649699075 scopus 로고    scopus 로고
    • IL-17 family member cytokines: regulation and function in innate immunity
    • COI: 1:CAS:528:DC%2BC3cXhsFant7rI, PID: 21074482
    • Reynolds JM, Angkasekwinai P, Dong C (2010) IL-17 family member cytokines: regulation and function in innate immunity. Cytokine Growth Factor Rev 21(6):413–423. doi:10.1016/j.cytogfr.2010.10.002
    • (2010) Cytokine Growth Factor Rev , vol.21 , Issue.6 , pp. 413-423
    • Reynolds, J.M.1    Angkasekwinai, P.2    Dong, C.3
  • 74
    • 32244442562 scopus 로고    scopus 로고
    • TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells
    • COI: 1:CAS:528:DC%2BD28XitVOks7s%3D, PID: 16473830
    • Veldhoen M, Hocking RJ, Atkins CJ, Locksley RM, Stockinger B (2006) TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 24(2):179–189. doi:10.1016/j.immuni.2006.01.001
    • (2006) Immunity , vol.24 , Issue.2 , pp. 179-189
    • Veldhoen, M.1    Hocking, R.J.2    Atkins, C.J.3    Locksley, R.M.4    Stockinger, B.5
  • 75
    • 36248965294 scopus 로고    scopus 로고
    • TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology
    • COI: 1:CAS:528:DC%2BD2sXhtlajtr7K, PID: 17994024
    • McGeachy MJ, Bak-Jensen KS, Chen Y, Tato CM, Blumenschein W, McClanahan T, Cua DJ (2007) TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology. Nat Immunol 8(12):1390–1397. doi:10.1038/ni1539
    • (2007) Nat Immunol , vol.8 , Issue.12 , pp. 1390-1397
    • McGeachy, M.J.1    Bak-Jensen, K.S.2    Chen, Y.3    Tato, C.M.4    Blumenschein, W.5    McClanahan, T.6    Cua, D.J.7
  • 76
    • 34547232503 scopus 로고    scopus 로고
    • IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells
    • COI: 1:CAS:528:DC%2BD2sXotFajurw%3D, PID: 17581588
    • Korn T, Bettelli E, Gao W, Awasthi A, Jager A, Strom TB, Oukka M, Kuchroo VK (2007) IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells. Nature 448(7152):484–487. doi:10.1038/nature05970
    • (2007) Nature , vol.448 , Issue.7152 , pp. 484-487
    • Korn, T.1    Bettelli, E.2    Gao, W.3    Awasthi, A.4    Jager, A.5    Strom, T.B.6    Oukka, M.7    Kuchroo, V.K.8
  • 77
    • 44049104564 scopus 로고    scopus 로고
    • The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat
    • COI: 1:CAS:528:DC%2BD1cXmtVWqurg%3D, PID: 18454151
    • Manel N, Unutmaz D, Littman DR (2008) The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat. Nat Immunol 9(6):641–649. doi:10.1038/ni.1610
    • (2008) Nat Immunol , vol.9 , Issue.6 , pp. 641-649
    • Manel, N.1    Unutmaz, D.2    Littman, D.R.3
  • 78
    • 0842266786 scopus 로고    scopus 로고
    • Interferon-gamma: an overview of signals, mechanisms and functions
    • COI: 1:CAS:528:DC%2BD2cXhsFKntrk%3D, PID: 14525967
    • Schroder K, Hertzog PJ, Ravasi T, Hume DA (2004) Interferon-gamma: an overview of signals, mechanisms and functions. J Leukoc Biol 75(2):163–189. doi:10.1189/jlb.0603252
    • (2004) J Leukoc Biol , vol.75 , Issue.2 , pp. 163-189
    • Schroder, K.1    Hertzog, P.J.2    Ravasi, T.3    Hume, D.A.4
  • 79
    • 35549003579 scopus 로고    scopus 로고
    • Regulation of interferon-gamma during innate and adaptive immune responses
    • COI: 1:CAS:528:DC%2BD1cXhs1ajtbw%3D, PID: 17981204
    • Schoenborn JR, Wilson CB (2007) Regulation of interferon-gamma during innate and adaptive immune responses. Adv Immunol 96:41–101. doi:10.1016/S0065-2776(07)96002-2
    • (2007) Adv Immunol , vol.96 , pp. 41-101
    • Schoenborn, J.R.1    Wilson, C.B.2
  • 81
    • 0035682336 scopus 로고    scopus 로고
