-
1
-
-
33747796236
-
National study of emergency department visits for sepsis, 1992 to 2001
-
331 e1-3
-
Strehlow MC, Emond SD, Shapiro NI, Pelletier AJ, Camargo CA Jr (2006) National study of emergency department visits for sepsis, 1992 to 2001. Ann Emerg Med 48(3):326-331, 331 e1-3
-
(2006)
Ann Emerg Med
, vol.48
, Issue.3
, pp. 326-331
-
-
Strehlow, M.C.1
Emond, S.D.2
Shapiro, N.I.3
Pelletier, A.J.4
Camargo Jr., C.A.5
-
2
-
-
0030854780
-
Epidemiology of sepsis syndrome in 8 academic medical centers
-
3
-
Sands KE, Bates DW, Lanken PN, Graman PS, Hibberd PL, Kahn KL, Parsonnet J, Panzer R, Orav EJ, Snydman DR, Black E, Schwartz JS, Moore R, Johnson BL Jr, Platt R (1997) Epidemiology of sepsis syndrome in 8 academic medical centers. JAMA 278(3):234-2340
-
(1997)
JAMA
, vol.278
, pp. 234-2340
-
-
Sands, K.E.1
Bates, D.W.2
Lanken, P.N.3
Graman, P.S.4
Hibberd, P.L.5
Kahn, K.L.6
Parsonnet, J.7
Panzer, R.8
Orav, E.J.9
Snydman, D.R.10
Black, E.11
Schwartz, J.S.12
Moore, R.13
Johnson Jr., B.L.14
Platt, R.15
-
3
-
-
0034958947
-
Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care
-
7
-
Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR (2001) Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med 29(7):1303-1310
-
(2001)
Crit Care Med
, vol.29
, pp. 1303-1310
-
-
Angus, D.C.1
Linde-Zwirble, W.T.2
Lidicker, J.3
Clermont, G.4
Carcillo, J.5
Pinsky, M.R.6
-
4
-
-
0037451929
-
The epidemiology of sepsis in the United States from 1979 through 2000
-
16
-
Martin GS, Mannino DM, Eaton S, Moss M (2003) The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med 348(16):1546-1554
-
(2003)
N Engl J Med
, vol.348
, pp. 1546-1554
-
-
Martin, G.S.1
Mannino, D.M.2
Eaton, S.3
Moss, M.4
-
5
-
-
0037426726
-
The pathophysiology and treatment of sepsis
-
2
-
Hotchkiss RS, Karl IE (2003) The pathophysiology and treatment of sepsis. N Engl J Med 348(2):138-150
-
(2003)
N Engl J Med
, vol.348
, pp. 138-150
-
-
Hotchkiss, R.S.1
Karl, I.E.2
-
6
-
-
0035826096
-
Efficacy and safety of recombinant human activated protein C for severe sepsis
-
10
-
Bernard GR, Vincent JL, Laterre PF, LaRosa SP, Dhainaut JF, Lopez-Rodriguez A, Steingrub JS, Garber GE, Helterbrand JD, Ely EW, Fisher CJ Jr (2001) Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med 344(10):699-709
-
(2001)
N Engl J Med
, vol.344
, pp. 699-709
-
-
Bernard, G.R.1
Vincent, J.L.2
Laterre, P.F.3
Larosa, S.P.4
Dhainaut, J.F.5
Lopez-Rodriguez, A.6
Steingrub, J.S.7
Garber, G.E.8
Helterbrand, J.D.9
Ely, E.W.10
Fisher Jr., C.J.11
-
7
-
-
0029115513
-
Long-term survival and function after suspected gram-negative sepsis
-
4
-
Perl TM, Dvorak L, Hwang T, Wenzel RP (1995) Long-term survival and function after suspected gram-negative sepsis. JAMA 274(4):338-345
-
(1995)
JAMA
, vol.274
, pp. 338-345
-
-
Perl, T.M.1
Dvorak, L.2
Hwang, T.3
Wenzel, R.P.4
-
8
-
-
0041878645
-
Quality of life six years after intensive care
-
8
-
Kaarlola A, Pettila V, Kekki P (2003) Quality of life six years after intensive care. Intensive Care Med 29(8):1294-1299
-
(2003)
Intensive Care Med
, vol.29
, pp. 1294-1299
-
-
Kaarlola, A.1
Pettila, V.2
Kekki, P.3
-
10
-
-
0001100915
-
Untersuchungen über das Cholera
-
Pfeiffer R (1892) Untersuchungen über das Cholera. Gift Z Hyg Infectionskr 11:393-412
-
(1892)
Gift Z Hyg Infectionskr
, vol.11
, pp. 393-412
-
-
Pfeiffer, R.1
-
11
-
-
0024342856
-
The cardiovascular response of normal humans to the administration of endotoxin
-
5
-
Suffredini AF, Fromm RE, Parker MM, Brenner M, Kovacs JA, Wesley RA, Parrillo JE (1989) The cardiovascular response of normal humans to the administration of endotoxin. N Engl J Med 321(5):280-287
-
(1989)
N Engl J Med
, vol.321
, pp. 280-287
-
-
Suffredini, A.F.1
Fromm, R.E.2
Parker, M.M.3
Brenner, M.4
Kovacs, J.A.5
Wesley, R.A.6
Parrillo, J.E.7
-
12
-
-
0032509295
-
Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene
-
5396
-
Poltorak A, He X, Smirnova I, Liu MY, Van Huffel C, Du X, Birdwell D, Alejos E, Silva M, Galanos C, Freudenberg M, Ricciardi-Castagnoli P, Layton B, Beutler B (1998) Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282(5396):2085-2088
-
(1998)
Science
, vol.282
, pp. 2085-2088
-
-
Poltorak, A.1
He, X.2
Smirnova, I.3
Liu, M.Y.4
Van Huffel, C.5
Du, X.6
Birdwell, D.7
Alejos, E.8
Silva, M.9
Galanos, C.10
Freudenberg, M.11
Ricciardi-Castagnoli, P.12
Layton, B.13
Beutler, B.14
-
13
-
-
0032170215
-
Genetic and physical mapping of the Lps locus: Identification of the toll-4 receptor as a candidate gene in the critical region
-
3
-
Poltorak A, Smirnova I, He X, Liu MY, Van Huffel C, McNally O, Birdwell D, Alejos E, Silva M, Du X, Thompson P, Chan EK, Ledesma J, Roe B, Clifton S, Vogel SN, Beutler B (1998) Genetic and physical mapping of the Lps locus: identification of the toll-4 receptor as a candidate gene in the critical region. Blood Cells Mol Diseases 24(3):340-55
-
(1998)
Blood Cells Mol Diseases
, vol.24
, pp. 340-55
-
-
Poltorak, A.1
Smirnova, I.2
He, X.3
Liu, M.Y.4
Van Huffel, C.5
McNally, O.6
Birdwell, D.7
Alejos, E.8
Silva, M.9
Du, X.10
Thompson, P.11
Chan, E.K.12
Ledesma, J.13
Roe, B.14
Clifton, S.15
Vogel, S.N.16
Beutler, B.17
-
14
-
-
12444341944
-
Toll-like receptors in innate immunity
-
1
-
Takeda K, Akira S (2005) Toll-like receptors in innate immunity. Int Immunol 17(1):1-14
-
(2005)
Int Immunol
, vol.17
, pp. 1-14
-
-
Takeda, K.1
Akira, S.2
-
15
-
-
20444366947
-
Adaptor usage and Toll-like receptor signaling specificity
-
15
-
Dunne A, O'Neill LA (2005) Adaptor usage and Toll-like receptor signaling specificity. FEBS Lett 579(15):3330-3335
-
(2005)
FEBS Lett
, vol.579
, pp. 3330-3335
-
-
Dunne, A.1
O'Neill, L.A.2
-
16
-
-
3142654210
-
Inferences, questions and possibilities in Toll-like receptor signalling
-
6996
-
Beutler B (2004) Inferences, questions and possibilities in Toll-like receptor signalling. Nature 430(6996):257-263
-
(2004)
Nature
, vol.430
, pp. 257-263
-
-
Beutler, B.1
-
17
-
-
0036157920
-
Structural decomposition and heterogeneity of commercial lipoteichoic acid preparations
-
2
-
Morath S, Geyer A, Spreitzer I, Hermann C, Hartung T (2002) Structural decomposition and heterogeneity of commercial lipoteichoic acid preparations. Infect Immun 70(2):938-944
-
(2002)
Infect Immun
, vol.70
, pp. 938-944
-
-
Morath, S.1
Geyer, A.2
Spreitzer, I.3
Hermann, C.4
Hartung, T.5
-
18
-
-
7944220803
-
Toll-like receptor 2-dependent bacterial sensing does not occur via peptidoglycan recognition
-
10
-
Travassos LH, Girardin SE, Philpott DJ, Blanot D, Nahori MA, Werts C, Boneca IG (2004) Toll-like receptor 2-dependent bacterial sensing does not occur via peptidoglycan recognition. EMBO Rep 5(10):1000-1006
-
(2004)
EMBO Rep
, vol.5
, pp. 1000-1006
-
-
Travassos, L.H.1
Girardin, S.E.2
Philpott, D.J.3
Blanot, D.4
Nahori, M.A.5
Werts, C.6
Boneca, I.G.7
-
19
-
-
0031728726
-
Antibiotic-induced release of lipoteichoic acid and peptidoglycan from Staphylococcus aureus: Quantitative measurements and biological reactivities
-
12
-
van Langevelde P, van Dissel JT, Ravensbergen E, Appelmelk BJ, Schrijver IA, Groeneveld PH (1998) Antibiotic-induced release of lipoteichoic acid and peptidoglycan from Staphylococcus aureus: quantitative measurements and biological reactivities. Antimicrob Agents Chemother 42(12):3073-3078
