A new cytokine-receptor binding mode revealed by the crystal structure of the IL-1 receptor with an antagonist

Nature

Volumn 386, Issue 6621, 1997, Pages 194-200

  Schreuder, Herman ^a   Tardif, Chantal ^a   Trump Kallmeyer, Susanne ^a,d   Soffientini, Adolfo ^b   Sarubbi, Edoardo ^b   Akeson, Ann ^a   Bowlin, Terry ^a,b,e   Yanofsky, Stephen ^c   Barrett, Ronald W ^c  

^a SANOFI   (France)

^b Gruppo Lepetit SpA   (Italy)

^c AFFYMAX RESEARCH INSTITUTE   (United States)

^d PFIZER INC   (United States)

^e Biochem Therapeutice   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE RECEPTOR; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; TUMOR NECROSIS FACTOR RECEPTOR;

ARTICLE; BINDING SITE; COMPLEX FORMATION; CRYSTAL STRUCTURE; INFLAMMATION; LIGAND BINDING; MOLECULAR MODEL; PRIORITY JOURNAL; RECEPTOR BINDING; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; ANIMALS; CHO CELLS; CRICETINAE; CRYSTALLOGRAPHY, X-RAY; HUMANS; INTERLEUKIN 1 RECEPTOR ANTAGONIST PROTEIN; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FOLDING; RECEPTORS, INTERLEUKIN-1; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT; SIALOGLYCOPROTEINS;

EID: 0031000052     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/386194a0     Document Type: Article

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