    • Severe sepsis induces deficient interferon-gamma and interleukin-12 production, but interleukin-12 therapy improves survival in peritonitis
    • COI: 1:CAS:528:DC%2BD3MXptFylsLc%3D, PID: 11754857
    • Ono S, Ueno C, Aosasa S, Tsujimoto H, Seki S, Mochizuki H (2001) Severe sepsis induces deficient interferon-gamma and interleukin-12 production, but interleukin-12 therapy improves survival in peritonitis. Am J Surg 182(5):491–497
    • (2001) Am J Surg , vol.182 , Issue.5 , pp. 491-497
    • Ono, S.1    Ueno, C.2    Aosasa, S.3    Tsujimoto, H.4    Seki, S.5    Mochizuki, H.6
  • 82
    • 78650668871 scopus 로고    scopus 로고
    • CXCL1 regulates pulmonary host defense to Klebsiella infection via CXCL2, CXCL5, NF-kappaB, and MAPKs
    • COI: 1:CAS:528:DC%2BC3cXhtlOhsbnN, PID: 20937845
    • Cai S, Batra S, Lira SA, Kolls JK, Jeyaseelan S (2010) CXCL1 regulates pulmonary host defense to Klebsiella infection via CXCL2, CXCL5, NF-kappaB, and MAPKs. J Immunol 185(10):6214–6225. doi:10.4049/jimmunol.0903843
    • (2010) J Immunol , vol.185 , Issue.10 , pp. 6214-6225
    • Cai, S.1    Batra, S.2    Lira, S.A.3    Kolls, J.K.4    Jeyaseelan, S.5
  • 83
    • 22344454821 scopus 로고    scopus 로고
    • Recruitment of Gr-1+ monocytes is essential for control of acute toxoplasmosis
    • COI: 1:CAS:528:DC%2BD2MXltFagu7k%3D, PID: 15928200
    • Robben PM, LaRegina M, Kuziel WA, Sibley LD (2005) Recruitment of Gr-1+ monocytes is essential for control of acute toxoplasmosis. J Exp Med 201(11):1761–1769. doi:10.1084/jem.20050054
    • (2005) J Exp Med , vol.201 , Issue.11 , pp. 1761-1769
    • Robben, P.M.1    LaRegina, M.2    Kuziel, W.A.3    Sibley, L.D.4
  • 86
    • 46249090513 scopus 로고    scopus 로고
    • Colony-stimulating factors in inflammation and autoimmunity
    • COI: 1:CAS:528:DC%2BD1cXns1ehs7k%3D, PID: 18551128
    • Hamilton JA (2008) Colony-stimulating factors in inflammation and autoimmunity. Nat Rev Immunol 8(7):533–544. doi:10.1038/nri2356
    • (2008) Nat Rev Immunol , vol.8 , Issue.7 , pp. 533-544
    • Hamilton, J.A.1
  • 88
    • 0031000052 scopus 로고    scopus 로고
    • A new cytokine-receptor binding mode revealed by the crystal structure of the IL-1 receptor with an antagonist
    • COI: 1:CAS:528:DyaK2sXhvFWjs7s%3D, PID: 9062194
    • Schreuder H, Tardif C, Trump-Kallmeyer S, Soffientini A, Sarubbi E, Akeson A, Bowlin T, Yanofsky S, Barrett RW (1997) A new cytokine-receptor binding mode revealed by the crystal structure of the IL-1 receptor with an antagonist. Nature 386(6621):194–200. doi:10.1038/386194a0
    • (1997) Nature , vol.386 , Issue.6621 , pp. 194-200
    • Schreuder, H.1    Tardif, C.2    Trump-Kallmeyer, S.3    Soffientini, A.4    Sarubbi, E.5    Akeson, A.6    Bowlin, T.7    Yanofsky, S.8    Barrett, R.W.9
  • 89
    • 17044455947 scopus 로고    scopus 로고
    • Induction of interleukin-1 and interleukin-1 receptor antagonist
    • Dinarello CA (1997) Induction of interleukin-1 and interleukin-1 receptor antagonist. Semin Oncol 24(3 Suppl 9):S9-81–S89-93
    • (1997) Semin Oncol , vol.24
    • Dinarello, C.A.1
  • 90
    • 0026655638 scopus 로고
    • Recombinant interleukin-1 receptor antagonist (IL-1ra): effective therapy against gram-negative sepsis in rats
    • COI: 1:STN:280:DyaK38zltFarsQ%3D%3D, PID: 1386478, discussion 193-184
    • Alexander HR, Doherty GM, Venzon DJ, Merino MJ, Fraker DL, Norton JA (1992) Recombinant interleukin-1 receptor antagonist (IL-1ra): effective therapy against gram-negative sepsis in rats. Surgery 112(2):188–193 discussion 193-184