-
(1998)
Antimicrob Agents Chemother
, vol.42
, pp. 3073-3078
-
-
Van Langevelde, P.1
Van Dissel, J.T.2
Ravensbergen, E.3
Appelmelk, B.J.4
Schrijver, I.A.5
Groeneveld, P.H.6
-
20
-
-
34548656855
-
Signaling pathways downstream of pattern-recognition receptors and their cross talk
-
Lee MS, Kim YJ (2007) Signaling pathways downstream of pattern-recognition receptors and their cross talk. Annu Rev Biochem 76:447-480
-
(2007)
Annu Rev Biochem
, vol.76
, pp. 447-480
-
-
Lee, M.S.1
Kim, Y.J.2
-
21
-
-
34249279516
-
Ligand-induced differential cross-regulation of Toll-like receptors 2, 4 and 5 in intestinal epithelial cells
-
15
-
van Aubel RA, Keestra AM, Krooshoop DJ, van Eden W, van Putten JP (2007) Ligand-induced differential cross-regulation of Toll-like receptors 2, 4 and 5 in intestinal epithelial cells. Mol Immunol 44(15):3702-3714
-
(2007)
Mol Immunol
, vol.44
, pp. 3702-3714
-
-
Van Aubel, R.A.1
Keestra, A.M.2
Krooshoop, D.J.3
Van Eden, W.4
Van Putten, J.P.5
-
22
-
-
0026874127
-
American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis
-
1992
-
American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. (1992) Crit Care Med 1992 20(6):864-874
-
(1992)
Crit Care Med
, vol.20
, Issue.6
, pp. 864-874
-
-
-
23
-
-
0033035861
-
Gram-positive sepsis. Mechanisms and differences from Gram-negative sepsis
-
2
-
Sriskandan S, Cohen J (1999) Gram-positive sepsis. Mechanisms and differences from Gram-negative sepsis. Infect Dis Clin North Am 13(2):397-412
-
(1999)
Infect Dis Clin North Am
, vol.13
, pp. 397-412
-
-
Sriskandan, S.1
Cohen, J.2
-
24
-
-
0027406403
-
Influence of an anti-tumor necrosis factor monoclonal antibody on cytokine levels in patients with sepsis. the CB0006 Sepsis Syndrome Study Group
-
3
-
Fisher CJ Jr, Opal SM, Dhainaut JF, Stephens S, Zimmerman JL, Nightingale P, Harris SJ, Schein RM, Panacek EA, Vincent JL et al (1993) Influence of an anti-tumor necrosis factor monoclonal antibody on cytokine levels in patients with sepsis. The CB0006 Sepsis Syndrome Study Group. Crit Care Med 21(3):318-327
-
(1993)
Crit Care Med
, vol.21
, pp. 318-327
-
-
Fisher Jr., C.J.1
Opal, S.M.2
Dhainaut, J.F.3
Stephens, S.4
Zimmerman, J.L.5
Nightingale, P.6
Harris, S.J.7
Schein, R.M.8
Panacek, E.A.9
Vincent, J.L.10
-
25
-
-
0029900294
-
Treatment of septic shock with the tumor necrosis factor receptor:Fc fusion protein. the Soluble TNF Receptor Sepsis Study Group
-
26
-
Fisher CJ Jr, Agosti JM, Opal SM, Lowry SF, Balk RA, Sadoff JC, Abraham E, Schein RM, Benjamin E (1996) Treatment of septic shock with the tumor necrosis factor receptor:Fc fusion protein. The Soluble TNF Receptor Sepsis Study Group. N Engl J Med 334(26):1697-702
-
(1996)
N Engl J Med
, vol.334
, pp. 1697-702
-
-
Fisher Jr., C.J.1
Agosti, J.M.2
Opal, S.M.3
Lowry, S.F.4
Balk, R.A.5
Sadoff, J.C.6
Abraham, E.7
Schein, R.M.8
Benjamin, E.9
-
26
-
-
1242342724
-
Plasma interferon-gamma and interleukin-10 concentrations in systemic meningococcal disease compared with severe systemic Gram-positive septic shock
-
2
-
Bjerre A, Brusletto B, Hoiby EA, Kierulf P, Brandtzaeg P (2004) Plasma interferon-gamma and interleukin-10 concentrations in systemic meningococcal disease compared with severe systemic Gram-positive septic shock. Crit Care Med 32(2):433-438
-
(2004)
Crit Care Med
, vol.32
, pp. 433-438
-
-
Bjerre, A.1
Brusletto, B.2
Hoiby, E.A.3
Kierulf, P.4
Brandtzaeg, P.5
-
27
-
-
0029835023
-
INTERSEPT: An international, multicenter, placebo-controlled trial of monoclonal antibody to human tumor necrosis factor-alpha in patients with sepsis. International Sepsis Trial Study Group
-
9
-
Cohen J, Carlet J (1996) INTERSEPT: an international, multicenter, placebo-controlled trial of monoclonal antibody to human tumor necrosis factor-alpha in patients with sepsis. International Sepsis Trial Study Group. Crit Care Med 24(9):1431-1440
-
(1996)
Crit Care Med
, vol.24
, pp. 1431-1440
-
-
Cohen, J.1
Carlet, J.2
-
28
-
-
0027945044
-
Platelet-activating factor receptor antagonist BN 52021 in the treatment of severe sepsis: A randomized, double-blind, placebo-controlled, multicenter clinical trial. BN 52021 Sepsis Study Group
-
11
-
Dhainaut JF, Tenaillon A, Le Tulzo Y, Schlemmer B, Solet JP, Wolff M, Holzapfel L, Zeni F, Dreyfuss D, Mira JP et al (1994) Platelet-activating factor receptor antagonist BN 52021 in the treatment of severe sepsis: a randomized, double-blind, placebo-controlled, multicenter clinical trial. BN 52021 Sepsis Study Group. Crit Care Med 22(11):1720-1728
-
(1994)
Crit Care Med
, vol.22
, pp. 1720-1728
-
-
Dhainaut, J.F.1
Tenaillon, A.2
Le Tulzo, Y.3
Schlemmer, B.4
Solet, J.P.5
Wolff, M.6
Holzapfel, L.7
Zeni, F.8
Dreyfuss, D.9
Mira, J.P.10
-
29
-
-
0008021312
-
Treatment of severe systemic inflammatory response syndrome and sepsis with a novel bradykinin antagonist, deltibant (CP-0127). Results of a randomized, double-blind, placebo-controlled trial. CP-0127 SIRS and Sepsis Study Group
-
6
-
Fein AM, Bernard GR, Criner GJ, Fletcher EC, Good JT Jr, Knaus WA, Levy H, Matuschak GM, Shanies HM, Taylor RW, Rodell TC (1997) Treatment of severe systemic inflammatory response syndrome and sepsis with a novel bradykinin antagonist, deltibant (CP-0127). Results of a randomized, double-blind, placebo-controlled trial. CP-0127 SIRS and Sepsis Study Group. JAMA 277(6):482-487
-
(1997)
JAMA
, vol.277
, pp. 482-487
-
-
Fein, A.M.1
Bernard, G.R.2
Criner, G.J.3
Fletcher, E.C.4
Good Jr., J.T.5
Knaus, W.A.6
Levy, H.7
Matuschak, G.M.8
Shanies, H.M.9
Taylor, R.W.10
Rodell, T.C.11
-
30
-
-
0037897393
-
Systemic host responses in severe sepsis analyzed by causative microorganism and treatment effects of drotrecogin alfa (activated)
-
1
-
Opal SM, Garber GE, LaRosa SP, Maki DG, Freebairn RC, Kinasewitz GT, Dhainaut JF, Yan SB, Williams MD, Graham DE, Nelson DR, Levy H, Bernard GR (2003) Systemic host responses in severe sepsis analyzed by causative microorganism and treatment effects of drotrecogin alfa (activated). Clin Infect Dis 37(1):50-58
-
(2003)
Clin Infect Dis
, vol.37
, pp. 50-58
-
-
Opal, S.M.1
Garber, G.E.2
Larosa, S.P.3
Maki, D.G.4
Freebairn, R.C.5
Kinasewitz, G.T.6
Dhainaut, J.F.7
Yan, S.B.8
Williams, M.D.9
Graham, D.E.10
Nelson, D.R.11
Levy, H.12
Bernard, G.R.13
-
31
-
-
9644308127
-
New developments in the diagnosis of bloodstream infections
-
12
-
Peters RP, van Agtmael MA, Danner SA, Savelkoul PH, Vandenbroucke-Grauls CM (2004) New developments in the diagnosis of bloodstream infections. Lancet Infect Dis 4(12):751-760
-
(2004)
Lancet Infect Dis
, vol.4
, pp. 751-760
-
-
Peters, R.P.1
Van Agtmael, M.A.2
Danner, S.A.3
Savelkoul, P.H.4
Vandenbroucke-Grauls, C.M.5
-
32
-
-
3242775982
-
Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock
-
3
-
Dellinger RP, Carlet JM, Masur H, Gerlach H, Calandra T, Cohen J, Gea-Banacloche J, Keh D, Marshall JC, Parker MM, Ramsay G, Zimmerman JL, Vincent JL, Levy MM (2004) Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. Crit Care Med 32(3):858-873
-
