Recruitment of Gr-1+ monocytes is essential for control of acute toxoplasmosis

Journal of Experimental Medicine

Volumn 201, Issue 11, 2005, Pages 1761-1769

  Robben, Paul M ^a   LaRegina, Marie ^a   Kuziel, William A ^b,c   Sibley, L David ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^c PROTEIN DESIGN LABS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR2; GAMMA INTERFERON; INTERLEUKIN 12; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL FUNCTION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; EFFECTOR CELL; HOST SUSCEPTIBILITY; IMMUNE RESPONSE; IMMUNOREACTIVITY; IN VIVO STUDY; INFECTION RESISTANCE; LEUKOCYTE ACTIVATION; MONOCYTE; MORTALITY; MOUSE; MOUSE STRAIN; NONHUMAN; PARASITE CONTROL; PARASITE SURVIVAL; PARASITE VIRULENCE; PARASITOSIS; PATHOGENESIS; PRIORITY JOURNAL; TH1 CELL; TOXOPLASMA GONDII; TOXOPLASMOSIS;

ACUTE DISEASE; ANIMALS; ANTIGENS, CD; CELL MOVEMENT; CHEMOKINE CCL2; CYTOKINES; HOST-PARASITE RELATIONS; MICE; MICE, KNOCKOUT; MONOCYTES; RECEPTORS, CHEMOKINE; TH1 CELLS; TOXOPLASMA; TOXOPLASMOSIS, ANIMAL;

EID: 22344454821     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20050054     Document Type: Article

References (50)