    • (1992) Surgery , vol.112 , Issue.2 , pp. 188-193
    • Alexander, H.R.1    Doherty, G.M.2    Venzon, D.J.3    Merino, M.J.4    Fraker, D.L.5    Norton, J.A.6
  • 92
    • 84928583743 scopus 로고    scopus 로고
    • Type 2 cytokines: mechanisms and therapeutic strategies
    • COI: 1:CAS:528:DC%2BC2MXht1Wru7zP, PID: 25882242
    • Wynn TA (2015) Type 2 cytokines: mechanisms and therapeutic strategies. Nat Rev Immunol 15(5):271–282. doi:10.1038/nri3831
    • (2015) Nat Rev Immunol , vol.15 , Issue.5 , pp. 271-282
    • Wynn, T.A.1
  • 93
    • 84867908227 scopus 로고    scopus 로고
    • Regulation of inflammation by interleukin-4: a review of “alternatives
    • COI: 1:CAS:528:DC%2BC38XhsFSmtrvO, PID: 22782966
    • Luzina IG, Keegan AD, Heller NM, Rook GA, Shea-Donohue T, Atamas SP (2012) Regulation of inflammation by interleukin-4: a review of “alternatives”. J Leukoc Biol 92(4):753–764. doi:10.1189/jlb.0412214
    • (2012) J Leukoc Biol , vol.92 , Issue.4 , pp. 753-764
    • Luzina, I.G.1    Keegan, A.D.2    Heller, N.M.3    Rook, G.A.4    Shea-Donohue, T.5    Atamas, S.P.6
  • 94
    • 44449096726 scopus 로고    scopus 로고
    • IL-10: the master regulator of immunity to infection
    • COI: 1:CAS:528:DC%2BD1cXkvVequ7o%3D, PID: 18424693
    • Couper KN, Blount DG, Riley EM (2008) IL-10: the master regulator of immunity to infection. J Immunol 180(9):5771–5777
    • (2008) J Immunol , vol.180 , Issue.9 , pp. 5771-5777
    • Couper, K.N.1    Blount, D.G.2    Riley, E.M.3
  • 95
    • 0034090602 scopus 로고    scopus 로고
    • Anti-inflammatory cytokines
    • COI: 1:CAS:528:DC%2BD3cXjtFahsb0%3D, PID: 10767254
    • Opal SM, DePalo VA (2000) Anti-inflammatory cytokines. Chest 117(4):1162–1172
    • (2000) Chest , vol.117 , Issue.4 , pp. 1162-1172
    • Opal, S.M.1    DePalo, V.A.2
  • 96
    • 84888325490 scopus 로고    scopus 로고
    • Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy
    • COI: 1:CAS:528:DC%2BC3sXhslygsb%2FI, PID: 24232462
    • Hotchkiss RS, Monneret G, Payen D (2013) Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy. Nat Rev Immunol 13(12):862–874. doi:10.1038/nri3552
    • (2013) Nat Rev Immunol , vol.13 , Issue.12 , pp. 862-874
    • Hotchkiss, R.S.1    Monneret, G.2    Payen, D.3
  • 99
    • 84963686144 scopus 로고    scopus 로고
    • Plasma cytokine levels predict response to corticosteroids in septic shock
    • COI: 1:CAS:528:DC%2BC28XlvV2lurk%3D, PID: 27071387
    • Bentzer P, Fjell C, Walley KR, Boyd J, Russell JA (2016) Plasma cytokine levels predict response to corticosteroids in septic shock. Intensive Care Med 42(12):1970–1979. doi:10.1007/s00134-016-4338-z
    • (2016) Intensive Care Med , vol.42 , Issue.12 , pp. 1970-1979
    • Bentzer, P.1    Fjell, C.2    Walley, K.R.3    Boyd, J.4    Russell, J.A.5
  • 100
    • 12544254834 scopus 로고    scopus 로고
    • Acute inflammatory response to endotoxin in mice and humans
    • COI: 1:CAS:528:DC%2BD2MXhsVWktr0%3D, PID: 15642986
    • Copeland S, Warren HS, Lowry SF, Calvano SE, Remick D, Inflammation, the Host Response to Injury I (2005) Acute inflammatory response to endotoxin in mice and humans. Clin Diagn Lab Immunol 12(1):60–67. doi:10.1128/CDLI.12.1.60-67.2005
    • (2005) Clin Diagn Lab Immunol , vol.12 , Issue.1 , pp. 60-67
    • Copeland, S.1    Warren, H.S.2    Lowry, S.F.3    Calvano, S.E.4    Remick, D.5
  • 101
    • 35848936089 scopus 로고    scopus 로고
    • From therapy to experimental model: a hundred years of endotoxin administration to human subjects