(2004)
Crit Care Med
, vol.32
, pp. 858-873
-
-
Dellinger, R.P.1
Carlet, J.M.2
Masur, H.3
Gerlach, H.4
Calandra, T.5
Cohen, J.6
Gea-Banacloche, J.7
Keh, D.8
Marshall, J.C.9
Parker, M.M.10
Ramsay, G.11
Zimmerman, J.L.12
Vincent, J.L.13
Levy, M.M.14
-
33
-
-
3943093972
-
Nosocomial bloodstream infections in US hospitals: Analysis of 24,179 cases from a prospective nationwide surveillance study
-
3
-
Wisplinghoff H, Bischoff T, Tallent SM, Seifert H, Wenzel RP, Edmond MB (2004) Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study. Clin Infect Dis 39(3):309-317
-
(2004)
Clin Infect Dis
, vol.39
, pp. 309-317
-
-
Wisplinghoff, H.1
Bischoff, T.2
Tallent, S.M.3
Seifert, H.4
Wenzel, R.P.5
Edmond, M.B.6
-
34
-
-
0042493163
-
Therapeutic targeting of Toll-like receptors for inflammatory and infectious diseases
-
4
-
O'Neill LA (2003) Therapeutic targeting of Toll-like receptors for inflammatory and infectious diseases. Curr Opin Pharmacol 3(4):396-403
-
(2003)
Curr Opin Pharmacol
, vol.3
, pp. 396-403
-
-
O'Neill, L.A.1
-
36
-
-
0035142605
-
Commercial preparations of lipoteichoic acid contain endotoxin that contributes to activation of mouse macrophages in vitro
-
2
-
Gao JJ, Xue Q, Zuvanich EG, Haghi KR, Morrison DC (2001) Commercial preparations of lipoteichoic acid contain endotoxin that contributes to activation of mouse macrophages in vitro. Infect Immun 69(2):751-757
-
(2001)
Infect Immun
, vol.69
, pp. 751-757
-
-
Gao, J.J.1
Xue, Q.2
Zuvanich, E.G.3
Haghi, K.R.4
Morrison, D.C.5
-
37
-
-
0034662239
-
Cutting edge: Repurification of lipopolysaccharide eliminates signaling through both human and murine toll-like receptor 2
-
2
-
Hirschfeld M, Ma Y, Weis JH, Vogel SN, Weis JJ (2000) Cutting edge: repurification of lipopolysaccharide eliminates signaling through both human and murine toll-like receptor 2. J Immunol 165(2):618-622
-
(2000)
J Immunol
, vol.165
, pp. 618-622
-
-
Hirschfeld, M.1
Ma, Y.2
Weis, J.H.3
Vogel, S.N.4
Weis, J.J.5
-
38
-
-
0034669910
-
Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection
-
10
-
Takeuchi O, Hoshino K, Akira S (2000) Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection. J Immunol 165(10):5392-5396
-
(2000)
J Immunol
, vol.165
, pp. 5392-5396
-
-
Takeuchi, O.1
Hoshino, K.2
Akira, S.3
-
39
-
-
0035674724
-
LBP, CD14, TLR4 and the murine innate immune response to a peritoneal Salmonella infection
-
6
-
Bernheiden M, Heinrich IM, Minigo G, Schutt C, Stelter F, Freeman M, Golenbock D, Jack RS (2001) LBP, CD14, TLR4 and the murine innate immune response to a peritoneal Salmonella infection. J Endotoxin Res 7(6):447-450
-
(2001)
J Endotoxin Res
, vol.7
, pp. 447-450
-
-
Bernheiden, M.1
Heinrich, I.M.2
Minigo, G.3
Schutt, C.4
Stelter, F.5
Freeman, M.6
Golenbock, D.7
Jack, R.S.8
-
40
-
-
0035971217
-
The extra domain a of fibronectin activates Toll-like receptor 4
-
13
-
Okamura Y, Watari M, Jerud ES, Young DW, Ishizaka ST, Rose J, Chow JC, Strauss JF 3rd (2001) The extra domain A of fibronectin activates Toll-like receptor 4. J Biol Chem 276(13):10229-10233
-
(2001)
J Biol Chem
, vol.276
, pp. 10229-10233
-
-
Okamura, Y.1
Watari, M.2
Jerud, E.S.3
Young, D.W.4
Ishizaka, S.T.5
Rose, J.6
Chow, J.C.7
Strauss III, J.F.8
-
41
-
-
8144222235
-
Increased expression of toll-like receptor-2 and -4 on leukocytes from patients with sepsis
-
5
-
Harter L, Mica L, Stocker R, Trentz O, Keel M (2004) Increased expression of toll-like receptor-2 and -4 on leukocytes from patients with sepsis. Shock 22(5):403-409
-
(2004)
Shock
, vol.22
, pp. 403-409
-
-
Harter, L.1
Mica, L.2
Stocker, R.3
Trentz, O.4
Keel, M.5
-
42
-
-
2142703865
-
Differential expression of Toll-like receptor (TLR)-2 and TLR-4 on monocytes in human sepsis
-
2
-
Armstrong L, Medford AR, Hunter KJ, Uppington KM, Millar AB (2004) Differential expression of Toll-like receptor (TLR)-2 and TLR-4 on monocytes in human sepsis. Clin Exp Immunol 136(2):312-319
-
(2004)
Clin Exp Immunol
, vol.136
, pp. 312-319
-
-
Armstrong, L.1
Medford, A.R.2
Hunter, K.J.3
Uppington, K.M.4
Millar, A.B.5
-
43
-
-
3142724031
-
Toll-like receptor signalling
-
7
-
Akira S, Takeda K (2004) Toll-like receptor signalling. Nat Rev Immunol 4(7):499-511
-
(2004)
Nat Rev Immunol
, vol.4
, pp. 499-511
-
-
Akira, S.1
Takeda, K.2
-
44
-
-
0034672088
-
Cutting edge: Naturally occurring soluble form of mouse Toll-like receptor 4 inhibits lipopolysaccharide signaling
-
12
-
Iwami KI, Matsuguchi T, Masuda A, Kikuchi T, Musikacharoen T, Yoshikai Y (2000) Cutting edge: naturally occurring soluble form of mouse Toll-like receptor 4 inhibits lipopolysaccharide signaling. J Immunol 165(12):6682-6686
-
(2000)
J Immunol
, vol.165
, pp. 6682-6686
-
-
Iwami, K.I.1
Matsuguchi, T.2
Masuda, A.3
Kikuchi, T.4
Musikacharoen, T.5
Yoshikai, Y.6
-
45
-
-
33751584426
-
Recombinant soluble forms of extracellular TLR4 domain and MD-2 inhibit lipopolysaccharide binding on cell surface and dampen lipopolysaccharide-induced pulmonary inflammation in mice
-
11
-
Mitsuzawa H, Nishitani C, Hyakushima N, Shimizu T, Sano H, Matsushima N, Fukase K, Kuroki Y (2006) Recombinant soluble forms of extracellular TLR4 domain and MD-2 inhibit lipopolysaccharide binding on cell surface and dampen lipopolysaccharide-induced pulmonary inflammation in mice. J Immunol 177(11):8133-8139
-
(2006)
J Immunol
, vol.177
, pp. 8133-8139
-
-
Mitsuzawa, H.1
Nishitani, C.2
Hyakushima, N.3
Shimizu, T.4
Sano, H.5
Matsushima, N.6
Fukase, K.7
Kuroki, Y.8
-
46
-
-
10744233851
-
Soluble forms of Toll-like receptor (TLR)2 capable of modulating TLR2 signaling are present in human plasma and breast milk
-
12
-
LeBouder E, Rey-Nores JE, Rushmere NK, Grigorov M, Lawn SD, Affolter M, Griffin GE, Ferrara P, Schiffrin EJ, Morgan BP, Labeta MO (2003) Soluble forms of Toll-like receptor (TLR)2 capable of modulating TLR2 signaling are present in human plasma and breast milk. J Immunol 171(12):6680-6689
-
(2003)
J Immunol
, vol.171
, pp. 6680-6689
-
-
Lebouder, E.1
Rey-Nores, J.E.2
Rushmere, N.K.3
Grigorov, M.4
Lawn, S.D.5
Affolter, M.6
Griffin, G.E.7
Ferrara, P.8
Schiffrin, E.J.9
Morgan, B.P.10
Labeta, M.O.11
-
47
-
-
20644450804
-
Negative regulation of toll-like receptor-mediated immune responses
-
6
-
Liew FY, Xu D, Brint EK, O'Neill LA (2005) Negative regulation of toll-like receptor-mediated immune responses. Nat Rev Immunol 5(6):446-458
-
(2005)
Nat Rev Immunol
, vol.5
, pp. 446-458
-
-
Liew, F.Y.1
Xu, D.2
Brint, E.K.3
O'Neill, L.A.4
-
48
-
-
0042236366
-
MyD88S, a splice variant of MyD88, differentially modulates NF-kappaB- and AP-1-dependent gene expression
-
1-3
-
Janssens S, Burns K, Vercammen E, Tschopp J, Beyaert R (2003) MyD88S, a splice variant of MyD88, differentially modulates NF-kappaB- and AP-1-dependent gene expression. FEBS Lett 548(1-3):103-107
-
(2003)
FEBS Lett
, vol.548
, pp. 103-107
-
-
Janssens, S.1
Burns, K.2
Vercammen, E.3
Tschopp, J.4
Beyaert, R.5
-
49
-
-
15544369643
-
Single nucleotide polymorphisms of Toll-like receptors and susceptibility to infectious disease
-
3
-
Schroder NW, Schumann RR (2005) Single nucleotide polymorphisms of Toll-like receptors and susceptibility to infectious disease. Lancet Infect Dis 5(3):156-164
