-
2
-
-
0028957549
-
Efficacy and safety of monoclonal antibody to human tumor necrosis factor alpha in patients with sepsis syndrome. A randomized, controlled, double-blind, multicenter clinical trial
-
TNF-alpha MAb Sepsis Study Group
-
Abraham E, Wunderink R, Silverman H, et al: Efficacy and safety of monoclonal antibody to human tumor necrosis factor alpha in patients with sepsis syndrome. A randomized, controlled, double-blind, multicenter clinical trial. TNF-alpha MAb Sepsis Study Group. JAMA 1995; 273:934-941
-
(1995)
JAMA
, vol.273
, pp. 934-941
-
-
Abraham, E.1
Wunderink, R.2
Silverman, H.3
-
3
-
-
0029835023
-
INTERSEPT: An international, multicenter, placebo-controlled trial of monoclonal antibody to human tumor necrosis factor-α in patients with sepsis
-
Cohen J, Carlet J: INTERSEPT: An international, multicenter, placebo- controlled trial of monoclonal antibody to human tumor necrosis factor-alpha in patients with sepsis. International Sepsis Trial Study Group. Crit Care Med 1996; 24:1431-1440 (Pubitemid 26313741)
-
(1996)
Critical Care Medicine
, vol.24
, Issue.9
, pp. 1431-1440
-
-
Cohen, J.1
Carlet, J.2
-
4
-
-
0032495658
-
Double-blind randomised controlled trial of monoclonal antibody to human tumour necrosis factor in treatment of septic shock
-
DOI 10.1016/S0140-6736(00)80009-4
-
Abraham E, Anzueto A, Gutierrez G, et al: Double-blind randomised controlled trial of monoclonal antibody to human tumour necrosis factor in treatment of septic shock. NORASEPT II Study Group. Lancet 1998; 351:929-933 (Pubitemid 28138465)
-
(1998)
Lancet
, vol.351
, Issue.9107
, pp. 929-933
-
-
Abraham, E.1
Anzueto, A.2
Gutierrez, G.3
Tessler, S.4
San Pedro, G.5
Wunderink, R.6
Dal Nogare, A.7
Nasraway, S.8
Berman, S.9
Cooney, R.10
Levy, H.11
Baughman, R.12
Rumbak, M.13
Light, R.B.14
Poole, L.15
Allred, R.16
Constant, J.17
Pennington, J.18
Porter, S.19
-
5
-
-
0027406403
-
Influence of an anti-tumor necrosis factor monoclonal antibody on cytokine levels in patients with sepsis
-
Fisher CJ Jr, Opal SM, Dhainaut JF, et al: Influence of an anti-tumor necrosis factor monoclonal antibody on cytokine levels in patients with sepsis. The CB0006 Sepsis Syndrome Study Group. Crit Care Med 1993; 21:318-327 (Pubitemid 23097025)
-
(1993)
Critical Care Medicine
, vol.21
, Issue.3
, pp. 318-327
-
-
Fisher Jr., C.J.1
Opal, S.M.2
Dhainaut, J.-F.3
Stephens, S.4
Zimmerman, J.L.5
Nightingale, P.6
Harris, S.J.7
Schein, R.M.H.8
Panacek, E.A.9
Vincent -, J.L.10
Foulke, G.E.11
Warren, E.L.12
Garrard, C.13
Park, G.14
Bodmer, M.W.15
Cohen, J.16
Van Der Linden, C.17
Cross, A.S.18
Sadoff, J.C.19
-
6
-
-
9344246862
-
Assessment of the safety and efficacy of the monoclonal anti-tumor necrosis factor antibody-fragment, MAK 195F, in patients with sepsis and septic shock: A multicenter, randomized, placebo-controlled, dose-ranging study
-
Reinhart K, Wiegand-Löhnert C, Grimminger F, et al: Assessment of the safety and efficacy of the monoclonal anti-tumor necrosis factor antibody-fragment, MAK 195F, in patients with sepsis and septic shock: A multicenter, randomized, placebo-controlled, dose-ranging study. Crit Care Med 1996; 24:733-742
-
(1996)
Crit Care Med
, vol.24
, pp. 733-742
-
-
Reinhart, K.1
Wiegand-Löhnert, C.2
Grimminger, F.3
-
7
-
-
0029132699
-
CDP571, a humanized antibody to human tumor necrosis factor-alpha: Safety, pharmacokinetics, immune response, and influence of the antibody on cytokine concentrations in patients with septic shock
-
CPD571 Sepsis Study Group
-
