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Volumn 45, Issue 3, 2016, Pages 259-270

The endothelium in sepsis

Author keywords

Barrier function; blood; endothelium; glycocalyx; hemostasis; inflammation; microcirculation; sepsis

Indexed keywords

HEPARANASE; HYDROGEN PEROXIDE; HYDROXYL GROUP; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; TUMOR NECROSIS FACTOR ALPHA; NITRIC OXIDE; THROMBOPLASTIN;

EID: 84959088957     PISSN: 10732322     EISSN: 15400514     Source Type: Journal    
DOI: 10.1097/SHK.0000000000000473     Document Type: Review
Times cited : (484)

References (98)
  • 1
    • 77956258291 scopus 로고    scopus 로고
    • The endothelium: Physiological functions, and role in microcirculatory failure during severe sepsis
    • Ait-Oufella H, Maury E, Lehoux S, Guidet B, Offenstadt G. The endothelium: physiological functions, and role in microcirculatory failure during severe sepsis. Intensive Care Med 36: 1286-1298, 2010
    • (2010) Intensive Care Med , vol.36 , pp. 1286-1298
    • Ait-Oufella, H.1    Maury, E.2    Lehoux, S.3    Guidet, B.4    Offenstadt, G.5
  • 2
    • 84959097578 scopus 로고    scopus 로고
    • Acute dialysis quality initiative (adqi) xiv sepsis phenotypes, and targets for blood purification in sepsis: The bogota consensus
    • Kellum JA, Gómez H, Gómez A, Murray P, Ronco C. Acute Dialysis Quality Initiative (ADQI) XIV sepsis phenotypes, and targets for blood purification in sepsis: The Bogota Consensus. Shock 45: 242-248, 2016
    • (2016) Shock , vol.45 , pp. 242-248
    • Kellum, J.A.1    Gómez, H.2    Gómez, A.3    Murray, P.4    Ronco, C.5
  • 3
  • 4
    • 35348904935 scopus 로고    scopus 로고
    • The structure, and function of the endothelial glycocalyx layer
    • Weinbaum S, Tarbell JM, Damiano ER. The structure, and function of the endothelial glycocalyx layer. Annu Rev Biomed Eng 9: 121-167, 2007
    • (2007) Annu Rev Biomed Eng , vol.9 , pp. 121-167
    • Weinbaum, S.1    Tarbell, J.M.2    Damiano, E.R.3
  • 5
    • 29544436180 scopus 로고    scopus 로고
    • Short-term hyperglycemia increases endothelial glycocalyx permeability, and decreases lineal density of capillaries with flowing rbc's
    • Zuurbier C, Vink H, Koeman A, Demirci C, Ince C. Short-term hyperglycemia increases endothelial glycocalyx permeability, and decreases lineal density of capillaries with flowing RBC's. J Appl Physiol 99: 1471-1476, 2005
    • (2005) J Appl Physiol , vol.99 , pp. 1471-1476
    • Zuurbier, C.1    Vink, H.2    Koeman, A.3    Demirci, C.4    Ince, C.5
  • 6
    • 33744924451 scopus 로고    scopus 로고
    • Reactive oxygen species mediate modification of glycocalyx during ischemia-reperfusion injury
    • Rubio-Gayosso I, Platts SH, Duling BR. Reactive oxygen species mediate modification of glycocalyx during ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol 290: H2247-H2256, 2006
    • (2006) Am J Physiol Heart Circ Physiol , vol.290 , pp. H2247-H2256
    • Rubio-Gayosso, I.1    Platts, S.H.2    Duling, B.R.3
  • 11
    • 51449107134 scopus 로고    scopus 로고
    • Lipopolysaccharide plus hypoxia, and reoxygenation synergistically reduce electrical coupling between microvascular endothelial cells by dephosphorylating connexin40
    • Bolon ML, Peng T, Kidder GM, Tyml K. Lipopolysaccharide plus hypoxia, and reoxygenation synergistically reduce electrical coupling between microvascular endothelial cells by dephosphorylating connexin40. J Cell Physiol 217: 350-359, 2008
    • (2008) J Cell Physiol , vol.217 , pp. 350-359
    • Bolon, M.L.1    Peng, T.2    Kidder, G.M.3    Tyml, K.4
  • 12
    • 84914670789 scopus 로고    scopus 로고
    • Neutrophil extracellular traps in sepsis
    • Camicia G, Pozner R, de Larranñaga G. Neutrophil extracellular traps in sepsis. Shock 42: 286-294, 2014
    • (2014) Shock , vol.42 , pp. 286-294
    • Camicia, G.1    Pozner, R.2    De Larranñaga, G.3
  • 13
    • 84873192406 scopus 로고    scopus 로고
    • Disseminated intravascular coagulation: A review for the internist
    • Levi M, Van Der Poll T. Disseminated intravascular coagulation: a review for the internist. Internal Emerg Med 8: 23-32, 2013
    • (2013) Internal Emerg Med , vol.8 , pp. 23-32
    • Levi, M.1    Van Der Poll, T.2
  • 14
    • 54549096095 scopus 로고    scopus 로고