-
(2005)
Lancet Infect Dis
, vol.5
, pp. 156-164
-
-
Schroder, N.W.1
Schumann, R.R.2
-
50
-
-
0037947560
-
Assay of locus-specific genetic load implicates rare Toll-like receptor 4 mutations in meningococcal susceptibility
-
10
-
Smirnova I, Mann N, Dols A, Derkx HH, Hibberd ML, Levin M, Beutler B (2003) Assay of locus-specific genetic load implicates rare Toll-like receptor 4 mutations in meningococcal susceptibility. Proc Natl Acad Sci U S A 100(10):6075-6080
-
(2003)
Proc Natl Acad Sci U S a
, vol.100
, pp. 6075-6080
-
-
Smirnova, I.1
Mann, N.2
Dols, A.3
Derkx, H.H.4
Hibberd, M.L.5
Levin, M.6
Beutler, B.7
-
51
-
-
0033794461
-
A novel polymorphism in the toll-like receptor 2 gene and its potential association with staphylococcal infection
-
11
-
Lorenz E, Mira JP, Cornish KL, Arbour NC, Schwartz DA (2000) A novel polymorphism in the toll-like receptor 2 gene and its potential association with staphylococcal infection. Infect Immun 68(11):6398-401
-
(2000)
Infect Immun
, vol.68
, pp. 6398-401
-
-
Lorenz, E.1
Mira, J.P.2
Cornish, K.L.3
Arbour, N.C.4
Schwartz, D.A.5
-
52
-
-
9144264994
-
Lack of association between Toll-like receptor 2 polymorphisms and susceptibility to severe disease caused by Staphylococcus aureus
-
6
-
Moore CE, Segal S, Berendt AR, Hill AV, Day NP (2004) Lack of association between Toll-like receptor 2 polymorphisms and susceptibility to severe disease caused by Staphylococcus aureus. Clin Diagn Lab Immunol 11(6):1194-1197
-
(2004)
Clin Diagn Lab Immunol
, vol.11
, pp. 1194-1197
-
-
Moore, C.E.1
Segal, S.2
Berendt, A.R.3
Hill, A.V.4
Day, N.P.5
-
53
-
-
1042269515
-
The Arg753GLn polymorphism of the human toll-like receptor 2 gene in tuberculosis disease
-
2
-
Ogus AC, Yoldas B, Ozdemir T, Uguz A, Olcen S, Keser I, Coskun M, Cilli A, Yegin O (2004) The Arg753GLn polymorphism of the human toll-like receptor 2 gene in tuberculosis disease. Eur Respir J 23(2):219-223
-
(2004)
Eur Respir J
, vol.23
, pp. 219-223
-
-
Ogus, A.C.1
Yoldas, B.2
Ozdemir, T.3
Uguz, A.4
Olcen, S.5
Keser, I.6
Coskun, M.7
Cilli, A.8
Yegin, O.9
-
54
-
-
0037378655
-
Cutting edge: A Toll-like receptor 2 polymorphism that is associated with lepromatous leprosy is unable to mediate mycobacterial signaling
-
7
-
Bochud PY, Hawn TR, Aderem A (2003) Cutting edge: a Toll-like receptor 2 polymorphism that is associated with lepromatous leprosy is unable to mediate mycobacterial signaling. J Immunol 170(7):3451-3454
-
(2003)
J Immunol
, vol.170
, pp. 3451-3454
-
-
Bochud, P.Y.1
Hawn, T.R.2
Aderem, A.3
-
55
-
-
2442714055
-
Toll-like receptor 2 Arg677Trp polymorphism is associated with susceptibility to tuberculosis in Tunisian patients
-
3
-
Ben-Ali M, Barbouche MR, Bousnina S, Chabbou A, Dellagi K (2004) Toll-like receptor 2 Arg677Trp polymorphism is associated with susceptibility to tuberculosis in Tunisian patients. Clin Diagn Lab Immunol 11(3):625-626
-
(2004)
Clin Diagn Lab Immunol
, vol.11
, pp. 625-626
-
-
Ben-Ali, M.1
Barbouche, M.R.2
Bousnina, S.3
Chabbou, A.4
Dellagi, K.5
-
56
-
-
10744226016
-
A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires' disease
-
10
-
Hawn TR, Verbon A, Lettinga KD, Zhao LP, Li SS, Laws RJ, Skerrett SJ, Beutler B, Schroeder L, Nachman A, Ozinsky A, Smith KD, Aderem A (2003) A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires' disease. J Exp Med 198(10):1563-1572
-
(2003)
J Exp Med
, vol.198
, pp. 1563-1572
-
-
Hawn, T.R.1
Verbon, A.2
Lettinga, K.D.3
Zhao, L.P.4
Li, S.S.5
Laws, R.J.6
Skerrett, S.J.7
Beutler, B.8
Schroeder, L.9
Nachman, A.10
Ozinsky, A.11
Smith, K.D.12
Aderem, A.13
-
57
-
-
34250205895
-
Cutting edge: A common polymorphism impairs cell surface trafficking and functional responses of TLR1 but protects against leprosy
-
12
-
Johnson CM, Lyle EA, Omueti KO, Stepensky VA, Yegin O, Alpsoy E, Hamann L, Schumann RR, Tapping RI (2007) Cutting edge: A common polymorphism impairs cell surface trafficking and functional responses of TLR1 but protects against leprosy. J Immunol 178(12):7520-7524
-
(2007)
J Immunol
, vol.178
, pp. 7520-7524
-
-
Johnson, C.M.1
Lyle, E.A.2
Omueti, K.O.3
Stepensky, V.A.4
Yegin, O.5
Alpsoy, E.6
Hamann, L.7
Schumann, R.R.8
Tapping, R.I.9
-
58
-
-
0037560071
-
Candida albicans phospholipomannan is sensed through toll-like receptors
-
1
-
Jouault T, Ibata-Ombetta S, Takeuchi O, Trinel PA, Sacchetti P, Lefebvre P, Akira S, Poulain D (2003) Candida albicans phospholipomannan is sensed through toll-like receptors. J Infect Dis 188(1):165-172
-
(2003)
J Infect Dis
, vol.188
, pp. 165-172
-
-
Jouault, T.1
Ibata-Ombetta, S.2
Takeuchi, O.3
Trinel, P.A.4
Sacchetti, P.5
Lefebvre, P.6
Akira, S.7
Poulain, D.8
-
59
-
-
0035313274
-
Toll-like receptor 4 mediates intracellular signaling without TNF-alpha release in response to Cryptococcus neoformans polysaccharide capsule
-
7
-
Shoham S, Huang C, Chen JM, Golenbock DT, Levitz SM (2001) Toll-like receptor 4 mediates intracellular signaling without TNF-alpha release in response to Cryptococcus neoformans polysaccharide capsule. J Immunol 166(7):4620-4626
-
(2001)
J Immunol
, vol.166
, pp. 4620-4626
-
-
Shoham, S.1
Huang, C.2
Chen, J.M.3
Golenbock, D.T.4
Levitz, S.M.5
-
60
-
-
0034610291
-
The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors
-
25
-
Ozinsky A, Underhill DM, Fontenot JD, Hajjar AM, Smith KD, Wilson CB, Schroeder L, Aderem A (2000) The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors. Proc Natl Acad Sci U S A 97(25):13766-13771
-
(2000)
Proc Natl Acad Sci U S a
, vol.97
, pp. 13766-13771
-
-
Ozinsky, A.1
Underhill, D.M.2
Fontenot, J.D.3
Hajjar, A.M.4
Smith, K.D.5
Wilson, C.B.6
Schroeder, L.7
Aderem, A.8
-
61
-
-
0037094116
-
The role of toll-like receptor (TLR) 2 and TLR4 in the host defense against disseminated candidiasis
-
10
-
Netea MG, Van Der Graaf CA, Vonk AG, Verschueren I, Van Der Meer JW, Kullberg BJ (2002) The role of toll-like receptor (TLR) 2 and TLR4 in the host defense against disseminated candidiasis. J Infect Dis 185(10):1483-1489
-
(2002)
J Infect Dis
, vol.185
, pp. 1483-1489
-
-
Netea, M.G.1
Van Der Graaf, C.A.2
Vonk, A.G.3
Verschueren, I.4
Van Der Meer, J.W.5
Kullberg, B.J.6
-
62
-
-
33748515009
-
Aspergillus fumigatus induces innate immune responses in alveolar macrophages through the MAPK pathway independently of TLR2 and TLR4
-
6
-
Dubourdeau M, Athman R, Balloy V, Huerre M, Chignard M, Philpott DJ, Latge JP, Ibrahim-Granet O (2006) Aspergillus fumigatus induces innate immune responses in alveolar macrophages through the MAPK pathway independently of TLR2 and TLR4. J Immunol 177(6):3994-4001
-
(2006)
J Immunol
, vol.177
, pp. 3994-4001
-
-
Dubourdeau, M.1
Athman, R.2
Balloy, V.3
Huerre, M.4
Chignard, M.5
Philpott, D.J.6
Latge, J.P.7
Ibrahim-Granet, O.8
-
63
-
-
0037033984
-
The economic and social burden of malaria
-
6872
-
Sachs J, Malaney P (2002) The economic and social burden of malaria. Nature 415(6872):680-685
-
(2002)
Nature
, vol.415
, pp. 680-685
-
-
Sachs, J.1
Malaney, P.2
-
65
-
-
14844337835
-