Dhainaut JF, Vincent JL, Richard C, et al: CDP571, a humanized antibody to human tumor necrosis factor-alpha: Safety, pharmacokinetics, immune response, and influence of the antibody on cytokine concentrations in patients with septic shock. CPD571 Sepsis Study Group. Crit Care Med 1995; 23:1461-1469
-
(1995)
Crit Care Med
, vol.23
, pp. 1461-1469
-
-
Dhainaut, J.F.1
Vincent, J.L.2
Richard, C.3
-
8
-
-
0031671231
-
Effect of a chimeric antibody to tumor necrosis factor-α on cytokine and physiologic responses in patients with severe sepsis - A randomized, clinical trial
-
DOI 10.1097/00003246-199810000-00016
-
Clark MA, Plank LD, Connolly AB, et al: Effect of a chimeric antibody to tumor necrosis factor-alpha on cytokine and physiologic responses in patients with severe sepsis-a randomized, clinical trial. Crit Care Med 1998; 26:1650-1659 (Pubitemid 28467672)
-
(1998)
Critical Care Medicine
, vol.26
, Issue.10
, pp. 1650-1659
-
-
Clark, M.A.1
-
9
-
-
8244235133
-
P55 Tumor necrosis factor receptor fusion protein in the treatment of patients with severe sepsis and septic shock: A randomized controlled multicenter trial
-
Abraham E, Glauser MP, Butler T, et al: p55 Tumor necrosis factor receptor fusion protein in the treatment of patients with severe sepsis and septic shock. A randomized controlled multicenter trial. Ro 45-2081 Study Group. JAMA 1997; 277:1531-1538 (Pubitemid 27213302)
-
(1997)
Journal of the American Medical Association
, vol.277
, Issue.19
, pp. 1531-1538
-
-
Abraham, E.1
Glauser, M.P.2
Butler, T.3
Garbino, J.4
Gelmont, D.5
Laterre, P.F.6
Kudsk, K.7
Bruining, H.A.8
Otto, C.9
Tobin, E.10
Zwingelstein, C.11
Lesslauer, W.12
Leighton, A.13
-
10
-
-
0029900294
-
Treatment of septic shock with the tumor necrosis factor receptor:Fc fusion protein
-
DOI 10.1056/NEJM199606273342603
-
Fisher CJ Jr, Agosti JM, Opal SM, et al: Treatment of septic shock with the tumor necrosis factor receptor:Fc fusion protein. The Soluble TNF Receptor Sepsis Study Group. N Engl J Med 1996; 334:1697-1702 (Pubitemid 26193621)
-
(1996)
New England Journal of Medicine
, vol.334
, Issue.26
, pp. 1697-1702
-
-
Fisher Jr., C.J.1
Agosti, J.M.2
Opal, S.M.3
Lowry, S.F.4
Balk, R.A.5
Sadoff, J.C.6
Abraham, E.7
Schein, R.M.H.8
Benjamin, E.9
-
11
-
-
0022411888
-
Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin
-
Beutler B, Milsark IW, Cerami AC: Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin. Science 1985; 229:869-871 (Pubitemid 16246587)
-
(1985)
Science
, vol.229
, Issue.4716
, pp. 869-871
-
-
Beutler, B.1
Milsark, I.W.2
Cerami, A.C.3
-
12
-
-
80053957554
-
The evolving experience with therapeutic TNF inhibition in sepsis: Considering the potential influence of risk of death
-
Qiu P, Cui X, Barochia A, et al: The evolving experience with therapeutic TNF inhibition in sepsis: Considering the potential influence of risk of death. Expert Opin Investig Drugs 2011; 20:1555-1564
-
(2011)
Expert Opin Investig Drugs
, vol.20
, pp. 1555-1564
-
-
Qiu, P.1
Cui, X.2
Barochia, A.3
-
13
-
-
0037179653
-
Treating sepsis
-
Wenzel RP: Treating sepsis. N Engl J Med 2002; 347:966-967
-
(2002)
N Engl J Med
, vol.347
, pp. 966-967
-
-
Wenzel, R.P.1
-
14
-
-
0034958947
-
Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care
-
Angus DC, Linde-Zwirble WT, Lidicker J, et al: Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care. Crit Care Med 2001; 29:1303-1310 (Pubitemid 32641789)
-
(2001)
Critical Care Medicine
, vol.29
, Issue.7
, pp. 1303-1310
-
-
Angus, D.C.1
Linde-Zwirble, W.T.2
Lidicker, J.3
Clermont, G.4
Carcillo, J.5
Pinsky, M.R.6
-
15
-
-
0038482456
-