    • Intensive plasma exchange increases a disintegrin, and metalloprotease with thrombospondin motifs-13 activity, and reverses organ dysfunction in children with thrombocytopenia-associated multiple organ failure
    • Nguyen TC, Han YY, Kiss JE, Hall MW, Hassett AC, Jaffe R, Orr RA, Janosky J, Carcillo JA. Intensive plasma exchange increases a disintegrin, and metalloprotease with thrombospondin motifs-13 activity, and reverses organ dysfunction in children with thrombocytopenia-associated multiple organ failure. Crit Care Med 36: 2878-2887, 2008
    • (2008) Crit Care Med , vol.36 , pp. 2878-2887
    • Nguyen, T.C.1    Han, Y.Y.2    Kiss, J.E.3    Hall, M.W.4    Hassett, A.C.5    Jaffe, R.6    Orr, R.A.7    Janosky, J.8    Carcillo, J.A.9
  • 15
    • 11244281582 scopus 로고    scopus 로고
    • Fatal congenital thrombotic thrombocytopenic purpura with apparent adamts13 inhibitor: In vitro inhibition of adamts13 activity by hemoglobin
    • Studt JD, Hovinga JA, Antoine G, Hermann M, Rieger M, Scheiflinger F, Lammle B. Fatal congenital thrombotic thrombocytopenic purpura with apparent ADAMTS13 inhibitor: in vitro inhibition of ADAMTS13 activity by hemoglobin. Blood 105(2): 542-544, 2005
    • (2005) Blood , vol.105 , Issue.2 , pp. 542-544
    • Studt, J.D.1    Hovinga, J.A.2    Antoine, G.3    Hermann, M.4    Rieger, M.5    Scheiflinger, F.6    Lammle, B.7
  • 16
    • 28844503491 scopus 로고    scopus 로고
    • Hemolytic uremic syndrome-associated Shiga toxins promote endothelial-cell secretion and impair adamts13 cleavage of unusually large von willebrand factor multimers
    • Nolasco LH, Turner NA, Bernardo A, Tao Z, Cleary TG, Dong JF, Moake JL. Hemolytic uremic syndrome-associated Shiga toxins promote endothelial-cell secretion, and impair ADAMTS13 cleavage of unusually large von Willebrand factor multimers. Blood 106: 4199-4209, 2005
    • (2005) Blood , vol.106 , pp. 4199-4209
    • Nolasco, L.H.1    Turner, N.A.2    Bernardo, A.3    Tao, Z.4    Cleary, T.G.5    Dong, J.F.6    Moake, J.L.7
  • 18
    • 84883654315 scopus 로고    scopus 로고
    • Blood purification, and mortality in sepsis: A meta-analysis of randomized trials
    • Zhou F, Peng Z, Murugan R, Kellum JA. Blood purification, and mortality in sepsis: a meta-analysis of randomized trials. Crit Care Med 41: 2209-2220, 2013
    • (2013) Crit Care Med , vol.41 , pp. 2209-2220
    • Zhou, F.1    Peng, Z.2    Murugan, R.3    Kellum, J.A.4
  • 19
    • 84919712097 scopus 로고    scopus 로고
    • Pharmacological targeting of sphingosine phosphate receptor 1 improves the renal microcirculation during sepsis in the mouse
    • Wang Z, Sims CR, Patil NK, Gokden N, Mayeux PR. Pharmacological targeting of sphingosine phosphate receptor 1 improves the renal microcirculation during sepsis in the mouse. J Pharmacol Exp Ther 352: 61-66, 2015
    • (2015) J Pharmacol Exp Ther , vol.352 , pp. 61-66
    • Wang, Z.1    Sims, C.R.2    Patil, N.K.3    Gokden, N.4    Mayeux, P.R.5
  • 20
    • 84866393115 scopus 로고    scopus 로고
    • Role of microparticles in sepsis
    • Reid VL, Webster NR. Role of microparticles in sepsis. Brit J Anaest 109: 503-513, 2012
    • (2012) Brit J Anaest , vol.109 , pp. 503-513
    • Reid, V.L.1    Webster, N.R.2
  • 21
    • 84891555200 scopus 로고    scopus 로고
    • TNFmediated damage to glomerular endothelium is an important determinant of acute kidney injury in sepsis
    • Xu C, Chang A, Hack BK, Eadon MT, Alper SL, Cunningham PN. TNFmediated damage to glomerular endothelium is an important determinant of acute kidney injury in sepsis. Kidney Int 85: 72-81, 2014
    • (2014) Kidney Int , vol.85 , pp. 72-81
    • Xu, C.1    Chang, A.2    Hack, B.K.3    Eadon, M.T.4    Alper, S.L.5    Cunningham, P.N.6
  • 23
    • 84856018760 scopus 로고    scopus 로고
    • Development of oxidative stress in the peritubular capillary microenvironment mediates sepsis-induced renal microcirculatory failure, and acute kidney injury
    • Wang Z, Holthoff JH, Seely KA, Pathak E, Spencer HJ 3rd, Gokden N, Mayeux PR. Development of oxidative stress in the peritubular capillary microenvironment mediates sepsis-induced renal microcirculatory failure, and acute kidney injury. Am J Pathol 180: 505-516, 2012
    • (2012) Am J Pathol , vol.180 , pp. 505-516
    • Wang, Z.1    Holthoff, J.H.2    Seely, K.A.3    Pathak, E.4    Spencer, H.J.5    Gokden, N.6    Mayeux, P.R.7