Induction of proinflammatory responses in macrophages by the glycosylphosphatidylinositols of Plasmodium falciparum: Cell signaling receptors, glycosylphosphatidylinositol (GPI) structural requirement, and regulation of GPI activity
-
9
-
Krishnegowda G, Hajjar AM, Zhu J, Douglass EJ, Uematsu S, Akira S, Woods AS, Gowda DC (2005) Induction of proinflammatory responses in macrophages by the glycosylphosphatidylinositols of Plasmodium falciparum: cell signaling receptors, glycosylphosphatidylinositol (GPI) structural requirement, and regulation of GPI activity. J Biol Chem 280(9):8606-8616
-
(2005)
J Biol Chem
, vol.280
, pp. 8606-8616
-
-
Krishnegowda, G.1
Hajjar, A.M.2
Zhu, J.3
Douglass, E.J.4
Uematsu, S.5
Akira, S.6
Woods, A.S.7
Gowda, D.C.8
-
66
-
-
33846911691
-
Malaria hemozoin is immunologically inert but radically enhances innate responses by presenting malaria DNA to Toll-like receptor 9
-
6
-
Parroche P, Lauw FN, Goutagny N, Latz E, Monks BG, Visintin A, Halmen KA, Lamphier M, Olivier M, Bartholomeu DC, Gazzinelli RT, Golenbock DT (2007) Malaria hemozoin is immunologically inert but radically enhances innate responses by presenting malaria DNA to Toll-like receptor 9. Proc Natl Acad Sci USA 104(6):1919-1924
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 1919-1924
-
-
Parroche, P.1
Lauw, F.N.2
Goutagny, N.3
Latz, E.4
Monks, B.G.5
Visintin, A.6
Halmen, K.A.7
Lamphier, M.8
Olivier, M.9
Bartholomeu, D.C.10
Gazzinelli, R.T.11
Golenbock, D.T.12
-
67
-
-
19944430901
-
Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin
-
1
-
Coban C, Ishii KJ, Kawai T, Hemmi H, Sato S, Uematsu S, Yamamoto M, Takeuchi O, Itagaki S, Kumar N, Horii T, Akira S (2005) Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin. J Exp Med 201(1):19-25
-
(2005)
J Exp Med
, vol.201
, pp. 19-25
-
-
Coban, C.1
Ishii, K.J.2
Kawai, T.3
Hemmi, H.4
Sato, S.5
Uematsu, S.6
Yamamoto, M.7
Takeuchi, O.8
Itagaki, S.9
Kumar, N.10
Horii, T.11
Akira, S.12
-
68
-
-
33845868751
-
Pathological role of Toll-like receptor signaling in cerebral malaria
-
1
-
Coban C, Ishii KJ, Uematsu S, Arisue N, Sato S, Yamamoto M, Kawai T, Takeuchi O, Hisaeda H, Horii T, Akira S (2007) Pathological role of Toll-like receptor signaling in cerebral malaria. Int Immunol 19(1):67-79
-
(2007)
Int Immunol
, vol.19
, pp. 67-79
-
-
Coban, C.1
Ishii, K.J.2
Uematsu, S.3
Arisue, N.4
Sato, S.5
Yamamoto, M.6
Kawai, T.7
Takeuchi, O.8
Hisaeda, H.9
Horii, T.10
Akira, S.11
-
69
-
-
34047098731
-
A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis
-
4
-
Khor CC, Chapman SJ, Vannberg FO, Dunne A, Murphy C, Ling EY, Frodsham AJ, Walley AJ, Kyrieleis O, Khan A, Aucan C, Segal S, Moore CE, Knox K, Campbell SJ, Lienhardt C, Scott A, Aaby P, Sow OY, Grignani RT, Sillah J, Sirugo G, Peshu N, Williams TN, Maitland K, Davies RJ, Kwiatkowski DP, Day NP, Yala D, Crook DW, Marsh K, Berkley JA, O'Neill LA, Hill AV (2007) A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis. Nat Genet 39(4):523-528
-
(2007)
Nat Genet
, vol.39
, pp. 523-528
-
-
Khor, C.C.1
Chapman, S.J.2
Vannberg, F.O.3
Dunne, A.4
Murphy, C.5
Ling, E.Y.6
Frodsham, A.J.7
Walley, A.J.8
Kyrieleis, O.9
Khan, A.10
Aucan, C.11
Segal, S.12
Moore, C.E.13
Knox, K.14
Campbell, S.J.15
Lienhardt, C.16
Scott, A.17
Aaby, P.18
Sow, O.Y.19
Grignani, R.T.20
Sillah, J.21
Sirugo, G.22
Peshu, N.23
Williams, T.N.24
Maitland, K.25
Davies, R.J.26
Kwiatkowski, D.P.27
Day, N.P.28
Yala, D.29
Crook, D.W.30
Marsh, K.31
Berkley, J.A.32
O'Neill, L.A.33
Hill, A.V.34
more..
-
70
-
-
30444459750
-
Toll-like receptor (TLR) polymorphisms in African children: Common TLR-4 variants predispose to severe malaria
-
1
-
Mockenhaupt FP, Cramer JP, Hamann L, Stegemann MS, Eckert J, Oh NR, Otchwemah RN, Dietz E, Ehrhardt S, Schroder NW, Bienzle U, Schumann RR (2006) Toll-like receptor (TLR) polymorphisms in African children: Common TLR-4 variants predispose to severe malaria. Proc Natl Acad Sci USA 103(1):177-182
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 177-182
-
-
Mockenhaupt, F.P.1
Cramer, J.P.2
Hamann, L.3
Stegemann, M.S.4
Eckert, J.5
Oh, N.R.6
Otchwemah, R.N.7
Dietz, E.8
Ehrhardt, S.9
Schroder, N.W.10
Bienzle, U.11
Schumann, R.R.12
-
72
-
-
0031912840
-
Multiple cases of life-threatening adenovirus pneumonia in a mental health care center
-
2
-
Klinger JR, Sanchez MP, Curtin LA, Durkin M, Matyas B (1998) Multiple cases of life-threatening adenovirus pneumonia in a mental health care center. Am J Respir Crit Care Med 157(2):645-649
-
(1998)
Am J Respir Crit Care Med
, vol.157
, pp. 645-649
-
-
Klinger, J.R.1
Sanchez, M.P.2
Curtin, L.A.3
Durkin, M.4
Matyas, B.5
-
73
-
-
33846100059
-
Principles of intracellular viral recognition
-
1
-
Saito T, Gale M Jr (2007) Principles of intracellular viral recognition. Curr Opin Immunol 19(1):17-23
-
(2007)
Curr Opin Immunol
, vol.19
, pp. 17-23
-
-
Saito, T.1
Gale Jr., M.2
-
74
-
-
22544455673
-
Cell type-specific involvement of RIG-I in antiviral response
-
1
-
Kato H, Sato S, Yoneyama M, Yamamoto M, Uematsu S, Matsui K, Tsujimura T, Takeda K, Fujita T, Takeuchi O, Akira S (2005) Cell type-specific involvement of RIG-I in antiviral response. Immunity 23(1):19-28
-
(2005)
Immunity
, vol.23
, pp. 19-28
-
-
Kato, H.1
Sato, S.2
Yoneyama, M.3
Yamamoto, M.4
Uematsu, S.5
Matsui, K.6
Tsujimura, T.7
Takeda, K.8
Fujita, T.9
Takeuchi, O.10
Akira, S.11
-
75
-
-
5944261457
-
Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus
-
5
-
Kurt-Jones EA, Popova L, Kwinn L, Haynes LM, Jones LP, Tripp RA, Walsh EE, Freeman MW, Golenbock DT, Anderson LJ, Finberg RW (2000) Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus. Nat Immunol 1(5):398-401
-
(2000)
Nat Immunol
, vol.1
, pp. 398-401
-
-
Kurt-Jones, E.A.1
Popova, L.2
Kwinn, L.3
Haynes, L.M.4
Jones, L.P.5
Tripp, R.A.6
Walsh, E.E.7
Freeman, M.W.8
Golenbock, D.T.9
Anderson, L.J.10
Finberg, R.W.11
-
76
-
-
34250873851
-
TLR4 polymorphisms mediate impaired responses to respiratory syncytial virus and lipopolysaccharide
-
1
-
Tulic MK, Hurrelbrink RJ, Prele CM, Laing IA, Upham JW, Le Souef P, Sly PD, Holt PG (2007) TLR4 polymorphisms mediate impaired responses to respiratory syncytial virus and lipopolysaccharide. J Immunol 179(1):132-40
-
(2007)
J Immunol
, vol.179
, pp. 132-40
-
-
Tulic, M.K.1
Hurrelbrink, R.J.2
Prele, C.M.3
Laing, I.A.4
Upham, J.W.5
Le Souef, P.6
Sly, P.D.7
Holt, P.G.8
-
77
-
-
0345505220
-
Human cytomegalovirus activates inflammatory cytokine responses via CD14 and Toll-like receptor 2
-
8
-
Compton T, Kurt-Jones EA, Boehme KW, Belko J, Latz E, Golenbock DT, Finberg RW (2003) Human cytomegalovirus activates inflammatory cytokine responses via CD14 and Toll-like receptor 2. J Virol 77(8):4588-4596
-
(2003)
J Virol
, vol.77
, pp. 4588-4596
-
-
Compton, T.1
Kurt-Jones, E.A.2
Boehme, K.W.3
Belko, J.4
Latz, E.5
Golenbock, D.T.6
Finberg, R.W.7
-
78
-
-
0036340341
-
Hemagglutinin protein of wild-type measles virus activates toll-like receptor 2 signaling
-
17
-
Bieback K, Lien E, Klagge IM, Avota E, Schneider-Schaulies J, Duprex WP, Wagner H, Kirschning CJ, Ter Meulen V, Schneider-Schaulies S (2002) Hemagglutinin protein of wild-type measles virus activates toll-like receptor 2 signaling. J Virol 76(17):8729-8736
-
(2002)
J Virol
, vol.76