Such stuff as dreams are made on: Mediator-directed therapy in sepsis
-
DOI 10.1038/nrd1084
-
Marshall JC: Such stuff as dreams are made on: Mediator-directed therapy in sepsis. Nat Rev Drug Discov 2003; 2:391-405 (Pubitemid 37361709)
-
(2003)
Nature Reviews Drug Discovery
, vol.2
, Issue.5
, pp. 391-405
-
-
Marshall, J.C.1
-
16
-
-
0032443734
-
The sirens' songs of confirmatory sepsis trials: Selection bias and sampling error
-
DOI 10.1097/00003246-199812000-00001
-
Natanson C, Esposito CJ, Banks SM: The sirens' songs of confirmatory sepsis trials: Selection bias and sampling error. Crit Care Med 1998; 26:1927-1931 (Pubitemid 29016658)
-
(1998)
Critical Care Medicine
, vol.26
, Issue.12
, pp. 1927-1931
-
-
Natanson, C.1
Esposito, C.J.2
Banks, S.M.3
Magnuson, W.G.4
-
17
-
-
0034913364
-
Anti-tumor necrosis factor therapy in sepsis: Update on clinical trials and lessons learned
-
Reinhart K, Karzai W: Anti-tumor necrosis factor therapy in sepsis: Update on clinical trials and lessons learned. Crit Care Med 2001; 29(7 Suppl):S121-S125 (Pubitemid 32681594)
-
(2001)
Critical Care Medicine
, vol.29
, Issue.7 SUPPL.
-
-
Reinhart, K.1
Karzai, W.2
-
18
-
-
84863404346
-
A placebo-controlled, double- blind, dose-escalation study to assess the safety, tolerability and pharmacokinetics/pharmacodynamics of single and multiple intravenous infusions of AZD9773 in patients with severe sepsis and septic shock
-
Morris PE, Zeno B, Bernard AC, et al: A placebo-controlled, double- blind, dose-escalation study to assess the safety, tolerability and pharmacokinetics/pharmacodynamics of single and multiple intravenous infusions of AZD9773 in patients with severe sepsis and septic shock. Crit Care 2012; 16:R31
-
(2012)
Crit Care
, vol.16
-
-
Morris, P.E.1
Zeno, B.2
Bernard, A.C.3
-
19
-
-
8544262221
-
2 fragment afelimomab in patients with severe sepsis and elevated interleukin-6 levels
-
DOI 10.1097/01.CCM.0000145229.59014.6C
-
Panacek EA, Marshall JC, Albertson TE, et al; Monoclonal Anti-TNF: A Randomized Controlled Sepsis Study Investigators: Efficacy and safety of the monoclonal anti-tumor necrosis factor antibody F(ab')2 fragment afelimomab in patients with severe sepsis and elevated interleukin-6 levels. Crit Care Med 2004; 32:2173-2182 (Pubitemid 39491795)
-
(2004)
Critical Care Medicine
, vol.32
, Issue.11
, pp. 2173-2182
-
-
Panacek, E.A.1
Marshall, J.C.2
Albertson, T.E.3
Johnson, D.H.4
Johnson, S.5
MacArthur, R.D.6
Miller, M.7
Barchuk, W.T.8
Fischkoff, S.9
Kaul, M.10
Teoh, L.11
Van Meter, L.12
Daum, L.13
Lemeshow, S.14
Hicklin, G.15
Doig, C.16
-
20
-
-
33747502519
-
Safety and efficacy of affinity-purified, anti-tumor necrosis factor-α, ovine fab for injection (CytoFab) in severe sepsis
-
DOI 10.1097/01.CCM.0000230385.82679.34, PII 0000324620060900000001
-
Rice TW, Wheeler AP, Morris PE, et al: Safety and efficacy of affinity- purified, anti-tumor necrosis factor-alpha, ovine fab for injection (CytoFab) in severe sepsis. Crit Care Med 2006; 34:2271-2281 (Pubitemid 44260009)
-
(2006)
Critical Care Medicine
, vol.34
, Issue.9
, pp. 2271-2281
-
-
Rice, T.W.1
Wheeler, A.P.2
Morris, P.E.3
Paz, H.L.4
Russell, J.A.5
Edens, T.R.6
Bernard, G.R.7
-
21
-
-
0006371989
-
Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. 1992
-
ACCP/SCCM Consensus Conference Committee
-
Bone RC, Balk RA, Cerra FB, et al; ACCP/SCCM Consensus Conference Committee: Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/ SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. 1992. Chest 2009; 136(5 Suppl):e28
-
(2009)
Chest
, vol.136
, Issue.5 SUPPL.