  • 24
    • 80054740939 scopus 로고    scopus 로고
    • The role of renal hypoperfusion in the development of renal microcirculatory dysfunction in endotoxemic rats
    • Legrand M, Bezemer R, Payen D, Ince C. The role of renal hypoperfusion in the development of renal microcirculatory dysfunction in endotoxemic rats. Intensive Care Med 37: 1534-1542, 2011
    • (2011) Intensive Care Med , vol.37 , pp. 1534-1542
    • Legrand, M.1    Bezemer, R.2    Payen, D.3    Ince, C.4
  • 25
    • 58849096295 scopus 로고    scopus 로고
    • Nonresuscitated endotoxemia induces microcirculatory hypoxic areas in the renal cortex in the rat
    • Johannes T, Mik EG, Ince C. Nonresuscitated endotoxemia induces microcirculatory hypoxic areas in the renal cortex in the rat. Shock 31: 97-103, 2009
    • (2009) Shock , vol.31 , pp. 97-103
    • Johannes, T.1    Mik, E.G.2    Ince, C.3
  • 27
    • 34249884479 scopus 로고    scopus 로고
    • Evidence for the role of reactive nitrogen species in polymicrobial sepsis-induced renal peritubular capillary dysfunction, and tubular injury
    • Wu L, Gokden N, Mayeux PR. Evidence for the role of reactive nitrogen species in polymicrobial sepsis-induced renal peritubular capillary dysfunction, and tubular injury. J Am Soc Nephrol 18: 1807-1815, 2007
    • (2007) J Am Soc Nephrol , vol.18 , pp. 1807-1815
    • Wu, L.1    Gokden, N.2    Mayeux, P.R.3
  • 28
    • 33847173829 scopus 로고    scopus 로고
    • Effects of the inducible nitric oxide synthase inhibitor L-N6-(1-iminoethyl)-lysine on microcirculation, and reactive nitrogen species generation in the kidney following lipopolysaccharide administration in mice
    • Wu L, Mayeux PR. Effects of the inducible nitric oxide synthase inhibitor L-N6-(1-iminoethyl)-lysine on microcirculation, and reactive nitrogen species generation in the kidney following lipopolysaccharide administration in mice. J Pharmacol Exp Ther 320: 1061-1067, 2007
    • (2007) J Pharmacol Exp Ther , vol.320 , pp. 1061-1067
    • Wu, L.1    Mayeux, P.R.2
  • 29
    • 33846318159 scopus 로고    scopus 로고
    • Peritubular capillary dysfunction, and renal tubular epithelial cell stress following lipopolysaccharide administration in mice
    • Wu L, Tiwari MM, Messer KJ, Holthoff JH, Gokden N, Brock RW, Mayeux PR. Peritubular capillary dysfunction, and renal tubular epithelial cell stress following lipopolysaccharide administration in mice. Am J Physiol Renal Physiol 292: F261-F268, 2007
    • (2007) Am J Physiol Renal Physiol , vol.292 , pp. F261-F268
    • Wu, L.1    Tiwari, M.M.2    Messer, K.J.3    Holthoff, J.H.4    Gokden, N.5    Brock, R.W.6    Mayeux, P.R.7
  • 30
    • 77956635947 scopus 로고    scopus 로고
    • Sepsis, and endothelial permeability
    • Lee WL, Slutsky AS. Sepsis, and endothelial permeability. N Engl JMed 7: 689-691, 2010
    • (2010) N Engl JMed , vol.7 , pp. 689-691
    • Lee, W.L.1    Slutsky, A.S.2
  • 31
    • 84859163198 scopus 로고    scopus 로고
    • Pharmacological targets in the renal peritubular microenvironment: Implications for therapy for sepsis-induced acute kidney injury
    • Mayeux PRI, MacMillan-Crow LA. Pharmacological targets in the renal peritubular microenvironment: implications for therapy for sepsis-induced acute kidney injury. Pharmacol Ther 134: 139-155, 2012
    • (2012) Pharmacol Ther , vol.134 , pp. 139-155
    • Mayeux, P.R.I.1    MacMillan-Crow, L.A.2
  • 32
    • 84893373090 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate protects endothelial glycocalyx by inhibiting syndecan-1 shedding
    • Zeng Y, Adamson RH, Curry FR, Tarbell JM. Sphingosine-1-phosphate protects endothelial glycocalyx by inhibiting syndecan-1 shedding. Am J Physiol Heart Circ Physiol 306: H363-H372, 2014
    • (2014) Am J Physiol Heart Circ Physiol , vol.306 , pp. H363-H372
    • Zeng, Y.1    Adamson, R.H.2    Curry, F.R.3    Tarbell, J.M.4
  • 33
    • 78751637560 scopus 로고    scopus 로고
    • Actinonin, a meprin A inhibitor, protects the renal microcirculation during sepsis
    • Wang Z, Herzog C, Kaushal GP, Gokden N, Mayeux PR. Actinonin, a meprin A inhibitor, protects the renal microcirculation during sepsis. Shock 35: 141-147, 2011
    • (2011) Shock , vol.35 , pp. 141-147
    • Wang, Z.1    Herzog, C.2    Kaushal, G.P.3    Gokden, N.4    Mayeux, P.R.5
  • 34
    • 84899449017 scopus 로고    scopus 로고