, pp. 8729-8736
-
-
Bieback, K.1
Lien, E.2
Klagge, I.M.3
Avota, E.4
Schneider-Schaulies, J.5
Duprex, W.P.6
Wagner, H.7
Kirschning, C.J.8
Ter Meulen, V.9
Schneider-Schaulies, S.10
-
79
-
-
26444549006
-
Varicella-zoster virus activates inflammatory cytokines in human monocytes and macrophages via Toll-like receptor 2
-
20
-
Wang JP, Kurt-Jones EA, Shin OS, Manchak MD, Levin MJ, Finberg RW (2005) Varicella-zoster virus activates inflammatory cytokines in human monocytes and macrophages via Toll-like receptor 2. J Virol 79(20):12658-12666
-
(2005)
J Virol
, vol.79
, pp. 12658-12666
-
-
Wang, J.P.1
Kurt-Jones, E.A.2
Shin, O.S.3
Manchak, M.D.4
Levin, M.J.5
Finberg, R.W.6
-
80
-
-
0842342607
-
Herpes simplex virus 1 interaction with Toll-like receptor 2 contributes to lethal encephalitis
-
5
-
Kurt-Jones EA, Chan M, Zhou S, Wang J, Reed G, Bronson R, Arnold MM, Knipe DM, Finberg RW (2004) Herpes simplex virus 1 interaction with Toll-like receptor 2 contributes to lethal encephalitis. Proc Natl Acad Sci USA 101(5):1315-1320
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 1315-1320
-
-
Kurt-Jones, E.A.1
Chan, M.2
Zhou, S.3
Wang, J.4
Reed, G.5
Bronson, R.6
Arnold, M.M.7
Knipe, D.M.8
Finberg, R.W.9
-
81
-
-
31344464954
-
Role of Toll-like receptors in infection and immunity: Clinical implications
-
1
-
Cristofaro P, Opal SM (2006) Role of Toll-like receptors in infection and immunity: clinical implications. Drugs 66(1):15-29
-
(2006)
Drugs
, vol.66
, pp. 15-29
-
-
Cristofaro, P.1
Opal, S.M.2
-
82
-
-
33846246749
-
Translational mini-review series on Toll-like receptors: Recent advances in understanding the role of Toll-like receptors in anti-viral immunity
-
2
-
Bowie AG (2007) Translational mini-review series on Toll-like receptors: recent advances in understanding the role of Toll-like receptors in anti-viral immunity. Clin Exp Immunol 147(2):217-226
-
(2007)
Clin Exp Immunol
, vol.147
, pp. 217-226
-
-
Bowie, A.G.1
-
83
-
-
0035909372
-
Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3
-
6857
-
Alexopoulou L, Holt AC, Medzhitov R, Flavell RA (2001) Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature 413(6857):732-738
-
(2001)
Nature
, vol.413
, pp. 732-738
-
-
Alexopoulou, L.1
Holt, A.C.2
Medzhitov, R.3
Flavell, R.A.4
-
84
-
-
11144273976
-
Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis
-
12
-
Wang T, Town T, Alexopoulou L, Anderson JF, Fikrig E, Flavell RA (2004) Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis. Nat Med 10(12):1366-1373
-
(2004)
Nat Med
, vol.10
, pp. 1366-1373
-
-
Wang, T.1
Town, T.2
Alexopoulou, L.3
Anderson, J.F.4
Fikrig, E.5
Flavell, R.A.6
-
85
-
-
33644833702
-
Microglia recognize double-stranded RNA via TLR3
-
6
-
Town T, Jeng D, Alexopoulou L, Tan J, Flavell RA (2006) Microglia recognize double-stranded RNA via TLR3. J Immunol 176(6):3804-3812
-
(2006)
J Immunol
, vol.176
, pp. 3804-3812
-
-
Town, T.1
Jeng, D.2
Alexopoulou, L.3
Tan, J.4
Flavell, R.A.5
-
86
-
-
27144440476
-
Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus
-
7062
-
Meylan E, Curran J, Hofmann K, Moradpour D, Binder M, Bartenschlager R, Tschopp J (2005) Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus. Nature 437(7062):1167-1172
-
(2005)
Nature
, vol.437
, pp. 1167-1172
-
-
Meylan, E.1
Curran, J.2
Hofmann, K.3
Moradpour, D.4
Binder, M.5
Bartenschlager, R.6
Tschopp, J.7
-
87
-
-
0037415598
-
The poxvirus protein A52R targets Toll-like receptor signaling complexes to suppress host defense
-
3
-
Harte MT, Haga IR, Maloney G, Gray P, Reading PC, Bartlett NW, Smith GL, Bowie A, O'Neill LA (2003) The poxvirus protein A52R targets Toll-like receptor signaling complexes to suppress host defense. J Exp Med 197(3):343-351
-
(2003)
J Exp Med
, vol.197
, pp. 343-351
-
-
Harte, M.T.1
Haga, I.R.2
Maloney, G.3
Gray, P.4
Reading, P.C.5
Bartlett, N.W.6
Smith, G.L.7
Bowie, A.8
O'Neill, L.A.9
-
88
-
-
17144366260
-
Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulence
-
6
-
Stack J, Haga IR, Schroder M, Bartlett NW, Maloney G, Reading PC, Fitzgerald KA, Smith GL, Bowie AG (2005) Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulence. J Exp Med 201(6):1007-1018
-
(2005)
J Exp Med
, vol.201
, pp. 1007-1018
-
-
Stack, J.1
Haga, I.R.2
Schroder, M.3
Bartlett, N.W.4
Maloney, G.5
Reading, P.C.6
Fitzgerald, K.A.7
Smith, G.L.8
Bowie, A.G.9
-
89
-
-
0034913364
-
Anti-tumor necrosis factor therapy in sepsis: Update on clinical trials and lessons learned
-
7 Suppl
-
Reinhart K, Karzai W (2001) Anti-tumor necrosis factor therapy in sepsis: update on clinical trials and lessons learned. Crit Care Med 29(7 Suppl):S121-S125
-
(2001)
Crit Care Med
, vol.29
-
-
Reinhart, K.1
Karzai, W.2
-
90
-
-
0028239555
-
Recombinant human interleukin 1 receptor antagonist in the treatment of patients with sepsis syndrome. Results from a randomized, double-blind, placebo-controlled trial. Phase III rhIL-1ra Sepsis Syndrome Study Group
-
23
-
Fisher CJ Jr, Dhainaut JF, Opal SM, Pribble JP, Balk RA, Slotman GJ, Iberti TJ, Rackow EC, Shapiro MJ, Greenman RL et al (1994) Recombinant human interleukin 1 receptor antagonist in the treatment of patients with sepsis syndrome. Results from a randomized, double-blind, placebo-controlled trial. Phase III rhIL-1ra Sepsis Syndrome Study Group. JAMA 271(23):1836-1843
-
(1994)
JAMA
, vol.271
, pp. 1836-1843
-
-
Fisher Jr., C.J.1
Dhainaut, J.F.2
Opal, S.M.3
Pribble, J.P.4
Balk, R.A.5
Slotman, G.J.6
Iberti, T.J.7
Rackow, E.C.8
Shapiro, M.J.9
Greenman, R.L.10
-
91
-
-
0037414274
-
Discovery of a potent small molecule IL-2 inhibitor through fragment assembly
-
13
-
Braisted AC, Oslob JD, Delano WL, Hyde J, McDowell RS, Waal N, Yu C, Arkin MR, Raimundo BC (2003) Discovery of a potent small molecule IL-2 inhibitor through fragment assembly. J Am Chem Soc 125(13):3714-3715
-
(2003)
J Am Chem Soc
, vol.125
, pp. 3714-3715
-
-
Braisted, A.C.1
Oslob, J.D.2
Delano, W.L.3
Hyde, J.4
McDowell, R.S.5
Waal, N.6
Yu, C.7
Arkin, M.R.8
Raimundo, B.C.9
-
92
-
-
33645097021
-
A novel cyclohexene derivative, ethyl (6R)-6-[N-(2-Chloro-4-fluorophenyl) sulfamoyl]cyclohex-1-ene-1-carboxylate (TAK-242), selectively inhibits toll-like receptor 4-mediated cytokine production through suppression of intracellular signaling
-
4
-
Ii M, Matsunaga N, Hazeki K, Nakamura K, Takashima K, Seya T, Hazeki O, Kitazaki T, Iizawa Y (2006) A novel cyclohexene derivative, ethyl (6R)-6-[N-(2-Chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate (TAK-242), selectively inhibits toll-like receptor 4-mediated cytokine production through suppression of intracellular signaling. Mol Pharmacol 69(4):1288-1295
-
(2006)
Mol Pharmacol
, vol.69
, pp. 1288-1295
-
-
Ii, M.1
Matsunaga, N.2
Hazeki, K.3
Nakamura, K.4
Takashima, K.5
Seya, T.6
Hazeki, O.7
Kitazaki, T.8
Iizawa, Y.9
-
93
-
-
28544447821
-
Discovery of novel and potent small-molecule inhibitors of NO and cytokine production as antisepsis agents: Synthesis and biological activity of alkyl 6-(N-substituted sulfamoyl)cyclohex-1-ene-1-carboxylate
-
23
-