    • COI: 1:CAS:528:DC%2BD2sXhsVersbzJ, PID: 17986486
    • Bahador M, Cross AS (2007) From therapy to experimental model: a hundred years of endotoxin administration to human subjects. J Endotoxin Res 13(5):251–279. doi:10.1177/0968051907085986
    • (2007) J Endotoxin Res , vol.13 , Issue.5 , pp. 251-279
    • Bahador, M.1    Cross, A.S.2
  • 103
    • 0025647250 scopus 로고
    • Experimental endotoxemia in humans: analysis of cytokine release and coagulation, fibrinolytic, and complement pathways
    • PID: 2124934
    • van Deventer SJ, Buller HR, ten Cate JW, Aarden LA, Hack CE, Sturk A (1990) Experimental endotoxemia in humans: analysis of cytokine release and coagulation, fibrinolytic, and complement pathways. Blood 76(12):2520–2526
    • (1990) Blood , vol.76 , Issue.12 , pp. 2520-2526
    • van Deventer, S.J.1    Buller, H.R.2    ten Cate, J.W.3    Aarden, L.A.4    Hack, C.E.5    Sturk, A.6
  • 108
    • 84902511727 scopus 로고    scopus 로고
    • The next generation of sepsis clinical trial designs: what is next after the demise of recombinant human activated protein C?*
    • COI: 1:CAS:528:DC%2BC2cXpvV2ksro%3D, PID: 24717456
    • Opal SM, Dellinger RP, Vincent JL, Masur H, Angus DC (2014) The next generation of sepsis clinical trial designs: what is next after the demise of recombinant human activated protein C?*. Crit Care Med 42(7):1714–1721. doi:10.1097/CCM.0000000000000325
    • (2014) Crit Care Med , vol.42 , Issue.7 , pp. 1714-1721
    • Opal, S.M.1    Dellinger, R.P.2    Vincent, J.L.3    Masur, H.4    Angus, D.C.5
  • 109
    • 84873766246 scopus 로고
    • Effect of cortisone on acute streptococcal infections and poststreptococcal complications
    • COI: 1:CAS:528:DyaG3MXislOisA%3D%3D, PID: 14824277
    • Hahn EO, Houser HB, Rammelkamp CH Jr, Denny FW, Wannamaker LW (1951) Effect of cortisone on acute streptococcal infections and poststreptococcal complications. J Clin Invest 30(3):274–281. doi:10.1172/JCI102441
    • (1951) J Clin Invest , vol.30 , Issue.3 , pp. 274-281
    • Hahn, E.O.1    Houser, H.B.2    Rammelkamp, C.H.3    Denny, F.W.4    Wannamaker, L.W.5
  • 110
    • 26844433194 scopus 로고    scopus 로고
    • Antiinflammatory action of glucocorticoids—new mechanisms for old drugs
    • COI: 1:CAS:528:DC%2BD2MXhtFansrrI, PID: 16236742
    • Rhen T, Cidlowski JA (2005) Antiinflammatory action of glucocorticoids—new mechanisms for old drugs. N Engl J Med 353(16):1711–1723. doi:10.1056/NEJMra050541
    • (2005) N Engl J Med , vol.353 , Issue.16 , pp. 1711-1723
    • Rhen, T.1    Cidlowski, J.A.2
  • 115
    • 0028957549 scopus 로고
    • Efficacy and safety of monoclonal antibody to human tumor necrosis factor alpha in patients with sepsis syndrome. A randomized, controlled, double-blind, multicenter clinical trial. TNF-alpha MAb Sepsis Study Group
    • COI: 1:STN:280:DyaK2M7ptFSruw%3D%3D, PID: 7884952
    • Abraham E, Wunderink R, Silverman H, Perl TM, Nasraway S, Levy H, Bone R, Wenzel RP, Balk R, Allred R et al (1995) Efficacy and safety of monoclonal antibody to human tumor necrosis factor alpha in patients with sepsis syndrome. A randomized, controlled, double-blind, multicenter clinical trial. TNF-alpha MAb Sepsis Study Group. JAMA 273(12):934–941
    • (1995) JAMA , vol.273 , Issue.12 , pp. 934-941
    • Abraham, E.1    Wunderink, R.2    Silverman, H.3    Perl, T.M.4    Nasraway, S.5    Levy, H.6    Bone, R.7    Wenzel, R.P.8    Balk, R.9    Allred, R.10
  • 116
    • 0028557981 scopus 로고