    • Camp with other signaling cues converges on rac1 to stabilize the endothelial barrier - A signaling pathway compromised in inflammation
    • Schlegel N, Waschke J. cAMP with other signaling cues converges on Rac1 to stabilize the endothelial barrier-a signaling pathway compromised in inflammation. Cell Tissue Res 355(3): 587-596, 2014
    • (2014) Cell Tissue Res , vol.355 , Issue.3 , pp. 587-596
    • Schlegel, N.1    Waschke, J.2
  • 36
    • 11144279836 scopus 로고    scopus 로고
    • How molecular microscopy revealed new insights in the dynamics of hepatic endothelial fenestrae in the past decade
    • Braet F. How molecular microscopy revealed new insights in the dynamics of hepatic endothelial fenestrae in the past decade. Liver Int 24: 532-539, 2004
    • (2004) Liver Int , vol.24 , pp. 532-539
    • Braet, F.1
  • 37
    • 33745777182 scopus 로고    scopus 로고
    • Mechanisms, and pathophysiological implications of sinusoidal endothelial cell gap formation following treatment with galactosamine/endotoxin in mice
    • Ito Y, Abril ER, Bethea NW, McCuskey MK, Cover C, Jae-schke H, McCuskey RS. Mechanisms, and pathophysiological implications of sinusoidal endothelial cell gap formation following treatment with galactosamine/endotoxin in mice. Am J Physiol Gastrointest Liver Physiol 291: G211-G218, 2006
    • (2006) Am J Physiol Gastrointest Liver Physiol , vol.291 , pp. G211-G218
    • Ito, Y.1    Abril, E.R.2    Bethea, N.W.3    McCuskey, M.K.4    Cover, C.5    Jae-Schke, H.6    McCuskey, R.S.7
  • 38
    • 0037235585 scopus 로고    scopus 로고
    • Bacterial lipopolysaccharide decreases thrombomodulin expression in the sinusoidal endothelial cells of rats: A possible mechanism of intrasinusoidal microthrombus formation, and liver dysfunction
    • Kume M, Hayashi T, Yuasa H, Tanaka H, Nishioka J, Ido M, Gabazza EC, Kawarada Y, Suzuki K. Bacterial lipopolysaccharide decreases thrombomodulin expression in the sinusoidal endothelial cells of rats: a possible mechanism of intrasinusoidal microthrombus formation, and liver dysfunction. J Hepatol 38: 9-17, 2003
    • (2003) J Hepatol , vol.38 , pp. 9-17
    • Kume, M.1    Hayashi, T.2    Yuasa, H.3    Tanaka, H.4    Nishioka, J.5    Ido, M.6    Gabazza, E.C.7    Kawarada, Y.8    Suzuki, K.9
  • 40
    • 0035293990 scopus 로고    scopus 로고
    • Protection by nitric oxide against liver inflammatory injury in animals carrying a nitric oxide synthase-2 transgene
    • Mojena M, Hortelano S, Castrillo A, et al. Protection by nitric oxide against liver inflammatory injury in animals carrying a nitric oxide synthase-2 transgene. FASEB J 15: 583-585, 2001
    • (2001) FASEB J , vol.15 , pp. 583-585
    • Mojena, M.1    Hortelano, S.2    Castrillo, A.3
  • 42
    • 38149077303 scopus 로고    scopus 로고
    • The endothelium in acute lung injury/acute respiratory distress syndrome
    • Maniatis NA, Orfanos SE. The endothelium in acute lung injury/acute respiratory distress syndrome. Curr Opin Crit Care 14: 22-30, 2008
    • (2008) Curr Opin Crit Care , vol.14 , pp. 22-30
    • Maniatis, N.A.1    Orfanos, S.E.2
  • 44
    • 84863469630 scopus 로고    scopus 로고
    • Endothelial connexin43 mediates acid-induced increases in pulmonary microvascular permeability
    • Parthasarathi K. Endothelial connexin43 mediates acid-induced increases in pulmonary microvascular permeability. Am J Physiol Lung Cell Mol Physiol 303: L33-L42, 2012
    • (2012) Am J Physiol Lung Cell Mol Physiol , vol.303 , pp. L33-L42
    • Parthasarathi, K.1
  • 48
    • 84875362828 scopus 로고    scopus 로고
    • Microcirculation in sepsis: New perspectives
    • Hernandez G, Bruhn A, Ince C. Microcirculation in sepsis: new perspectives. Curr Vasc Pharmacol 11: 161-169, 2013
    • (2013) Curr Vasc Pharmacol , vol.11 , pp. 161-169
    • Hernandez, G.1    Bruhn, A.2    Ince, C.3
  • 49
    • 84874934644 scopus 로고    scopus 로고
    • Microcirculatory alterations in patients with severe sepsis: Impact of time of assessment, and relationship with outcome
    • De Backer D, Donadello K, Sakr Y, Ospina-Tascon G, Salgado D, Scolletta S, Vincent JL. Microcirculatory alterations in patients with severe sepsis: impact of time of assessment, and relationship with outcome. Crit Care Med 41: 791-799, 2013
    • (2013) Crit Care Med , vol.41 , pp. 791-799