Yamada M, Ichikawa T, Ii M, Sunamoto M, Itoh K, Tamura N, Kitazaki T (2005) Discovery of novel and potent small-molecule inhibitors of NO and cytokine production as antisepsis agents: synthesis and biological activity of alkyl 6-(N-substituted sulfamoyl)cyclohex-1-ene-1-carboxylate. J Med Chem 48(23):7457-7467
-
(2005)
J Med Chem
, vol.48
, pp. 7457-7467
-
-
Yamada, M.1
Ichikawa, T.2
Ii, M.3
Sunamoto, M.4
Itoh, K.5
Tamura, N.6
Kitazaki, T.7
-
94
-
-
34548496023
-
Therapeutic effects of TAK-242, a novel selective Toll-like receptor 4 signal transduction inhibitor, in mouse endotoxin shock model
-
2-3
-
Sha T, Sunamoto M, Kitazaki T, Sato J, Ii M, Iizawa Y (2007) Therapeutic effects of TAK-242, a novel selective Toll-like receptor 4 signal transduction inhibitor, in mouse endotoxin shock model. Eur J Pharmacol 571(2-3):231-239
-
(2007)
Eur J Pharmacol
, vol.571
, pp. 231-239
-
-
Sha, T.1
Sunamoto, M.2
Kitazaki, T.3
Sato, J.4
Ii, M.5
Iizawa, Y.6
-
95
-
-
0037372661
-
Inhibition of endotoxin response by e5564, a novel Toll-like receptor 4-directed endotoxin antagonist
-
3
-
Mullarkey M, Rose JR, Bristol J, Kawata T, Kimura A, Kobayashi S, Przetak M, Chow J, Gusovsky F, Christ WJ, Rossignol DP (2003) Inhibition of endotoxin response by e5564, a novel Toll-like receptor 4-directed endotoxin antagonist. J Pharmacol Exp Ther 304(3):1093-1102
-
(2003)
J Pharmacol Exp Ther
, vol.304
, pp. 1093-1102
-
-
Mullarkey, M.1
Rose, J.R.2
Bristol, J.3
Kawata, T.4
Kimura, A.5
Kobayashi, S.6
Przetak, M.7
Chow, J.8
Gusovsky, F.9
Christ, W.J.10
Rossignol, D.P.11
-
96
-
-
0037442501
-
Blocking of responses to endotoxin by E5564 in healthy volunteers with experimental endotoxemia
-
4
-
Lynn M, Rossignol DP, Wheeler JL, Kao RJ, Perdomo CA, Noveck R, Vargas R, D'Angelo T, Gotzkowsky S, McMahon FG (2003) Blocking of responses to endotoxin by E5564 in healthy volunteers with experimental endotoxemia. J Infect Dis 187(4):631-639
-
(2003)
J Infect Dis
, vol.187
, pp. 631-639
-
-
Lynn, M.1
Rossignol, D.P.2
Wheeler, J.L.3
Kao, R.J.4
Perdomo, C.A.5
Noveck, R.6
Vargas, R.7
D'Angelo, T.8
Gotzkowsky, S.9
McMahon, F.G.10
-
97
-
-
9144257824
-
Extended in vivo pharmacodynamic activity of E5564 in normal volunteers with experimental endotoxemia
-
1
-
Lynn M, Wong YN, Wheeler JL, Kao RJ, Perdomo CA, Noveck R, Vargas R, D'Angelo T, Gotzkowsky S, McMahon FG, Wasan KM, Rossignol DP (2004) Extended in vivo pharmacodynamic activity of E5564 in normal volunteers with experimental endotoxemia. J Pharmacol Exp Ther 308(1):175-181
-
(2004)
J Pharmacol Exp Ther
, vol.308
, pp. 175-181
-
-
Lynn, M.1
Wong, Y.N.2
Wheeler, J.L.3
Kao, R.J.4
Perdomo, C.A.5
Noveck, R.6
Vargas, R.7
D'Angelo, T.8
Gotzkowsky, S.9
McMahon, F.G.10
Wasan, K.M.11
Rossignol, D.P.12
-
98
-
-
20844463064
-
A synthetic TLR4 antagonist has anti-inflammatory effects in two murine models of inflammatory bowel disease
-
10
-
Fort MM, Mozaffarian A, Stover AG, Correia Jda S, Johnson DA, Crane RT, Ulevitch RJ, Persing DH, Bielefeldt-Ohmann H, Probst P, Jeffery E, Fling SP, Hershberg RM (2005) A synthetic TLR4 antagonist has anti-inflammatory effects in two murine models of inflammatory bowel disease. J Immunol 174(10):6416-6423
-
(2005)
J Immunol
, vol.174
, pp. 6416-6423
-
-
Fort, M.M.1
Mozaffarian, A.2
Stover, A.G.3
Correia Jda, S.4
Johnson, D.A.5
Crane, R.T.6
Ulevitch, R.J.7
Persing, D.H.8
Bielefeldt-Ohmann, H.9
Probst, P.10
Jeffery, E.11
Fling, S.P.12
Hershberg, R.M.13
-
99
-
-
85047690873
-
Antagonistic antibody prevents Toll-like receptor 2-driven lethal shock-like syndromes
-
10
-
Meng G, Rutz M, Schiemann M, Metzger J, Grabiec A, Schwandner R, Luppa PB, Ebel F, Busch DH, Bauer S, Wagner H, Kirschning CJ (2004) Antagonistic antibody prevents Toll-like receptor 2-driven lethal shock-like syndromes. J Clin Invest 113(10):1473-1481
-
(2004)
J Clin Invest
, vol.113
, pp. 1473-1481
-
-
Meng, G.1
Rutz, M.2
Schiemann, M.3
Metzger, J.4
Grabiec, A.5
Schwandner, R.6
Luppa, P.B.7
Ebel, F.8
Busch, D.H.9
Bauer, S.10
Wagner, H.11
Kirschning, C.J.12
-
100
-
-
0742304355
-
Is there a place for granulocyte colony-stimulating factor in non-neutropenic critically ill patients?
-
1
-
Azoulay E, Delclaux C (2004) Is there a place for granulocyte colony-stimulating factor in non-neutropenic critically ill patients? Intensive Care Med 30(1):10-17
-
(2004)
Intensive Care Med
, vol.30
, pp. 10-17
-
-
Azoulay, E.1
Delclaux, C.2
-
101
-
-
0036172413
-
Impairment of polymorphonuclear neutrophil functions precedes nosocomial infections in critically ill patients
-
2
-
Stephan F, Yang K, Tankovic J, Soussy CJ, Dhonneur G, Duvaldestin P, Brochard L, Brun-Buisson C, Harf A, Delclaux C (2002) Impairment of polymorphonuclear neutrophil functions precedes nosocomial infections in critically ill patients. Crit Care Med 30(2):315-322
-
(2002)
Crit Care Med
, vol.30
, pp. 315-322
-
-
Stephan, F.1
Yang, K.2
Tankovic, J.3
Soussy, C.J.4
Dhonneur, G.5
Duvaldestin, P.6
Brochard, L.7
Brun-Buisson, C.8
Harf, A.9
Delclaux, C.10
-
102
-
-
8444247042
-
Toll-like receptor (TLR)-3, but not TLR4, agonist protects against genital herpes infection in the absence of inflammation seen with CpG DNA
-
10
-
Ashkar AA, Yao XD, Gill N, Sajic D, Patrick AJ, Rosenthal KL (2004) Toll-like receptor (TLR)-3, but not TLR4, agonist protects against genital herpes infection in the absence of inflammation seen with CpG DNA. J Infect Dis 190(10):1841-1849
-
(2004)
J Infect Dis
, vol.190
, pp. 1841-1849
-
-
Ashkar, A.A.1
Yao, X.D.2
Gill, N.3
Sajic, D.4
Patrick, A.J.5
Rosenthal, K.L.6
-
103
-
-
33748297497
-
Treatment of viral and neoplastic diseases with double-stranded RNA derivatives and other new agents
-
8
-
Ambrus JL Sr, Chadha KC, Islam A, Akhter S, Ambrus JL Jr (2006) Treatment of viral and neoplastic diseases with double-stranded RNA derivatives and other new agents. Exp Biol Med (Maywood) 231(8):1283-1286
-
(2006)
Exp Biol Med (Maywood)
, vol.231
, pp. 1283-1286
-
-
Ambrus Sr., J.L.1
Chadha, K.C.2
Islam, A.3
Akhter, S.4
Ambrus Jr., J.L.5
-
104
-
-
0036008014
-
Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway
-
2
-
Hemmi H, Kaisho T, Takeuchi O, Sato S, Sanjo H, Hoshino K, Horiuchi T, Tomizawa H, Takeda K, Akira S (2002) Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nat Immunol 3(2):196-200
-
(2002)
Nat Immunol
, vol.3
, pp. 196-200
-
-
Hemmi, H.1
Kaisho, T.2
Takeuchi, O.3
Sato, S.4
Sanjo, H.5
Hoshino, K.6
Horiuchi, T.7
Tomizawa, H.8
Takeda, K.9
Akira, S.10
-
105
-
-
0036088492
-
Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848
-
6
-
Jurk M, Heil F, Vollmer J, Schetter C, Krieg AM, Wagner H, Lipford G, Bauer S (2002) Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848. Nat Immunol 3(6):499
-
(2002)
Nat Immunol
, vol.3
, pp. 499
-
-
Jurk, M.1
Heil, F.2
Vollmer, J.3
Schetter, C.4
Krieg, A.M.5
Wagner, H.6
Lipford, G.7
Bauer, S.8
-
107
-
-
33646125599
-
Topical imiquimod for recurrent acyclovir-resistant HSV infection
-
5
-
Martinez V, Molina JM, Scieux C, Ribaud P, Morfin F (2006) Topical imiquimod for recurrent acyclovir-resistant HSV infection. Am J Med 119(5):e9-e11
-
(2006)
Am J Med
, vol.119
-
-
Martinez, V.1
Molina, J.M.2
Scieux, C.3
Ribaud, P.4
Morfin, F.5
-
108
-
-
34248338345
-
Treatment of molluscum contagiosum and herpes simplex virus cutaneous infections