    • Treatment of septic shock with human monoclonal antibody HA-1A. A randomized, double-blind, placebo-controlled trial. CHESS Trial Study Group
    • COI: 1:STN:280:DyaK2c3ls1OhsQ%3D%3D, PID: 8198341
    • McCloskey RV, Straube RC, Sanders C, Smith SM, Smith CR (1994) Treatment of septic shock with human monoclonal antibody HA-1A. A randomized, double-blind, placebo-controlled trial. CHESS Trial Study Group. Ann Intern Med 121(1):1–5
    • (1994) Ann Intern Med , vol.121 , Issue.1 , pp. 1-5
    • McCloskey, R.V.1    Straube, R.C.2    Sanders, C.3    Smith, S.M.4    Smith, C.R.5
  • 118
    • 84884887658 scopus 로고    scopus 로고
    • Antitumor necrosis factor therapy is associated with improved survival in clinical sepsis trials: a meta-analysis
    • COI: 1:CAS:528:DC%2BC3sXhsFars7fE, PID: 23887234
    • Qiu P, Cui X, Sun J, Welsh J, Natanson C, Eichacker PQ (2013) Antitumor necrosis factor therapy is associated with improved survival in clinical sepsis trials: a meta-analysis. Crit Care Med 41(10):2419–2429. doi:10.1097/CCM.0b013e3182982add
    • (2013) Crit Care Med , vol.41 , Issue.10 , pp. 2419-2429
    • Qiu, P.1    Cui, X.2    Sun, J.3    Welsh, J.4    Natanson, C.5    Eichacker, P.Q.6
  • 119
    • 43349096795 scopus 로고    scopus 로고
    • Inflammation, endothelium, and coagulation in sepsis
    • COI: 1:CAS:528:DC%2BD1cXjtVaqt78%3D, PID: 18032692
    • Schouten M, Wiersinga WJ, Levi M, van der Poll T (2008) Inflammation, endothelium, and coagulation in sepsis. J Leukoc Biol 83(3):536–545. doi:10.1189/jlb.0607373
    • (2008) J Leukoc Biol , vol.83 , Issue.3 , pp. 536-545
    • Schouten, M.1    Wiersinga, W.J.2    Levi, M.3    van der Poll, T.4
  • 123
    • 84891051959 scopus 로고    scopus 로고
    • Slit2-Robo4 pathway modulates lipopolysaccharide-induced endothelial inflammation and its expression is dysregulated during endotoxemia
    • COI: 1:CAS:528:DC%2BC3sXhvFOmsrfM, PID: 24272999
    • Zhao H, Anand AR, Ganju RK (2014) Slit2-Robo4 pathway modulates lipopolysaccharide-induced endothelial inflammation and its expression is dysregulated during endotoxemia. J Immunol 192(1):385–393. doi:10.4049/jimmunol.1302021
    • (2014) J Immunol , vol.192 , Issue.1 , pp. 385-393
    • Zhao, H.1    Anand, A.R.2    Ganju, R.K.3
  • 124
    • 84855303523 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate signaling and its role in disease
    • COI: 1:CAS:528:DC%2BC38Xmt1Wguw%3D%3D, PID: 22001186
    • Maceyka M, Harikumar KB, Milstien S, Spiegel S (2012) Sphingosine-1-phosphate signaling and its role in disease. Trends Cell Biol 22(1):50–60. doi:10.1016/j.tcb.2011.09.003
    • (2012) Trends Cell Biol , vol.22 , Issue.1 , pp. 50-60
    • Maceyka, M.1    Harikumar, K.B.2    Milstien, S.3    Spiegel, S.4
  • 125
    • 80052940381 scopus 로고    scopus 로고
    • Endothelial cells are central orchestrators of cytokine amplification during influenza virus infection
    • COI: 1:CAS:528:DC%2BC3MXhtF2htL7J, PID: 21925319
    • Teijaro JR, Walsh KB, Cahalan S, Fremgen DM, Roberts E, Scott F, Martinborough E, Peach R, Oldstone MB, Rosen H (2011) Endothelial cells are central orchestrators of cytokine amplification during influenza virus infection. Cell 146(6):980–991. doi:10.1016/j.cell.2011.08.015
    • (2011) Cell , vol.146 , Issue.6 , pp. 980-991
    • Teijaro, J.R.1    Walsh, K.B.2    Cahalan, S.3    Fremgen, D.M.4    Roberts, E.5    Scott, F.6    Martinborough, E.7    Peach, R.8    Oldstone, M.B.9    Rosen, H.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.