    • De Backer, D.1    Donadello, K.2    Sakr, Y.3    Ospina-Tascon, G.4    Salgado, D.5    Scolletta, S.6    Vincent, J.L.7
  • 50
    • 84860240248 scopus 로고    scopus 로고
    • Quantitative assessment of the microcirculation in healthy volunteers, and in patients with septic shock
    • Edul VS, Enrico C, Laviolle B, Vazquez AR, Ince C, Dubin A. Quantitative assessment of the microcirculation in healthy volunteers, and in patients with septic shock. Crit Care Med 40: 1443-1448, 2012
    • (2012) Crit Care Med , vol.40 , pp. 1443-1448
    • Edul, V.S.1    Enrico, C.2    Laviolle, B.3    Vazquez, A.R.4    Ince, C.5    Dubin, A.6
  • 51
    • 36448971317 scopus 로고    scopus 로고
    • Monitoring of the sublingual microcirculation in cardiac surgery using orthogonal polarization spectral imaging: Preliminary results
    • Bauer A, Kofler S, Thiel M, Eifert S, Christ F. Monitoring of the sublingual microcirculation in cardiac surgery using orthogonal polarization spectral imaging: preliminary results. Anesthesiology 107: 939-945, 2007
    • (2007) Anesthesiology , vol.107 , pp. 939-945
    • Bauer, A.1    Kofler, S.2    Thiel, M.3    Eifert, S.4    Christ, F.5
  • 52
    • 31344453457 scopus 로고    scopus 로고
    • The effects of dobutamine on microcirculatory alterations in patients with septic shock are independent of its systemic effects
    • De Backer D, Creteur J, Dubois MJ, Sakr Y, Koch M, Verdant C, Vincent JL. The effects of dobutamine on microcirculatory alterations in patients with septic shock are independent of its systemic effects. Crit Care Med 34: 403-408, 2006
    • (2006) Crit Care Med , vol.34 , pp. 403-408
    • De Backer, D.1    Creteur, J.2    Dubois, M.J.3    Sakr, Y.4    Koch, M.5    Verdant, C.6    Vincent, J.L.7
  • 54
    • 84855816724 scopus 로고    scopus 로고
    • Clinical utility of biomarkers of endothelial activation in sepsis: A systematic review
    • Xing K, Murthy S, Liles WC, Singh JM. Clinical utility of biomarkers of endothelial activation in sepsis: a systematic review. Crit Care 16(1): R7, 2012
    • (2012) Crit Care , vol.16 , Issue.1 , pp. R7
    • Xing, K.1    Murthy, S.2    Liles, W.C.3    Singh, J.M.4
  • 58
    • 85132475528 scopus 로고    scopus 로고
    • Cytocam-idf (incident dark field illumination) imaging for bed-side monitoring of the microcirculation
    • Aykut G, Veenstra G, Scorcella, Ince C, Boerma C. Cytocam-IDF (incident dark field illumination) imaging for bed-side monitoring of the microcirculation. Inten Care Med Exp 3: 4, 2015
    • (2015) Inten Care Med Exp , vol.3 , pp. 4
    • Aykut, G.1    Veenstra, G.2    Scorcella Ince, C.3    Boerma, C.4
  • 60
    • 84900430905 scopus 로고    scopus 로고
    • The rationale for microcirculatory-guided fluid therapy
    • Ince C. The rationale for microcirculatory-guided fluid therapy. Curr Opin in Crit Care 20: 301-308, 2014
    • (2014) Curr Opin in Crit Care , vol.20 , pp. 301-308
    • Ince, C.1
  • 61
    • 84860440667 scopus 로고    scopus 로고
    • Balanced vs unbalanced crystalloid resuscitation in a near-fatal model of hemorrhagic shock, and the effects on renal oxygenation, oxidative stress, and inflammation
    • Aksu U, Bezemer R, Yavuz B, Kandil A, Demirci C, Ince C. Balanced vs. unbalanced crystalloid resuscitation in a near-fatal model of hemorrhagic shock, and the effects on renal oxygenation, oxidative stress, and inflammation. Resuscitation 83: 767-773, 2012
    • (2012) Resuscitation , vol.83 , pp. 767-773
    • Aksu, U.1    Bezemer, R.2    Yavuz, B.3    Kandil, A.4    Demirci, C.5    Ince, C.6
  • 62
    • 34447633939 scopus 로고    scopus 로고
    • Influence of fluid resuscitation on renal microvascular PO2 in a normotensive rat model of endotoxemia
    • Johannes T, Mik EG, Nohé B, Raat NJH, Unertl KE, Ince C. Influence of fluid resuscitation on renal microvascular PO2 in a normotensive rat model of endotoxemia. Crit Care 10(R88): 1-13, 2006
    • (2006) Crit Care , vol.10 , Issue.R88 , pp. 1-13
    • Johannes, T.1    Mik, E.G.2    Nohé, B.3    Raat, N.J.H.4    Unertl, K.E.5    Ince, C.6
  • 66
    • 84900558112 scopus 로고    scopus 로고
    • Inactivation of renal mitochondrial respiratory complexes, and manganese superoxide dismutase during sepsis: Mitochondria-targeted antioxidant mitigates injury