-
-
Bone, R.C.1
Balk, R.A.2
Cerra, F.B.3
-
22
-
-
0029914622
-
Assessing the quality of reports of randomized clinical trials: Is blinding necessary?
-
DOI 10.1016/0197-2456(95)00134-4
-
Jadad AR, Moore RA, Carroll D, et al: Assessing the quality of reports of randomized clinical trials: Is blinding necessary? Control Clin Trials 1996; 17:1-12 (Pubitemid 26120810)
-
(1996)
Controlled Clinical Trials
, vol.17
, Issue.1
, pp. 1-12
-
-
Jadad, A.R.1
Moore, R.A.2
Carroll, D.3
Jenkinson, C.4
Reynolds, D.J.M.5
Gavaghan, D.J.6
McQuay, H.J.7
-
23
-
-
0034895949
-
A multicenter, open-label, prospective, randomized, dose-ranging pharmacokinetic study of the anti-TNF-α antibody afelimomab in patients with sepsis syndrome
-
Gallagher J, Fisher C, Sherman B, et al: A multicenter, open-label, prospective, randomized, dose-ranging pharmacokinetic study of the anti-TNF-alpha antibody afelimomab in patients with sepsis syndrome. Intensive Care Med 2001; 27:1169-1178 (Pubitemid 32710204)
-
(2001)
Intensive Care Medicine, Supplement
, vol.27
, Issue.1
, pp. 1169-1178
-
-
Gallagher, J.1
Fisher, C.2
Sherman, B.3
Munger, M.4
Meyers, B.5
Ellison, T.6
Fischkoff, S.7
Barchuk, W.T.8
Teoh, L.9
Velagapudi, R.10
-
24
-
-
0035046049
-
Randomized, placebo-controlled trial of the anti-tumor necrosis factor antibody fragment afelimomab in hyperinflammatory response during severe sepsis: The RAMSES study
-
Reinhart K, Menges T, Gardlund B, et al: Randomized, placebocontrolled trial of the anti-tumor necrosis factor antibody fragment afelimomab in hyperinflammatory response during severe sepsis: The RAMSES study. Crit Care Med 2001; 29:765-769 (Pubitemid 32299714)
-
(2001)
Critical Care Medicine
, vol.29
, Issue.4
, pp. 765-769
-
-
Reinhart, K.1
Menges, T.2
Gardlund, B.3
Zwaveling, J.4
Smithes, M.5
Vincent, J.-L.6
Tellado, J.M.7
Salgado-Remigio, A.8
Zimlichman, R.9
Withington, S.10
Tschaikowsky, K.11
Brase, R.12
Damas, P.13
Kupper, H.14
Kempeni, J.15
Eiselstein, J.16
Kaul, M.17
-
25
-
-
0035100346
-
Lenercept (p55 tumor necrosis factor receptor fusion protein) in severe sepsis and early septic shock: A randomized, double-blind, placebo-controlled, multicenter phase III trial with 1,342 patients
-
Abraham E, Laterre PF, Garbino J, et al; Lenercept Study Group: Lenercept (p55 tumor necrosis factor receptor fusion protein) in severe sepsis and early septic shock: A randomized, double-blind, placebo-controlled, multicenter phase III trial with 1,342 patients. Crit Care Med 2001; 29:503-510 (Pubitemid 32225290)
-
(2001)
Critical Care Medicine
, vol.29
, Issue.3
, pp. 503-510
-
-
Abraham, E.1
Laterre, P.-F.2
Garbino, J.3
Pingleton, S.4
Butler, T.5
Dugernier, T.6
Margolis, B.7
Kudsk, K.8
Zimmerli, W.9
Anderson, P.10
Reynaert, M.11
Lew, D.12
Lesslauer, W.13
Passe, S.14
Cooper, P.15
Burdeska, A.16
Modi, M.17
Leighton, A.18
Salgo, M.19
Van Der Auwera, P.20
more..