-
4 Suppl
-
Jones S, Kress D (2007) Treatment of molluscum contagiosum and herpes simplex virus cutaneous infections. Cutis 79(4 Suppl):11-17
-
(2007)
Cutis
, vol.79
, pp. 11-17
-
-
Jones, S.1
Kress, D.2
-
109
-
-
34249890840
-
Role of imiquimod and parenteral meglumine antimoniate in the initial treatment of cutaneous leishmaniasis
-
12
-
Arevalo I, Tulliano G, Quispe A, Spaeth G, Matlashewski G, Llanos-Cuentas A, Pollack H (2007) Role of imiquimod and parenteral meglumine antimoniate in the initial treatment of cutaneous leishmaniasis. Clin Infect Dis 44(12):1549-1554
-
(2007)
Clin Infect Dis
, vol.44
, pp. 1549-1554
-
-
Arevalo, I.1
Tulliano, G.2
Quispe, A.3
Spaeth, G.4
Matlashewski, G.5
Llanos-Cuentas, A.6
Pollack, H.7
-
110
-
-
34447632621
-
Pharmacokinetics of 852A, an imidazoquinoline toll-like receptor 7-specific agonist, following intravenous, subcutaneous, and oral administrations in humans
-
8
-
Harrison LI, Astry C, Kumar S, Yunis C (2007) Pharmacokinetics of 852A, an imidazoquinoline toll-like receptor 7-specific agonist, following intravenous, subcutaneous, and oral administrations in humans. J Clin Pharmacol 47(8):962-969
-
(2007)
J Clin Pharmacol
, vol.47
, pp. 962-969
-
-
Harrison, L.I.1
Astry, C.2
Kumar, S.3
Yunis, C.4
-
111
-
-
33845542139
-
Toll-like receptor agonists in the treatment of chronic lymphocytic leukemia
-
1
-
Spaner DE, Masellis A (2007) Toll-like receptor agonists in the treatment of chronic lymphocytic leukemia. Leukemia 21(1):53-60
-
(2007)
Leukemia
, vol.21
, pp. 53-60
-
-
Spaner, D.E.1
Masellis, A.2
-
112
-
-
33846181945
-
Administration of a dual toll-like receptor 7 and toll-like receptor 8 agonist protects against influenza in rats
-
1
-
Hammerbeck DM, Burleson GR, Schuller CJ, Vasilakos JP, Tomai M, Egging E, Cochran FR, Woulfe S, Miller RL (2007) Administration of a dual toll-like receptor 7 and toll-like receptor 8 agonist protects against influenza in rats. Antiviral Res 73(1):1-11
-
(2007)
Antiviral Res
, vol.73
, pp. 1-11
-
-
Hammerbeck, D.M.1
Burleson, G.R.2
Schuller, C.J.3
Vasilakos, J.P.4
Tomai, M.5
Egging, E.6
Cochran, F.R.7
Woulfe, S.8
Miller, R.L.9
-
113
-
-
33947624651
-
Designing recombinant vaccines with viral properties: A rational approach to more effective vaccines
-
2
-
Jennings GT, Bachmann MF (2007) Designing recombinant vaccines with viral properties: a rational approach to more effective vaccines. Curr Mol Med 7(2):143-155
-
(2007)
Curr Mol Med
, vol.7
, pp. 143-155
-
-
Jennings, G.T.1
Bachmann, M.F.2
-
114
-
-
0037726807
-
A phase I study of the safety and immunogenicity of recombinant hepatitis B surface antigen co-administered with an immunostimulatory phosphorothioate oligonucleotide adjuvant
-
19-20
-
Halperin SA, Van Nest G, Smith B, Abtahi S, Whiley H, Eiden JJ (2003) A phase I study of the safety and immunogenicity of recombinant hepatitis B surface antigen co-administered with an immunostimulatory phosphorothioate oligonucleotide adjuvant. Vaccine 21(19-20):2461-2467
-
(2003)
Vaccine
, vol.21
, pp. 2461-2467
-
-
Halperin, S.A.1
Van Nest, G.2
Smith, B.3
Abtahi, S.4
Whiley, H.5
Eiden, J.J.6
-
115
-
-
11344257404
-
CPG 7909, an immunostimulatory TLR9 agonist oligodeoxynucleotide, as adjuvant to Engerix-B HBV vaccine in healthy adults: A double-blind phase I/II study
-
6
-
Cooper CL, Davis HL, Morris ML, Efler SM, Adhami MA, Krieg AM, Cameron DW, Heathcote J (2004) CPG 7909, an immunostimulatory TLR9 agonist oligodeoxynucleotide, as adjuvant to Engerix-B HBV vaccine in healthy adults: a double-blind phase I/II study. J Clin Immunol 24(6):693-701
-
(2004)
J Clin Immunol
, vol.24
, pp. 693-701
-
-
Cooper, C.L.1
Davis, H.L.2
Morris, M.L.3
Efler, S.M.4
Adhami, M.A.5
Krieg, A.M.6
Cameron, D.W.7
Heathcote, J.8
-
116
-
-
3142690381
-
Taking a Toll on human disease: Toll-like receptor 4 agonists as vaccine adjuvants and monotherapeutic agents
-
7
-
Baldridge JR, McGowan P, Evans JT, Cluff C, Mossman S, Johnson D, Persing D (2004) Taking a Toll on human disease: Toll-like receptor 4 agonists as vaccine adjuvants and monotherapeutic agents. Expert Opin Biol Ther 4(7):1129-38
-
(2004)
Expert Opin Biol Ther
, vol.4
, pp. 1129-38
-
-
Baldridge, J.R.1
McGowan, P.2
Evans, J.T.3
Cluff, C.4
Mossman, S.5
Johnson, D.6
Persing, D.7
-
117
-
-
29144462494
-
Hepatitis C virus protease NS3/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunity
-
49
-
Li XD, Sun L, Seth RB, Pineda G, Chen ZJ (2005) Hepatitis C virus protease NS3/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunity. Proc Natl Acad Sci U S A 102(49):17717-17722
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 17717-17722
-
-
Li, X.D.1
Sun, L.2
Seth, R.B.3
Pineda, G.4
Chen, Z.J.5
-
118
-
-
33749360242
-
Rapid decline of viral RNA in hepatitis C patients treated with VX-950: A phase Ib, placebo-controlled, randomized study
-
4
-
Reesink HW, Zeuzem S, Weegink CJ, Forestier N, van Vliet A, van de Wetering de Rooij J, McNair L, Purdy S, Kauffman R, Alam J, Jansen PL (2006) Rapid decline of viral RNA in hepatitis C patients treated with VX-950: a phase Ib, placebo-controlled, randomized study. Gastroenterology 131(4):997-1002
-
(2006)
Gastroenterology
, vol.131
, pp. 997-1002
-
-
Reesink, H.W.1
Zeuzem, S.2
Weegink, C.J.3
Forestier, N.4
Van Vliet, A.5
Van De Wetering De Rooij, J.6
McNair, L.7
Purdy, S.8
Kauffman, R.9
Alam, J.10
Jansen, P.L.11
-
119
-
-
7644232426
-
Short-term antiviral efficacy of BILN 2061, a hepatitis C virus serine protease inhibitor, in hepatitis C genotype 1 patients
-
5
-
Hinrichsen H, Benhamou Y, Wedemeyer H, Reiser M, Sentjens RE, Calleja JL, Forns X, Erhardt A, Cronlein J, Chaves RL, Yong CL, Nehmiz G, Steinmann GG (2004) Short-term antiviral efficacy of BILN 2061, a hepatitis C virus serine protease inhibitor, in hepatitis C genotype 1 patients. Gastroenterology 127(5):1347-1355
-
(2004)
Gastroenterology
, vol.127
, pp. 1347-1355
-
-
Hinrichsen, H.1
Benhamou, Y.2
Wedemeyer, H.3
Reiser, M.4
Sentjens, R.E.5
Calleja, J.L.6
Forns, X.7
Erhardt, A.8
Cronlein, J.9
Chaves, R.L.10
Yong, C.L.11
Nehmiz, G.12
Steinmann, G.G.13
-
120
-
-
0344201903
-
An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus
-
6963
-
Lamarre D, Anderson PC, Bailey M, Beaulieu P, Bolger G, Bonneau P, Bos M, Cameron DR, Cartier M, Cordingley MG, Faucher AM, Goudreau N, Kawai SH, Kukolj G, Lagace L, LaPlante SR, Narjes H, Poupart MA, Rancourt J, Sentjens RE, St George R, Simoneau B, Steinmann G, Thibeault D, Tsantrizos YS, Weldon SM, Yong CL, Llinas-Brunet M (2003) An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus. Nature 426(6963):186-189
-
(2003)
Nature
, vol.426
, pp. 186-189
-
-
Lamarre, D.1
Anderson, P.C.2
Bailey, M.3
Beaulieu, P.4
Bolger, G.5
Bonneau, P.6
Bos, M.7
Cameron, D.R.8
Cartier, M.9
Cordingley, M.G.10
Faucher, A.M.11
Goudreau, N.12
Kawai, S.H.13
Kukolj, G.14
Lagace, L.15
Laplante, S.R.16
Narjes, H.17
Poupart, M.A.18
Rancourt, J.19
Sentjens, R.E.20
St George, R.21
Simoneau, B.22
Steinmann, G.23
Thibeault, D.24
Tsantrizos, Y.S.25
Weldon, S.M.26
Yong, C.L.27
Llinas-Brunet, M.28
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