    • Patil NK, Parajuli N, MacMillan-Crow LA, Mayeux PR. Inactivation of renal mitochondrial respiratory complexes, and manganese superoxide dismutase during sepsis: mitochondria-targeted antioxidant mitigates injury. Am J Physiol Renal Physiol 306(7): F734-F743, 2014
    • (2014) Am J Physiol Renal Physiol , vol.306 , Issue.7 , pp. F734-F743
    • Patil, N.K.1    Parajuli, N.2    MacMillan-Crow, L.A.3    Mayeux, P.R.4
  • 67
    • 80051793463 scopus 로고    scopus 로고
    • Effects of sepiapterin infusion on renal oxygenation, and early acute renal injury following supra-renal aortic clamping in rats
    • Legrand M, Kandil A, Payen D, Ince C. Effects of sepiapterin infusion on renal oxygenation, and early acute renal injury following supra-renal aortic clamping in rats. J Cardiovasc Pharmacol 58: 192-198, 2011
    • (2011) J Cardiovasc Pharmacol , vol.58 , pp. 192-198
    • Legrand, M.1    Kandil, A.2    Payen, D.3    Ince, C.4
  • 69
    • 84874398826 scopus 로고    scopus 로고
    • Sepsis-induced leukocyte adhesion in the pulmonary microvasculature in vivo is mediated by CD11a, and CD11b
    • 28
    • Wang Y, Roller J, Menger MD, Thorlacius H. Sepsis-induced leukocyte adhesion in the pulmonary microvasculature in vivo is mediated by CD11a, and CD11b. Eur J Pharmacol 702: 135-141, 2013. 28
    • (2013) Eur J Pharmacol , vol.702 , pp. 135-141
    • Wang, Y.1    Roller, J.2    Menger, M.D.3    Thorlacius, H.4
  • 70
    • 84901588287 scopus 로고    scopus 로고
    • Phosphodiesterase 4 inhibition dose dependently stabilizes microvascular barrier functions, and microcirculation in a rodent model of polymicrobial sepsis
    • Flemming S, Schlegel N, Wunder C, Meir M, Baar W, Wollborn J, Roewer N, Germer CT, Schick MA. Phosphodiesterase 4 inhibition dose dependently stabilizes microvascular barrier functions, and microcirculation in a rodent model of polymicrobial sepsis. Shock 41: 537-545, 2014
    • (2014) Shock , vol.41 , pp. 537-545
    • Flemming, S.1    Schlegel, N.2    Wunder, C.3    Meir, M.4    Baar, W.5    Wollborn, J.6    Roewer, N.7    Germer, C.T.8    Schick, M.A.9
  • 71
    • 84856410344 scopus 로고    scopus 로고
    • Resveratrol improves renal microcirculation, protects the tubular epithelium, and prolongs survival in a mouse model of sepsis-induced acute kidney injury
    • Holthoff JH, Wang Z, Seely KA, Gokden N, Mayeux P. Resveratrol improves renal microcirculation, protects the tubular epithelium, and prolongs survival in a mouse model of sepsis-induced acute kidney injury. Kidney Int 81: 370-378, 2012
    • (2012) Kidney Int , vol.81 , pp. 370-378
    • Holthoff, J.H.1    Wang, Z.2    Seely, K.A.3    Gokden, N.4    Mayeux, P.5
  • 72
    • 84882702050 scopus 로고    scopus 로고
    • Emerging therapeutic strategies to prevent infectionrelated microvascular endothelial activation, and dysfunction
    • Darwish I, Liles WC. Emerging therapeutic strategies to prevent infectionrelated microvascular endothelial activation, and dysfunction. Virulence 4(6): 572-582, 2013
    • (2013) Virulence , vol.4 , Issue.6 , pp. 572-582
    • Darwish, I.1    Liles, W.C.2
  • 73
    • 84881144881 scopus 로고    scopus 로고
    • Endothelium dependent vasomotion, and in vitro markers of endothelial repair in patients with severe sepsis: An observational study
    • Van Ierssel SH, Van Craenenbroeck EM, Hoymans VY, Vrints CJ, Conraads VM, Jorens PG. Endothelium dependent vasomotion, and in vitro markers of endothelial repair in patients with severe sepsis: an observational study. PLoS One 8(8): e69499, 2013
    • (2013) Plos One , vol.8 , Issue.8 , pp. e69499
    • Van Ierssel, S.H.1    Van Craenenbroeck, E.M.2    Hoymans, V.Y.3    Vrints, C.J.4    Conraads, V.M.5    Jorens, P.G.6
  • 74
    • 70349307058 scopus 로고    scopus 로고
    • A pivotal role of endothelial-specific NF-kappab signaling in the pathogenesis of septic shock, and septic vascular dysfunction
    • 15
    • Ding J, Song D, Ye X, Liu SF. A pivotal role of endothelial-specific NF-kappab signaling in the pathogenesis of septic shock, and septic vascular dysfunction. J Immunol 183: 4031-4038, 2009. 15
    • (2009) J Immunol , vol.183 , pp. 4031-4038
    • Ding, J.1    Song, D.2    Ye, X.3    Liu, S.F.4
  • 76
    • 67649386390 scopus 로고    scopus 로고
    • Low-dose dexamethasone supplemented fluid resuscitation reverses Endotoxin-induced acute renal failure, and prevents cortical microvascular hypoxia