-
26
-
-
84869866090
-
Outcomes of the Surviving Sepsis Campaign in intensive care units in the USA and Europe: A prospective cohort study
-
Levy MM, Artigas A, Phillips GS, et al: Outcomes of the Surviving Sepsis Campaign in intensive care units in the USA and Europe: A prospective cohort study. Lancet Infect Dis 2012; 12:919-924
-
(2012)
Lancet Infect Dis
, vol.12
, pp. 919-924
-
-
Levy, M.M.1
Artigas, A.2
Phillips, G.S.3
-
28
-
-
65449188293
-
The effects of steroids during sepsis depend on dose and severity of illness: An updated meta-analysis
-
Minneci PC, Deans KJ, Eichacker PQ, et al: The effects of steroids during sepsis depend on dose and severity of illness: An updated meta-analysis. Clin Microbiol Infect 2009; 15:308-318
-
(2009)
Clin Microbiol Infect
, vol.15
, pp. 308-318
-
-
Minneci, P.C.1
Deans, K.J.2
Eichacker, P.Q.3
-
29
-
-
33646786804
-
Neutralization of tumor necrosis factor in preclinical models of sepsis
-
Lorente JA, Marshall JC: Neutralization of tumor necrosis factor in preclinical models of sepsis. Shock 2005; 24(Suppl 1):107-119
-
(2005)
Shock
, vol.24
, Issue.SUPPL. 1
, pp. 107-119
-
-
Lorente, J.A.1
Marshall, J.C.2
-
30
-
-
0036840629
-
Risk and the efficacy of antiinflammatory agents: Retrospective and confirmatory studies of sepsis
-
DOI 10.1164/rccm.200204-302OC
-
Eichacker PQ, Parent C, Kalil A, et al: Risk and the efficacy of antiinflammatory agents: Retrospective and confirmatory studies of sepsis. Am J Respir Crit Care Med 2002; 166:1197-1205 (Pubitemid 35222596)
-
(2002)
American Journal of Respiratory and Critical Care Medicine
, vol.166
, Issue.9
, pp. 1197-1205
-
-
Eichacker, P.Q.1
Parent, C.2
Kalil, A.3
Esposito, C.4
Cui, X.5
Banks, S.M.6
Gerstenberger, E.P.7
Fitz, Y.8
Danner, R.L.9
Natanson, C.10
-
31
-
-
9344240407
-
Use of predicted risk of mortality to evaluate the efficacy of anticytokine therapy in sepsis. The rhIL-1ra Phase III Sepsis Syndrome Study Group
-
Knaus WA, Harrell FE Jr, LaBrecque JF, et al: Use of predicted risk of mortality to evaluate the efficacy of anticytokine therapy in sepsis. The rhIL-1ra Phase III Sepsis Syndrome Study Group. Crit Care Med 1996; 24:46-56
-
(1996)
Crit Care Med
, vol.24
, pp. 46-56
-
-
Knaus, W.A.1
Harrell Jr., F.E.2
Labrecque, J.F.3
-
32
-
-
84884894957
-
-
Accessed January 13, 2013
-
BTG kills AZD9773 development. Available at: http://www.dddmag.com/news/ 2012/08/btg-kills-azd9773-development. Accessed January 13, 2013
-
BTG Kills AZD9773 Development
-
-
|