1. Muller, W.A., and G.J. Randolph. 1999. Migration of leukocytes across endothelium and beyond: molecules involved in the transmigration and fate of monocytes. J. Leukoc. Biol. 66:698-704.
2. Passlick, B., D. Flieger, and H.W. Ziegler-Heitbrock. 1989. Identification and characterization of a novel monocytes subpopulation in human peripheral blood. Blood. 74:2527-2534.
3. Geissmann, F., S. Jung, and D.R. Littman. 2003. Blood monocytes consist of two principle subsets with distinct migratory properties. Immunity. 19:71-82.
4. Henderson, R.B., J.A.R. Hobbs, M. Mathies, and N. Hogg. 2003. Rapid recruitment of inflammatory monocytes is independent of neutrophil migration. Blood. 102:328-335.
5. Taylor, P.R., and S. Gordon. 2003. Pattern recognition receptors and differentiation antigens define murine myeloid cell heterogeneity ex vivo. Eur. J. Immunol. 33:2090-2097.
6. Luther, S.A., and J.G. Cyster. 2001. Chemokines as regulators of T cell differentiation. Nat. Immunol. 2:102-122.
7. Homey, B., A. Muller, and A. Zlotnik. 2002. Chemokines: agents for the immunotherapy of cancer? Nat. Rev. Immunol. 2:175-184.
8. Lu, B., B.J. Rutledge, L. Gu, J. Fiorillo, N.W. Lukacs, S.L. Kunkel, R. North, C. Gerard, and B.J. Rollins. 1998. Abnormalities in monocyte recruitment and cytokine expression in monocyte chemoattractant protein 1-deficient mice. J. Exp. Med. 187:601-608.
9. Kuziel, W.A., S.J. Morgan, T.C. Dawson, S. Griffin, O. Smithies, K. Ley, and N. Maeda. 1997. Severe reduction in leukocyte adhesion and monocyte extravasation in mice deficient in CC chemokine receptor 2. Proc. Natl. Acad. Sci. USA. 94:12053-12058.
10. Serbina, N.V., T.P. Salazar-Mather, C.A. Biron, W.A. Kuziel, and E.G.P. Am. 2003. TNF/iNOS-producing dendritic cells mediate innate immune defense against bacterial infection. Immunity. 19:59-70.
11. Hunter, C.A., and G. Reichmann. 2001. Immunology of Toxoplasma infection. In Toxoplasmosis. A Comprehensive Clinical Guide. D.H. Joynson and T.J. Wreghitt, editors. Cambridge University Press, New York. 43-57.
12. Suzuki, Y., M.A. Orellana, R.D. Schreiber, and J.S. Remington. 1988. Interferon-γ: the major mediator of resistance against Toxoplasma gondii. Science. 240:516-518.
13. Yap, G.S., and A. Sher. 1999. Effector cells of both nonhemopoietic and hemopoietic origin are required for interferon (IFN)-γ- and tumor necrosis factor (TNF)-α-dependent host resistance to the intracellular pathogen, Toxoplasma gondii. J. Exp. Med. 189:1083-1091.
14. Khan, I.A., T. Matsuura, and L.H. Kasper. 1994. Interleukin-12 enhances murine survival against acute toxoplasmosis. Infect. Immun. 62:1639-1642.
15. Gazzinelli, R.T., S. Heiny, T.A. Wynn, S. Wolf, and A. Sher. 1993. Interleukin 12 is required for the T-lymphocyte-independent induction of interferon γ by an intracellular parasite and induces resistance in T-cell-deficient mice. Proc. Natl. Acad. Sci. USA. 90:6115-6119.
16. Scharton-Kersten, T.M., T.A. Wynn, E.Y. Denkers, S. Bala, E. Grunvald, S. Hieny, R.T. Gazzinelli, and A. Sher. 1996. In the absence of endogenous IFN-γ mice develop unimpaired IL-12 responses to Toxoplasma gondii while failing to control acute infection. J. Immunol. 157:4045-4054.
17. Bennouna, S., S.K. Bliss, T.J. Curiel, and E.Y. Denkers. 2003. Cross-talk in the innate immune system: neutrophils instruct recruitment and activation of dendritic cells during microbial infection. J. Immunol. 171:6052-6058.
18. Bliss, S.K., L.C. Gavrilescu, A. Alcaraz, and E.Y. Denkers. 2001. Neutrophil depletion during Toxoplasma gondii infection leads to impaired immunity and lethal systemic pathology. Infect. Immun. 69:4898-4905.
19. Bliss, S.K., B.A. Butcher, and E.Y. Denkers. 2000. Rapid recruitment of neutrophils containing prestored IL-12 during microbial infection. J. Immunol. 165:4515-4521.
20. +. Nat. Immunol. 1:83-87.
21. Sousa, C.R., S. Hieny, T. Scharton-Kersten, D. Jankovic, H. Charest, R.N. Germain, and A. Sher. 1997. In vivo microbial stimulation induces rapid CD40 ligand-independent production of interleukin 12 by dendritic cells and their redistribution to T cell areas. J. Exp. Med. 186:1819-1829.
22. Sousa, C.R., G. Yap, O. Schulz, N. Rogers, M. Schito, J. Aliberti, S. Hieny, and A. Sher. 1999. Paralysis of dendritic cell IL-12 production by microbial products prevents infection-induced immunopathology. Immunity. 11:637-647.
23. Robben, P.M., D.G. Mordue, S.M. Truscott, K. Takeda, S. Akira, and L.D. Sibley. 2004. Induction of IL-12 by Toxoplasma gondii depends on the parasite genotype. J. Immunol. 172:3686-3694.
24. + activated macrophages induced during acute toxoplasmosis. J. Leukoc. Biol. 74:1015-1025.
25. Bliss, S.K., A.J. Marshall, Y. Zhang, and E.Y. Denkers. 1999. Human polymorphonuclear leukocytes produce IL-12, TNF-α, and the chemokines macrophage-inflammatory protein-1α and -1β in response to Toxoplasma gondii antigens. J. Immunol. 162:7369-7375.
26. Bliss, S.K., Y. Zhang, and E.Y. Denkers. 1999. Murine neutrophil stimulation by Toxoplasma gondii antigen drives high level production of IFN-γ-independent IL-12. J. Immunol. 163:2081-2088.
27. Adams, L.B., J.B. Hibbs, R.R. Taintor, and J.L. Krahenbuhl. 1990. Microbiostatic effect of murine-activated macrophages for Toxoplasma gondii: role for synthesis of inorganic nitrogen oxides from L-arginine. J. Immunol. 144:2725-2729.