    • Johannes T, Mik EG, Klingel K, Dieterich HJ, Unertl KE, Ince C. Low-dose dexamethasone supplemented fluid resuscitation reverses Endotoxin-induced acute renal failure, and prevents cortical microvascular hypoxia. Shock 31: 521-528, 2009
    • (2009) Shock , vol.31 , pp. 521-528
    • Johannes, T.1    Mik, E.G.2    Klingel, K.3    Dieterich, H.J.4    Unertl, K.E.5    Ince, C.6
  • 77
    • 8544232153 scopus 로고    scopus 로고
    • Inhibition of glucocorticoid receptor binding by nitric oxide in endotoxemic rats
    • Duma D, Silva-Santos J, Assreuy J. Inhibition of glucocorticoid receptor binding by nitric oxide in endotoxemic rats. Crit Care Med 32: 2304-2310, 2004
    • (2004) Crit Care Med , vol.32 , pp. 2304-2310
    • Duma, D.1    Silva-Santos, J.2    Assreuy, J.3
  • 78
    • 42149084524 scopus 로고    scopus 로고
    • Endothelial glycocalyx damage during endotoxemia coincides with microcirculatory dysfunction, and vascular oxidative stress
    • Marechal X, Favory R, Joulin O, Montaigne D, Hassoun S, Decoster B, Zerimech F, Neviere R. Endothelial glycocalyx damage during endotoxemia coincides with microcirculatory dysfunction, and vascular oxidative stress. Shock 29: 572-576, 2008
    • (2008) Shock , vol.29 , pp. 572-576
    • Marechal, X.1    Favory, R.2    Joulin, O.3    Montaigne, D.4    Hassoun, S.5    Decoster, B.6    Zerimech, F.7    Neviere, R.8
  • 79
    • 84892576501 scopus 로고    scopus 로고
    • Effect of hemoperfusion using polymyxin B-immobilized fibers on acute lung injury in a rat sepsis model
    • Iba T, Nagaoka I, Yamada A, Nagayama M, Miki T. Effect of hemoperfusion using polymyxin B-immobilized fibers on acute lung injury in a rat sepsis model. Int J Med Sci 11: 255-256, 2014
    • (2014) Int J Med Sci , vol.11 , pp. 255-256
    • Iba, T.1    Nagaoka, I.2    Yamada, A.3    Nagayama, M.4    Miki, T.5
  • 80
    • 33645774438 scopus 로고    scopus 로고
    • Intravenous administration of activated protein C in Pseudomonas-induced lung injury: Impact on lung fluid balance, and the inflammatory response
    • Robriquet L, Collet F, Tournoys A, Prangère T, Nevière R, Fourrier F, Guery BP. Intravenous administration of activated protein C in Pseudomonas-induced lung injury: impact on lung fluid balance, and the inflammatory response. Respir Res 7: 41, 2006
    • (2006) Respir Res , vol.7 , pp. 41
    • Robriquet, L.1    Collet, F.2    Tournoys, A.3    Prangère, T.4    Nevière, R.5    Fourrier, F.6    Guery, B.P.7
  • 81
    • 0029750207 scopus 로고    scopus 로고
    • Heterogeneity of oxygen delivery impairs oxygen extraction by peripheral tissues: Theory
    • Walley KR. Heterogeneity of oxygen delivery impairs oxygen extraction by peripheral tissues: theory. J Appl Physiol 81: 885-894, 1996
    • (1996) J Appl Physiol , vol.81 , pp. 885-894
    • Walley, K.R.1
  • 82
    • 0032790876 scopus 로고    scopus 로고
    • Microcirculatory oxygenation, and shunting in sepsis, and shock
    • Ince C, Sinaasappel M. Microcirculatory oxygenation, and shunting in sepsis, and shock. Crit Care Med 27: 1369-1377, 1999
    • (1999) Crit Care Med , vol.27 , pp. 1369-1377
    • Ince, C.1    Sinaasappel, M.2
  • 84
    • 33744941056 scopus 로고    scopus 로고
    • Effect of decreased O2 supply on skeletal muscle oxygenation, and O2 consumption during sepsis: Role of heterogeneous capillary spacing, and blood flow
    • Goldman D, Bateman RM, Ellis CG. Effect of decreased O2 supply on skeletal muscle oxygenation, and O2 consumption during sepsis: role of heterogeneous capillary spacing, and blood flow. Am J Physiol Heart Circ Physiol 290: H2277-H2285, 2006
    • (2006) Am J Physiol Heart Circ Physiol , vol.290 , pp. H2277-H2285
    • Goldman, D.1    Bateman, R.M.2    Ellis, C.G.3
  • 85
    • 34547115685 scopus 로고    scopus 로고
    • Myocardial hypoxia-inducible HIF-1alpha, VEGF, and GLUT1 gene expression is associated with microvascular, and ICAM-1 heterogeneity during endotoxemia
    • Bateman RM, Tokunaga C, Kareco T, Dorscheid DR, Walley KR. Myocardial hypoxia-inducible HIF-1alpha, VEGF, and GLUT1 gene expression is associated with microvascular, and ICAM-1 heterogeneity during endotoxemia. Am J Physiol Heart Circ Physiol 293: H448-H456, 2007
    • (2007) Am J Physiol Heart Circ Physiol , vol.293 , pp. H448-H456
    • Bateman, R.M.1    Tokunaga, C.2    Kareco, T.3    Dorscheid, D.R.4    Walley, K.R.5
  • 86
    • 1942487804 scopus 로고    scopus 로고
    • Impact of leukocytes, and platelets in mediating hepatocyte apoptosis in a rat model of systemic endotoxemia
    • Eipel C, Bordel R, Nickels RM, Menger MD, Vollmar B. Impact of leukocytes, and platelets in mediating hepatocyte apoptosis in a rat model of systemic endotoxemia. Am J Physiol Gastrointest Liver Physiol 286: G769-G776, 2004
    • (2004) Am J Physiol Gastrointest Liver Physiol , vol.286 , pp. G769-G776
    • Eipel, C.1    Bordel, R.2    Nickels, R.M.3    Menger, M.D.4    Vollmar, B.5
  • 87
    • 80053175825 scopus 로고    scopus 로고
    • The association of near infrared spectroscopy-derived tissue oxygenation measurements with sepsis syndromes, organ dysfunction, and mortality in emergency department patients with sepsis
    • Shapiro NI, Arnold R, Sherwin R, O'Connor J, Najarro G, Singh S, Lundy D, Nelson T, Trzeciak SW, Jones AE. The association of near infrared spectroscopy-derived tissue oxygenation measurements with sepsis syndromes, organ dysfunction, and mortality in emergency department patients with sepsis. Crit Care 15: R223, 2011
    • (2011) Crit Care , vol.15 , pp. R223
    • Shapiro, N.I.1    Arnold, R.2    Sherwin, R.3    O'Connor, J.4    Najarro, G.5    Singh, S.6    Lundy, D.7    Nelson, T.8    Trzeciak, S.W.9    Jones, A.E.10
  • 89
    • 78651232635 scopus 로고    scopus 로고
    • Persistent low microcirculatory vessel density in nonsurvivors of sepsis in pediatric intensive care
    • Top AP, Ince C, de Meij N, Van Dijk M, Tibboel D. Persistent low microcirculatory vessel density in nonsurvivors of sepsis in pediatric intensive care. Crit Care Med 39: 8-13, 2011
    • (2011) Crit Care Med , vol.39 , pp. 8-13
    • Top, A.P.1    Ince, C.2    De Meij, N.3    Van Dijk, M.4    Tibboel, D.5
  • 91
    • 0034831025 scopus 로고    scopus 로고
    • Sublingual capnography: A clinical validation study
    • Marik PE. Sublingual capnography: a clinical validation study. Chest 120: 923-927, 2001
    • (2001) Chest , vol.120 , pp. 923-927
    • Marik, P.E.1
  • 92
    • 78349287380 scopus 로고    scopus 로고
    • Cutaneous ear lobe Pco2 at 378C to evaluate microperfusion in patients with septic shock
    • Vallée F, Mateo J, Dubreuil G, Poussant T, Tachon G, Ouanounou I, Payen D. Cutaneous ear lobe Pco2 at 378C to evaluate microperfusion in patients with septic shock. Chest 138: 1062-1070, 2010
    • (2010) Chest , vol.138 , pp. 1062-1070
    • Vallée, F.1    Mateo, J.2    Dubreuil, G.3    Poussant, T.4    Tachon, G.5    Ouanounou, I.6    Payen, D.7
  • 94
    • 33846918427 scopus 로고    scopus 로고
    • Microcirculatory dysfunction in the brain precedes changes in evoked potentials in endotoxininduced sepsis syndrome in rats
    • Rosengarten B, Hecht M, Auch D, Ghofrani HA, Schermuly RT, Grimminger F, Kaps M. Microcirculatory dysfunction in the brain precedes changes in evoked potentials in endotoxininduced sepsis syndrome in rats. Cerebrovasc Dis 23: 140-147, 2007
    • (2007) Cerebrovasc Dis , vol.23 , pp. 140-147
    • Rosengarten, B.1    Hecht, M.2    Auch, D.3    Ghofrani, H.A.4    Schermuly, R.T.5    Grimminger, F.6    Kaps, M.7
  • 95
    • 40749160044 scopus 로고    scopus 로고
    • Erythropoietin improves skeletal muscle microcirculation, and tissue bioenergetics in a mouse sepsis model
    • Kao R, Xenocostas A, Rui T, Yu P, Huang W, Rose J, Martin CM. Erythropoietin improves skeletal muscle microcirculation, and tissue bioenergetics in a mouse sepsis model. Crit Care 11: R58, 2007
    • (2007) Crit Care , vol.11 , pp. R58
    • Kao, R.1    Xenocostas, A.2    Rui, T.3    Yu, P.4    Huang, W.5    Rose, J.6    Martin, C.M.7
  • 98
    • 34548218270 scopus 로고    scopus 로고
    • The influence of early hemodynamic optimization on biomarker patterns of severe sepsis, and septic shock
    • Rivers EP, Kruse JA, Jacobsen G, Shah K, Loomba M, Otero R, Childs EW. The influence of early hemodynamic optimization on biomarker patterns of severe sepsis, and septic shock. Crit Care Med 35: 2016-2024, 2007
    • (2007) Crit Care Med , vol.35 , pp. 2016-2024
    • Rivers, E.P.1    Kruse, J.A.2    Jacobsen, G.3    Shah, K.4    Loomba, M.5    Otero, R.6    Childs, E.W.7


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