28. Collazo, C.M., G.S. Yap, G.D. Sempowski, K.C. Lusby, L. Tessarollo, G.F. Woude, A. Sher, and G.A. Taylor. 2001. Inactivation of LRG-47 and IRG-47 reveals a family of interferon γ-inducible genes with essential, pathogen-specific roles in resistance to infection. J. Exp. Med. 194:181-188.
29. Pfefferkorn, E.R. 1984. Interferon-γ blocks the growth of Toxoplasma gondii in human fibroblasts by inducing the host to degrade tryptophan. Proc. Natl. Acad. Sci. USA. 81:908-912.
30. Del Rio, L., B.A. Butcher, S. Bennouna, S. Hieny, A. Sher, and E.Y. Denkers. 2004. Toxoplasma gondii triggers myeloid differentiation factor 88-dependent IL-12 and chemokine ligand 2 (monocyte chemoattractant protein 1) responses using distinct parasite molecules and host receptors. J. Immunol. 172:6954-6960.
31. Scanga, C.A., J. Aliberti, D. Jankovic, F. Tilloy, S. Bennouna, E.Y. Denkers, R. Medzhitov, and A. Sher. 2002. Cutting edge: MyD88 is required for resistance to Toxoplasma gondii infection and regulates parasite-induced IL-12 production by dendritic cells. J. Immunol. 168:5997-6001.
32. Del Rio, L., S. Bennouna, J. Salinas, and E.Y. Denkers. 2001. CXCR2 deficiency confers impaired neutrophil recruitment and increased susceptibility during Toxoplasma gondii infection. J. Immunol. 167:6503-6509.
33. Sayles, P.C., and L.L. Johnson. 1996-97. Exacerbation of toxoplasmosis in neutrophil-depleted mice. Nat. Immun. 15:249-258.
34. Mordue, D.G., F. Monroy, M. La Regina, C.A. Dinarello, and L.D. Sibley. 2001. Acute toxoplasmosis leads to lethal overproduction of Th1 cytokines. J. Immunol. 167:4574-4584.
35. Jung, S., J. Aliberti, P. Graemmel, M.J. Sunshine, G.W. Kreutzberg, A. Sher, and D.R. Littman. 2000. Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion. Mol. Cell. Biol. 20:4106-4114.
36. Gavrilescu, L.C., B.A. Butcher, L. Del Rio, G.A. Taylor, and E.Y. Denkers. 2004. STAT1 is essential for antimicrobial effector function but dispensable for gamma interferon production during Toxoplasma gondii infection. Infect. Immun. 72:1257-1264.
37. Peters, W., H.M. Scott, H.F. Chambers, J.L. Flynn, I.F. Charo, and J.D. Ernst. 2001. Chemokine receptor 2 serves and early and essential role in resistance to Mycobacterium tuberculosis. Proc. Natl. Acad. Sci. USA. 98:7958-7963.
38. Sato, N., W.A. Kuziel, P.C. Melby, R.L. Reddick, V. Kostecki, W. Zhao, N. Maeda, S.K. Ahuja, and S.S. Ahuka. 1999. Defects in the generation of IFN-gamma are overcome to control infection with Leishmania donovani in CC chemokine receptor (CCR) 5-, macrophage inflammatory protein-1 alpha- or CCR2-deficient mice. J. Immunol. 163:5519-5525.
39. Traynor, T.R., W.A. Kuziel, G.B. Toews, and G.B. Huffnagle. 2000. CCR2 expression determines T1 versus T2 polarization during pulmonary Cryptococcus neoformans infection. J. Immunol. 164:2021-2027.
40. Yap, G.S., T. Scharton-Kersten, H. Charest, and A. Sher. 1998. Decreased resistance of TNF receptor p55- and p75-deficient mice to chronic toxoplasmosis despite normal activation of inducible nitric oxide synthase in vivo. J. Immunol. 160:1340-1345.
41. Gu, L., S.C. Tseng, and B.J. Rollins. 1999. Monocyte chemoattractant protein-1. Chem. Immunol. 72:7-29.
42. Combiadere, C., S.K. Ahuka, J. Van Damme, H.L. Tiffany, J.L. Gao, and P.M. Murphy. 1995. Monocyte chemoattractant protein-3 is a functional ligand for CC chemokine receptors 1 and 2B. J. Biol. Chem. 270:29671-29675.
43. Sarafi, M.N., E.A. Garcia-Zepeda, J.A. MacLean, I.F. Charo, and A.D. Luster. 1997. Murine monocyte chemoattractant protein (MCP)-5: a novel CC chemokine that is a structural and functional homologue of human MCP-1. J. Exp. Med. 185:99-109.
44. Huang, D.R., J. Wang, P. Kivisakk, B.J. Rollins, and R.M. Ransohoff. 2001. Absence of monocyte chemoattractant protein 1 in mice leads to decreased local macrophage recruitment and antigen-specific T helper cell type 1 immune response in experimental autoimmune encephalomyelitis. J. Exp. Med. 193:713-726.
45. Denney, C.F., L. Eckmann, and S.L. Reed. 1999. Chemokine secretion of human cells in response to Toxoplasma gondii infection. Infect. Immun. 67:1547-1552.
46. Luangsay, S., L.H. Kasper, N. Rachinel, L.A. Minns, F.J. Mennechet, A. Vandewalle, and D. Buzoni-Gatel. 2003. CCR5 mediates specific migration of Toxoplasma gondii-primed CD8 lymphocytes to inflammatory intestinal epithelial cells. Gastroenterology. 125:491-500.
47. Khan, I.A., J.A. MacLean, F.S. Lee, L. Casciotti, E. DeHaan, J.D. Schwartzman, and A.D. Luster. 2000. IP-10 is critical for effector T cell trafficking and host survival in Toxoplasma gondii infection. Immunity. 12:483-494.
48. Yap, G.S., and A. Sher. 1999. Cell-mediated immunity to Toxoplasma gondii: initiation, regulation and effector function. Immunobiology. 201: 240-247.
49. Khan, I.A., P.M. Murphy, L. Casciotti, J.D. Schwartzman, J. Collins, J.L. Gao, and G.R. Yeaman. 2001. Mice lacking the chemokine receptor CCR1 show increased susceptibility to Toxoplasma gondii infection. J. Immunol. 166:1930-1937.
50. Kuehl, R.O. 1994. Statistical Principles of Research Design and Analysis. Duxbury Press, Belmont, CA. 686 pp.